|
HS Code |
213573 |
| Chemicalname | 4-Chloro-5-Methyl-2-Nitrophenol |
| Casnumber | 119-31-3 |
| Molecularformula | C7H6ClNO3 |
| Molecularweight | 187.58 g/mol |
| Appearance | Yellow crystalline powder |
| Meltingpoint | 96-98°C |
| Solubilityinwater | Slightly soluble |
| Boilingpoint | Decomposes before boiling |
| Density | 1.5 g/cm³ (approximate) |
| Storageconditions | Store in a cool, dry, well-ventilated place |
| Purity | Typically ≥98% |
| Smiles | CC1=CC(=C(C=C1Cl)[N+](=O)[O-])O |
As an accredited 4-Chloro-5-Methyl-2-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Chloro-5-Methyl-2-Nitrophenol, sealed, with hazard labeling and tamper-evident cap. |
| Shipping | 4-Chloro-5-Methyl-2-Nitrophenol is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It is typically handled as a hazardous material, following relevant transport regulations (such as DOT, IATA, or IMDG). Proper labeling and documentation ensure safe handling and compliance during transit. Store in a cool, dry environment. |
| Storage | 4-Chloro-5-Methyl-2-Nitrophenol should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and store it separately from incompatible substances such as strong oxidizing or reducing agents. Use appropriate chemical storage cabinets, and clearly label the container to avoid accidental misuse or contamination. |
Competitive 4-Chloro-5-Methyl-2-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615380400285
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In our years manufacturing advanced specialty chemicals, we’ve come to respect the fine details that separate an average batch from a flawless one. Our 4-Chloro-5-Methyl-2-Nitrophenol solidifies its place as one of those hard-working intermediates that’s often hidden in the final product but is absolutely crucial behind the scenes. Customers turn to this compound with specific goals in mind, looking for reliability and consistency that support both small-batch innovation and large-scale production. We produce 4-Chloro-5-Methyl-2-Nitrophenol from raw material all the way up, in our own plant, where every step gets careful attention from our team. The result: a product that meets the high standards set by pharmaceutical and agricultural sectors, as well as custom synthesis labs looking for that rare blend of purity, color, and performance.
Chemists and process engineers want to trust what comes in each drum—and with the scrutiny applied to today’s active ingredients and intermediates, that trust is built on evidence. We understand the difference a tight assay range can make when your plant’s yield hinges on precision. So, our lot-to-lot assay values for 4-Chloro-5-Methyl-2-Nitrophenol typically fall within 98% minimum, confirmed by HPLC and validated using NMR during final QC. Moisture content control stands as another key differentiator; too much water risks undesired reactions downstream. Regular KF testing keeps our moisture values within a narrow range, contributing to stability and storage life.
One critical issue users encounter with specialty nitrophenols is the color—an indicator that often betrays impurities or byproducts from reaction optimization. The yellow hue of this compound has become a signature benchmark in our facility. We don’t outsource coloring or purification. Instead, we’ve improved each stage from nitration through recrystallization, dialing in time, temperature, and pH to ensure every batch comes out free-flowing, light yellow, and free from dark specks or clumping, which often signal contamination. Few things sap efficiency like lost time in granule breaking or dissolving clumps in a production tank.
Our main customers for this product often work at the intersection of organic synthesis and highly regulated downstream markets. 4-Chloro-5-Methyl-2-Nitrophenol has been adopted as a valued intermediate in the development of anti-infective drugs and herbicide actives. Several leading research labs, including some of our long-term partners, have proven out the advantages of this compound for Suzuki coupling, nitration, and as a key input in custom building blocks for agrochemicals.
The nitro and chloro functional groups offer points for further substitution, enabling tailored synthesis. For instance, the methyl group at the fifth position doesn’t just differentiate this material structurally. It has a direct influence in many coupling reactions, allowing end-users to expand complexity without risking unpredictability from stray side products. Because we produce to tight analytical standards, our customers cut down on waste and eliminate costly purification steps in the next stage.
Performance in stability testing shows 4-Chloro-5-Methyl-2-Nitrophenol storing well at ambient conditions when kept sealed, away from direct sunlight or damp. We’ve run accelerated testing at higher temperatures and see negligible degradation over several months, which speaks directly to the quality of upstream synthesis and the care invested in packaging for transit.
Our direct gains from investing in upgraded filtration lines and precision crystallization tanks became most obvious once downstream customers started reporting fewer filtration or dissolution issues. Some vendors might neglect the significance of controlled particle size in this intermediate, but we’ve observed fast, predictable dissolving behavior due to uniform granule size distribution, averaging 100–350µm. Customers mixing this compound into bulk phase reactions report smoother transfers, and sidestep filtration headaches compared to lower-cost, coarser lots elsewhere on the market.
Trace impurity levels can make or break an API synthesis campaign, especially where even sub-0.1% contaminants create reaction anomalies or yield drops. We subject random lots to GC-MS and LC-MS screening to keep unknowns out of the final barrel, and we’re open about our findings—transparency has forged stronger partnerships over guessing games. This approach also pays off for end-users operating under GMP, ISO, or similar frameworks, since every certificate issued from our plant matches real batch findings, not vague promises.
Making fine chemicals like 4-Chloro-5-Methyl-2-Nitrophenol is both science and discipline. Our setup starts with locally sourced chlorotoluene and nitro precursors. We structure our process across several controlled reactors, each monitored rigorously for exotherm risk, oxygen ingress, and byproduct formation. The real trick is in managing heat and flow. Too hot, and you risk over-nitration and colored byproducts; too cold, and reaction rates crawl, driving costs needlessly. Thanks to process control upgrades over the years, we strike a balance that delivers high yields and pure output at commercial scale, without shortcuts.
After reaction and neutralization, the purification stages bring out the best of our hands-on manufacturing approach. Sequential filtration removes residual salts, while pH-controlled recrystallization draws out high-purity product, avoiding the formation of sticky cakes or excessive fines. Every production run gets cross-referenced against retention samples and archived process logs. We back this with regular staff training and open feedback across departments—a culture learned from years refining our production lines, not just to meet specs but to push performance higher.
There’s a persistent push for finding cheaper nitrophenols or using close analogs in place of specific models. We’ve tested readily available 2-chloro-4-nitrophenol, as well as related compounds with either an extra methyl or altered nitro positions. Each time, the story remains consistent: even minor shifts in substitution patterns lead to notable changes in reactivity, solubility, color, or compatibility during coupling steps. Downstream, users reported unpredictable crystal forms, altered toxicology, or decreased biological activity—a risk that often costs more than initial savings.
Our long-term experience shows there’s no real equivalent for 4-Chloro-5-Methyl-2-Nitrophenol when the synthesis route or regulatory filing calls for that exact structure. If you’re matching reference standards for drug filings, or need to replicate a patent process without deviation, cutting corners rarely pays off in the long run. We keep our plant focused on a single, validated route for this compound, which means robust supply chains and less regulatory drama for our customers.
Industry standards never stand still. Customers today expect traceless lots, full raw material transparency, and ever more robust supply security. Batch failures downstream don’t just waste resources—they can halt clinical timelines, delay regulatory submissions, or spoil planting seasons. That’s why we’ve placed continuous improvement at the core of our operation. Each year, we upgrade parts of our line to minimize downtime and environmental impact. Our switch to closed-loop solvents dropped emissions, while quarterly audits sharpen traceability for every intermediate and finished batch.
Working closely with downstream processors and formulators highlighted the demand for flexible quantities—microscale for pilot runs, bulk for commercial launches without switching suppliers midstream. After years of packaging and shipping, we redesigned liners and outer bags to resist punctures or humidity, and added tracking for every container sent out.
The surge in regulatory oversight, especially in pharmaceutical and agrochemical supply chains, adds new hurdles each year. Meeting not just local requirements but expectations across markets like the US, EU, and Asia takes real investment in documentation, analytical method development, and traceability. We continually upgrade our documentation and testing protocols to withstand audits at every level. Every customer comes to us with different expectations—some want extended impurity profiling, others require detailed traceability back to raw material batch codes. We document, store, and ship this with every order, knowing it supports not just their compliance, but ours as we step up to global market demand.
New requests for more sustainable or green chemistry add to the priority list. Sourcing, minimizing waste streams, and finding ways to close the loop on packaging align with where this industry is heading. We’re working toward greater solvent recovery and recycling on site, with newer water treatment methods in trial. Our teams welcome collaboration—customers bringing specific concerns or requirements often help us identify and solve blind spots inside our workflow.
The way we see it, real customer confidence comes from sharing successes and setbacks openly. Years ago, a mid-size pharmaceutical manufacturer running a scale-up came to us with yield instability using a competitor’s 4-Chloro-5-Methyl-2-Nitrophenol. Small differences in color and moisture caused unpredictable reaction behavior. We ran comparative analytics, identified minor side products, and offered replacement batches with tighter purification. The client’s process stabilized, avoiding both downtime and regulatory impact. This kind of troubleshooting fostered a relationship that’s lasted a decade, during which adoption of this compound has grown.
Process optimization isn’t just an internal issue. Our technical support team, including chemists who’ve worked the same reactors as our customers, regularly visit partner sites for troubleshooting. We’ve helped resolve issues from unexpected odorous off-gassing (traced to stale storage methods) to caking in warm, humid climates solved with bulk desiccant shipments. Customers trust solutions that reflect deep understanding of both our own plant and real-world production needs.
Beyond tight analytical control and proven supply security, we put our focus on relationship-based production. Every lot ships with batch-specific spectral data, full trace impurity profiles, and a cross-check against the final COA issued in house. Regular external audits of our site and third-party verifications reinforce compliance. We don’t chase every new market or try to be everything at once; our core business revolves around a handful of compounds made exceptionally well, with a continuity that global customers can rely on across years of changing regulation and shifting supply chains.
Closing the gap between customer needs, regulatory realities, and sustainable manufacturing isn’t a marketing slogan. Our work on 4-Chloro-5-Methyl-2-Nitrophenol reflects an ethos driven by listening: shorter lead times, clear certificates, and products that perform predictably across the toughest end-uses. We believe this mindset needs to drive specialty chemical production going forward.
Knowledge sharing plays a big role. We invest in webinars, open process documentation, and technical deep-dives both in-person and online, giving customers access to chemical know-how as much as finished product. Our own lab teams test potential applications, share improvements, and feed results back into production, closing a circle that keeps us competitive and our partners well-equipped.
Our decades at the reactor face have shown that real quality in 4-Chloro-5-Methyl-2-Nitrophenol isn’t just about a single analytical value on a certificate, nor about chasing the cheapest price per kilo. The real value builds up from a steady supply, transparency, science-driven process control, and a reputation for solving—not just selling. Though often unseen, these attributes make all the difference for customers with precise needs. We continue refining our approach each year, keeping the conversations with users central to how we work, because in specialty chemistry as in life, it’s the details that drive results.
