|
HS Code |
920579 |
| Chemical Name | 4-Bromo-2,3-difluorophenol |
| Cas Number | 190907-09-2 |
| Molecular Formula | C6H3BrF2O |
| Molecular Weight | 208.99 |
| Appearance | White to off-white solid |
| Melting Point | 56-60°C |
| Density | 1.83 g/cm3 (estimated) |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Smiles | C1=C(C(=C(C=C1Br)O)F)F |
| Inchi | InChI=1S/C6H3BrF2O/c7-3-1-4(8)5(9)6(10)2-3/h1-2,10H |
As an accredited 4-Bromo-2,3-Difluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-Bromo-2,3-difluorophenol, tightly sealed with a screw cap and detailed hazard labeling. |
| Shipping | 4-Bromo-2,3-difluorophenol is shipped in tightly sealed containers, protected from moisture and light. Transport complies with hazardous goods regulations, typically using UN-approved packaging. It is labeled as a corrosive and environmentally hazardous substance, requiring appropriate safety documentation and temperature control to ensure stability during transit. Handle with care to avoid spills. |
| Storage | 4-Bromo-2,3-difluorophenol should be stored in a tightly sealed container, away from light, heat, and moisture. Keep it in a cool, dry, well-ventilated area, separated from incompatible substances such as strong oxidizers and bases. Use appropriate containment to prevent environmental contamination. Proper labeling and storage within a dedicated chemical storage cabinet are recommended for safety and regulatory compliance. |
Competitive 4-Bromo-2,3-Difluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Crafting 4-Bromo-2,3-Difluorophenol has taught us a lot about attention to detail and the discipline molecular synthesis demands. When working directly with halogenated phenols, repeatability matters as much as yield. This compound—recognized by its CAS number 137465-05-5—takes center stage in intermediates for pharmaceuticals and novel agrochemicals because of its reliable purity and consistent reactivity. Our process engineers developed this material through painstaking optimization, not just to meet industry norms but to exceed the routine standards that have frustrated downstream processors for years.
We routinely produce 4-Bromo-2,3-Difluorophenol with a purity exceeding 98 percent, thanks to rigorous fractional crystallization and precise vacuum drying. The compound’s molecular formula—C6H3BrF2O—may look simple to a chemist, but its preparation uses sequential halogen exchange and selective fluorination; a small deviation in temperature or reagent stoichiometry disrupts the whole run. Every batch gets confirmed through HPLC and NMR, so our partners can count on their syntheses kicking off with confidence. Trace impurities aren’t just numbers to us—they are known causes of color changes, off-odors, or unwanted side reactions, so we minimize them at every stage.
We see plenty of manufacturers offering generic halogenated phenol blends. Over time, our clients have shared stories about dustiness, inconsistent melt-points, and unexpected batch-to-batch variation. Our method produces a free-flowing, nearly white crystalline solid, with narrow melting range and low volatility—meaning downstream operators spend less time filtering or compensating for loss during transfers. Our quality control team checks moisture by Karl Fischer titration before packing; low water content helps maintain chemical stability during transit and storage, even in humid environments. We use HDPE-lined drums or foil pouches based on customer requirements, so the product resists caking or lumping through long sea shipments and dry warehouse conditions alike.
Demand for 4-Bromo-2,3-Difluorophenol spans several sectors. Pharmaceutical R&D teams rely on its versatility in constructing bioactive heterocycles, where para-bromo and ortho-fluoro substitutions direct regioselective cross-coupling. Agrochemical designers have flagged this molecule for fitting into fungicide and herbicide pathways, due to its ready availability and predictable reactivity under Buchwald-Hartwig and Suzuki couplings. What surprises some end-users is the flexibility within process development. Chemists find that our product’s predictable melting profile and minimal colored impurities make reaction workups much easier compared to less-refined grades.
Some people ask whether 4-Bromo-2,3-Difluorophenol offers any clear benefit over simpler phenol derivatives. Adding two fluorine atoms and a bromine atom might seem like a heavy lift, but each atom influences reactivity in important ways. Bromine on the ring opens up routes for selective cross-coupling, so functional groups can be introduced without cumbersome directing steps. The 2,3-difluoro motif increases the molecule’s electron-withdrawing capacity, boosting metabolic stability for medicinal chemists and improving biological activity in agricultural projects.
Unsubstituted phenols tend to undergo more rapid oxidative decomposition and are notorious for polymerizing under light or elevated temperatures. Monofluorinated and monochlorinated siblings lack the same balance of stability and synthetic versatility. Careful selection of the substitution pattern gives our clients more options for protecting groups, faster ligation steps, and lower catalyst loadings. Experience has shown that projects using cruder halophenols often see inconsistent yields, more challenging purifications, and failed analytical testing at the final stage. That feedback keeps us motivated to refine every aspect of our process, from recrystallization solvent choices to container sealing techniques.
Halogenated phenols like 4-Bromo-2,3-Difluorophenol are not forgiving to sloppy synthesis. Early attempts at scale-up taught us the importance of working with corrosion-resistant reactors—fluorine chemistry can ruin equipment in a matter of days if overlooked. Our team uses bespoke glass-lined or PTFE reactor vessels and always tests the mixing efficiency after each cycle. We keep careful logs on reagent sources and batch numbers, so if an inconsistency arises, we trace the source quickly and prevent recurrence. Our drying procedures are adjusted in response to seasonal humidity and not just standardized recipes; even a small uptick in ambient water can encourage unwanted hydrolysis if left unchecked.
Packing and transport often pose overlooked threats to product quality. Powder caking, atmospheric contamination, or accidental exposure to sunlight hurt not just appearance but also reactivity. Along the production line, we use nitrogen flushing after filling drums, and our dispatch team signs off only when physical integrity and labeling line up. It’s one thing to promise purity and another to ensure that purity survives two months at sea or the truck ride to a remote laboratory.
Our facility recognizes its responsibility to steward hazardous materials thoughtfully. Manufacturing 4-Bromo-2,3-Difluorophenol can risk releasing halogenated effluent, so we operate closed-loop waste capture and neutralization, verified by external audits twice a year. Our floor supervisors insist on area monitoring, leak detection, and full PPE compliance. Each year brings new environmental regulations, but we don’t wait for new rules before improving our protocols—we partner with compliance teams from our largest clients to share best practices and anticipate corrective steps before they become mandates.
Most handlers know that halogenated phenols can cause skin and respiratory irritation. We’ve replaced older manual transfer steps with automated dosing and solid handling, not only to boost consistency but also to reduce operator exposure. Regular training and procedural drills keep complacency at bay. Delivering on these safety procedures shows up in everyday operations: staff turnover remains low, incidents rare, and regulatory inspections uneventful. Satisfied technical staff mean better product and fewer hidden risks.
Large pharma clients sometimes require 10-kilo quantities and strict batch records; startup R&D labs need only a few grams but demand fast turnaround. We know both worlds. In our experience, successful project launches start by clarifying intended synthesis routes, preferred package sizes, and documentation needs well in advance. Our technical team consults on optimum storage practices, compatible solvents, and safe reaction conditions. For custom requestors—say, a tweak in particle size or an alternate packaging format—we don’t shrug off unconventional asks. A recent contract needed needle-crystal morphology for improved reaction dispersion; our process team adjusted cooling profiles in crystallization to deliver it.
After years in the business, one lesson stands out: paperwork matters. Supporting analytical documentation—COA, batch chromatograms, spectra—ships with every order, not as an afterthought. Chemists call us directly to discuss past reaction bottlenecks if something deviates from plan, and we work through troubleshooting together, drawing from actual run logs rather than marketing brochures.
Technology and market needs keep evolving, and so does demand for sophisticated phenolic intermediates. We’ve invested in pilot-scale fluorination and bromination reactors to improve both safety and throughput. Our research chemists exchange data with downstream developers—not because of any contractual mandate, but because their process feedback lets us map out future process improvements. A synthetic bottleneck today can often be traced back to small issues in intermediate quality from years before. Our open-book attitude with customers saves time and effort on both sides.
Once, a repeat customer struggled with catalyst poisoning in Pd-coupling using material sourced elsewhere. After a few calls and cross-checking their NMR spectra, we pinpointed a transition-metal impurity originating from subpar starting material—not present in our product. As a result of that troubleshooting cycle, we began routinely screening not just for main organic and halogenated byproducts, but for trace metal content in our own QC program. Shared learning reduced wasted effort for both sides.
Regulations on halogenated organics have only grown stricter in our main shipping destinations. Our compliance group stays tuned in to upcoming changes—new requirements for container labeling, mandatory electronic COA submissions, or calls to reduce hazardous solvent consumption. Several years ago, one market insisted on child-resistant lids for every chemical above a certain hazard threshold. Without waiting for clients to complain, we sourced certified closures and rolled out new packaging lines to meet that need.
Sustainability also factors into production. Rather than send byproducts or spent solvents into centralized incineration, we reclaim and fractionate in-house, keeping cradle-to-gate data on waste generation. Customers now ask not just about product reliability, but also carbon footprint per kilogram. Our operations group compiles annual data, so that institutions or multinationals can satisfy their own reporting requirements when auditing their supply chains.
Being a chemical manufacturer means shouldering more responsibility than a re-packer or distributor. If a user experiences trouble, it traces back to our batch notes, not just a lot number from some anonymous warehouse. We forge partnerships with customers—customs, freight forwarders, port officials—to keep shipments predictable, transparent, and free from unnecessary hold-ups. Every success we claim comes stamped with the time and effort of our team: chemists refining methods, operators monitoring vessels, logistics managers tracking temperature and humidity during every shipment.
Customer loyalty comes from consistency, not headlines. Several generics manufacturers return to us precisely because they remember what happens with inconsistent material from third parties: costs rise, stress builds, deadlines slip, and nobody can pin down why the chemistry fails. By opening up our labs for periodic audits, we ensure transparency. Our philosophy: if we experience a production snag or spot an opportunity for improvement, users deserve to know as soon as we do. Discerning clients rely on that level of honesty.
4-Bromo-2,3-Difluorophenol holds its reputation because the synthetic community demands intermediates that do more than just “meet minimum specifications.” Its combination of reactivity and shelf life attracts both research chemists and process chemists, who look for materials that fit well-characterized reaction conditions without nasty surprises. Technical teams prefer our product for its clean dissolution profile; procurement specialists know it clears customs with full regulatory and safety documentation. Every drum or bottle from our facility brings the same promise: predictable quality, straightforward support, and a realistic approach to real-world chemistry challenges.
We know that our customers care about more than an analytical number—they look for minimal color, reliable packaging, and readiness to tackle regulatory or environmental headwinds. By focusing on improving our own process, we help advance everyone else’s. There’s no mystery here, just the hard work of good chemistry and the lessons learned from listening to the people who use our product every day.
