|
HS Code |
834321 |
| Chemicalname | 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol |
| Molecularformula | C16H19N3O |
| Molecularweight | 269.34 g/mol |
| Casnumber | 63558-12-3 |
| Appearance | White to off-white powder |
| Meltingpoint | 218-220°C |
| Solubility | Soluble in DMSO, slightly soluble in water |
| Purity | Typically ≥98% |
| Storagetemperature | 2-8°C (refrigerated) |
| Synonyms | 4-(4-Aminophenyl)-1-piperazinylphenol |
| Smiles | c1cc(ccc1N)N2CCN(CC2)c3ccc(O)cc3 |
| Inchikey | XFGPIHZHINWBGP-UHFFFAOYSA-N |
| Usage | Used in chemical research and pharmaceutical synthesis |
| Hazardclass | Non-hazardous (for research use only) |
As an accredited 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Sealed amber glass bottle containing 10 grams, labeled "4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol," with hazard and handling instructions. |
| Shipping | The chemical **4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol** is shipped in tightly sealed containers to prevent contamination and degradation. It is packaged according to standard chemical safety regulations, including labeling for identification and hazard information. Shipping typically follows protocols for handling organic compounds, potentially requiring temperature control and compliance with relevant transport regulations. |
| Storage | 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol should be stored in a tightly closed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizers and acids. Store at room temperature and avoid exposure to extreme temperatures. Use appropriate safety precautions when handling to prevent contamination or accidental contact. |
Competitive 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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In the chemical industry, every step from raw material sourcing to final product testing matters. Working in synthesis over the past decade, I have observed fundamental shifts in how research laboratories and pharmaceutical manufacturers select their intermediates. Today, chemists aren’t simply looking for a product; they’re searching for reliability, consistency, and a direct dialogue with those of us actually producing the compounds they depend on. That expectation shapes the way we've approached 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol, which we've been manufacturing for clients who don’t have time for guesswork.
Every batch of 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol produced on our lines serves as a touchstone for our attention to detail. This compound presents as a solid, starting with careful raw material selection since trace impurities upstream easily propagate to downstream synthesis. Our synthesis method has been refined over numerous cycles in both pilot and commercial-scale reactors. The final product brings high purity for sensitive downstream chemistry, especially critical for pharmaceutical applications where certain contaminants, even at low ppm levels, might threaten the reliability of clinical results.
Users often come to us after trying material from traders or brokers, reporting inconsistencies between lots or trace unknowns that challenge their analytics. Our protocol includes in-house HPLC, NMR, and LC-MS verification, but manufacturing goes deeper. Achieving the targeted isomer, maintaining a narrow particle distribution, and avoiding solvent entrapment presents daily challenges. The end result—stable free-flowing solid, no excessive clumping or oiling off—means the material delivers predictable performance in bench, pilot, and production scale-ups.
From the standpoint of a chemical producer, models and specifications aren’t marketing terms but records of process success. Our most requested grade of 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol exceeds 99% purity by HPLC. Solubility profiles for a given solvent, bulk density, polymorph tendency, and residual solvent levels remain tightly controlled. Yearly reviews and real-world feedback drive incremental upgrades; for example, switching to a new filtration mesh cut batch filtration times by a fifth and led to less residual inorganic salt in lab analyses. We never ship a product batch unless COA matches our latest in-house control data.
Our standard packaging reflects the sensitivity of this molecule—double-lined bags under inert gas prevent gradual oxidation. Past clients pointed out humidity pickup with single layering, and we adapted accordingly. In routine chemical literature and among non-manufacturers, such storage is rarely discussed, but these real-world lessons come only through handling and customer dialogue rather than specification sheets.
The main users for 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol work in pharmaceutical discovery and scale-up, often in organizations where every reagent needs a paper trail and traceability. This aromatic piperazine structure is a sought-after intermediate when assembling complex small molecules, especially for drug candidates that need both a phenolic moiety and a piperazine ring in proximity. We see this intermediate show up in route scouting for kinase inhibitors, CNS-active agents, and ligand libraries for receptor-based explorations.
In practice, chemists rely on high-purity stock as they can ill afford batch-to-batch variability. Analytical development in these organizations uses our supplied characterization data to run parallel controls. Peptide and heterocycle chemists often praise our material’s minimized extraneous peaks for aiding subsequent transformations, like selective acylation or Suzuki coupling, without the “shoulder peaks” or microcontaminants common in less-controlled supply chains.
I’ve seen plenty of users get frustrated after batches from brokers start degrading or showing unexpected coloration, leading to labor-intensive purification. This feedback loop means modification in drying, packaging, or even process controls at our end. It’s a process not guided solely by specs but by actual laboratory outcomes and dialogue with organic chemists trying to convert our product into finalized pharmaceuticals.
As a manufacturer, I have found that the strictest controls on process variables translate into better reliability and stronger end-user confidence. Small shifts in pH during work-up or subtle differences in source reagent lots show up in final purity and reaction performance. In cases where the client’s downstream protocol is sensitive to residual color or odor, we track these attributes batchwise and willingly provide archival process logs. It’s not about being the lowest-cost supplier but the most communicative and dependable partner.
We don’t take shortcuts with solvent recovery or reprocessing. Years of feedback and internal QA have solidified our stance: reprocessing introduces risk, especially for heterocycles and amines that tend to form stable impurities even at trace levels. Instead, we have invested in robust process design and batch-specific release criteria correlated to practical use in target syntheses. We invite back-and-forth discussions with customers to capture new insights and refine processes so that specs tie into real, observable chemical behavior, not just numbers on a page.
Our direct approach in synthesis and testing means that users talk straight to the people handling the reactors, not to a sales layer removed from daily production. This open line to manufacturing means user suggestions turn into process changes. Multiple requests for smaller batch sizes or custom packing inspired us to offer tailored lots, which circumvent unnecessary holding time and keep the product fresh for sensitive reactions.
Other sources, especially trading houses and non-manufacturers, typically can’t provide current batch traceables or deeper explanations for batch anomalies. We routinely assist in method development—if a customer needs to tweak an assay or faces solubility challenges, our technical staff respond directly, providing OR two-dimensional NMR or expanded solvent profile data. This arms the practitioner with genuine tools directly connected to the production process.
Another noticeable difference comes in online reviews and follow-up feedback. Project chemists, especially in pharma and high-tech, describe sharp contrast between product performance and supply reliability when sourcing directly from a manufacturer. Backed by over five years of continuous production, we have a data log of how minor changes—the size of piperazine supplier, agitation protocol, or solvent grade—impact each output characteristic. We draw on this operational memory to anticipate user needs and preemptively address them in routine batch reviews.
Traceability is not a buzzword but a critical aspect of modern chemistry procurement. Audit trails, consistent lot traceables, and detailed certificates of analysis underpin trust. For 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol, our clients receive full documentation linked directly to production batches—including storage conditions, shelf-life studies, and real-world account of process deviations when they occur. Our lot histories stretch back through every batch; this data becomes pivotal when a pharmaceutical scale-up project requires guaranteed process reproducibility for regulatory filings.
Long-term business comes from reliable user experience. We survey customers on material handling, solution making, and post-reaction work-up. Chemists have noted that our product dissolves predictably in common solvents without residue or crystallization artifacts, reducing rework and speeding up screening efforts. This reproducibility saves time and materially reduces downstream analytical trouble, especially for discovery chemists under tight deadlines and fast-moving programs.
On storage and longevity, our observations show that improper packaging or residual solvent hastens degradation, particularly under humid air. This prompted us to trial and adopt inert gas flushing years before many competitors followed suit. Our shipping department records every deviation from optimal temperature or transit compromise, which ensures users receive product in peak condition. No substitute exists for ongoing attention to real-world feedback and how it shapes both packaging and process controls.
Feedback from the front lines drove many incremental design choices. Years ago, some customers reported crystalline clumping on long storage, complicating weighing. This led us to modify our drying process, verify residual moisture content at multiple stages, and add silica gel packs within the secondary packaging. By keeping water activity low, we improved both shelf-life and ease of handling without making users invest in additional desiccation systems.
Other chemists reported issues downstream with acylation byproducts. Tracing the root cause led us to tighten rein on side-product controls at an earlier synthetic stage and upgrade our filtration protocol. Establishing a reproducible particle size range required investment in new sieving equipment and more rigid quality checks. Each operational fix had an origin story tied to user feedback, not generic process descriptions.
The trace amine aroma challenge, common for this class of compounds, prompted a full round of adsorbent research. We now use activated carbon at a precise stage to avoid over-treatment, which can result in adsorption of usable product. There’s no substitute for direct experience when finding this equilibrium in process tune-ups; theory and lab-scale don’t always match up once real-world volumes are in play.
Labs working in medicinal chemistry or advanced materials synthesis often reach out to us during method development. They value direct access to practical chemical insight from those on the plant floor rather than scripted responses from intermediaries. On more than one occasion, our raw data and firsthand operational notes have helped troubleshoot complex downstream reactions or highlight otherwise unnoticed process contaminants.
Our technical staff routinely adapt methods and develop parallel pilot samples for customer method validation. The team documents every stage, from initial charge through isolation, not only for compliance but to ensure reproducibility for time-pressed teams. In sourcing 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol directly from us, users bypass multiple levels of communication and gain access to producers who recognize just how fast project parameters shift in today’s research and development landscape.
Real improvement in quality and process comes from the push and pull with practicing chemists. Our ongoing process reviews leverage both formal reporting and informal troubleshooting stories passed along by users. Adjustments in bulk density, optimization of filtration, and fine-tuning of drying protocols all stem from trying to make the product as user-friendly as possible for real experiments, not just as a theoretical metric.
By staying close to the actual users—the chemists and engineers—we iterate faster and address challenges before they become bottlenecks. Upgrades happen on the shop floor, not just in the management boardroom. As a manufacturer, that’s the source of real confidence in our product.
Purchasing from a direct manufacturer offers clear, practical benefits. Laboratories get firsthand answers to technical questions. If an issue arises, we do not hide behind layers of middlemen or standard scripts. Customers call us, email us, and sometimes video in to see specific handling techniques for this or related intermediates. This boots-on-the-ground knowledge transfer streamlines projects and improves outcomes. Users know the real conditions under which the product was synthesized, dried, and packed. That kind of transparency is rarely available when material gets handed from broker to trader before reaching the lab.
In the case of 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol, our users frequently point out that knowing the manufacturer makes all the difference when troubleshooting or planning a new synthesis. Information about process conditions, impurity profile, and recent batch experience transforms how labs approach reaction setup and risk management.
Our team maintains active communication channels to tackle challenges head-on. If a client flags a new requirement—like a restriction on certain trace metals for advanced pharmaceutical research—we run specialized analytics and share the unvarnished results. Collaboration with users at the bench level keeps us grounded in the realities of research and manufacturing no textbook or database can match.
As a producer, we recognize there’s always space to improve. New regulatory guidelines or user-led demands can upend old processes. For example, increasing pharmaceutical focus on extractables and leachables made us re-examine our packaging and liner choices, leading to a verified set of compatible materials approved for long-term storage and global transport.
The narrative behind 4-[4-(4-Aminophenyl)-1-Piperazinyl]Phenol from our factory isn’t just a story about yields or specifications—it’s a chronicle shaped by chemists, engineers, and researchers who need more than generic intermediates. Quality emerges from direct engagement, relentless process attention, and mutual respect between users and manufacturer. By welcoming feedback, investing in long-term improvements, and holding ourselves accountable to real-world results, we ensure that every batch stands up not just to laboratory scrutiny, but to the practical demands of advanced synthesis.
For teams navigating the pressure of discovery, scale-up, and regulatory hurdles, a direct connection to a committed manufacturer offers more than cost savings—it provides the partnership and practical confidence needed to turn vision into reality. In every kilogram produced, every feedback call received, and every incremental improvement trialed, our experience speaks through the compound itself.
