|
HS Code |
174251 |
| Chemical Name | 4-Ethoxy-2,3-Difluorophenol |
| Molecular Formula | C8H8F2O2 |
| Molecular Weight | 174.15 g/mol |
| Cas Number | 356783-33-8 |
| Appearance | Colorless to pale yellow liquid |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents (e.g., DMSO, ethanol) |
| Smiles | CCOC1=CC(=C(C(=C1)F)F)O |
| Inchi | InChI=1S/C8H8F2O2/c1-2-12-6-3-5(9)8(11)7(10)4-6/h3-4,11H,2H2,1H3 |
| Synonyms | 2,3-Difluoro-4-ethoxyphenol |
| Storage Conditions | Store at 2-8°C, tightly closed |
As an accredited 4-Ethoxy-2,3-Difluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Ethoxy-2,3-Difluorophenol, sealed with a screw cap and labeled with hazard information. |
| Shipping | 4-Ethoxy-2,3-Difluorophenol is shipped in sealed, chemically-resistant containers to prevent leaks and contamination. Packaging complies with international regulations for hazardous chemicals. It is transported under ambient conditions with clear hazard labeling and safety documentation. Ensure secure handling and storage during transit to avoid exposure or environmental release. |
| Storage | 4-Ethoxy-2,3-difluorophenol should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers or acids. Clearly label the container and avoid excessive heat. Follow all relevant safety, handling, and disposal guidelines as recommended by regulatory authorities or the Safety Data Sheet (SDS). |
Competitive 4-Ethoxy-2,3-Difluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Every new product we bring to the market reflects years of development within our own labs. Our journey with 4-Ethoxy-2,3-difluorophenol started after several requests from our long-term partners in pharmaceutical research. They were exploring fluorinated scaffolds that could help adjust physicochemical properties in their lead compounds. We understood that slight molecular modifications—such as the combination of fluoro and ethoxy substitutions—offer researchers new handles for interacting with biological targets, adjusting solubility, and improving metabolic stability. That’s when our specialized team took on the technical challenge of preparing this compound at a scale that would exceed the typical milligram lots available from research shops. Instead, we aimed for reproducibility, reliability, and batch-to-batch consistency, always a step ahead of the unpredictable availability often seen in less mature supply chains.
This compound’s backbone comes from phenol, a tried-and-true aromatic ring. By modifying the positions at carbon atoms two and three with fluorine, and at position four with an ethoxy group, we tune both electronic and steric influences. Fluorine situated ortho to the phenol delivers key differences in hydrogen bonding, pKa, and metabolic pathway engagement, while the ethoxy group broadens the scope for downstream functionalization. Our product offers a defined substitution pattern that stands out from the more common 2,4-difluoro analogs and simple mono-ethoxy phenols.
To the eye, our batches appear as a clear liquid or, at colder temperatures, lightly yellow crystals. We produce this compound according to well-established synthetic routes, honed by chemists in our workforce who have several years working with unstable fluorinated intermediates. We’ve learned that minimizing trace water and controlling reaction atmospheres play large roles in yield and purity. Every bottle we ship comes with a chromatogram and full NMR profile—transparency we believe researchers deserve.
True value in our field comes from how a material fits into customers’ workflows. We do not sell 4-ethoxy-2,3-difluorophenol based on broad claims or niche curiosity. Instead, our efforts focus on actual customer feedback. Most interest comes from medicinal chemists looking to explore structure-activity relationships or improve lead molecules’ metabolic stability. In our experience, replacing a hydrogen with fluorine—especially on an aromatic ring—slows metabolic breakdown by particular liver enzymes. Ethoxy substitution affects partitioning between aqueous and lipid phases, which often has a direct bearing on oral bioavailability or cell membrane permeability.
Some clients have found that the compound serves as a novel core segment in diversity-oriented synthesis. Others appreciate its potential in agrochemical R&D, where small changes in molecular design can tip the balance toward improved residence time on crops or reduced off-target toxicity. A recurring theme involves the use of our product in the synthesis of fluorinated biphenyls and biaryls. The electronically deactivated ring, combined with phenolic hydroxyl, opens up opportunities for coupling reactions that otherwise falter with unsubstituted phenols. Feedback suggests that the product also cuts the number of protection and deprotection steps in routes to more complex molecules.
Process chemists often tell us they welcome the shift from using hazardous fluorinating reagents themselves, instead sourcing our material as a finished intermediate. This shift doesn’t just reduce workplace hazards; it leads to more predictable timeframes and eliminates frustration from low-yielding, temperature-sensitive reactions. The oxidizing and reducing steps leading up to the difluoro motif demand strict control, and our in-house monitoring ensures every kilogram leaves according to specification.
Offering high purity translates directly into less downstream purification and higher confidence in test results. Typical batches from us come in above 98% purity, with trace metal and solvent residues well within recognized international research limits. Aside from the standard liquid chromatography and proton NMR, our labs conduct fluorine and carbon NMR to provide a full structural confirmation. This triple verification approach caught a few outliers in early pilot batches—something only direct manufacturer oversight makes possible.
Our scale-up engineers took special care to understand how fluctuating conditions—humidity, agitation, container choice—could influence long-term chemical stability. This material shows moderate volatility. We pack every bottle using fluoropolymer-lined closures, balancing chemical resistance and package tightness. Temperature excursions during transit can cause semi-crystalline solidification, but quick warming returns the product to its intended state. We label every batch with a recommended minimum storage temperature based on actual observations, not just theoretical extrapolation.
Experience in custom synthesis often centers on variations within a single scaffold. Customers query us on the differences between 4-ethoxy-2,3-difluorophenol and related structures, such as 2,4-difluorophenol, 4-ethoxyphenol, and mono-fluorinated or diethoxy versions. The key lies in both reactivity and property profile. Researchers report that the 2,3-difluoro substitution pattern introduces a distinct electronic pattern across the ring that influences metal-catalyzed cross-couplings and regioselective functionalizations, outpacing what’s possible with the 2,4-analogs.
From a formulation angle, the ethoxy tail imparts a degree of lipophilicity that tailors the compound for work in slightly less polar solvents. Many phenols, especially those used in small-molecule discovery, struggle when dissolved in organic media. This variant performs better in those systems, reducing precipitation or aggregation issues in high-throughput screening.
The presence of both ortho and meta fluorines shifts aromatic proton environments, simplifying spectra and helping researchers avoid problematic overlaps during analytical work. Those involved in patent investigations or scalability studies often comment that the rare substitution pattern—relatively uncommon in both commercial and academic literature—can offer new IP space or generate fresh ideas for problem-solving in route development.
Our team frequently consults with collaborators who’ve worked through the pain of using less stable or less selective alternatives. Early on, a major pain point involved the hydrolytic instability seen in certain difluorinated intermediates offered elsewhere. They often contained higher levels of impurities, stemming from side reactions or over-fluorination. Learning directly from these experiences, we made small upstream tweaks: drying all reagents rigorously, double-checking gas purity, and keeping a close eye on reaction times. These efforts yielded a more reliable product—a difference we could measure in standard deviation across batch purity over a twelve-month span.
Being a manufacturer with its own reactors and QC suites offers a unique vantage point. We see firsthand how shortages in fluorinated intermediates ripple through project schedules, causing missed targets or stalled programs on the research end. Our planning team tracks volatile raw materials and maintains buffer stocks to shield customers from sudden price swings. This involves staying ahead with supplier audits and not postponing maintenance on foundational equipment.
If a process glitch occurs—a temperature runaway or filtration delay—we address it internally instead of pushing the problem downstream. We publish deviation notes as part of our batch documentation, inviting customers to reach out with questions or audit the process trails themselves. On more than one occasion, a head of research has walked our production floor to review chain-of-custody and storage practices, offering their own insights to strengthen our controls. These exchanges create a cycle of mutual improvement that no distributor acting purely as a broker can fully replicate.
Turnaround time remains a top concern, especially for customers balancing calendar-year reporting or critical path dependencies. Our decision to rescale production must factor in cleaning protocols, downtime, and competing slotting for high-demand building blocks. As a result, we maintain flexibility in batch-size planning, keeping open lines to returning clients about availability swings. By sharing our production forecasts, we help R&D teams adjust trial timing without last-minute surprises.
Our executive team has long recognized that manufacturing specialty chemicals, particularly fluorinated aromatics, comes with environmental and regulatory scrutiny. We deploy closed systems for gas and solvent handling, using monitoring equipment to detect leaks and avoid process upsets that could result in unplanned emissions. Every year, we review our waste stream avoidance plans and look for new end users for byproducts that might once have gone unused.
We also engage in partnerships with waste treatment specialists to confirm that our outflows, whether liquid or solid, meet or exceed regulations. This level of attention stems not from compliance pressures alone, but from an awareness that neighbors, employees, and customers alike judge our reputation on how we manage risk. Our technical leads regularly report findings at industry symposia, focusing on best practices in safe fluorination and upstream vendor selection.
Our R&D teams take note of new catalytic methods for selective fluorination, aiming to incrementally lessen the need for harsh reagents. Early pilot work suggests we can introduce lower temperature methods at scale, trimming both power demands and unwanted byproducts. Every incremental improvement trickles down to customer labs in the form of easier regulatory documentation and less complex downstream purification.
We do not view 4-ethoxy-2,3-difluorophenol as a finished story. CSU collaboration brings new requests for physical forms, modifications to packaging, or batched aliquots for screening. Our technical support team maintains a line of communication, collecting both praise and critiques, then cycling those insights to our process group. The outcome has included adapting our bottling line to accept smaller vessels, improving label readability, and introducing QR-coded batch histories.
Individual researchers often ask for comparative data on solubility and reactivity in novel solvents or under emerging reaction conditions. We answer by dedicating time to method scouting and sharing half-page notes on newer findings. Larger institutional clients request full exposure data, impurity profiles, or guidance when incorporating material into regulatory filings. Our data transparency philosophy grew from years of fielding such inquiries, and we see it as a necessary trust-builder in complex R&D supply chains.
We have learned to respect the inherent risks of scale-up in fluorine chemistry, given exothermic tendencies and unpredictable trace reactivity. Investment in real-time process analytical technologies—NIR probes, flow meters, gas sensors—has reduced our turnaround for troubleshooting. Every risk mitigation measure came after an incident or near-miss during our early production runs. We applied lessons quickly, documenting root causes and modifying SOPs. Where possible, we train three sets of eyes on each batch handoff, from reactor draining to bottled product.
There are times when a new customer requests adaptation—a tweak in composition or a change in final form—that stretches our existing capabilities. Instead of issuing a flat refusal, our technical team collaborates directly, reevaluating upstream stocks and feasibility. These on-the-ground conversations build expertise on both sides, with outcomes ranging from new grades of intermediate to better packaging answers for sensitive applications. The cycle repeats, fueled by new discoveries at the lab bench or shifts in regulatory landscapes.
Chemical manufacturing does not stand still. Researchers continue to probe the boundaries of what fluorinated phenols can deliver, especially as new screening platforms and computational tools suggest molecular designs undreamed of a decade ago. We watch patents pour in featuring unusual substitution patterns; our job evolves as we work to anticipate demand, scale responses, and keep supply lines intact despite shifting macro environments.
Customers we work with often share updates on late-stage trials or early clinical data that inform our technical planning. We remain open to all evidence that suggests ways to improve value, reduce hidden costs, or adapt products to new regulations on fluorinated intermediates. Safe, stable supply matters more than ever, given tightening supply chains for both upstream fluorinated raw materials and analytical reference substances.
Our commitment lies with those who rely on our products to break new ground, from bench chemists driving discovery to manufacturing teams translating research into scaled processes. Years of investment in personnel, plant, and process have kept us in a position to adapt, refine, and deliver—always on the backs of real-world feedback, documented improvements, and a dedication to accountability.
4-Ethoxy-2,3-difluorophenol will continue to play a role within research and applied chemistry alike. Our focus remains fixed on supporting your efforts, responding to shifting needs, and ensuring each batch shipped represents hard-earned expertise. In this way, manufacturing delivers not just a product, but a foundation for progress in chemical discovery.
