|
HS Code |
110378 |
| Chemicalname | 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol |
| Molecularformula | C15H23BrO |
| Molecularweight | 299.25 g/mol |
| Casnumber | 3278-89-5 |
| Appearance | White to off-white crystalline powder |
| Meltingpoint | 110-114 °C |
| Solubility | Insoluble in water; soluble in organic solvents |
| Purity | Typically ≥98% |
| Storagetemperature | Store at 2-8 °C |
| Density | 1.16 g/cm³ (approximate) |
| Synonyms | Bromothymol |
| Pubchemcid | 6256 |
| Ecnumber | 221-896-9 |
As an accredited 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol, sealed with a screw cap and safety label. |
| Shipping | 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol is shipped in tightly sealed containers to prevent contamination and moisture ingress. It is packed in accordance with applicable chemical safety regulations, stored in a cool, dry place, and transported under conditions that ensure stability. Proper labeling and documentation accompany the shipment for safe handling. |
| Storage | 4-Bromo-2,6-Bis(2-methyl-2-propanyl)phenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep it separated from strong oxidizing agents, acids, and incompatible materials. Ensure proper labeling and avoid moisture exposure. Store at room temperature, and follow all applicable chemical safety guidelines and local regulations. |
Competitive 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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At our facility, the lines between research, process development, and reliable production often blur. Every day, we handle ingredients and intermediates that require precision and a respect for their quirks. 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol, often recognized for the stability brought about by its tert-butyl groups at the 2 and 6 positions and a reactive bromo substituent at the para site, fits that profile well. Our production team works closely with chemists and technical experts to keep quality high and impurities controlled. This particular phenolic compound rarely leaves room for error, especially when destined for advanced applications, from specialty resins to key steps in pharmaceutical synthesis.
Our daily experience in manufacturing has taught us the difference between a material that behaves by-the-book and one that can keep up with the demands of a pilot plant or scale-up scenario. 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol is robust. The presence of tert-butyl groups gives superior heat resistance and shields the molecule from unwanted oxidation. During production, intermediate solutions stay clear even under prolonged exposure to moderate heat and light—a sign that the structure resists common degradation pathways. The bromo group stands ready for functionalization, providing synthetic chemists an effective launching point for further transformations. This combination of stability and reactivity is not universal among phenolic chemicals, as we often see with more rudimentary alkyl- or halogen-substituted analogs.
Several steps set this compound apart from others we make. Batch control takes on extra importance with bulky tert-butyl groups. Handling the alkylation stage requires attention to both temperature and time, as minor deviations can introduce isomer impurities that complicate downstream synthesis. Our technicians keep a close eye on every reactor during the bromo-stage because of the high reactivity and volatility of the reagents used; safety is more than a protocol here, it’s a daily focus.
The importance of process discipline shows up in the final analytical results. Our experience has shown that poor agitation, even for a single batch, increases the risk of mono- or tri-alkyl byproducts. These disrupt purification steps for downstream users, affecting yields and residue profiles. The difference with our 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol sits in the fact that we deliberately build extra time into every QA check for GC and NMR analysis, weeding out substandard lots before they reach packaging. This isn’t just attention to detail: it is direct feedback from users on the bench, who have seen too many syntheses derailed by trace impurities.
Much of the value behind this compound comes from both steric shielding and functional versatility. Classic substituted phenols don’t always fare well under harsher synthetic conditions, especially when exposed to bases or oxidizers, or when scale-up reactors challenge subtle structural weaknesses. The tert-butyl groups at both ortho positions give this phenol a unique ability to resist many degradation pathways. They provide a physical barrier against electrophilic attack and slow down unwanted oxidation. In a side-by-side test, we have seen common 4-bromo-phenol darken under lab lights in less than a week. This t-butylated variant stays clear and colorless for longer, both on the shelf and during processing.
Another distinguishing feature shows up during coupling or further substitution reactions. The bromo group isn’t hindered by problem sterics, and cross-coupling stays high yielding in both small and larger-scale runs. Many researchers need reliable Suzuki or Buchwald-Hartwig partners, and this compound has delivered those benefits under a wide sweep of conditions. The bromine’s position opens the door to various arylation, amination, or alkylation steps, which have proven value especially for those who want to explore new libraries of advanced fine chemicals, drug intermediates, or functional polymer backbones.
A core belief in our manufacturing approach is that knowing what goes into each step pays dividends when the compound gets into the hands of our customers. Specifications for this material reflect not just laboratory norms, but the realities of repeated scaling, shipment, and end-user feedback. Typical lots exhibit a melting point in a tight, predictable range, and the material remains free flowing in controlled storage. Moisture control, a routine headache for fine chemicals, means we invest in dedicated drying and inert-packaging lines.
One topic that surfaces during technical customer visits is color and odor. Impure or poorly purified batches give off a faint phenolic aroma and pick up tan or yellow tones, signs that stabilizers or filtration have failed. By maintaining deep-vacuum protocols and running in stainless steel, plant-to-lab feedback confirms we minimize byproducts that bring about this discoloration. End-users often ask for assurance that the product meets consistent performance levels from run to run, especially for regulated applications or repeat synthesis. For us, that means every drum is traceable to its batch, and reference samples remain archived for years.
Working with bromo-substituted tert-butyl phenols means facing challenges in both the lab and full scale. We have firsthand knowledge of how important logistics and storage become for these solids. Bulk lots move in sealed containers with tightly controlled headspace; we avoid long transits in hot, humid conditions to reduce clumping or hydrolysis. In our plant, we store 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol under nitrogen, as the combination of low volatility and high purity allows for easy recovery. This attention results from actual delivery failures we have witnessed with less robust phenolics—caking, moisture uptake, and partial liquefaction that cause downstream headaches.
Operators in applications ranging from fine chemical manufacturing to specialty material development report strong compatibility with polar aprotic solvents. The powdered form dissolves efficiently in DMF, DMSO, and acetone, offering flexibility during process design. The presence of bulky tert-butyl groups keeps the compound from engaging in unwanted self-condensation or polymerization, even under basic conditions. This trait gives synthetic chemists confidence in pushing process windows that would break down less hindered phenolic analogs. On our side, regular collaboration with end-users lets us suggest safe and efficient handling protocols, reducing contamination risk and downtimes.
We have seen a wide range of users benefit from this product’s design. Specialty polymer developers prize it for introducing rigidity and bulk to polymer backbones—a feature less pronounced in analogs like 4-bromo-phenol or simple tert-butylphenol derivatives, which don’t bring the combined halogen and dual alkyl protection. Pharmaceutical and agrochemical advanced intermediates routines benefit from the halogen’s controlled reactivity, offering them a pivotal coupling site while the tert-butyl groups prevent side reactions.
Through information exchanges with formulation scientists, we have tracked how these substituted phenols can help in additive masterbatches for plastics, prolonging performance under heat and sunlight. The molecule’s structure helps it resist both physical and chemical breakdown, supporting longer use and minimizing failures in field testing. In contrast, simpler or less hindered phenols lose potency as antioxidants or stabilizers under the same stress. It’s not just about delivering to specs—it’s about practical, real-world success in complex applications.
Over multiple production campaigns, quality consistency becomes the ultimate challenge. As bulk producers, we take direct responsibility for lot-to-lot reliability, not just the purity but also color, odor, and reactivity. Unpredictable physical properties point to failures in synthesis or purification, not just process drift. The plant team tracks everything from starting material lots to vessel cleaning steps. We employ both rapid and detailed analytical screens—GC, HPLC, NMR—on every lot, not just spot checks, and update validation protocols based on real customer feedback.
Customers depend on this discipline across repeated cargoes and seasons. A missed spec here doesn’t just lead to rework—it can shut down a critical campaign at the user’s site. Our own experience has shown that deviations, even on small parameters like moisture or trace organics, ripple downstream during scale-up. Large users have returned batches from other sources showing strange byproducts that never showed up at gram scale. In-house, we use our own synthesized product as a reference, stress-testing it under tougher conditions than most labs would ever see. This real-time learning loop not only guides our own production but shapes every improvement in the process, never losing sight of the practical needs on both ends.
Comparing 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol with similar catalog compounds reveals the effect of design choices. Introducing two tert-butyl groups transforms its thermal and oxidative tolerance, making it viable for harsher processing than mono-substituted or unprotected phenols. In solvent-exposed equipment and open reactors, the chemical resists air and light better, giving users a longer shelf life and fewer headaches during material transfers.
Researchers familiar with 4-bromo-phenol often report frustration with breakdown or browning after weeks in common storage. The bulk of the tert-butyl groups here changes everything—they physically block unwanted access and stabilize the aromatic ring. This opens application possibilities for longer, more demanding process cycles. These same features translate to higher yields and less downtime for users focused on downstream functionalization, such as Grignard reactions or transition-metal catalyzed cross-couplings.
Simple phenolic competitors lack this combination; two tert-butyl groups in the ortho positions are not just cosmetic. Our plant chemists confirmed this in repeated head-to-head stability studies, seeing dramatic preservation of clarity and functional group integrity. Some have tried to mimic the advantages with process tweaks or additives, but direct substitution works best when designed from the ground up. Our chemists and operators can speak to the difference this makes, not just for shelf life but also for day-to-day handling.
Consistent feedback from technical users points toward another benefit—the ability to withstand aggressive synthetic routes. Less hindered phenols succumb to polymerization or undesirable side reactions under conditions such as chlorination, alkylation, or direct metalation. Here, the tert-butyl blocks allow more latitude in process development and experimental design. In one case, a research group scaled up a Suzuki coupling to kilo quantities using our material, encountering fewer filtration and purification bottlenecks than with standard alternatives. Practical benefits emerged not just in yield, but in downstream operational simplicity.
Our own process engineers stress the importance of this flexibility. New chemical entities, custom building blocks, and advanced monomer programs increasingly demand more of their input materials. Process chemistry now rarely stands still—a robust, forgiving starting material saves both time and money. We have worked with groups who had to abandon promising synthetic routes until they switched to a higher-performing tert-butylated bromo-phenol. Production timelines shrank, and quality control stopped being a bottleneck.
A practical lesson from our regular work is the value of clear communication with customers. We share packing, handling, and storage tips not just from written protocols, but from years of actual mishaps and successes. In our experience, moisture control and temperature management rank highest on the list. A well-designed packing protocol, combined with clear instructions, prevents loss in transit and storage. Regular refresher training for warehouse and technical teams on handling sensitive powders like this avoids costly mistakes.
We always aim for transparency about the minor but real differences between this compound and more basic phenols. The price might run higher, due to added raw material costs and more stringent purification steps, but end-users often find this more than offset by productivity gains and fewer failed batches. In conversations with process chemists, it’s common to hear how switching compounds avoided weeks of troubleshooting and reduced rework.
A question that arises in every industry segment concerns supply reliability and responsiveness to customer needs. Unlike traders or bulk resellers, our role as direct manufacturers hooks us into not only delivering on time, but in being accountable for every canister shipped. Adjustments in process conditions, batch sizing, and logistics come straight from our own daily experience. We know that every new application brings fresh challenges—be it solubility shifts, equipment changes, or regulatory shifts. Our staff remains available for direct technical conversations, aiming to address these realities and adapt quickly.
Supply chain volatility has also pushed us to reinforce our upstream sourcing, with multiple reliable suppliers for key raw materials, and to maintain buffer stock in dedicated, climate-controlled storage. Our reliability score doesn’t just sit in paperwork—it’s measured in the ability to cover last-minute shipment changes and support users facing unplanned run-ups in demand.
Working with 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol shapes our broader outlook on innovation. Seeing this molecule perform in actual process and formulation environments helps us identify broader trends in the specialty and fine chemicals world. Increasingly, advanced materials and pharmaceuticals expect more from raw materials—greater resilience, higher reactivity, and minimal unpredictable side reactions. By investing in tight quality control and robust process design, we set up a foundation for exploring new chemistries and supporting breakthroughs that once seemed out of reach.
Experience as direct manufacturers sharpens our sense of what works and what doesn’t—both in the plant and at the customer’s bench. The feedback loop between daily operations and product evolution keeps us focused on meaningful improvements, instead of theoretical gains. This is where reliable, consistently high-purity 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol stands out—not just for its chemical properties, but for its ability to drive forward real-world progress in tough, dynamic production environments.
Direct relationships with partners and users have taught us that innovation doesn’t stop at product launch. Whether in-person site visits or remote technical troubleshooting, the partnership mindset yields better outcomes for all. Our technical service team spends much of its time not just on the phone, but in labs and on factory floors, learning firsthand how our material performs, what bottlenecks crop up, and which emerging needs require fine-tuning our process or specs. This keeps product quality in sync with industry’s real challenges, and opens the door for ongoing improvements.
From our view as chemical manufacturers, the message is clear. Products like 4-Bromo-2,6-Bis(2-Methyl-2-Propanyl)Phenol play a foundational role in today’s innovation pipeline. Solid, practical experience, deep engagement with real-world processes, and continuous learning from every shipped batch anchor both product excellence and customer trust. That partnership, built on years of direct feedback, remains our strongest asset as makers for a demanding, rapidly evolving field.
