|
HS Code |
634112 |
| Productname | 4-Bromo-2-Fluorothiophenol |
| Casnumber | 1360427-47-1 |
| Molecularformula | C6H4BrFS |
| Molecularweight | 207.06 |
| Appearance | Light yellow to brown solid |
| Meltingpoint | 43-46°C |
| Purity | Typically >=97% |
| Synonyms | 4-Bromo-2-fluorobenzenethiol |
| Smiles | C1=CC(=C(C=C1Br)S)F |
| Inchi | InChI=1S/C6H4BrFS/c7-4-1-2-5(8)6(3-4)9/h1-3,9H |
As an accredited 4-Bromo-2-Fluorothiophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, tightly sealed, labeled with hazard symbols and “4-Bromo-2-Fluorothiophenol, 5g,” includes safety information and batch number. |
| Shipping | 4-Bromo-2-Fluorothiophenol is shipped in tightly sealed containers under an inert atmosphere to prevent degradation. It is classified as a hazardous chemical, requiring appropriate labeling and packaging according to international regulations. Temperature control and protective measures are employed to ensure safe transit, minimizing the risk of leaks, spills, or exposure. |
| Storage | 4-Bromo-2-Fluorothiophenol should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and protected from light. Store under inert gas if possible to prevent oxidation. Use appropriate chemical-resistant containers and ensure the storage area is clearly labeled and secure. |
Competitive 4-Bromo-2-Fluorothiophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Over the years, chemists have always looked for molecules that open new doors in synthetic methodology, inspire new pharmaceutical structures, or bring efficiency to agrochemical projects. 4-Bromo-2-fluorothiophenol, a specialty chemical we craft at our facility, stands out as one of these versatile building blocks. We use it daily in our work with both established and early-stage partners, and its clean performance, reactivity, and reliability have consistently proven valuable.
4-Bromo-2-fluorothiophenol reflects the careful introduction of fluorine and bromine atoms into the aromatic thiol architecture. The product’s empirical formula shows up as C6H4BrFS, and customers often reference its CAS number 183658-34-2. The solid material comes off the production line as a pale to off-white crystalline powder. During handling, it emits that distinctive, pungent aroma so typical of thiophenols—a small but useful sensory checkpoint for those who work hands-on with it.
Our in-process testing uses a combination of NMR, GC-MS, and HPLC methods. The purity in most lots exceeds 98% without the need for extra purification. Rigorous control of trace impurities keeps halide shifts and unwanted regioisomers low, so researchers start their chemistry without the noise of off-target products interfering with R&D goals.
The appeal of 4-bromo-2-fluorothiophenol comes from the way its substituents shape reactivity. The bromine atom opens pathways for Suzuki-Miyaura and Buchwald-Hartwig couplings. This gives synthetic chemists the chance to rapidly diversify aromatic scaffolds, making it especially valuable in drug lead generation. The fluorine at the ortho position changes the electronics of the benzene ring, sometimes blocking unwanted side-reactions and often fine-tuning metabolic stability in downstream molecules. The thiol group, so versatile in linking to other moieties or metal complexes, forms thioethers or sulfonium salts with reliability—even at modest temperatures.
Much of the early feedback from our collaborators, especially medicinal chemists, reflected surprise at how reliably the bromo-fluoro combination held up to complex reaction conditions. In one case, a partner screened hundreds of aryl halides for a targeted kinase inhibitor. Out of that series, only our 4-bromo-2-fluorothiophenol held the selectivity profile once it moved into animal studies. Small numbers sometimes tell a larger story in jobbing chemistry: being able to trust a supply of high-purity intermediate matters, especially during critical-path project stages.
It’s not uncommon to see confusion in selection of aryl thiophenols, so it’s important to break down what sets 4-bromo-2-fluorothiophenol apart from more traditional entries like 4-bromothiophenol or 2-fluorothiophenol. We’ve synthesized and compared these molecules, with firsthand knowledge of their limitations and capabilities.
4-Bromothiophenol reacts quickly in coupling chemistry but lacks the subtle electronic adjustment that a fluorine atom delivers. It’s somewhat more prone to oxidation during storage and may require extra stabilization if held over several months. 2-Fluorothiophenol, while reactive at the thiol, loses out in modularity—the absence of a heavy halide at the para position limits options for subsequent functionalization. Mixing both substituents in the same molecule, as in our product, leads to a reactivity and stability profile that neither parent can provide on its own.
During batch testing, we control for moisture and residual solvents far more stringently with 4-bromo-2-fluorothiophenol than we do with mono-substituted aryl thiols. Water picks up with some thiophenol lots, but the denser lattice of the bromo-fluoro compound resists hygroscopic drift. This trait means fewer surprises during scale-up and smoother transition for chemists planning kilo-lab or pilot lots on a tight deadline.
What truly shapes our approach to 4-bromo-2-fluorothiophenol lies in real laboratory workflow. Sourcing this niche aromatic thiol often comes with headaches: late deliveries, unpredictable impurity spikes, crystals that fail to dissolve as expected, or subtle—but project-derailing—inconsistencies from batch to batch. By anchoring every step in our own shop, from bromination through thiol insertion and purification, we keep control over the material’s truth-to-label promises.
One of our core strengths involves responding to requests for custom lots—whether a pharma client requires five kilos for scale-up or an academic group needs a few grams for SAR mapping. At these scales, customizability improves project choreography. Unlike large commodity suppliers that blend outputs for economies of scale, we tune the campaign to the real needs of the discovery chemist. Our operators monitor every column, check the end-product for both kilogram and gram samples, and record actual experience with each lot, adding to a tactile sense of what works and what doesn’t in the bench-top world.
Much of 4-bromo-2-fluorothiophenol’s field-proven value emerges in the design of pharmaceuticals and crop-protection agents. Medicinal chemists routinely turn to it for late-stage diversification. For instance, we supported a biotech startup optimizing allosteric modulators. Their SAR strategy called for fast library expansion on aryl scaffolds and relied on a series of robust Suzuki couplings. Our product’s outstanding purity meant fewer false leads cluttering the screening deck—real, measurable time savings for a small team with budget constraints.
Agricultural companies, aiming for subtle tweaks to pesticidal efficacy, have used 4-bromo-2-fluorothiophenol in fine-tuning active site interactions on emerging fungicide candidates. The dual halogen motif gave enhanced resistance to environmental degradation, a result that trickled down to better shelf-life and field performance. We have documented reductions in degradation rates in post-treatment samples, building trust in the molecule as a reliable intermediate in real-world use.
On the flip side, some customers initially hoped to use this product in protocols that called for radical thiol-ene chemistry under UV activation. We’ve found, through both internal and customer trials, that the bromo-fluoro arene combination doesn’t always survive high-energy conditions without some side reactions—especially in nonpolar media. We keep those limitations transparent, so scientists anticipate and plan around them.
Producing 4-bromo-2-fluorothiophenol in-house rather than outsourcing synthesis means we see the chemical through every transformation. Starting with high-purity fluorobenzene as a core material, we control each halogenation step, end up with thiol installation, and finish with a careful, solvent-free drying stage. This method tunes particles for quick solution preparation, reproducibility in coupling reactions, and minimal byproduct formation.
In our plant, batch yields can shift with subtle season-to-season changes in solvent quality or water content. Technicians keep close records and adapt—sometimes with slow, careful distillation, other times with extended vacuum drying to push solvents out of the dense lattice. We also tweak process conditions if an uptick in dimer formation appears. Through decades of combined chemical experience, our operators recognize the fingerprints of problems before they become shipment issues.
Stability screens run regularly on retained samples. Extended storage at room temperature reveals that our packing standard—lightproof, air-tight HDPE bottles—delivers reliable potency for at least a year. For clients with unusually demanding logistics, our team finds custom packaging solutions, including unit-dose vials or nitrogen backgrounds for extended storage.
It’s common to worry about the hazards of thiophenol derivatives. In our years of manufacture, the smell alone keeps lab workers aware, but risk extends further. 4-Bromo-2-fluorothiophenol can irritate skin and mucous membranes, a truth we reinforce through regular staff training and generous access to PPE. Some early process tinkering exposed over-optimistic operators to vapor phase, especially when heating near open vessels. That mistake now drives our good habits: always work under a fume hood, minimize open transfers, and maintain careful inventory.
Waste management draws equal attention. Our facility treats mother liquors as halogenated waste, separating streams before sending for incineration or authorized reclamation. Any process water gets carbon filtered to remove trace organics. Small changes in how we contain and destroy reactive aryl thiols have kept downstream discharge within regulatory bounds for over a decade.
Shipping to clients, especially internationally, brings its own set of responsibilities. All parcels ship with classification under the appropriate transport regulations. Now and then, consignees ask for extra assurance—such as independent lab certificates or extra handling notes. We’ve set up a simple internal tracing system, so any pack or bottle leaving our site stays trackable.
In the conversation around rare aryl intermediates, we’ve seen the same cycle: thrill of initial promise, letdown after realizing impure or variant products, relief at finding a consistent maker. Our history with 4-bromo-2-fluorothiophenol fits that arc. Refusing to cut corners, enforcing full traceability, and listening to the real headaches of synthetic chemists has shaped product and protocol alike.
Take the case of a university group who relied on generic stock, only to realize mid-series that half their experiments were based on degraded material. We offered freshly made lots, with every test tabulated and impurity profiling public. Within a week, their reactions ran as published. No drama—just the solid confidence that what you weigh out on the balance matches what you designed at the desk.
Our facility is organized to encourage chemists’ feedback. Every production lot spawns a round of real-world reports that loop back into improved practices. If a partner struggles to dissolve the solid at room temperature, we investigate solubility across a range of solvents and update our recommendations. If storage hasn’t stood up under high humidity, the remedy follows as tighter packaging or clear cold storage notes.
What sets a manufacturer apart from a trader is the living memory of past campaigns, the discipline of troubleshooting, and the sheer number of hands who know what they’re doing. 4-Bromo-2-fluorothiophenol represents both the promise and the responsibility of niche chemicals: real value for those bold enough to push the boundaries of modern chemistry, and lasting trust for those who return for repeat campaigns.
Years of data support every decision we make with this product. If residual tin or iodine from precursor steps rises above one part per thousand, we reject the batch. If a change in raw material sourcing nudges impurity profiles, chemists and QC staff scrutinize every NMR and mass spectrum. It’s not about perfectionism for its own sake but about avoiding cascading issues as intermediates become final products—especially in regulated pharma pipelines.
Our journey with 4-bromo-2-fluorothiophenol reflects the evolving requirements of the chemical and life sciences. From the days of knock-out reactions in glassware to modern robotic screening stations, this molecule has grown into a foundation for targeted synthetic plans and creative molecular designs. Manufacturing isn’t just about producing a compound—it’s about sharing hard-won knowledge, being honest about supply chain wobbles, and investing in the real work that goes into breakthrough discoveries.
The demands placed on chemical intermediates only grow sharper as expectations climb. We recognize that every bottle of 4-bromo-2-fluorothiophenol we ship could end up as the backbone of a new therapeutic agent or a safer crop-protection formula. With that knowledge, our team keeps every step transparent, from raw material checks to after-sale technical support.
No short-cuts or compromises shape our approach. The future will no doubt require even tighter specs, faster delivery, and broader regulatory compliance. By using a hands-on, open-door approach, our customers help improve both the molecule and how we make and share it.
4-Bromo-2-fluorothiophenol started as another line in our product catalog, but through countless lab hours and feedback cycles, it became something else—a quietly crucial tool for research chemists and formulation specialists worldwide. We take pride in making things you can trust with your project’s future, and we look forward to adding new chapters to our shared history in synthesis.
