|
HS Code |
625884 |
| Chemical Name | 4-Iodo-2,6-Dimethylphenol |
| Cas Number | 645-92-1 |
| Molecular Formula | C8H9IO |
| Molecular Weight | 248.06 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 105-109°C |
| Boiling Point | No data available (decomposes) |
| Solubility In Water | Slightly soluble |
| Density | 1.8 g/cm³ (approximate) |
| Purity | Typically ≥98% |
| Structural Formula | C1=CC(=C(C(=C1I)C)O)C |
| Smiles | Cc1c(cc(c(c1I)C)O) |
As an accredited 4-Lodo-2,6-Dimethyl Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 100 grams of 4-Iodo-2,6-Dimethyl Phenol, tightly sealed with a screw cap, labeled for laboratory use. |
| Shipping | **4-Iodo-2,6-Dimethyl Phenol** is shipped as a hazardous chemical. It must be securely packaged in tightly sealed, chemical-resistant containers, clearly labeled, and transported according to relevant regulations (such as DOT, IATA, or IMDG). During shipping, appropriate documentation and safety data sheets (SDS) must accompany the shipment. |
| Storage | 4-Iodo-2,6-dimethylphenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from heat, light, and incompatible substances such as strong oxidizers. Keep container tightly closed when not in use. Store away from sources of ignition, and ensure proper labeling. Follow relevant safety regulations for hazardous chemicals, and wear appropriate personal protective equipment when handling. |
Competitive 4-Lodo-2,6-Dimethyl Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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Each day in our manufacturing plant, the familiar scent of phenolic compounds drifts through the air—a reminder of the foundation we help build across industries. Among our core materials stands 4-Iodo-2,6-Dimethyl Phenol, a specialty compound that’s earned its place through reliable performance and unique chemical behavior. Crafting this product isn’t a simple run-of-the-mill process. The chemical structure—iodinated and dimethyl-substituted on a phenol ring—gives the compound a personality of its own, different from the dozens of parent phenols or substituted phenols we have run through reactors over the years.
What sets 4-Iodo-2,6-Dimethyl Phenol apart starts at the very first reaction step. Unlike non-iodinated phenols or mono-methyl variants, iodination at the 4-position dramatically changes its reactivity and environmental persistence. The methyl groups—flanking the iodine both at 2 and 6—escort the molecule into a select club. We see this in crystallization steps and how the product solidifies at different cooling conditions compared to cousins such as cresols or simple iodo-phenols. Even small differences in substitution patterns on the aromatic ring shift melting points, solubility, and downstream application profiles.
We manufacture 4-Iodo-2,6-Dimethyl Phenol in batch reactors using controlled halogenation in a protected, ventilated environment. Years of scaling up the process taught us that iodine’s behavior diverges sharply from bromine or chlorine, not just in reactivity but in how the intermediates impact final purity. The presence of two methyl groups narrows the byproduct window, giving a cleaner batch than single-methyl or three-methyl phenols, where side reactions spike.
In our experience, specialty phenolic compounds demand close attention to purity. Our 4-Iodo-2,6-Dimethyl Phenol typically achieves an assay upwards of 98% by HPLC. Sub-par material impacts formulation yields and the reliability customers demand in their formulations. Whether it’s serving as an intermediate in organic synthesis or as a monomer for advanced polymers, this compound’s reactivity—and its selective ortho/para properties—matters for both efficiency and safety.
Pharmaceutical development teams have looked to this material thanks to the heavy atom effect of iodine. This property changes the electronic distribution on the phenol ring, affecting things like antioxidant profiles, halogen bonding for drug discovery, and even radiolabeling for tracing compounds. Unlike lighter halogenated phenols, the iodo-variant offers higher mass and different reactivity, lending it to specialty imaging or diagnostic research that can’t be matched by chlorinated or brominated analogues.
Synthetic chemists tell us the ortho-dimethyl arrangement allows for directed ortho-metalation or Suzuki couplings with improved yields, precisely because the 2,6-methyl groups steer the reactivity of the ring. We see this reflected in purchasing patterns: research labs and API (active pharmaceutical ingredient) developers turn to this product when conventional phenols can’t deliver the specificity their syntheses require.
Experience running phenolic lines reveals small changes in substitution can rewrite a compound’s performance. Toluene-based phenols, even with added methyls, can't replicate iodine’s impact on molecular stability or resonance effects. Pure 2,6-Dimethyl Phenol tends to be too volatile for some applications and lacks the mass and electron-withdrawing properties the iodine atom provides. 4-Iodo Phenol, without the dimethyl groups, offers higher reactivity—but also higher risk of unwanted side reactions and lower stability under light or heat.
It’s the combination—iodine at the para position, methyls at the ortho—that delivers a balance between reactivity and resistance to thermal degradation. Over the years, customers in electronics have shared that this material’s unique properties make it indispensable for fine-tuning dielectric materials and specialty resins. Comparing reaction kinetics across similar halogenated phenols confirms that our 4-Iodo-2,6-Dimethyl Phenol can resist oxidation better, tolerate broader pH ranges, and deliver repeatable outcomes in multi-step syntheses where downstream yields depend on input purity.
We’ve invested in closed-system handling and vacuum drying for this compound. The extra steps pay off, because iodine introduces not just cost but also volatility and environmental management challenges that manufacturers simply can't ignore. Years before regulatory pressure around halogenated chemicals, we were already optimizing for reduced emissions and minimized waste. That experience shapes our current operation: continuous sampling during synthesis to ensure single-digit ppm impurity levels, and post-synthesis vacuum treatment to lock in shelf life.
Delivering on consistency means more than a passing grade on the certificate of analysis. For 4-Iodo-2,6-Dimethyl Phenol, we run multiple purity assessments—UV/vis, HPLC, and sometimes GC-MS depending on customer requirements. We store the compound in amber glass, double-sealed, and monitor for light-induced decomposition. Our packaging lines reject any batch with traces of residual iodine vapor. With each kilogram, our goal is to provide not just the expected chemical, but one as close to the analytical ideal as modern methods allow.
World demand for fine chemical intermediates has been moving towards greater sustainability and traceability. Regulatory authorities in Europe and North America require increasingly detailed provenance and stability data—not only for pharma intermediates but for any chemical with complex halogenation. Our work on 4-Iodo-2,6-Dimethyl Phenol stands at this intersection. More process audits from on-site visitors keep us refining batch records, trace heavy metal analyses, and impurity profiles. Customers want to know not just how the chemical performs but how it was made, and what steps we have taken to minimize footprint.
Logistics have also changed the landscape. The iodine used in iodination is a controlled material and acquisition, storage, and usage protocols now run more sophisticated than before. Global supply fluctuations force us to maintain long-run contracts and to keep extra inventory of raw materials. The result: supply interruptions are rare and our customers aren’t left waiting on delayed shipments. Real manufacturing experience means not making promises unless the inventory and batch runs allow it.
A key lesson over years of production: this is a compound that rewards attention to detail. The methyl groups are electron-donating, altering the phenol’s reactivity and potential for side-chain halogenation. During the iodination, controlling temperature and rate of iodine feed means the difference between a high-yield batch and an unmanageable tangle of side-products. Avoiding air and moisture ingress prevents iodide formation, keeping the chemistry neat and reproducible.
We’ve seen that shipping this compound even short distances in the wrong packaging material leads to off-odors or caking. We switched to moisture-barrier linings and now run periodic stability checks over six months to confirm that color and assay both hold. Each year, we revisit environmental risk management for residual iodine and waste handling, because what worked a decade ago needs to adapt with current rules and best practices.
Feedback from laboratories confirms what we’ve experienced in pilot and plant-scale syntheses. A well-prepared sample of 4-Iodo-2,6-Dimethyl Phenol dissolves evenly, melts sharply, and doesn’t introduce fine particulate matter—a nuisance found in lower-grade halogenated samples on the market. Chemists find the higher melting point and consistent color save them time, since it signals fewer hidden contaminants.
Researchers working on cross-coupling and halogen-exchange reactions show genuine preference for compounds delivered with a tight melting point range and minimized trace metal content. On the industrial side, stable supply and reproducibility mean project timelines don’t slip due to ingredient variability.
Manufacturing 4-Iodo-2,6-Dimethyl Phenol means dealing with live reaction hazards, trace side products, and fastidious purity targets. Over the years, we learned that no digital recipe or scale-up protocol replaces vigilant batch monitoring. Early in the scale-up process, uncontrolled iodine addition led to runaway exotherms and purity below specification. Now, every batch run uses process analytical technology to track reaction paths in real time.
Serious investment in staff training and equipment calibration pays back as low batch-to-batch variance and less waste. In one case, switching from open reactor cooling to closed-loop recirculators eliminated contamination through airborne particles, saving rework costs and decreasing product loss. Minor modifications—such as upgrading filtration aids and using high-purity solvents—combine to make each lot as close as possible to the target specification, improving performance not only in synthesis but also in customer satisfaction.
Fine chemicals respond to manufacturing quality like few other commodities. Tighter process controls allowed us to push the measurable residual solvent content below 1000 ppm, a threshold that not only matches but often exceeds customer expectations and current regulation. Analysis data forms the backbone of our process adjustments. Our quality assurance team runs random sampling, blind retests, and cross-lab validation at least once a quarter to ensure incoming raw materials and outgoing finished product both tell the same story from start to finish.
Supply chains challenge every manufacturer, not just in securing high-purity iodine but also specialty solvents and consumables. We pre-qualify vendors and keep documentation for every lot of starting material, so traceability is never in question. These data records can clear up regulatory queries and smooth qualification audits for our buyers, many of whom need solid provenance steps to validate their end products.
Chemical manufacturing sits at the intersection of tradition and innovation. Each market cycle brings new expectations. As automation and digital analysis further evolve, our hope is to mature right alongside them, ensuring 4-Iodo-2,6-Dimethyl Phenol keeps meeting the stricter standards in research and industry.
Our manufacturing journey underscores one simple truth: quality starts not in the test lab, but in every control decision at every stage—raw material sourcing, reactor charge, process monitoring, post-processing workflows, and final quality assessment. Years spent fine-tuning every step, responding to direct researcher feedback, and overhauling old SOPs gives the compound a reliability end users can count on. This kind of attention pays off not just in assay numbers but in trust earned over years of steady partnership.
Among the broad family of phenols and halogenated phenolic intermediates, this compound finds a strong position because of smart molecular design and process attention. Every batch shipped resonates with our years of practical experience—knowing how to handle sensitive halogenations, appreciating how methyl groups tune reactivity, and steering through regulatory and environmental currents with resilience. As application spaces grow from pharma to advanced materials, 4-Iodo-2,6-Dimethyl Phenol stays ready to meet the need for clean, reliable, and effective building blocks in research and industry alike.
