|
HS Code |
102435 |
| Chemicalname | Phenol, 2,4-Difluoro-5-Nitro- |
| Casnumber | 329-73-7 |
| Molecularformula | C6H3F2NO3 |
| Molecularweight | 175.09 g/mol |
| Appearance | Yellow crystalline solid |
| Meltingpoint | 78-82°C |
| Solubilityinwater | Slightly soluble |
| Purity | Typically ≥98% |
| Smiles | OC1=C(F)C=C([N+](=O)[O-])C(F)=C1 |
| Inchi | InChI=1S/C6H3F2NO3/c7-3-1-4(8)6(10(12)13)2-5(3)9/h1-2,9H |
As an accredited Phenol, 2,4-Difluoro-5-Nitro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The packaging for Phenol, 2,4-Difluoro-5-Nitro- typically features a 25g amber glass bottle with a secure, chemical-resistant screw cap. |
| Shipping | Phenol, 2,4-Difluoro-5-Nitro- should be shipped in tightly sealed, properly labeled containers. Protect from light, heat, and moisture. Transport according to relevant regulations (e.g., DOT, IATA, IMDG) for hazardous chemicals. Handle with care, using protective gear. Ensure documentation includes hazard identification and emergency contact details during shipping. |
| Storage | **Phenol, 2,4-Difluoro-5-Nitro-** should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition, moisture, and direct sunlight. Store separately from incompatible substances such as strong oxidizers, bases, and reducing agents. Clearly label the container and ensure access is limited to trained personnel. Use secondary containment to prevent spills. |
Competitive Phenol, 2,4-Difluoro-5-Nitro- prices that fit your budget—flexible terms and customized quotes for every order.
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Phenol, 2,4-Difluoro-5-Nitro-, often recognized in laboratories by its CAS number, stands apart in the field of halogenated nitrophenols. Over decades of hands-on chemical synthesis, our team has worked alongside many types of nitrated phenolic compounds. 2,4-Difluoro-5-Nitrophenol consistently attracts attention among research chemists, material scientists, and pharmaceutical developers because of its combination of electronic influences from both fluorine and nitro substituents.
The molecular backbone, a phenol ring substituted at the 2- and 4- positions by fluorine atoms and at the 5- position by a nitro group, lends a distinctive profile: high electron-withdrawing capacity without compromising reactivity at other points on the aromatic core. This unique arrangement changes how it interacts both with reagents and with biological systems.
After years of continuous process improvement, our synthesis yields a product with typically greater than 99% purity, verified by HPLC and GC. Most professional clients prefer crystalline powder, pale yellow to light tan in color, free-flowing, non-caking, and with an identifiable melting point in the 90s Celsius, properties that match our routine output. Details go beyond checklist specifications.
With this molecule, batch-to-batch consistency comes from stringent temperature control during nitration and careful timing during halogenation. Even trace moisture left before final filtration affects not only appearance but also solubility parameters in downstream reactions. Every regular production run comes with its own challenges: fluorine substitution at both ortho and para positions introduces handling difficulties, including increased volatility of byproducts and more pronounced potential for skin or respiratory irritation during open transfer.
Our workers, equipped with years of practice handling halogenated phenolics, avoid dust generation and maintain clean working surfaces between steps. Routine safety and standard operating procedures evolved from actual near-misses. For example, a few years ago a clogged glass line during precipitation created an unexpected exotherm; since then, modified agitation and venting methods have kept that risk at bay. These lessons do not show up on a standard product spec sheet.
In practice, 2,4-Difluoro-5-Nitrophenol finds strong utility as an intermediate for more complex organic synthesis. Its activated phenolic hydrogen enables quick subsequent reactions with alkylating agents or nucleophiles, making it a dependable stepping stone for many advanced pharmaceutical and agrochemical ingredients. Our customers have provided feedback: some pharmaceuticals rely on the unique electron-withdrawing pattern to stabilize specific intermediates, supporting syntheses not feasible with related nitrophenols or plain difluorophenols.
Analytical chemists appreciate the molecule’s behavior in spectroscopic analysis, particularly its predictable shifts in NMR and its high absorbance in UV-vis, helping in purity assays and research structure elucidation.
Materials scientists occasionally leverage it as a monomer or precursor when working toward specialty polymers or as a starting point for advanced functionalized aromatic compounds. A difference emerges when customers attempt to substitute this compound with related chemicals; loss in selective reactivity, altered physical properties, and changes in downstream yields force many teams to return to this original compound.
Across decades in this industry, we have handled wide spans of nitrophenols, difluorophenols, and other halogenated aromatics. Subtle shifts in the substitution pattern yield massive changes in reactivity and safety profile. Compared to the more familiar 4-nitrophenol or 2,4-dinitrophenol, 2,4-Difluoro-5-Nitrophenol brings distinctive value because of its balanced electron-withdrawing influence. Dual fluorine atoms on the aryl ring shift electron density away, but not so aggressively as multiple nitros. This enhances stability yet preserves accessibility at desired reaction sites.
Other nitrophenols may provide higher acidity or stronger coloration, but they tend to reduce yields or create excess tarry byproducts when subjected to similar downstream alkylation or condensation reactions. Our long-term researchers note that while 2,4-difluorophenol, for example, maintains good stability and moderate reactivity, it fails to offer the same level of activation in coupling or substitution reactions. The addition of a nitro group at the 5-position without overloading the ring with electron withdrawal preserves synthetic flexibility, important in complex molecule construction.
Material handling properties also differ dramatically. We have observed over the years that certain batches of isomeric nitrophenols clump or self-ignite during scale-up, but batches of 2,4-Difluoro-5-Nitro-Phenol remain relatively free-flowing and less sensitive to accidental static discharge, provided normal handling standards are followed.
Real-world manufacturing goes far beyond the text of a chemical catalog. Every bulk customer shares common worries: supply chain reliability, impurity management, and regulatory hazards. Meeting those concerns starts with honest production tracking and sharing real data from every batch—not just final purity but also trace impurity profile, appearance, and moisture content. Over multiple years, analytical records show that differences in minor byproducts can alter downstream process reproducibility, especially for pharmaceutical clients. We recommend in-person pre-ship product reviews when a new customer intends to use this phenol for high-value or highly regulated applications.
On top of supply reliability, regulatory frameworks keep evolving. Early on, we made sure to catalog our precursors, intermediates, and waste streams according to emerging standards in Europe, North America, and East Asia. By controlling and documenting each step, we help our customers speed their own compliance efforts. Sometimes a project stalls not because of technical failure but because a regulator asks for historical sourcing records or batch control evidence. Decades of documentation in our own plant have rescued more than one downstream launch.
We do not believe in cut corners. Plant-scale processing exposes quality issues that remain invisible in laboratory glassware. To avoid customer recalls and product returns, we monitor for persistent contaminants, including halogenated tars, excess acidity from incomplete neutralization, and rare meta-substituted isomers. In one instance, a shift in our own local water supply increased chloride content, requiring a new filtration step and rework protocols.
Nitrophenolic compounds introduce special handling and health risks, both operationally and in downstream workplaces. Over the years, direct exposure incidents, though rare, have taught us to establish double-layered containment in key processing rooms, special negative-pressure ventilation around fine powder transfer areas, and scheduled medical checks for handling personnel. Every product label and safety document we circulate has evolved out of actual incidents and regulator inspections, making our expertise in regulatory reporting a real value to our buyers.
Customers frequently ask for tailored particle size distributions or alternate solvent recrystallizations. Not every request proves feasible at industrial scale, and some proposals would increase worker risk or environmental discharge hazards. Rather than promise the impossible, we invite customer teams on-site to discuss process options. This policy emerged after a client insisted on an ultra-fine powder for high-speed reactors—a project that, once tested in our own facility, resulted in bulk product bridging and handling blockages, risking both batch loss and employee safety. We both agreed to revert to a less specialized grind, maintaining process safety and reliability.
Our experience tells us that demand for 2,4-Difluoro-5-Nitrophenol comes in cycles: new pharmaceutical actives, specialty monomer demands, and fine chemical advances all trigger sudden surges. As a manufacturing company, keeping finished stock on hand only goes so far—real customer trust comes from candid forecasts, conservative supply promises, and letting long-term partners know about potential upstream disruptions. During a global fluorine raw material shortage a few years ago, regular calls with key customers let many adapt recipes or change production schedules with minimal disruption.
Digitalization and traceability have become industry imperatives. We now tie every package, drum, and tote to individual quality and batch production records and maintain digital access logs, so investigative or compliance requests are handled in minutes, not weeks. Secure data retention extends beyond compliance—it helps researchers at customer sites confirm historic lots if anomalous results appear years later.
Recurring field reports from our partners illustrate how 2,4-Difluoro-5-Nitrophenol’s balance of reactivity and safety allows expansion into applications not planned in original plant design. One large materials group engineered a polymer additive using this molecule as their building block, reporting enhanced flame resistance and novel mechanical properties. In another case, a biotech startup experimented with it in screening libraries, leveraging its reactivity and unique electronic profile to generate tool compounds for enzyme inhibitor research. This feedback loop between manufacturer and end-user shapes not only process improvements but also research investments.
Users concerned about residue control and environmental safety gain confidence from our long-term waste handling protocols: phenolic, nitrate, and fluorinated wastes follow full regulatory tracking, meaning downstream users can present documentation during inspections. Site visits by environmental auditors yielded recommendations—in response, we implemented upgraded storage for spent mother liquor and installed finer particulate capture filters, reducing downstream discharges and achieving stricter compliance at lower cost.
Technical support grows from hands-on experience, not just certificate training. Our process engineers share live video walkthroughs, troubleshoot customer plant integration issues, and help with analytical method validation. On plant visits, we often uncover user errors caused by process misunderstanding—solving these on-site saves time, cuts cost, and builds trust. Training documents we provide are tailored, reflecting both customer SOPs and our most reliable in-house practices.
Over time, we have curated a library of case studies based on real bottlenecks: filtration steps that unexpectedly grind to a halt, product stability issues resulting from improper container use, and even incidents of color changes from unintended light exposure—all situations our staff resolved by drawing on firsthand process experience. These success stories flow back to our core processes and resource planning.
Manufacturing a complex aromatic like 2,4-Difluoro-5-Nitrophenol at industrial scale demands more than equipment and raw materials. Long-standing business relationships, institutional memory, and detailed record-keeping separate dependable sources from occasional traders. As chemical regulations grow stricter and supply chains stretch across borders, we double down on the fundamentals: clean, reproducible reactions, accurate record-keeping, direct client communication, and sharing best safety practices with all partners.
Chemicals like this one are not just products—they are the outcome of teamwork, attention to detail, and honest dialogue between those who make them and those who depend on them. We believe that by sharing our production experience and real-world lessons, everyone in the value chain gains capacity to innovate, adapt, and deliver safer, more effective technologies.
Every new application for 2,4-Difluoro-5-Nitrophenol further clarifies its place at the intersection of performance, practicality, and safety. Our direct involvement in its manufacture has reinforced one truth: genuine, transparent production practices outweigh technical data sheets and standard marketing. Customers consistently learn that proper supplier selection means fewer problems, more predictable results, and the confidence to expand their own businesses. By prioritizing real technical support, ongoing process improvement, and a willingness to tackle tough operational questions, we aim to stand as a reliable resource in a world full of complexity and change.
