|
HS Code |
393059 |
| Product Name | Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) |
| Cas Number | 3964-52-1 |
| Molecular Formula | C6H6ClNO · HCl |
| Molecular Weight | 196.04 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water |
| Melting Point | 228-233°C (decomposes) |
| Purity | Typically ≥ 98% |
| Storage Conditions | Store at room temperature, away from light and moisture |
| Synonyms | 4-Amino-3-chlorophenol hydrochloride |
| Hazard Classification | Irritant |
As an accredited Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | White, tamper-evident, screw-cap plastic bottle labeled "Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1), 25g" with hazard warnings. |
| Shipping | Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) should be shipped in tightly sealed containers, protected from moisture, light, and incompatible substances. It is typically transported as a hazardous chemical, following relevant regulations for toxic and corrosive materials, with appropriate labeling and documentation. Ensure secure packaging to prevent leaks and spills during transit. |
| Storage | Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers. Protect from light and moisture. Store at room temperature and avoid exposure to heat. Ensure proper labeling and secure storage to prevent unauthorized access or accidental release. |
Competitive Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) prices that fit your budget—flexible terms and customized quotes for every order.
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Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) belongs to a small group of aromatic intermediates used with precision in fields ranging from specialty dyes to pharmaceutical synthesis. Having produced this compound for years, we view it not as just another chemical, but as a fine-tuned result of controlled synthesis and mindful process management. Every batch leaves our plant only after passing rigorous quality benchmarks. Our teams have learned, through hands-on experience, how sensitive this material can be to trace impurities, changes in temperature, or handling protocols. These insights shape how we structure each stage of production, right from choosing reliable raw materials to drying and packaging for shipment.
Laboratory teams working with intermediates like Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) often focus on how small differences in purity shift results at scale. During early years, we encountered situations where even trace levels of competing isomers or residual solvents led to off-target synthesis or unexpected color changes in dye precursors. Several pharmaceutical partners—especially in pilot campaigns—shared feedback that only batches tested to a high degree of purity functioned as intended in catalyst-driven processes.
Years of iterative feedback from formulation partners taught us to double down on analytical checks, including specific attention to moisture, residual chlorides, and trace nitrogen-containing byproducts. Unlike some standard phenol derivatives, the hydrochloride salt form binds up reactivity in a way that's both useful and demanding. This version’s stability under normal plant storage stands higher compared to its free base, but even faint temperature spikes can open the door for breakdown—resulting in yellowing or loss of desired activity. We invested in jacketed reactors and inerted packaging lines because earlier basic setups couldn’t deliver repeatability for loads measured even in the tens of kilograms.
Process chemists lean on our certificate of analysis, but more than a piece of paper, it reflects our manufacturing know-how. For example, the sharp melting point of this hydrochloride salt combined with clear color reflects hands-on troubleshooting in our crystallization process to minimize ambiguities for the downstream user.
Synthetic chemists looking for diversity in amine-substituted chloro phenol units focus on availability and reactivity. Unlike common spa chemicals or mass-market cleaning agents, this compound finds its home in targeted, high-value steps. We supply to developers working on azo dyes, especially those seeking tailored hues for specialty textiles or pigment applications. A color shift or a drop in yield often traces not to the dye process, but the consistency of this particular intermediate.
Over time, we've learned that its utility in the pharmaceutical sector sits in derivatization—where ring-substituted phenols form the heart of more complex, bioactive molecules. During early years supplying to custom manufacturers, our teams would get callback requests for clarification on crystalline state or solubility profile. Because we manage every step on-site, we’re able to walk clients through process adjustments, whether that means selecting an extra filtration step or ensuring the blend matches a defined polymorph. In one project, the difference between a failed and successful coupling reaction sat with our shift to a slightly slower hydrochloride salt precipitation, a discovery guided by hands-on troubleshooting rather than guesswork.
The hydrochloride form ensures that during handling and measurement in humid conditions, users get measured, reproducible results. Moisture uptake shifts both purity and performance, which is why process improvements pursue minimized exposure at every step. Other phenol derivatives, especially those carrying only amine or chloro groups without the additional hydrochloride binding, fall short of this stability when scaled up or stored for longer periods. This distinction only becomes clear once projects move from analytical scales to full manufacturing.
From the first step, our approach remains hands-on. We start with high-grade phenol and skilled operators. Chloro substitution and amination take place under controlled batch reactions—each one tracked by in-line sensors and lab checks. We transitioned from open kettles to closed-loop reactors years ago. This change cut down side reactions and let us better track the exact moment hydrochloride forms. Strict nitrogen blanketing at the hydrochloride addition step matters, especially when process temperatures rise. Experience showed that missing this step led to subtle color shifts, causing downstream delays for clients.
Each batch undergoes TLC and HPLC checks not just for the main product, but for any residual raw materials or side-aromatics. We track both melting point and spectral purity, and internal teams run process improvement loops every month. Some competitors buy in intermediates or partially processed lots, introducing variability that shows up during client pilot runs. We keep everything under our own roof which helps us troubleshoot faster, answer technical queries accurately, and guarantee our batches behave the same way in every order—as evidenced by customer retention.
Batches ship out after comprehensive drying and stability checks because moisture isn’t simply a matter of caking or clumping. It triggers real-world losses in reactivity or shelf life. Colleagues in storage and handling have worked directly with our supply chain partners, training on packaging best practices and early warning indicators of temperature or humidity spikes in transit. This sort of feedback loop makes a visible difference in keeping our product shelf-stable months after receipt.
Lab teams and process heads often ask for a direct comparison with plain 4-amino-3-chlorophenol or the free base. Over the years, field data makes the choice between them less about price, more about performance and reliability. The hydrochloride 1:1 salt delivers higher shelf stability and a defined, tightly clustered melting point. This becomes especially valuable in any process where fine weighing or dosage forms matter. We see labs switching back to our hydrochloride version after encountering unexplained losses with the free base, which tends to oxidize or brown under typical plant lighting or at moderate humidity.
Other derivatives such as 4-Amino-2-Chlorophenol and 4-Amino-3-Bromophenol, though similar on the surface, display distinctly different reactivity and handling needs. Our clients working in dyestuff synthesis report the 4-amino-3-chloro-hydrochloride gives more consistent coupling and cleaner end-colors. The same feedback arises in pharmaceutical settings: predictable purification and absence of extra salt byproducts make the 1:1 hydrochloride easier to work up, saving both time and solvent use downstream.
From direct observation, the hydrochloride version compares favorably for anyone scaling up. During trial runs aimed at transitioning from pilot scale to full plant batch, monitoring a stable melting range and low hygroscopicity reduced waste and the need for batch reprocessing. Knowing your input responds the same way month in and month out can turn an arduous process into an efficient, repeatable one. In contrast, the free base and unsalted forms, while slightly cheaper, often catch teams off-guard with undefined impurity profiles or shifts in flowability and solubility. Such issues carry real costs measured in delayed project timelines and upset production schedules.
Safety and shelf life join together as both practical and regulatory concerns. Handling aromatic amines and chlorinated compounds brings hazards that go beyond routine PPE. We’ve faced evolving emission standards, especially as local regulations flagged aromatic amine volatility and potential exposure risks. Upgrading venting and containment along with in-plant monitoring became non-negotiable after older open system methods led to odor issues and employee concerns. This hard-won experience prompted a makeover of our plant’s air handling and filtration infrastructure.
Transporting hydrochloride salts comes with unique challenges. Early shipments faced issues with packaging integrity, particularly under long-haul or summer routes. Desiccant packs, double-layered PE liners, and bottles designed to withstand light and air ingress now ship standard with every order. Rather than viewing packaging as an afterthought, our shipping team puts every design through mock stress tests—simulating bumpy roads, stacking, and seasonal humidity. This approach came directly out of hard lessons learned from minor leaks or compromised seals on earlier batches, when quick fixes after arrival turned into costly rework or returns.
Maintaining regulatory compliance and staff training has become second nature in efficient production runs of Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1). Every process chemist on our team spends time both at the bench and in the control room, learning what each variance means in practical terms. Checklists alone won’t sustain a safe, reliable operation. Embedded mentorship—pairing new hires with proven staff—has led to early detection of process deviations and faster troubleshooting. A strong in-house culture of communication ensures process upsets or customer feedback translate into proactive change rather than paper fixes.
Traceability from incoming raw materials to outgoing finished product stands as one of our key lessons. After discovering a single drum of phenol with atypical iron content led to months of customer complaints downstream, we instituted tracked batch numbers, routine supplier audits, and parallel sampling of key raw materials. This discipline isn’t glamorous, but it’s the backbone of meeting demanding regulatory reviews, especially in pharmaceutical supply chains.
Supplying Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) means interacting daily with experts beyond our own plant. Customers’ process development teams often run pilot trials and call for recommendations when scaling up or troubleshooting. We encourage early, direct technical exchanges. Often a project manager or chemist calls about a critical reaction step and asks for advice about optimal handling, dissolution, or purification. Because we operate our own production and testing, we can suggest real adjustments—such as storage conditions, optimal solvents, and agitation rates—that save lab time and production resources.
Feedback isn’t a paperwork afterthought. It shapes how we plan upcoming batches or tweak purification steps. A case in point—one partner in pigment formulation noticed subtle tint shifts with our product compared to another supplier. This led us to review and refine particle size controls and off-gas venting earlier in the process, closing the loop between measurement and application. Customers benefit from the improvements, and so does our plant, with reduced need for complaint follow-ups and returns.
In the early days, troubleshooting often felt like putting out fires after the fact. Over time, open communication with clients and solicitation of real-world feedback helped us reduce those surprises. For example, we now provide optional technical bulletins detailing moisture handling and test results from accelerated aging, drawn straight from our own stability workshops. Sharing what we’ve learned empowers our customers’ engineers and lab teams to get successful results without expensive do-overs or extended learning curves.
Meeting rising demand means more than increasing warehouse stocks. Expansion planning points to the need for more robust automation and environmentally sound waste management. Process safety becomes even more critical as we scale, so our upcoming investments center on in-line analytics, advanced waste scrubbers, and tighter solvent loop closures.
As downstream regulatory standards toughen—especially in pharmaceutical and specialty dye chains—we see an ongoing push for transparency in chemical sourcing and production practices. Maintaining open process logs and providing batch-by-batch analytical history builds customer confidence and meets evolving compliance standards. Continuous education and technical outreach form a cornerstone of this approach. Our veteran staff pass along lessons learned to both new colleagues and industry partners, ensuring knowledge doesn’t bottleneck with one department or retire along with one person.
Clarity also drives our relationship with end users. Markets for specialty intermediates demand tailored storage solutions, specific solubility profiles, and clearly documented impurity limits. Documentation means little without the manufacturing expertise to back it up. In-house innovation and the willingness to revisit even long-set procedures enable us to keep pace with every industry trend and regulatory shift. For Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1), success at scale involves more than a successful synthesis—it’s about ensuring reliable performance batch after batch, across every application, and through close partnerships that drive improvements from plant floor to final formulation.
Manufacturing Phenol, 4-Amino-3-Chloro-, Hydrochloride (1:1) stands as a demonstration of the interplay between chemistry and practical know-how. Every improvement, from reaction optimization to storage and shipping, comes through direct learning and honest appraisal of what works. Experience in this space tells us that details count: purity, particle size, color, and even small process tweaks impact both the bottom line and the final product experienced by the end user. Staying grounded in direct manufacturing and collaborative exchange, rather than insulating ourselves behind paperwork or templates, helps us evolve and deliver more than just a commodity—it cements our role as a partner in innovation and reliability.
