|
HS Code |
561474 |
| Productname | 4-Bromo-3-(Trifluoromethyl)Phenol |
| Casnumber | 320-41-2 |
| Molecularformula | C7H4BrF3O |
| Molecularweight | 241.01 |
| Appearance | White to off-white solid |
| Meltingpoint | 55-59°C |
| Density | 1.80 g/cm3 |
| Smiles | C1=CC(=C(C=C1O)Br)C(F)(F)F |
| Inchi | InChI=1S/C7H4BrF3O/c8-5-2-1-4(12)3-6(5)7(9,10)11/h1-3,12H |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Purity | Typically ≥ 98% |
| Synonyms | 2-Hydroxy-1-bromo-5-(trifluoromethyl)benzene |
As an accredited 4-Bromo-3-(Trifluoromethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Bromo-3-(Trifluoromethyl)Phenol, securely sealed, labeled with hazard and product information. |
| Shipping | 4-Bromo-3-(Trifluoromethyl)Phenol is typically shipped in sealed, chemically resistant containers to prevent moisture and contamination. It is classified as a hazardous material; shipping complies with all relevant regulations (IATA, DOT, IMDG). The package is clearly labeled with proper hazard symbols, and handling instructions are provided to ensure safe transportation and storage. |
| Storage | **4-Bromo-3-(Trifluoromethyl)Phenol** should be stored in a tightly closed container, kept in a cool, dry, and well-ventilated area away from sources of heat or ignition. Protect it from moisture and direct sunlight. Store separately from incompatible substances such as strong oxidizers. Ensure proper labeling and access restricted to trained personnel. Follow all relevant safety regulations and guidelines. |
Competitive 4-Bromo-3-(Trifluoromethyl)Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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Manufacturing 4-Bromo-3-(Trifluoromethyl)Phenol over the years, the practical purpose of chemistry has become a day-to-day reality for us. Every batch, stepwise from raw material to packed drum, reflects not simply a chemical transformation but a response to the world’s growing need for advanced, reliable, consistent intermediates. The business of fine chemicals rarely stands still; it demands precise composition, clear process logic, and a full grasp of the product’s place in the value chain. Our perspective shapes every kilo leaving our gates, sharpened by lessons from lab expeditions and scaled-up batch handling.
4-Bromo-3-(Trifluoromethyl)Phenol, with the CAS number 327-19-9, stands out in aromatic chemistry, recognized quickly by its bromo and trifluoromethyl substitutions on the phenol ring. Its structure unlocks versatility. At our plant, precise control of microconditions gives material a purity well-suited for synthesis environments, where trace impurities can impair progress downstream. Our material is typically provided as an off-white to pale beige crystalline powder—solid, manageable, and, above all, reproducible from batch to batch.
Customers seek this molecule chiefly for its role as a building block in complex organic syntheses, especially in pharmaceuticals and agrochemicals. Over a decade’s experience, we've noticed its popularity in processes that require high halogen and fluorine content for increased metabolic stability or tailored bioactivity. In big pharma, it's a staple for custom syntheses, sometimes for advanced intermediates or core pharmacophores. Those in plant protection chemistry, for example, favor the molecule as a key structure for new actives, counting on its electron-withdrawing nature to direct reactivity and confer properties not available with simpler analogs.
On the production line, real quality assurance starts with raw materials. Every drum, tote, or tanker entering our gates is screened, checked for elemental composition and risk of cross-contamination. Unlike commodities, 4-Bromo-3-(Trifluoromethyl)Phenol demands attention to detail. Analytical checks—mainly by HPLC and NMR—confirm the product meets a minimum purity of 98%, with single-digit ppm levels of related substances and a melting point in the specified, stable range. Internal release standards always aim higher; over 99% purity batches are routine. Even during dispatch, we use tamper-evident packaging and desiccated containers for high moisture or oxidation-sensitive material.
Our QC team always samples at multiple stages, as phenol groups catch atmospheric moisture and trace oxidants quickly. In earlier days, storage issues sometimes led to color change, hinting at slow degradation. We solved that—welding a standard of vacuum-sealed bags inside HDPE drums. Years later, customer complaints about inconsistent form are few.
One mistake customers make: treating all substituted phenols the same. Over time, we've seen what happens. The trifluoromethyl group at position 3, in tandem with the bromo at 4, isn't a cosmetic difference. Together, they tune reactivity as well as physical behavior. The electron-withdrawing group changes the acidity of the phenol hydrogen, allowing downstream functionalization that would stall with other analogs. Simple bromo-phenols or trifluoromethyl-phenols lack this edge. Customers report higher yields and faster reactions in Suzuki couplings, for instance, compared with 4-bromophenol or 3-trifluoromethylphenol starting materials.
Solubility also shifts. This product dissolves well in chlorinated solvents; lightly less so in pure alcohols. Handling characteristics—clumping, flow—differ due to the fluorine’s low polarizability. In the plant, that means easy filtration and drying on the last step, with minimal caking. Colleagues who handled the synthesized batches in cold, damp weather can recall how other bromophenols can stick and bridge in drums, complicating handling during winter. Not so with this material, whose flow characteristics stay predictable over a wide temperature band.
Our development chemists also found that certain downstream oxidations, often unreliable with other substituted phenols due to side reactions, run cleanly with this derivative. Over time, contract development orders began to ask specifically for this molecular pattern when requesting novel agrochemical or pharmaceutical intermediates.
The landscape for chemical makers tightens every year. Regulatory frameworks focus on trace levels of impurities, worker exposure standards, and environmental care. Our operational protocols now trace every batch to origin, linking upstream and downstream records for audit-ready transparency. As of the last round of self-initiated process hazard reviews, inert atmosphere charging and continuous fume scrubbing have become standard for this line, reducing halogen emissions near zero. Our waste minimization, through solvent recovery and in-house distillation, improves economics and lessens the plant’s environmental load. After long feedback cycles, it is clear that customers trust partners who address both product integrity and lifecycle impacts.
Buyers have increasingly asked for details on both residual metals and potential genotoxic impurities, particularly as the pharmaceutical sector grapples with ever-stricter cGMP interpretations. With our material, the elemental profile is well-defined, usually under 5ppm total heavy metals by ICP-MS. We work closely with clients' analyst teams during tech transfer or validation, often running comparative stability or cross-compatibility tests with their process components.
On sustainability, our commitment is personal. As colleagues with families in the communities near our plant, we pay keen attention to effluent load and solid waste. Our latest process tweak swapped out halogenated solvents for a greener alternative during recrystallization—something that forced adjustment in process time but improved safety and waste metrics.
Nearly every region, from North America to Asia-Pacific, has shipped our material, sometimes under urgent timelines and complex regulatory procedures. Direct communication between our production chemists and client’s technical teams has smoothed hundreds of projects. In more than one case, the original synthetic route planned by a customer failed to scale because of raw material variance, driving a collaborative troubleshooting effort between our analytical team and theirs. Testing new process aids, solvents, or microfiltration setups, we’re always looking for faster, better, and cleaner ways to deliver.
Some projects begin with small volumes. Early-phase discovery chemists depend on accurate packing, lots that match stated weights, and clear impurity analysis. Later, kilo-labs or full-scale pilot plants expect larger runs with identical quality. We tailor our batch sizes within feasible process windows and never dilute the product to adjust cost. Over decades, we learned that rushed production schedules or overpromised capacities only lead to lost trust.
Pharmaceutical innovators now demand supply chains with near-real-time data. Our ERP system tracks every order, every batch, integrating logistics, customs declaration, and pull-from-inventory operations. This level of end-to-end oversight sprang up from practical customer requests: clients want traceability, immediate answers on shelf-life, and a clear sense of what’s different about this shipment compared with last month’s.
Scaling niche molecules involves more than reaction chemistry. With 4-Bromo-3-(Trifluoromethyl)Phenol, downstream users sometimes reported clogging in automated handling units, especially in high-humidity settings. Our solution grew from on-the-floor conversations; after pilot trials, we switched to new anti-caking agents and sealed packaging, yielding cleaner flow even weeks after a drum was first opened. Feedback loops between plant workers, delivery trucks, and customer process techs transformed this from a nuisance to a solved case.
We face shipping headaches, too. Regulations around bromo-organics and fluorochemicals differ country by country, often changing every few years. To avoid customs detainment and resultant shelf-life loss, we maintain updated regulatory filings and keep designated compliance staff in direct contact with carrier companies. Our export paperwork matches all globally harmonized system requirements, from labeling to MSDS, mindful that one mistake at the border creates long bottlenecks and financial strain.
The global shape of the consumer market means adapting to periodic supply chain snags—container shortages, route delays, local shutdowns. Our warehouse space now holds buffer stocks for priority clients, all in climate-stabilized spaces. Customers with urgent, time-sensitive projects often pull from these reserved lots, confident in continuity.
Research is perpetual; new reaction pathways, green chemistry agents, and more sustainable catalysts are topics we engage daily. Our partnership with academic labs sometimes brings new reaction insights that feed back into our internal technology. One project underway investigates using a solid-state catalyst to reduce waste in the main coupling step, promising a leap in atom economy. Should routine success follow, this will set a new internal benchmark for production efficiency, letting us offer even tighter control on cost and supply schedule.
We invite end-users to bring us their toughest process pain points. Our people enjoy solving these—be it optimizing scale-up, handling micro-level impurities, or ensuring regulatory compliance in a world of shifting targets. The core lesson holds: the molecules matter, but so does the way they're made and moved. Our shared future rests in lean process improvements, excellent science, and constant conversation between maker and user.
Behind every drum stands a diverse team—synthetic chemists, process engineers, safety inspectors, logistics planners—drawn together by a shared aim to deliver reliability and safe handling. Colleagues bring in insights from years on demanding lines, drawing from a deep pool of real mistakes and crucial wins. Communication isn’t a slogan here; it is the underpinning of every successful shipment. Our staff take pride in knowing that each shipment helps power next-generation drug therapies or advanced crop solutions, linking daily effort to long-term benefit.
We never see ourselves as simply packing and shipping molecules. Instead, we view each transaction as an ongoing technical partnership, rooted in mutual trust and developed on years of listening, learning, and adapting. There is satisfaction in seeing a new pharma launch or field trial based on intermediates first synthesized on our site—proof that small changes in process, people, and raw material handling make all the difference in final product success. It’s a long path from bench flask to industrial drum, but it is one walked intentionally, creatively, and with an eye on shared progress.
Choosing 4-Bromo-3-(Trifluoromethyl)Phenol direct from a maker reflects more than price or paper specifications. It’s about a lived commitment to quality, transparent production, proven logistics, environmental stewardship, and the science that makes innovation possible. The real differences show not in specifications sheets but in project outcomes, regulatory approvals, and long relationships. We speak from years at the reactors and batch halls: real-world quality shapes tomorrow’s breakthroughs, and the hands that make a molecule set the pace for what the industry achieves next.
