|
HS Code |
556940 |
| Product Name | 5-Bromo-2-Chloro-4-Fluorophenol |
| Molecular Formula | C6H3BrClFO |
| Molecular Weight | 225.44 g/mol |
| Cas Number | 885270-59-9 |
| Appearance | White to off-white solid |
| Melting Point | 75-79°C |
| Solubility | Slightly soluble in organic solvents |
| Purity | Typically ≥98% |
| Smiles | C1=C(C=C(C(=C1F)Br)O)Cl |
| Inchi | InChI=1S/C6H3BrClFO/c7-3-1-4(8)6(10)2-5(3)9/h1-2,10H |
| Storage Conditions | Store at room temperature, dry and well-ventilated place |
| Hazard Statements | Irritant |
As an accredited 5-Bromo-2-Chloro-4-Fluorphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 5-Bromo-2-Chloro-4-Fluorophenol is packaged in a 25g amber glass bottle with a secure screw cap and safety labeling. |
| Shipping | 5-Bromo-2-Chloro-4-Fluorophenol should be shipped in tightly sealed containers, protected from moisture and light. It must be packed according to chemical safety regulations, labeled appropriately, and transported by certified carriers. Ensure compliance with local and international hazardous materials guidelines. Handle with proper personal protective equipment during loading and unloading. |
| Storage | 5-Bromo-2-Chloro-4-Fluorophenol should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of ignition, moisture, and incompatible substances such as strong oxidizers. Protect from direct sunlight. Label storage area with appropriate hazard warnings, and ensure containment to prevent environmental release. Handle using appropriate personal protective equipment to avoid exposure. |
Competitive 5-Bromo-2-Chloro-4-Fluorphenol prices that fit your budget—flexible terms and customized quotes for every order.
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In the field of pharmaceutical and agrochemical research, intermediate selection can shape the entire course of product development. Over the past decade, our team has relied on 5-Bromo-2-Chloro-4-Fluorphenol to push forward synthesis that demands consistent performance and clear structural outcomes. Around the world, this aromatic compound has seen growing attention from laboratories tackling complex molecular design. Its unique halogenated pattern offers a distinct platform that rarely overlaps directly with standard phenol derivatives.
The architecture of 5-Bromo-2-Chloro-4-Fluorphenol features bromine, chlorine, and fluorine, each at carefully appointed ring positions. Chemists see benefits in the way these groups direct reactivity during subsequent coupling, oxidation, or further substitution. Unlike monochlorinated or brominated phenols, this molecule grants synthetic flexibility by letting developers control subsequent steps with fewer by-products. Over the years, our facility has learned the importance of carefully managing halogen introduction—not all positional isomers provide the same cost-value ratio or meet today's regulatory scrutiny.
Take fluorine addition as an example. Its presence in the para position not only enhances the molecule’s metabolic stability, but helps control electronic properties, especially where downstream products involve pharmaceutical targets. The introduction of multiple halogens on a single ring opens up new catalytic pathways. These benefits do not show up in single-halogen or non-fluorinated phenols, which struggle with regioselectivity and poor downstream yields in heterocycle synthesis.
Our main production model for 5-Bromo-2-Chloro-4-Fluorphenol has evolved after thorough feedback from advanced synthetic teams. Starting from sourcing high-purity precursors, all batches run through a multi-stage purification, monitored by GC and NMR at every critical junction. Finished product usually exceeds 99% purity, supported by our in-house chromatography data and third-party certificates where needed for regulated markets.
Controlling moisture remains non-negotiable. Each lot carries water content under 0.5%, based on Karl Fischer analysis. Any sign of decomposition or colored impurity calls for batch reprocessing or rejection. Physical characteristics—white crystalline powder, stable under normal storage—come standard, but we also tailor particle size if a specific application justifies the adaptation. Such changes are always discussed with clients, with data shared up front. From order to dispatch, we can vouch for consistency because every stage stays under our direct supervision, not shunted to a generic toll manufacturer.
In most development labs, the choice of intermediates follows a balance of price, performance, and regulatory profile. Competition exists, but few molecules combine electrophilic and nucleophilic activation points as efficiently as 5-Bromo-2-Chloro-4-Fluorphenol.
Medicinal chemistry projects count on this compound for efficient building of aryl ether and diaryl amine scaffolds. The electron-withdrawing halogens, tucked into three ring positions, streamline the SNAr process, minimizing overreaction and complicated by-product profiles. Our customer feedback shows this consistently: cycle times drop by 20–30% where this intermediate replaces older dual-substituted phenols.
Agricultural research teams look for metabolic robustness and resistance to photolytic breakdown. The pattern of bromine, chlorine, and fluorine complicates enzymatic cleavage, which translates into products with longer residual effects and improved resistance profiles. That is not something usually found with 2,4-dichlorophenol or 4-bromophenol—both of which degrade faster and yield more environmental metabolites. Our product has supported successful launches for at least three registered agrochemical ingredients on the Asian and North American markets.
Producing 5-Bromo-2-Chloro-4-Fluorphenol at scale is not a process that benefits from simplification. Over time, we have learned that merely following generic literature procedures seldom meets the accuracy targets set by our clients. Early on, discrepancies in halogen distribution would generate isomeric impurities, causing trouble in downstream reactions and regulatory headaches at the submission stage. That experience pushed us to invest in early in-process monitoring.
Heated halogenation and subsequent fluorination each trigger risks—not just for yield loss, but for occupational safety and batch stability. Engineering controls and operator training take priority; these are not duties we outsource. By overseeing every lot, we can prevent persistence of unreacted precursors and deal with any exothermic anomalies that threaten plant safety and quality outcomes.
It’s easy to find multi-substituted phenols on the open market, but genuine 5-Bromo-2-Chloro-4-Fluorphenol remains a specialty item. Traders and third-party channels may advertise vague purity claims, yet without direct process oversight, batch-to-batch variability creeps in and puts your research at risk. We maintain not just vertical integration of our supply chain, but complete transparency in sourcing halogenated feedstocks.
Feedback from pharmaceutical synthesis groups often highlights not just purity, but the way our compound handles during scale-up. Filterability, dusting rate, and even reactivity trends are all rooted in our direct control of crystallization and drying protocol. Effects like agglomeration slow downstream throughput and have driven us to tighten controls on every parameter we can measure in real time.
Compared to single-halogen phenols or even closely related isomers, our process yields more consistent coupling results and dramatically reduces chromatographic purification loads. In pilot scale tests, labs have reported a 15% higher isolated yield when starting from our product versus more commonly sourced alternatives. This real-world impact sets us apart more than a paper specification ever could.
Real chemical manufacturing never follows a simple recipe. In our journey, high selectivity in the halogenation stage has required sourcing fresh catalysts and optimizing solvent ratios. Early attempts to push throughput by shortcutting solvent drying or skipping extractions cost more time and money than anyone anticipated. Today, we screen every drum and track solvent performance across shifts. Staff in our facility receive regular hands-on retraining, focused not just on compliance, but on real outcomes from every fault analysis we conduct.
On the analytical side, matching customer chromatographic signatures has taken more than just method validation. We have adopted MS-based tracking to map trace impurities, working hand-in-hand with research partners to ensure unusual spectral signals don’t undermine project timelines. This is how we've responded to new client demands, especially those with tight regulatory frameworks in Europe and North America.
Partner chemists frequently remind us that specifications printed on a sheet mean little if the product doesn't perform in the flask or on plant scale-up. One client noted how reduction in colored impurities from our lots lowered their time spent on pre-purification by two full days per batch. Pharmaceutical CROs often face shortages or delivery issues with less direct sources; we keep onsite stock and track every order from production to shipment.
In agriculture, major formulation projects have pivoted entirely to 5-Bromo-2-Chloro-4-Fluorphenol after initial field trial performance bested incumbent phenol alternatives. Rapid availability, supported by documentation and direct supply, helped win over safety assessors worried about trace halide contaminants. Where batch uniformity translates into field performance and regulatory confidence, the difference becomes clear.
Regulatory pressure to limit halogenated by-products and control environmental persistence shapes every step we take, from precursor screening to finished lot shipment. We document and minimize off-target halogenation, keep to strict emissions standards, and prepare full traceability packages when clients face audit. Working with environmental chemists and regulatory consultants, we continuously update risk profiles—no one benefits from surprises when a project moves from pilot to field, or from lab bench to human trial.
Our quality management embraces real-world requirements set by evolving REACH and EPA guidelines. From routine SDS updates to on-demand submission files, our team stays engaged in the paperwork—because we know a single hiccup in agency review can erase hard-won time and investment in bringing a new product or therapy to market.
Living up to best practices means treating every production cycle as a learning opportunity. When analytical results diverge, we translate those findings into actionable changes, whether that means swapping out a faulty valve or redesigning a work-up protocol. Both management and manufacturing staff sit down monthly to review what’s worked and what needs change. Regular capital investment keeps us at the front of the curve, whether through upgraded process reactors, safer waste handling, or more sensitive in-line monitoring.
In the last year alone, these routines have halved reprocessing rates and improved employee satisfaction, translating directly into lower costs for our partners. Smaller companies and multinational pharma groups alike see faster turnaround and more transparent communication, rather than opaque promises and missed delivery windows.
5-Bromo-2-Chloro-4-Fluorphenol is not a mass-market commodity. Most of its applications take shape through close cooperation between manufacturers and R&D teams. Every year, we host site visits for formulation specialists, encourage collaborative pilot runs, and support new patent filings with analytical documentation and process affidavits as needed. We recognize that the successful use of our product can anchor an entire development portfolio, not just a single molecule or field project.
Recently, a number of research groups working in next-generation fluorinated polymers have approached us for larger trial volumes and extended technical support. Their interest reflects a larger trend—custom halogenated phenols are reshaping fields from specialty coatings to advanced ligand chemistry. We stand ready to adapt production to new needs, including custom packaging or supply chain arrangements for sensitive applications.
Every claim about our 5-Bromo-2-Chloro-4-Fluorphenol rests on real data, not marketing gloss. We back each batch with complete sets of COAs, supply original chromatograms, and keep archive samples for every delivered lot. Customers routinely request splits for third-party testing, and we welcome the extra layer of accountability. If a downstream process deviates from expectations, our development chemists are on hand to review data, discuss protocols, and suggest adjustments based on our own plant data.
Years of experience taught us that open data flow and fast troubleshooting build trust. No batch is considered final until analytical and user feedback line up. We don’t ship what we wouldn’t trust in our own labs. That’s the standard our team expects every morning on shift.
The market for multi-halogenated phenols will continue to evolve as new synthetic and environmental challenges emerge. Demand for tailored intermediates in both small molecule pharma and advanced agrochemicals has grown steadily, even as price and environmental pressures mount. We see opportunity in further refining our halogenation steps, minimizing waste, and improving both the environmental and human health footprints associated with our product.
Innovation in fine chemical manufacturing remains inseparable from the willingness to invest, adapt, and collaborate. Every decision we make about 5-Bromo-2-Chloro-4-Fluorphenol, from raw material sourcing to plant design upgrades, speaks to the demands of forward-looking science. We believe the product will find even more novel utility as new fields demand precision and traceable supply chains. Our facility’s investment in talent and equipment stands ready to deliver on those needs.
