|
HS Code |
572081 |
| Chemicalname | 3-Trifluoromethyl-4-nitrophenol |
| Casnumber | 886-77-5 |
| Molecularformula | C7H4F3NO3 |
| Molecularweight | 207.11 g/mol |
| Appearance | Yellow to orange solid |
| Meltingpoint | 78-82°C |
| Solubility | Slightly soluble in water |
| Density | 1.62 g/cm3 (approximate) |
| Purity | Typically ≥98% |
| Smiles | CC1=CC(=C(C=C1O)[N+](=O)[O-])C(F)(F)F |
| Inchi | InChI=1S/C7H4F3NO3/c8-7(9,10)4-1-2-5(12)6(3-4)11(13)14/h1-3,12H |
As an accredited 3-Trifluoromethyl-4-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle labeled “3-Trifluoromethyl-4-Nitrophenol, 25g.” Includes hazard symbols, lot number, and tightly sealed cap for safety. |
| Shipping | 3-Trifluoromethyl-4-Nitrophenol should be shipped in tightly sealed, chemical-resistant containers, protected from light, moisture, and incompatible substances. It must be labeled according to hazardous chemical regulations and transported following relevant safety guidelines, such as those outlined by DOT, IATA, or IMDG, due to its potentially harmful and hazardous nature. |
| Storage | **3-Trifluoromethyl-4-nitrophenol** should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and direct sunlight. Keep it separate from incompatible substances such as strong bases and reducing agents. Ensure that storage areas are clearly labeled and access is restricted to trained personnel using appropriate personal protective equipment. |
Competitive 3-Trifluoromethyl-4-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615380400285 or mail to sales2@liwei-chem.com.
We will respond to you as soon as possible.
Tel: +8615380400285
Email: sales2@liwei-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Here in our manufacturing facility, chemistry does not just fill warehouses and datasheets—it defines our day-to-day work. 3-Trifluoromethyl-4-nitrophenol stands out on our production line, not just as a functionalized nitrophenol, but as an example of what good process control and genuine experience with scale-up can bring to the specialty chemicals industry. Years of manufacturing this compound have shown its unique character, and applications chemists keep finding new possibilities that go far past the textbook.
We have handled hundreds of aromatic compounds, but this molecule brings certain challenges—and rewards. The trifluoromethyl group at the meta-position resists many reactions but also lends the molecule the right kind of resilience against breakdown when used in downstream transformations. That single functional group changes how each batch crystallizes, how it handles on the filter, and how small process changes show up in the quality of final product. Add a nitro group at the para-position, and the result is a compound resistant to easy reduction or unwanted side reactions. Our line operators have seen powders clump if the drying goes wrong, and we have seen customers frustrated by yellowed residues from poor purification. Years of getting the recrystallization and drying right have all but eliminated those surprises for us.
No story of an aromatic intermediate feels complete without mention of raw material issues. Sourcing the correct trifluoromethylated benzenes was shaky a decade back, and there were plenty of headaches tied to inconsistent quality or off cuts. Our supply chain had to evolve: we found vendors who actually controlled their isomer ratios and avoided those who didn't. That paid off when downstream reactions started running smoother and final content of ortho- or para-isomers dropped to near zero in our chromatogram reports. For a compound like 3-trifluoromethyl-4-nitrophenol, that difference gives the product an edge in reproducibility for our partners in pharma and crop protection.
The devil always hides in the physical properties. In our runs, we monitor everything from batch-to-batch color (pale yellow if clean, darker if the temperature swings during nitration) to particle size. Handling fluorinated aromatics, especially those that also carry a nitro group, brings an extra need for local exhaust and proper PPE—not just in large-batch production but even at the small scale. Kilo-scale lots go out for high-pressure hydrogenation, and our customers want to see no black contamination and no lingering acids. So, after multiple washes and a tight control on acid scavenging, we package only after confirming purity above 98%.
The model most customers seek rests on confidence in the real purity, and on knowing you will not see surprises under NMR or HPLC. Over the past five years, purity drift emerged as an industry issue, especially with commerce shifting globally and some vendors cutting corners on work-up. As actual manufacturers, we face the customer’s feedback directly, not filtered through a distributor. Maybe that is why our own internal QC goes beyond a simple melting point or TLC scan. Every lot undergoes HPLC comparison with certified references, and each shipment carries a record of dry weight and residual solvent trace.
Every compound tells a different story in its application. Our chemists field regular questions about solubility changes, stability during bromination or Suzuki couplings, and compatibility with protecting group strategies. 3-Trifluoromethyl-4-nitrophenol became a favored intermediate in the synthesis of certain agrochemical scaffolds and as core structure for fluorinated pharmaceuticals. That use is not accidental. The meta CF3 group blocks oxidative metabolism, and the para nitro aids in further reduction or condensation, making this compound much more versatile than a simple para-nitrophenol.
Pharmaceutical researchers appreciate its predictable behavior in SNAr reactions and its compatibility with polyether chain extensions. Crop chemists care about its resilience in sunlit or wet field conditions when used as a precursor. Our job does not end when we ship a drum—we regularly hear follow-up questions about how a product handled in a pilot plant or whether crystallization seeded as expected. If something feels off, our production team runs it again, fixes the issue, and tells the customer exactly what changed.
It is easy to mistake this molecule for other fluorinated phenols, but years in the plant have taught us that subtle differences change outcomes—and customer satisfaction. Compare it to the ortho-trifluoromethyl derivative: ortho substitution usually lowers melting points, increases volatility during work-up, and produces ortho-quinone byproducts in some reactions. The para isomer, while sometimes easier to crystallize, behaves less reliably during SNAr attachment because of less favorable electron withdrawal.
We have learned from experience that 3-trifluoromethyl-4-nitrophenol outperforms simpler nitrophenols by avoiding darkening under long-term storage and holding up during high-temperature hydrogenation steps. Its relatively narrow melting point lowers the risk of oiling out during large crystallizations, meaning rework is rare. Minor byproducts that plague unmixed batches of similar chemicals barely show up in this compound when manufactured under consistent parameters.
Handling fluorinated intermediates brings its own hazards—for example, the monofluorinated analogs tend to hydrolyze more easily, and difluoromethyl compounds sometimes split apart in strongly basic washes. For the trifluoromethyl group, the molecule relaxes; its robust structure stands up to a wider process window. This quality alone earns it favor with process chemists who need to scale up syntheses safely.
Manufacturers like us carry a unique role in improving process safety and efficiency. Our production team spent years perfecting the nitration’s exothermic profile and keeping the final product in its desired monoisomeric form. We have increased throughput on the distillation stage, which not only helps control waste but also pushes purity up, because second-cut fractions rarely meet our in-house benchmark. To rinse out leftover acids, we run additional washing cycles and use vacuum-drying systems fitted with solvent recovery—sustainable practice meets cost control.
Quality control always starts at source material, so we test every batch of fluoroaromatic precursor before reaction. You will not find us skipping a water wash—trace acid in the final product can cause drift in customer coupling reactions or promote discoloration. Solvent recovery not only keeps plant costs down, it helps our environmental compliance, which our clients often ask about these days. Our track record with environmental auditors means the product doesn’t just meet synthetic chemistry needs—it also fits a changing regulatory landscape.
Maybe the best insights into our product’s performance come not from chemical analysis, but from the people who run the reactors. Outsourcing labs working on new generics and large-scale pharmaceutical plants both call in with their results. Issues like clumping during transfer, odd impurities in long-stored materials, or poor performance under mild reducing conditions rarely escape notice. Our commitment to manufacturing—watching the reaction, not just running the numbers—gives us an edge. For example, customers making amines by hydrogenation want to avoid small amounts of dinitro byproducts, so our focus centers on keeping the nitration narrow.
What makes this process unique is the blend of hands-on operator feedback and analytical rigidity. Chromatograms tell part of the story. An operator who records a slight sulfur odor instead of the usual faintly sweet smell can flag a contaminated batch faster than any machine. The ability to respond and adjust, to see these details, sets an actual manufacturer apart from a repacker.
Experience has taught us where the typical pitfalls lie. The first appears in purification: excess solvent during final recrystallization can lead to misshapen crystals that dry poorly, leading to lower purity and shipping headaches. We have redone more than a few lots to keep quality high. Another issue: improper filtration sometimes leaves behind traces of mother liquor, which encourages product discoloration and even sporadic decomposition. Our plant workers implemented an extra pressure filtration stage with inert gas to cut this issue significantly.
Handling toxic nitro compounds means dealing with safety head-on. Routine plant reviews, air monitoring, and real training (not just classroom safety videos) keep exposure to vapors and crystalline dust below regulatory thresholds. As a result, absenteeism due to chemical exposure has dropped nearly to zero over recent years. Waste management also enters the picture. Our in-house waste neutralization system reduces costs and sharpens our environmental profile.
Chemicals stored poorly soon become liabilities. Customers who received early batches in subpar drums or with ineffective seals felt the sting of degraded quality: gel formation and inconsistent melting ranges hampered downstream applications. Now, moisture-resistant, food-grade linings and nitrogen-purged filling improve long-term shelf life and cut incidents of hidden decomposition. We track batch stability for up to two years, recording assay drop and color change, which arms both us and our customers with real data. This matters for bulk users planning their syntheses months ahead, not just for quick-turn research labs.
Our experiences with environmental authorities and industry certification bodies always stress responsible waste handling. Early efforts at solvent recycling and process water neutralization made an impact: those moves cut discharge by two-thirds and saved disposal fees beyond what we expected. Each time the product leaves the site, documentation links back to each batch’s raw material trace, which stands up to customer audits without fail. Nobody wants a recall or compliance violation, and the responsibility sits ultimately with the manufacturer, not a supply chain middleman.
The applications for 3-trifluoromethyl-4-nitrophenol are deepening. Our R&D partners put the compound through new routes, establishing it as a starting point for heterocycle synthesis and as a platform for multi-step functionalizations, not just for standard aryl ether or amine formation. We participate in research partnerships where feedback cycles quickly: if a synthetic hurdle arises—hydrolysis under basic conditions, slow reaction rates in Suzuki couplings, or yield losses in reductive steps—we offer customized lots or process tweaks to resolve the issue. That ongoing dialogue speeds innovation compared to purely catalog-based supply.
Manufacturers who do not respond directly to synthetic challenges often lag when customers encounter new technical hurdles. For us, solving those synthetic roadblocks keeps the partnership strong and improves the chemistry itself.
A chemical’s journey does not end at the drum; its manufacturing story trails throughout its use. 3-Trifluoromethyl-4-nitrophenol’s reliability shows up in places like assay retention after cross-continental shipping, or in the ease of redissolving for scale-up reactions. Competitors sometimes repack bulk material with little QC, missing telltale issues spotted by practiced eyes. Our reputation, earned batch by batch over the years, ties directly to the effort spent on plant upkeep and the discipline of experienced operators. Customers picking up the phone to ask about last-minute analytical quirks always get a real answer—not a rerouted email or a marketing line.
As synthesis techniques shift and regulatory demands grow, the importance of trustworthy intermediates grows with them. 3-Trifluoromethyl-4-nitrophenol’s balanced reactivity and robust performance continue to open new applications in advanced materials, new drugs, and robust crop protection agents. Supporting this, our team keeps improving logistics, introducing bulk packaging options, and tightening in-plant QA systems. Customers now expect detailed origin records, rapid COA delivery, and readiness to customize specifications on short notice. Real-world feedback shapes these improvements—not templated suggestions from a distant office.
Having direct oversight of the manufacturing floor means we prevent problems before they slip into the supply chain. We keep learning, adjusting, and responding to an ever-evolving field. That is where the value of the real producer comes into sharpest focus.
Looking back, a product’s true quality always reflects the care poured into its manufacture. Our experience with 3-trifluoromethyl-4-nitrophenol, from sourcing raw materials to shipping the finished product, shows how diligence and experience make the difference. Whether facing the obscure solubility issues in a new coupling reaction or clarifying the subtle variances batch-to-batch, our hands-on approach keeps customers moving forward.
Manufacturing specialty chemicals delivers both technical challenges and real-world rewards, and our time with this compound proves that quality and process control set the best apart from the rest. That commitment infuses every shipment and every answer we provide, every day.
