|
HS Code |
873700 |
| Chemical Name | 4-Trifluoromethyl Thiophenol |
| Cas Number | 461-84-7 |
| Molecular Formula | C7H5F3S |
| Molecular Weight | 178.18 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 186-188°C |
| Density | 1.293 g/cm3 at 25°C |
| Refractive Index | 1.542 |
| Flash Point | 69°C |
| Purity | Typically ≥98% |
| Solubility | Insoluble in water; soluble in organic solvents |
| Smiles | C1=CC(=CC=C1S)C(F)(F)F |
| Inchi | InChI=1S/C7H5F3S/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4,11H |
As an accredited 4-Trifluoromethyl Thiophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 25 grams, tightly sealed with a screw cap; features hazard labels, product name, and chemical information on the label. |
| Shipping | **4-Trifluoromethyl Thiophenol** is shipped as a hazardous chemical. It requires secure, leak-proof packaging, labeled with appropriate hazard warnings (flammable, toxic). Shipment must comply with regulations such as DOT, IATA, and IMDG. Temperature control and documentation, including Safety Data Sheets (SDS), are essential for safe transport and legal compliance. |
| Storage | 4-Trifluoromethyl Thiophenol should be stored in a tightly sealed container, placed in a cool, dry, and well-ventilated area away from sources of ignition. It must be protected from moisture, heat, and incompatible substances such as oxidizing agents. Proper labeling and secondary containment are recommended to prevent leaks or accidental exposure. Store in a designated chemical storage area. |
Competitive 4-Trifluoromethyl Thiophenol prices that fit your budget—flexible terms and customized quotes for every order.
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4-Trifluoromethyl thiophenol has grown in importance across fine chemical and pharmaceutical sectors. As a manufacturer accustomed to working directly with this material every day, I see its clear advantages and some real challenges, both in the plant and downstream. The molecular formula is C7H5F3S. Its CAS number, which chemists rely on to ensure consistent quality and identity, is 98-17-9. In the drum or bulk tank, 4-trifluoromethyl thiophenol looks like a light yellow to nearly colorless liquid carrying a sharp odor typical of many organosulfur compounds.
What distinguishes this compound is the trifluoromethyl group attached to a thiophenol backbone. That moiety endows it with electronic and steric properties you will not find in unsubstituted thiophenol or even other fluorinated analogues. For a working chemist, this means different reactivity profiles during synthesis, transformations, and downstream reactions. We routinely see that customers working on agrochemical or pharmaceutical intermediates come to us for this product because no combination of standard thiophenol and fluorinating agent gets them to the same results in purity or yield.
Speaking from years in the plant, not all 4-trifluoromethyl thiophenol batches are created equal. High-quality product starts from controlling raw materials. Fluorinated aromatic compounds sometimes arrive with fine contaminants from earlier process steps that can later bother hydrogenation catalysts or cause unwanted background reactions. In our experience, even low levels of halogenated byproducts can pester downstream steps if not removed by rigorous distillation and purification. When the feedstocks meet our standards, we proceed under strictly monitored temperature and atmospheric controls. Oxygen scrubbing cuts down unwanted side reactions that tend to bump up color or odor.
Output consistency occupies much of our attention. Each batch comes with GC analysis and NMR profiling, but real confidence comes from how the material handles in our own small-scale tests. Once in a while, color or a stubborn sulfur note signals the need for a redistillation or polishing run before we approve a lot for customer shipment. Regular customers tell us the difference stands out at bench scale—fewer surprises, faster reaction times, less byproduct cleanup.
4-Trifluoromethyl thiophenol earns its place on lab and production shelves not from volume, but versatility. In pharmaceutical settings, it acts as a building block for active pharmaceutical ingredients, helping researchers and development teams incorporate trifluoromethylthio moieties into drug candidates. This functional group can increase metabolic stability, alter lipophilicity, and finesse the pharmacokinetic profiles of compounds. Our technical liaisons receive plenty of feedback during scale-up projects—what works on milligram scale often needs adjustment on kilogram lots. Tracking actual yield and impurity drift, we have adjusted our purification steps to supply material that helps downstream chemists reduce step counts.
Agricultural chemistry also benefits from this compound’s properties. It often finds use as a precursor for crop protection agents, giving the finished product better weather resistance, uptake, or mode-of-action behavior than standard aromatic thiols. Our agricultural partners note the increased market demand for active ingredients that maintain potency across diverse soil and climate conditions. Formulators in these sectors are quick to spot differences in trace impurity profiles, especially with regards to elemental sulfur or organofluorine carryover. Years spent improving our process have paid off here—a low-sulfur, high-purity lot saves time and money compared to more reactive, impurity-laden alternatives.
We often field questions about differences between our 4-trifluoromethyl thiophenol and generic items from non-production sources or trading companies. As a manufacturer, I have to look beyond simple assay or purity numbers. Competitive material sometimes hits 98 percent purity by chromatogram, but fails downstream stability or leaves behind enough residual acetic acid or oxidized species to corrode glass equipment or drag down yields. Fluorinated thiophenols—unlike plain thiophenol—emphasize the importance of a tightly controlled process environment. Air, moisture, and trace acids or bases can shift the composition in subtle but meaningful ways.
Practically, our material ships under nitrogen with sealed tight packaging. We learned early that even a few hours exposed to air generates off-odors and cuts shelf-life. Our storage tanks receive inert gas blankets, not just because guidance documents say so, but because repeated customer feedback proved that product stored under air begins to drift in color and assay after only a few weeks, especially after partial drum withdrawals. That difference determines whether a kilogram lot survives transport and blends seamlessly into downstream processes or leaves the customer troubleshooting at every stage.
Working on the production floor with organosulfur compounds demands respect. 4-Trifluoromethyl thiophenol carries a strong, tenacious odor that resists even the best ventilation systems. Operators wear full PPE, not only for safety, but to avoid taking the odor home on their clothes. We routinely test air levels in the plant and the drum-filling stations, not just to check boxes but to keep our team safe.
In the field, end users have reported that material handled in open-air labs or weighed on open balances quickly fills the workspace with noticeable thiol odor. We recommend tight packaging, short exposure times, and secondary containers where feasible. Colder, dark storage stretches the product’s practical shelf-life. Over the years, we have refined our shipping drum choices: lined steel, always thoroughly cleaned, never recycled from other chemical classes. Stickers and warnings remind handlers at every stage—air and light accelerate degradation, but simple precautions prevent headaches.
Many of our early buyers, especially R&D groups, reported issues ranging from slow conversion to discolored final product. Learning from shared experience, we saw how trace impurities common in less-controlled production chased downstream, creating stubborn side products during sulfenylation or coupling steps. Analysis often found halogenated minor impurities or trace peroxide left over. By closing these gaps in our internal process—upgrading distillation, validating all cleaning steps, and testing beyond standard specs—we witnessed a marked drop in customer troubleshooting calls.
Some users attempted to substitute trifluoromethyl thiophenol with mixtures of thiophenol and commercial trifluoromethylation reagents, chasing cost savings. Reaction records proved this approach routinely generates hard-to-separate byproducts and requires substantial post-reaction cleanup, reducing overall throughput and reproducibility. We compare GC, NMR, and application results across numerous lots and spot the same trend: only genuine 4-trifluoromethyl thiophenol delivers uniform results in critical applications.
2023 and early 2024 have both highlighted the importance of reliable supply chains for fine chemicals. We’ve seen surges in demand linked to new pharmaceutical process approvals, and spikes in agricultural formulations driven by seasonal pest pressures. Manufacturing at scale gives us early warning when raw material sourcing tightens or shipping routes face delays. As a manufacturer, we base projections on on-the-ground realities. Having tank farm reserves, backup suppliers, and flexible shift schedules supports consistent delivery, so customers know their orders make it from dock to bench without surprises.
During recent raw material crunches, some brokers tried to fill gaps with off-grade or repackaged stock. Downstream users in both large and small companies reported inconsistent performance, even after double-checking COAs. Here, manufacturing experience and a clear supply chain history make the difference. Each kilogram we ship has a documented batch history, logged handling conditions, and test results beyond what goes on a standard data sheet. We consider this not just quality assurance, but basic industrial responsibility.
Duty to safety and responsible waste management comes with any sulfur-based chemical. Dealing with bulk quantities means not only preventing emissions, but handling spent reactants and wash water according to strict compliance rules. Our investment in gas scrubbing and liquid waste processing goes beyond what regulatory minimums demand. Auditors and partners appreciate not just our record, but a public commitment to open incident reporting, so everyone can see both our progress and our learning moments.
Process improvements focused on minimizing byproducts led us to optimize reaction routes over several production cycles. Real-time monitoring at each reaction stage, paired with dedicated waste stream segregation, prevents unexpected emissions. We work with reputable partners for offsite destruction of high-sulfur or residue fractions, maintaining traceability.
Looking ahead, several research groups are exploring new catalytic routes or biological alternatives for thiol synthesis. We track these developments as potential future pivots. For now, tried-and-tested chemical synthesis still serves end users best, provided each manufacturing step gets the thoroughness it deserves.
Open lines of communication with end users define our entire operation. Our team fields direct technical questions, often helping chemists troubleshoot real-world issues: solubility changes, reactivity drops, separation bottlenecks, or packaging leaks. Providing timely, accurate answers—grounded in daily production know-how—separates us from traders or third-party vendors. Customers send samples or application details and receive thoughtful advice, backed by hands-on work from operators, analysts, and engineers with tangible stake in the outcome.
Plain communication sometimes means delivering hard news—a shipment delay or a raw material hiccup. We do not gloss over these. Experience shows that transparency, alongside proposed corrective actions, preserves trust and productive working relationships. Recurring discussions about purity grades, trace element content, or waste minimization feed directly into our ongoing product and process improvement cycles.
Manufacturing 4-trifluoromethyl thiophenol stands as a demanding but rewarding process. It serves as a clear example of how a single chemical—when made well, and with the right attention—creates outsized value for research, development, and industrial production. The differences begin at the molecular level, but ripple outward through every process stage, affecting not only yield and throughput, but safety, sustainability, and the day-to-day experience of those relying on the compound.
We know from daily shifts that delivering true value to customers means not just shipping a liquid in a drum, but building reproducibility and reliability into every stage. Consistency and technical openness, backed by years of troubleshooting and hands-on batch work, make the decisive difference. As new applications emerge and market needs shift, we keep learning and adapting—committed to doing the hard work so that others, down the line, can trust the compounds they use every day.
