|
HS Code |
397455 |
| Chemical Name | 3-Fluorophenol |
| Molecular Formula | C6H5FO |
| Molecular Weight | 112.10 g/mol |
| Cas Number | 372-20-3 |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 179-181 °C |
| Melting Point | 10-12 °C |
| Density | 1.202 g/cm3 at 25 °C |
| Refractive Index | 1.535 |
| Solubility In Water | Moderate |
| Purity | Typically ≥98% |
| Flash Point | 69 °C (closed cup) |
| Smiles | C1=CC(=CC(=C1)O)F |
| Pubchem Cid | 31217 |
| Synonyms | m-Fluorophenol; 3-Hydroxyfluorobenzene |
As an accredited 3-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 3-Fluorophenol is supplied in a 100g amber glass bottle with a secure screw cap, labeled with safety and identification details. |
| Shipping | 3-Fluorophenol is shipped in tightly sealed containers, typically glass or fluoropolymer, to prevent leakage and contamination. It should be transported as a hazardous chemical, with proper labeling and documentation, under cool, dry conditions. Ensure compliance with local, national, and international shipping regulations for toxic and flammable substances. |
| Storage | 3-Fluorophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition. Keep it away from incompatible substances such as strong oxidizing agents and acids. Store at room temperature, protected from light and moisture. Proper labeling and secondary containment are recommended to prevent leaks or spills and ensure safe handling. |
Competitive 3-Fluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615380400285 or mail to sales2@liwei-chem.com.
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Tel: +8615380400285
Email: sales2@liwei-chem.com
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Factories shape the backbone of the specialty chemicals sector with daily routines spent at reactors, distillation units, and packing lines. At our plant, 3-Fluorophenol rolls off the line with years of collective knowhow packed into every drum and bottle. Our experience with aromatic fluorinated compounds has taught us that nothing replaces careful material selection, clean feedstocks, and hands-on process monitoring when it comes to ensuring a consistent product.
3-Fluorophenol, with the molecular formula C6H4FOH and CAS number 372-20-3, doesn’t see the spotlight like some aromatic alcohols, but chemists and lab managers working on fine organic synthesis, intermediates, and APIs know it by its sharp, slightly sweet odor and high reactivity in electrophilic substitution reactions. Our finished batches deliver a transparent liquid—sometimes slightly yellow if handled at open trays—prepped to meet tight purity standards, usually above 99%. Each step, from raw material checking to final sealing, stays grounded in hard practice and regular lab checks.
Compared with non-fluorinated phenols, 3-Fluorophenol’s physical and chemical behavior brings a unique set of benefits and considerations. The fluorine atom increases acidity and shifts reactivity, influencing the compound’s performance as a building block and as a cross-coupling partner. It boils at 174–176°C, a useful range that lets our customers handle it with standard glassware or metal systems. Its flash point, usually around 68°C, deserves attention during storage and shipping, and we run repeated checks with safety staff before anything leaves our site.
On the manufacturing side, we favor continuous distillation and fractionation, with real-time quality checks, striving to eliminate tars and side-products. Impurities like unreacted fluorobenzene or higher molecular condensates get tracked batch-by-batch. Our teams keep a close watch on water content and trace metals because even trace contamination can derail later syntheses down the line for our clients.
Laboratories depend on single-step transformations and selective reactivity, but scaled-up production brings its own headaches. We’ve seen how a small inconsistency in phenol purity can affect catalyst loading or color of the final product. 3-Fluorophenol, compared to its ortho- and para-substituted relatives, offers a balance between cost, ease of handling, and synthesis pathway flexibility. In complex pharmaceutical intermediates, having a meta-positioned fluorine atom opens different functionalization strategies. We work closely with process chemists who want sharp substitution patterns or specific downstream reactivities; from our experience, even trace positional isomers can bring serious headaches in final isolation.
The range of target products using 3-Fluorophenol keeps widening. Its main uses include fluorinated pharmaceuticals, agricultural actives, specialty dyes, and electronic materials. In drug development, meta-fluoro aryl motifs strengthen molecular interactions and modulate pharmacokinetics. Years ago, one of our earliest collaborations saw a Japanese pharma partner pivot a candidate molecule with a meta-fluoro group, shaving weeks off route development and improving product clean-up. Similar stories come from pigment companies reaching for higher lightfastness with tailored aryl sulfonates. Robust sourcing means we have regular conversations about scale, supply certainty, and backup logistics, rather than leaving customers to call resellers who cannot explain batch deviations.
Lab managers frequently ask how 3-Fluorophenol stands apart from its ortho- or para-configured cousins. Unlike 2-Fluorophenol, which often brings steric problems in cross-coupling, and 4-Fluorophenol, which sometimes struggles in forming meta-substituted scaffolds, the 3-isomer threads the needle. It fits specific synthetic schemes where regioselectivity must hit a narrow target. Our in-house R&D, in collaboration with outside partners, has repeatedly shown the 3-substituted analogs unlock transformations that remain out of reach for the other isomers, especially when building complex, fluorine-enriched aromatic rings that power next-generation active ingredients and specialty polymers.
We notice differences not only in reactivity but also in downstream handling. 3-Fluorophenol’s stability makes it manageable on larger scale, where less stable phenols can oxidize or degrade under storage or transit. Our warehouse teams log each lot’s exposure conditions and rotate stock based on shelf life, making sure the product stays ready for time-sensitive production schedules. Over time, we’ve developed a feel for signs of possible instability—bottle coloration, odor shifts, and moisture uptake—and pass these practical guidelines to our customer tech support teams.
Growing regulatory scrutiny today demands more from every chemical manufacturer in the value chain. We maintain full documentation on the provenance of our raw materials, chain-of-custody records, and batch traceability. Each step matters—fluctuating prices or out-of-spec intermediates at the supplier level wind their way down to the final user, and as a manufacturing plant, we take responsibility for clarifying every link in the production chain. Years of audits have taught us the importance of open records, swift recall protocols, and clear labeling, moving beyond surface-level compliance.
Responsible manufacturing includes environmental impact. Our production site operates with on-site wastewater treatment and solvent recovery. It’s not just about ticking green boxes—solvent residues from halogenated compounds like fluorobenzene increase requirements for on-site abatement. We have invested in process upgrades that lower emissions, cut down on energy use per kilogram, and streamline distillation column operation. Lab staff receive training on safe fluorinated waste handling, so that packers, drivers, and even dock workers all know what separates a routine shipment from a hazardous material.
Many buyers, especially at mid-size firms or new startups, eventually realize the value of working straight with a manufacturer. We run our own reactors and blending tanks, so each specification discussion leads straight to adjustments in real production runs. We field technical questions daily about reactivity, solubility, and purity—often custom-matching batch profiles for partner pilot trials. Our technical staff communicates directly with customer chemists and handles special purification runs or customized fill sizes for research and pilot use. We've seen clients bring us favorite schemes, established old routes, or even non-standard product grades that never appear in generic datasheets.
We support pre-sales samples and follow-up batches, tracking any issues as customers scale from laboratory grams up to full production drums. This offers a level of certainty that doesn’t filter down through the layers of traders, resellers, and market consolidators. When problems pop up—batch drift, transport delays, or unexpected impurity peaks—we work with plant operators and shipping managers straight away to resolve the issue. That’s experience talking, not marketing.
End-use scenarios shape how we refine our process. In fluorinated agrochemicals, a major customer once found that marginal increases in ortho contamination wreaked havoc during column purification, cutting their overall yield by nearly 20%. After reviewing reactor hold-up, we modified our condensation protocol and implemented an in-line analytic step that flagged suspect lots. The experience reinforced how even minor process tweaks impact users miles downstream.
In API manufacturing, 3-Fluorophenol often serves as a precursor to key building blocks through Suzuki or Buchwald–Hartwig couplings. Moisture management takes priority since water lowers yield and complicates purification, especially when forming boronates or coupling with aryl halides. We built in dual-location moisture detection, catching even tiny upticks, and share those results with customers so batch-to-batch adjustments run smoother. Each tweak reflects feedback from years of direct engagement with scientists who don’t have time for generic “one-size-fits-all” solutions.
Chemical plants live by minimizing recalls and reworks. Over the last decade, we learned to prioritize both document clarity and operational control for our fluorinated products. Each container gets batch-specific COAs with not just numbers, but detailed breakdowns showing aromatic content, specific impurity figures, and even stabilizer levels, if needed. We hear, time and again, how direct traceability reduces project risks—especially at the scale-up phase, where every unexpected variance can set production back days or weeks. Researchers often return to us not only for price but for the predictability of outcomes.
For sensitive synthesis, especially in pharma or materials science, spot purity means the difference between a wasted week and headline results. Since our founding, we have built analytical protocols (NMR, GC-MS, Karl Fischer, and titration) right into process checkpoints. It’s saved projects during tight timelines, and kept our lot rejection rates well below industry averages. We’re transparent about both strengths and limitations, sharing insights if a batch nears shelf-life or if stability data raises flags.
On the research front, industry chatter often hypes the next big molecule or killer reaction, but it’s the steady advancement—smarter coupling reactions, higher-yield intermediates, and new fields like fluorinated polymers—that keeps us improving our own approaches. We maintain relationships with academic chemists and startup partners exploring new uses for aryl fluorides in both life sciences and high-performance materials. Process innovation sometimes means revamping our own reactors or training operators for new hazard protocols. In one example, we shifted from batch to semi-continuous processing, boosting throughput, cutting downtime, and opening new business with clients requiring rapid-response shipping.
We measure our real-world impact by the projects our 3-Fluorophenol enables—pharmaceutical candidates progressing into Phase II trials, new pigment classes, or up-and-coming battery materials. It’s not just about meeting old standards, but anticipating the next generation of market needs. This outlook keeps our teams on their toes, revisiting everything from raw material audits to final drum sealing, always open to honest customer dialogue.
Manufacturers navigate both big-picture trends and gritty on-the-ground realities. We take pride in meeting the expectations of customers who refuse to cut corners. From first batch to finished shipment, every stage of our 3-Fluorophenol manufacturing follows a disciplined, transparent routine grounded in decades of cumulative trial and improvement. We listen to user stories, answer honest questions, and work with real-world constraints—be it safety compliance, purity targets, or logistics headaches. Product quality arises from more than a spec sheet; it builds from a sustained commitment that only a hands-on manufacturer can provide.
Our goal isn’t to promise the moon, but to offer reliable, practical supplies of 3-Fluorophenol to laboratories, manufacturers, and innovation teams worldwide. By sticking closely to customers, sharing in successes and setbacks, we keep the product performing to the highest standard—every shipment, every time. If you’re aiming for dependable materials in a crowded market, driving new discovery, or tackling production scale challenges, you’ll appreciate what years of manufacturing have taught us about every kilogram of this critical compound.
