|
HS Code |
728992 |
| Productname | 4-Chloro-2-(Trifluoromethyl)Phenol |
| Casnumber | 39890-95-4 |
| Molecularformula | C7H4ClF3O |
| Molecularweight | 196.56 |
| Appearance | White to off-white solid |
| Meltingpoint | 41-44°C |
| Boilingpoint | 210-212°C at 760 mmHg |
| Density | 1.54 g/cm3 |
| Refractiveindex | 1.517 |
| Purity | ≥98% |
| Solubility | Slightly soluble in water |
| Smiles | CC1=CC(=C(C=C1)O)C(F)(F)F |
| Inchi | InChI=1S/C7H4ClF3O/c8-5-3-4(1-2-6(5)12)7(9,10)11/h1-3,12H |
As an accredited 4-Chloro-2-(Trifluoromethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 25g, sealed with a screw cap; white label displaying chemical name, formula, hazard symbols, and batch information. |
| Shipping | **Shipping Description:** 4-Chloro-2-(Trifluoromethyl)phenol is shipped in tightly sealed containers, protected from light and moisture. It must comply with local and international regulations for hazardous chemicals, including appropriate labeling and documentation. Handle with care, using appropriate personal protective equipment, and store in a cool, well-ventilated area away from incompatible substances. |
| Storage | 4-Chloro-2-(trifluoromethyl)phenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible materials such as strong oxidizing agents. Protect from moisture, heat, and direct sunlight. Ensure containers are labeled properly and kept away from sources of ignition. Use secondary containment if possible to prevent spills or leaks. |
Competitive 4-Chloro-2-(Trifluoromethyl)Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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Manufacturing chemicals is not just about producing a compound—it’s about understanding why it matters, what it contributes to the end application, and how it behaves compared to alternatives. At the heart of our product line, 4-Chloro-2-(Trifluoromethyl)Phenol has shown a unique profile that continues to draw attention from researchers, process chemists, and product formulators. The model we offer carries a purity that aligns with the strictest laboratory and industrial synthesis needs. We have spent years optimizing our batch and continuous production methods, ensuring a stable product that matches the evolving demands of our clients’ projects.
Having manufactured thousands of batches, we notice subtle variations in color, crystal texture, and moisture absorption, even within accepted quality ranges. 4-Chloro-2-(Trifluoromethyl)Phenol is harder to synthesize cleanly than most phenols. The electron-withdrawing properties of its trifluoromethyl group, coupled with the impact of the chloro substituent, create side reactions if process controls slip. Our engineers tightened temperature profiles and optimized solvent choices over time, responding directly to the bottlenecks observed in actual plant runs. Our current process produces a consistent, pale powder that avoids the greenish tint common in less carefully refined material. Each drum is filled under inert gas, which we introduced after observing sensitivity to airborne moisture—especially in humid months.
Chemists prize this molecule for two main reasons: its reactivity and its functional groups. The combination of a chloro and trifluoromethyl group alters reactivity on the aromatic ring, steering downstream reactions more predictably than with unsubstituted phenol. We hear from clients working on specialty agrochemicals and fluorinated pharmaceutical intermediates. They report that this compound often provides the unique electronic environment needed to develop target molecules that resist degradation or display improved activity profiles. For those pursuing custom syntheses, having this phenol on hand enables new reaction strategies that simply won’t work with more conventional aromatic compounds.
With purity levels exceeding 98.5 percent—measured by HPLC and confirmed batch by batch—our product avoids the side impurities that sometimes clog up syntheses or reduce reaction yields. Critically, we have learned through feedback that residual solvents from production, even below 0.2 percent, can sometimes create downstream compatibility issues. To address this, we adopted an additional vacuum drying step that has made a noticeable impact on customer satisfaction and process reliability.
Each lot receives moisture testing before packaging, since trace water disrupts several cross-coupling and direct substitution reactions in aryl halides and phenols. This testing developed after a large pharma customer reported unexpected side products, tracing the cause to a drum that had absorbed moisture during an extended period in a warehouse. Now, with better quality controls in place and real-time monitoring, we have eliminated such risks for current and future batches.
Those new to working with halogenated phenols (such as 4-chlorophenol or 2-trifluoromethylphenol) often assume their performance will be similar across a suite of reactions. Our experience shows otherwise. The combined resonance and inductive effects from both substituents change the electrophilicity of positions on the ring, as well as the acidity of the hydroxyl group. In several Suzuki or Buchwald-Hartwig couplings, researchers have reported that our product gives higher selectivity and cleaner conversions compared to monosubstituted or non-fluorinated analogs.
We have seen generic 4-chlorophenol supplied by other manufacturers perform less consistently, partly due to residual monochloro isomers or uninhibited oxidation. Fluorinated compounds sourced from low-cost suppliers often degrade faster, with increased peroxide formation in storage. Our formulation and packaging process targets both purity and shelf-life, having learned from storage trials that product handled in regular air deteriorates over a period of months, while our stabilized packaging dramatically slows this process. These improvements came from working directly with formulation chemists and shelf-life testing in actual storage conditions.
In our own labs, we frequently scale up reactions to understand any bottlenecks before shipment. Researchers using 4-Chloro-2-(Trifluoromethyl)Phenol in aromatic substitution often find that even small inconsistencies—such as a change in pH or the presence of trace metals—lead to differences in conversion yield. Addressing these, we rigorously control all contact surfaces during synthesis and minimize background metal content, which is a structural difference from some suppliers who rely on older equipment susceptible to pitting and leaching.
Customers synthesizing agrochemical intermediates describe increased throughput when starting materials are both pure and physically uniform, preventing clogging or inconsistent feeds in automated systems. Our investment in continuous drying and sieving provides free-flowing powder that can be fed into automated processing lines without bridging or sticking, a lesson learned by watching finished goods pile up behind stuck feed reactors before we modified our process.
The structure of 4-Chloro-2-(Trifluoromethyl)Phenol brings more than a theoretical advantage—it solves specific challenges in multi-step organic synthesis. In fluorinated product development, unwanted side reactions and rearrangements often plague analogs without the right substituents. Feedback from scale-up teams reported substantially cleaner mass spectra and less need for costly downstream purification after switching to our high-purity grade.
We provide support for custom reactors, since we notice heat transfer and agitation challenges with dense, low-flowing powders. Some formulators approached us for help reducing static and clumping. In response, we altered our particle size distribution—not just aiming for a theoretical mean size, but by minimizing fines at the sub-10 micron level that cause dusting problems in automated dispensing.
Anyone who has handled halogenated phenols knows that storage controls matter as much as initial purity. Our early production batches taught us that even slight exposure to moisture or heat over time generates small but significant breakdown products. As a manufacturer, we spend effort educating warehousing partners about these sensitivities and supply our drums with secondary liners. We field tested these in tropical and temperate climates to measure impact on product stability, eventually settling on packaging that costs more but shows superior protection in both warehouse and transport.
Safety also plays into handling practices. Our technical teams provide on-site and virtual support for customers learning to move and weigh the material, sharing practical tools for minimizing dust exposure and controlling spills. These tools evolved after internal audits and near-miss incidents in our own facility underscored how even experienced handlers can underestimate static accumulation or underestimate the corrosiveness of some tool materials when in contact with concentrated phenol.
Direct feedback from laboratories and plants using our product has shaped how we manufacture and supply 4-Chloro-2-(Trifluoromethyl)Phenol. We learned as much from customers scaling up new projects as from established users. In one case, an unexpected thermal runaway traced back to a contaminated raw material issue pushed us to trace every lot of precursor back to the original source, not just the latest shipment.
We value failures as much as successes. Every complaint about off-odors or analytically difficult impurities prompts a process review. In a recent example, our team traced subtle batch-to-batch color variation to a rarely considered step in our synthesis, leading to an improvement in our quench protocol. A university client noted an unexpected UV absorbance pattern, helping us uncover trace byproducts that escaped our regular GC analysis.
Producing halogenated, fluorinated aromatics raises environmental and safety concerns. Our plant has transitioned to more efficient scrubber systems, both for air emission control and liquid effluent management. Observing the impact of regulatory changes, we now provide full compositional transparency with every drum, sharing not just a certificate of analysis but detailed accounts of origin, synthesis route improvements, and environmental footprint for clients interested in sustainability audits.
Our experience with fluorine chemistry has driven us to invest in additional personal protective equipment for operators and to limit manual handling through investment in semi-automated packing lines. We are transparent about process safety not to follow trend, but because scrutiny over residual contaminants, side product formation, and environmental persistence has shaped the reputation of every chemical manufacturer in our sector.
Nobody who has worked with this chemical expects it to behave exactly like a simple phenol. Its trifluoromethyl group makes it more hydrophobic and affects volatility. In certain applications, evaporation losses during open-air transfer lead to product waste and facility odors. After incidents where plant operators experienced unexpected fumes, we revised both our plant’s air handling and provided improved technical sheets to clients to reduce open transfers.
Halogenated aromatic residues in process equipment can be more challenging to remove—the result of increased resin formation during high temperature or catalytic operation. Continuous improvement in cleaning protocols has reduced carryover batch-to-batch, especially in multi-purpose plants handling both chlorinated and non-chlorinated production. We document and share these best practices, offering on-site start-up support to larger users and remote troubleshooting to help clients avoid the “ghost peaks” sometimes caused by adsorbed product in stainless steel lines.
Markets often drive demand unpredictably. Our R&D partners in pharmaceuticals and advanced polymers alert us when new synthetic routes require even tighter specs, or when small changes in impurity profiles shift the suitability of standard supply. We've seen entire pilot projects move forward or fall apart based on the decision to use 4-Chloro-2-(Trifluoromethyl)Phenol in a key step. Close collaboration with end users means we don’t just offer a fixed product—we adapt specs and delivery formats, such as low-dust microgranules or solution forms, where project needs dictate.
Innovation cycles are speeding up, and clients often request packaging sizes or blend compatibilities not considered a decade ago. We've accommodated kilo-scale research projects in customized bottles as well as multi-ton runs in lined drums, always adapting to handle labeling, documentation, and traceability. Our digital tracking ensures that every container’s production history, from raw material acquisition to final analytical report, is never lost—a detail that matters for both regulatory compliance and troubleshooting in advanced syntheses.
In specialty chemistry, a product’s consistency and purity go beyond meeting minimum specs. Many customers have found that starting with a high-integrity product reduces their need for technical interventions, minimizes rework, and builds confidence in both pilot and full-scale launches. Plant chemists have shared that switching to our grade of 4-Chloro-2-(Trifluoromethyl)Phenol shortened project timelines, as less batch-to-batch variation meant reduced need for revalidation of reaction conditions or downstream analytics.
Each process step, from shipment to storage to addition on line, introduces variables. Decades of dealing with halogenated aromatics has taught us that hands-on support and transparent communication provide as much value as the compound itself. Every improvement in purity, packaging, or logistics is a response to real-world experience, not a generic approach.
The landscape for specialty phenols will keep evolving as new regulatory standards and technical requirements emerge. We prepare by investing in testing capabilities and by maintaining close relationships with our clients. Advances in synthetic methodology—such as metal-catalyzed coupling, asymmetric functionalization, and sustainable process design—will challenge producers to deliver ever-purer, ever-more-consistent inputs.
Our commitment goes beyond regulatory compliance and shelf appeal. By putting process transparency, safety, and technical collaboration front and center, we offer more than just a chemical—we help project teams in pharmaceuticals, crop science, advanced materials, and beyond achieve measurable progress in their work.
While competitive suppliers sometimes focus only on price, our experience tells us that value comes from time saved, from avoidance of troubleshooting headaches, and from supplying a product that continues to perform as research projects shift into commercial reality. Every drum shipped represents decades of practical learning, mistakes made and fixed, and lessons shared openly with our clients. In this way, 4-Chloro-2-(Trifluoromethyl)Phenol stands as a real-world example of what reliable specialty manufacturing looks like for today’s—and tomorrow’s—chemistry challenges.
