|
HS Code |
807850 |
| Chemical Name | 4-(2-Aminoethyl)-2-Methoxyphenol |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Cas Number | 770-05-8 |
| Synonyms | 2-Methoxytyramine; 4-Hydroxy-2-methoxyphenethylamine |
| Appearance | Off-white to light beige solid |
| Melting Point | 162-165°C |
| Solubility | Soluble in water, ethanol, and methanol |
| Purity | Typically ≥98% |
| Storage Temperature | 2-8°C (Refrigerated) |
| Chemical Class | Phenol derivative |
| Smiles | COC1=CC=C(CCN)C=C1O |
| Inchi | InChI=1S/C9H13NO2/c1-12-9-4-3-7(2-5-10)6-8(9)11 |
| Pka | Approx. 9.3 (phenolic OH) |
As an accredited 4-(2-Aminoethyl)-2-Methoxyphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A sealed, amber glass bottle containing 25 grams of 4-(2-Aminoethyl)-2-Methoxyphenol, clearly labeled with hazard and identification information. |
| Shipping | Shipping for 4-(2-Aminoethyl)-2-Methoxyphenol requires secure, leak-proof packaging and clear labeling as a chemical substance. It should be transported under controlled conditions, avoiding extreme temperatures and moisture. Compliance with local and international regulations, including Safety Data Sheet (SDS) inclusion, is essential to ensure safe handling and delivery. |
| Storage | Store 4-(2-Aminoethyl)-2-Methoxyphenol in a tightly sealed container, in a cool, dry, well-ventilated area, away from direct sunlight, heat, and incompatible substances such as strong oxidizers and acids. Minimize exposure to moisture. Use appropriate personal protective equipment when handling. Properly label the container and ensure it is kept away from food and combustible materials. |
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After working with specialty chemicals for years, few molecules draw as much practical interest in industrial laboratories as 4-(2-Aminoethyl)-2-Methoxyphenol. The unique configuration—a phenolic ring with an aminoethyl side chain and a methoxy substituent—brings properties useful in pharmaceutical synthesis, dyestuff manufacturing, and advanced organic chemistry. The chemical model, often referenced as 2-Methoxy-4-(2-aminoethyl)phenol, demonstrates both reactivity and selectivity, making it a mainstay for manufacturers looking for reliability and performance. Here in our facility, we’ve seen demand steadily grow as more chemists appreciate what this product can deliver compared to standard catecholamines or basic phenolic compounds.
One common question concerns consistency. Over time, we have noticed frustrated researchers come to us after other sources failed. Impurities—often trace byproducts from uncontrolled reactions—cause headaches during scale-up. We tackle this by setting firm controls on every step: starting material selection, temperature management, filtration, and rigorous drying protocols. Regular feedback from clients tells us that a batch that comes out clear, crystallizes well, and hits spec every time saves both money and research time down the line.
Every shipment gets scrutinized with liquid chromatography and GC-MS. A little extra effort in isolation pays off, especially since downstream reactions are sensitive to even low levels of oxidized byproducts. This attention to purity is not just industry talk. We’ve seen projects grind to a halt because amino-phenol intermediates fall short in quality. Once we switched to a continuous process for oxirane ring-opening, followed by an optimized workup, our material started passing even the tightest internal quality protocols for major pharma clients.
Over the past decade, we have observed applications for 4-(2-Aminoethyl)-2-Methoxyphenol expand. Historically, its main role was as a protected intermediate in cardiovascular and neurological drug development. Small differences in structure alter biological targets in surprising ways. The methoxy group at the ortho position, in combination with the primary amine, steers selectivity toward certain receptor classes. Our partners in medicinal chemistry often highlight the ease of downstream functionalization. Whether forming amide bonds, coupling with protecting groups, or building custom ligands, this molecule adapts.
Production teams reported similar flexibility. Whether working with solvents on a bench scale or moving to reactor vessels of over 200 liters, the product holds up. Workers handling the compound note its stability at room temperature and good solubility in common polar solvents. Process technicians appreciate that the off-white crystalline solid form is easy to weigh and transfer, and it doesn’t cake up or degrade as fast as some less protected phenols. This has allowed us to extend shelf life under nitrogen for more than a year, and regular QA audits show consistently low water content even after extended storage.
Not all aminophenols behave alike in harsh conditions. Some researchers still ask why go with the 2-methoxy substituted form. From years on the production line and endless customer feedback, we see the difference in actual use. The methoxy-protected phenol doesn’t oxidize as quickly as unsubstituted catechols, which lessens hazing and color formation in solution. Chemists trying both forms quickly realize that the 2-methoxy group stabilizes the aromatic system without drastically cutting reactivity. Oxidative coupling steps show better yields. Long-term storage rarely brings the same reddish tint that plagues standard aminophenols. From a handling perspective, we rarely hear of resinous byproduct buildup when customers switch from plain p-hydroxyphenethylamine to our methoxylated analog.
We also see significant advantages during purification. Once the basic synthetic route is dialed in, the difference becomes clear—less column fouling, fewer tails during preparative HPLC, and easier recrystallization. We get inquiries from teams who have worked for months on a scale-up only to hit bottlenecks at the final isolation. Switching to our material lets them run more straightforward workups, spend less time cleaning glassware, and get more reproducible results. Even after years, these little operational benefits keep people coming back.
Today, medicinal chemists push boundaries faster than ever. Working with evolving targets, they demand raw materials that accommodate both classic and next-generation synthetic methods. Thanks to the selective reactivity of 4-(2-Aminoethyl)-2-Methoxyphenol, researchers can introduce custom acyl groups, form robust C-N bonds, or modify the molecule with fluorescent tags for tracing in biological assays. In one case, we helped a team prepare a radiolabeled variant for PET imaging—a growing application in neuroscience.
Our process developers paid attention to yield and safety at every stage, especially when substituting hazardous solvents or swapping out sensitive reagents. Through iterative improvements, we reduced exothermicity during amination and kept contamination from side reactions to a minimum. These efforts improve cost control and limit the environmental impact of waste streams. The feedback loop from customers helps hone these optimizations so the product arrives ready for demanding applications, not just as an off-the-shelf intermediate.
Outside of pharmaceuticals, customers in diagnostic reagent manufacturing use this molecule in conjugation strategies for enzyme labels and chromogenic agents. The stability of the methoxy-protected form means less background development in sensitive immunoassays. Sorting through the requests from clients in clinical labs, we heard repeated issues with color change and drift in test sensitivity when using less stable aminophenols. This drove us to develop processes that wash out even trace oxidants, improving the product’s resistance to shelf degradation.
For calibrating sensors in analytical instruments, consistent conductivity and low side-product contamination matter. Our batches come with detailed analytical reports. Partnering closely with instrument manufacturers, we have validated our product against international standards, which paves the way for reliable downstream usage in calibration kits and fine chemical assays around the world.
Working on the production floor, safety can't ever slip. Early on, the handling protocols were shaped by mishaps—spills during filtration, inhalation risk during solvent transfers, and reaction runaways from too-fast additions. Everyone learns from these stories. In our current workflow, powder transfers stay contained in gloveboxes, and all temperature-sensitive stages carry dual monitors. Acid-base reactions take place in reinforced vessels with overflow trays. Training new staff means sharing both the formal rules and the unwritten tips picked up from years of trial and error.
Our facilities moved away from batchwise open-system protocols and toward sealed, monitored reactors. Each improvement finds its way into repeatable routines, and customers benefit downstream. The focus on safety isn’t just about keeping regulators appeased. Long-term experience tells us that uncontrolled ammonia evolution or runaway exotherms put product quality at risk. Robust standard operating procedures save costly downtime, protect our people, and guarantee the material our partners depend on.
Sustainability sits at the core of any modern chemical manufacturing process, but applying these ideals on the ground takes more than lip service. Over time, we committed to solvent recycling, rigorous waste stream monitoring, and the replacement of less biodegradable reagents. Our team worked project-by-project to phase out dichloromethane in place of greener alternatives, shifted from heavy-metal catalysts to enzymatic or biocompatible versions where possible, and piloted energy-saving distillation setups.
Each change began as small trials before becoming permanent features. After installing three-stage scrubbers and continuously monitoring pH in discharged water, we caught and corrected sources of unintentional phenolic runoff. The lessons came one at a time, driven by real-world challenges—unusual discharge odors, problems with off-spec product lots, or tighter local regulations. The net result is a manufacturing process for 4-(2-Aminoethyl)-2-Methoxyphenol that not only protects our staff and the community but satisfies clients who must stand behind their own green chemistry commitments.
Hearing regularly from discovery chemists and pilot plant teams, we adapted our approach. What works in a five-gram batch doesn’t simply scale up to a reactor run. Early scale-ups faced yield drops from emulsion formation or thermal gradients in larger vessels. The solution came from hands-on trouble-shooting—one team found that slower addition rates and staged solvent changes gave far more predictable crystallization. Today, our large-scale preparations routinely deliver material that matches research-grade purity, whether a team needs a hundred grams for a new project or hundreds of kilos for a production campaign.
Feedback matters. One pharmaceutical group explained that their key step failed until they switched to a product lot we synthesized after a process adjustment. Stories like this reinforce our belief that building in flexibility, open communication, and continuous refinement benefits everyone in the value chain. We document every batch, monitor every tweak, and share data so buyers know what they’re getting.
In the shifting landscape of global supply, manufacturers find risk everywhere: delayed shipments, interrupted raw material flows, logistics bottlenecks, and regulatory curves. Our team built redundancy into sourcing, relying on multiple suppliers for aromatic precursors and keeping inventory calibrated to anticipated demand. This minimizes disruption for customers working on critical project timelines.
Recently, during a supply chain crunch, we leveraged reserve stocks and prioritized shipments to pharmaceutical and diagnostic clients who faced production deadlines. Our approach to transparency—regular status updates, early notice on production runs, and flexible fulfillment options—has helped customers weather uncertainty. These behind-the-scenes practices are built from experience and a desire to earn long-term trust, not just a one-off sale.
We believe in sharing not only what we make, but also how we make it. Detailed reports accompany every batch, including chromatographic signature, water content, and full identification spectra. Chemists often call to ask about changes to reaction profiles or differences between lots. Having our team on hand to answer with clear, direct information not only saves time, it helps laboratory projects progress smoothly.
After years of producing 4-(2-Aminoethyl)-2-Methoxyphenol, we’ve come to see transparency as an essential service, not an add-on. Mistakes happen, and chemistry rarely follows a straight path. We openly document deviations, communicate realistic lead times, and stand behind our data. This open-book approach serves both experienced buyers and newcomers wrestling with unfamiliar process challenges.
The best practices today arise from hands-on learning and close partnerships with users. Every process refinement, every batch that performs better, builds on questions and feedback from the community. For every piece of equipment we upgrade and every analytical tool we implement, the same principle applies: long-term quality and reliability take priority over short-term cost-cutting or shortcuts.
Looking at the path ahead, we see demand for high-purity 4-(2-Aminoethyl)-2-Methoxyphenol trending upward alongside innovations in neuroscience, analytical chemistry, and biotechnology. Each new application pushes us to refine workflows, raise standards, and explore new ways to minimize waste and improve process efficiency. Our role as a manufacturer is not only to deliver a chemical but to stand behind our customers as they break new ground.
Ask the crew who have cleaned reactors at 3am or solved dosing pump failures after a single misplaced decimal: reliability and process know-how matter most. The hundreds of batches produced, each with its own story, sharpen both our intuition and our precision. These lessons aren’t written down in handbooks. They live in the habits, tweaks, and constant vigilance that only come from making a product, day after day, for real-world users.
So as researchers, production managers, or procurement specialists weigh options for sourcing 4-(2-Aminoethyl)-2-Methoxyphenol, the most valuable questions go beyond a product’s purity spec or data sheet details. Look for what stands behind every shipment—an experienced team, transparent data, practical problem-solving, and a commitment to improvement rooted in daily reality. This is how we earn trust and drive discovery, one batch at a time.
