|
HS Code |
334955 |
| Productname | 4-Chloro-3-Iodophenol |
| Casnumber | 63703-74-6 |
| Molecularformula | C6H4ClIO |
| Molecularweight | 254.45 g/mol |
| Appearance | Off-white to light yellow solid |
| Meltingpoint | 74-78°C |
| Purity | Typically ≥97% |
| Solubility | Soluble in organic solvents (e.g., DMSO, ethanol) |
| Smiles | C1=CC(=C(C=C1I)Cl)O |
| Inchi | InChI=1S/C6H4ClIO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H |
| Storagecondition | Store at 2-8°C in a dry, well-ventilated place |
As an accredited 4-Chloro-3-Iodophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle labeled "4-Chloro-3-Iodophenol, 25g," with hazard symbols, lot number, and tightly sealed cap for safety. |
| Shipping | 4-Chloro-3-Iodophenol is shipped in tightly sealed, chemically resistant containers, compliant with international transport regulations for hazardous chemicals. The shipment is labeled with appropriate hazard symbols and handling instructions. It is stored away from moisture, heat, and incompatible substances, and typically shipped via ground or air freight by certified carriers. |
| Storage | 4-Chloro-3-iodophenol should be stored in a tightly sealed container, protected from light and moisture, and kept in a cool, dry, well-ventilated area. Store away from incompatible substances such as strong oxidizing agents and acids. Use secondary containment if possible and ensure proper labeling. Avoid excessive heat and sources of ignition. Follow all institutional safety guidelines and local regulations. |
Competitive 4-Chloro-3-Iodophenol prices that fit your budget—flexible terms and customized quotes for every order.
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4-Chloro-3-Iodophenol stands apart as a key intermediate for synthetic routes that lead into both pharmaceutical and agrochemical innovations. At our manufacturing site, this aromatic halogenated phenol gets handled daily by a team who understands that precision and purity make all the difference. Over years of refinement and testing, our chemists have learned that the structural combination of a chlorine atom on the para position and an iodine atom at meta position gives this compound unique reactivity. This foundation makes it invaluable where selectivity and downstream versatility matter most.
Our lot holds a proven CAS number of 1620-95-3. The powder we regularly supply comes with white to tan coloration, owing to tight controls on starting raw materials and process conditions. Batch after batch, the melting point and assay surface dependable repeatability—a trait that research scientists and process engineers often mention to us as their top concern. Structural purity presents as a defining characteristic, not an afterthought. The balance of chlorine and iodine within the molecule provides the springboard for coupling reactions, further halogenations, and many forms of heterocyclic assembly.
Production experience demonstrates that halogenated phenols easily fall prey to trace-level impurities when synthesis, isolation, or packing break from strict routines. Our teams avoid shortcuts, choosing multi-step recrystallization and advanced filtration setups. Going beyond the minimum standards, the final product exhibits exceptionally low residual solvents—making it better suited for sensitive downstream reactions, such as Suzuki couplings or Ullmann-type condensations.
Through in-house analytics, including NMR, HPLC, and GC-MS, every lot gets scrutinized for both identity and by-products. Routine analysis drives us to adjust parameters quickly should any deviation arise in color, melting range, or chromatographic fingerprint. Using this close-looped feedback, our scale-up team continually tightens control over halogen exchange mechanisms. Ultimately, these habits open doors for customers to achieve cleaner reactions, higher yields, and reduced side-product formation.
Within pharmaceutical chemistry labs, 4-Chloro-3-Iodophenol often enters as a building block in multi-step synthesis where regioselectivity cannot be sacrificed. Its pattern of reactivity underpins coupling reactions that would prove difficult or unpredictable with related analogs. For instance, chemists relay stories of convergent syntheses for kinase inhibitors or heterocyclic scaffolds hinging on this compound’s reactivity profile. Iodine at the meta position enhances conversation into more sophisticated structures—providing reactive access via palladium-catalyzed transformations, without excessive risk of over-halogenation or dehalogenation that may occur with unbalanced halides.
Beyond the pharmaceutical sector, specialty crop protection molecules emerge from preparative routes that include this product. Its inherent structure, which resists air and moisture to an extent, makes storage longer and reactions more predictable, especially compared to mono-halogenated phenols that degrade or volatilize more readily. Development labs working on fungicides and herbicides testify to the added confidence they find in the stability and clean reactivity of this molecule.
Material science researchers have picked out 4-Chloro-3-Iodophenol for functional polymers—employing its dual-halogenated benzene ring as a platform for targeted modifications. Since the molecular scaffold allows for dual-point functionalization, it fits prototype work in sensors, optical materials, and coatings, avoiding the complications that come from less distinctly substituted rings.
The combination of chlorine and iodine on the aromatic ring distinguishes this compound from either the 4-chlorophenol or 3-iodophenol alone. Each brings certain benefits. Chlorine stabilizes the oxidative profile, preventing troublesome oxidation under ambient air, while iodine introduces high reactivity toward cross-coupling. Alternatives with only one halogen group either lack stability or restrain the possibilities for transformation. Double-halogenation, tuned as in 4-Chloro-3-Iodophenol, supplies substrate scope without compromising handling properties.
Within our own facility, direct substitution routes to this molecule eliminate many by-products associated with stepwise mono-halogenation. This direct method lets us avoid costs and delays tied to sequential substitution and extensive purification—pain points customers sometimes mention when buying from less-equipped sources. In the lab, you see reaction time decrease and batch yields increase from this difference.
Compared to close analogs bearing substitutions at ortho positions (like 2-chloro-3-iodophenol), the 4-chloro-3-iodo arrangement shows improved solubility in common organic solvents. This eases formulation in experimental setups and scale-up processes. Research feedback draws attention to the reduced tar and side-product build-up during high-temperature transformations as a consequence of this stability.
Handling halogenated phenols means facing challenges like corrosiveness, sensitivity to light, and potential safety hazards tied to dust. Over years of operation, our team built robust engineering controls: closed transfer systems, environment-controlled storage, and fine-particulate containment. Such infrastructure prevents not just product loss, but also accidental exposure—protecting both product quality and personnel safety.
Our operations crew meets regularly with synthesis chemists and customers to gather first-hand reports. We’ve learned that clear labeling and rigor in packaging (high-quality drums or laminated barrier bags) pays off when shipments must survive global journeys. On-site, anti-caking agents or inert overlays prevent clumping, ensuring the end user never struggles with inconsistent pours or blocked feed in reactors.
Disposal and environmental regulations continue to tighten worldwide. As producers, the responsibility does not end once a drum leaves the warehouse. Integrated waste-stream processing means we capture and neutralize spent raw materials, using catalytic incineration and chemical neutralization. Recent process upgrades minimize our own waste footprint—something customers often ask about, and which we track for both internal goals and regulatory compliance.
Our path with 4-Chloro-3-Iodophenol has not always run smoothly. Early on, we contended with batch-to-batch variability that emerged from underestimated moisture exposure. It took equipment upgrades and tighter protocol adherence to bring water content consistently below detection limits. This had a visible impact—not just in analytic readings, but in feedback loops with partners who stopped seeing unexpected reactivity swings. Today, every upshift in specification gets tested and validated not just internally, but in partnership with long-term users ranging from biotech startups to established international firms.
We also faced requests for tighter control over metal residues—some downstream applications fail with palladium even below traditional impurity thresholds. Adopting in-line scavenging and double-depth filtration has now brought post-reaction metal traces to near-analytical zero. Each customer request prompted a process rethink, and these incremental steps compounded into the cleaner, more reliable product we now offer.
Learning directly from researchers has shaped our priorities. Discussions with medicinal chemists, for example, brought us to understand the value of a low-odor product. By managing phenolic precursor volatility through improved reaction temperature profiles, the finished product retains lower headspace volatiles, making bench work less unpleasant and improving lab safety. Fine details—like using dedicated lines to avoid cross contamination with related compounds—resulted from these front-line exchanges.
As production scale has grown, early-stage pain points like raw material variability or color shift have given way to new lessons about global logistics and changing regulations. Our teams regularly work with compliance professionals to preempt delays or rejections at customs. Getting a chemical safely and quickly to a research center in Europe or a scale-up plant in Asia stays a hands-on process, cementing the importance of product traceability and supply chain resilience.
Delivering on high-purity starts long before a batch reaches a reactor. Sourcing of raw materials relies on decades-old supplier relationships, with vetting routines that catch trace contaminants early. We’ve seen what happens to finished product quality when raw ingredient QC slides just once. Process consistency is not only about checks and tests, but ingrained in production culture—every technician feels the impact of minor missteps.
Our analysts handle every lot against in-house specifications well beyond standard certificates of analysis. In production trials, even slight deviations prompt a hold for in-depth review. Any observed physical variation—powder color, crystal size, even static charge—gets listed and discussed with those who use the material downstream. These touchpoints reduce returns or rework and save customers costly troubleshooting.
Informatics support guides our batch tracking and lot genealogy. These systems let our chemists address any reported anomaly with speed, and close gaps before they affect customer work. The feedback system remains open—users, process engineers, compliance officers, and shippers all share updates as they arise, anchoring a rapid response culture.
Placing the user’s application at the center of ongoing improvement makes the biggest lasting impact. We track complaints and implement corrections not as fire drills, but as part of monthly improvement cycles. Our team considers a batch shipped only after three distinct verifications confirm it meets target specs.
Manufacturing halogenated phenols draws scrutiny from multiple regulators for good reason. Over time, our EHS staff built compliance programs covering both transport and storage labeling, adapting quickly to local and international requirements. We manage documentation using constantly updated hazard communication standards. Safety Data Sheets receive ongoing review as toxicological or environmental data is revised.
Some processes may still expose operators to vapor or dust if not properly contained. Our response has been to automate filling operations as far as possible, implement facility-wide air filtration, and set mandatory PPE guidelines above minimum standards. These steps lower concertation both in-plant and in waste streams.
Environmental stewardship forms part of our own agenda. Between waste stream treatment and emissions control, facilities devote real energy and resources to capturing halogenated waste before it leaves site. We remain closely watched for compliance, and audits serve as a catalyst for new controls and upgrades to packaging practices.
With authorities and customers both demanding ever-greater assurance, quality and compliance support remains a year-round commitment. Our quality and safety department works in parallel with R&D to tune production sequences whenever a reagent supply issue or new best practice emerges abroad.
4-Chloro-3-Iodophenol’s trajectory has evolved through listening. Early batches served mainly research-scale trials. As requests grew for kilo-scale drum lots with ultra-high purity, so did our capability. Adapting reactor setups, developing new purification steps, and working with both existing and new downstream users, opened more demanding applications.
Collaboration with industrial partners highlighted the need for batch traceability and expanded audit trails. System upgrades now track lot histories and retain samples for years, giving customers confidence in consistency over time. Pilot-scale runs tested beforehand ensure any process change delivers benefits without rerunning into issues we already solved.
Feedback from advanced materials researchers asked for more granularity in product specifications—moving away from “acceptable ranges” to exact, measured values. Transparent reporting and open sharing of NMR, IR, and chromatography data have since become the standard, supporting not only specification compliance but partnering in customers’ process verification.
Changing patterns in global trade have pushed for more resilient packaging and backup logistics chains. Adjustments include adding temperature and humidity monitors to bulk shipments and updating outer packaging materials to withstand cross-border handling. Ongoing process review ensures products reach their destinations without alteration—a factor that matters greatly, as time- and temperature-sensitive compounds risk performance decline after long transit.
Long-term work with 4-Chloro-3-Iodophenol shows that specialty compound supply rewards diligence. Progress depends on acting quickly on problems, investing in feedback, and sharing insight across teams and with partners outside our walls. Every solution—better filtration, purer batches, tighter packaging, faster response—grew from real-world needs surfaced by users. Quality becomes not just a specification, but a series of habits reinforced by real outcomes in the lab and on the production floor. In manufacturing, the chemical profile alone never tells the full story. It is the practical, sometimes hard-won details, developed alongside users, that determine whose material truly performs under demand.
