|
HS Code |
292430 |
| Productname | 3-Ethyl-2-Fluorophenol |
| Casnumber | 885278-70-8 |
| Molecularformula | C8H9FO |
| Molecularweight | 140.16 |
| Appearance | Colorless to pale yellow liquid |
| Boilingpoint | 225-227°C |
| Density | 1.137 g/cm³ |
| Purity | Typically ≥ 97% |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Refractiveindex | 1.525 (approx) |
| Flashpoint | 101°C |
| Smiles | CCc1cccc(O)c1F |
| Inchi | InChI=1S/C8H9FO/c1-2-6-4-3-5-8(10)7(6)9 |
| Synonyms | 2-Fluoro-3-ethylphenol |
As an accredited 3-Ethyl-2-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, screw cap, 25g net weight. White tamper-evident seal, hazard labels, chemical name and CAS on printed label. |
| Shipping | **Shipping Description for 3-Ethyl-2-Fluorophenol:** 3-Ethyl-2-Fluorophenol is shipped in tightly sealed, inert containers to prevent leakage and contamination. It should be kept away from heat, open flames, and incompatible substances. During transit, it requires labeling as a chemical substance and compliance with relevant transport regulations for hazardous materials, if applicable. |
| Storage | Store **3-Ethyl-2-Fluorophenol** in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the container tightly closed and protected from direct sunlight and moisture. Use corrosion-resistant containers and ensure proper labeling. Follow standard chemical safety protocols, and store at room temperature unless otherwise specified by the manufacturer’s safety data sheet. |
Competitive 3-Ethyl-2-Fluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615380400285 or mail to sales2@liwei-chem.com.
We will respond to you as soon as possible.
Tel: +8615380400285
Email: sales2@liwei-chem.com
Flexible payment, competitive price, premium service - Inquire now!
In the landscape of specialty chemicals, distinct advantages come from close involvement in raw material selection, process refinement, and large-volume production. 3-Ethyl-2-Fluorophenol is a product that often finds its demand among companies focused on innovative chemistry and precision formulation. Our experience as a chemical manufacturer tells a clear story: understanding both the strengths and limits of this compound shapes its real value for research and industrial applications.
3-Ethyl-2-Fluorophenol is an aromatic compound built on a phenolic ring, with an ethyl group anchored at the 3-position and a fluorine sitting at the 2-position. Its model number varies depending on operational labeling, but the key differentiator always lies in its structure and resulting reactivity. The purity levels we achieve often fall in the upper 97%+ range, driven by recrystallization, vacuum distillation, and high-performance liquid chromatographic checks across every batch.
Sourcing quality fluorinated aromatics takes more than just following protocols. Our plants use high-grade fluorination reagents under controlled low-temperature conditions because uncontrolled thermal spikes favor side reactions. The combination of precise stoichiometry and gentle temperature ramps is necessary to shape a consistent product where both impurity profile and batch-to-batch variation stay within tight windows.
Research organizations and specialty manufacturers often approach us with projects demanding both the electron-withdrawing nature of the fluorine and the hydrophobic push imparted by the ethyl group. In medicinal chemistry, this arrangement can fine-tune the metabolic stability of lead compounds, push selectivity windows, and support SAR studies into functionalized phenols. Agrochemical developers appreciate the reliable reactivity of 3-ethyl-2-fluorophenol for building selective herbicide and fungicide candidates.
Process engineers sometimes comment on how this product supports synthetic diversity without introducing the extra reactivity headaches seen in di-halogenated phenols. Its moderate volatility lets it play well in automated dispensing systems, and cleanup proceeds with less environmental load.
We have witnessed extraction chemists rely on this molecule for phase-transfer catalysis and as an intermediate in custom ligand synthesis. Its electron profile means it resists some oxidizing conditions that trip up non-fluorinated phenols, giving project scientists flexibility in reaction sequence design. Over the years, the diversity of uses has only grown as both scale and technical creativity increase across the user base.
Our typical output offers 3-ethyl-2-fluorophenol in crystalline or liquid form, depending on shipment destination and customer system setup. We favor amber glass and inert gas-blanketed containers, particularly for long-term storage.
Each batch runs through gas chromatography and proton NMR screening before dispatch. We verify that the ortho-fluorine signal separates cleanly from the phenolic region, confirming both structure and substitution pattern. Moisture content receives regular testing, as water promotes hydrolysis under storage or reaction conditions.
Anecdotally, customers using the product in high-sensitivity synthesis have noticed the difference: muted batch odor, absence of unknown peaks in HPLC readout, and predictable yield profiles. Our drive for upstream improvement traces all the way back to raw fluorinated precursor choice. A process adjustment two years ago switched to a higher-purity ethanol source; since then, customer complaints about trace aldehyde contamination have essentially disappeared.
Expanding laboratory synthesis into viable multi-kilo production introduces several hurdles. We see three stand out: controlling exothermic reaction cascades, managing by-product profile, and containerizing for safe transit. Our reactors feature automated jacket cooling, real-time FTIR monitoring, and pressure-relief loops. A robust process means new orders get fulfilled on time—no reruns for out-of-spec product.
Backlogs in the global fluorochemistry supply chain sometimes pose pressure on production, especially during quarters when major fluorine raw material plants swing into maintenance. Our experience says that maintaining a live register of qualified alternate suppliers can mean the difference between holding up customer deliveries and keeping relationships strong. Over the last five years, we have invested in closer regional partnerships, keeping real conversation channels open with upstream suppliers to manage spikes or shortfalls.
Waste minimization remains a frontline concern for scale-up. Fluorinated by-products can be hard to treat, and strict regulations guide their safe destruction. We invested in on-site scrubber upgrades and moved to a solvent recovery system that cuts hazardous waste by about 30%. Long-term, retaining process flexibility means we can keep adapting as regulations evolve—future-proofing both compliance and market continuity.
Plenty of phenol derivatives crowd the market, from simple methyl- or chloro-substituted types to more exotic fluoro-variations like 2,4-difluorophenol. What marks out 3-ethyl-2-fluorophenol is practical: it brings both hydrophobic and electron-withdrawing modifications without the instability that often trails heavily substituted rings.
Researchers who have relied on 4-fluorophenol or 2-ethylphenol in the past regularly share stories about solubility headaches or over-reactivity in downstream couplings. Swapping to 3-ethyl-2-fluorophenol, they report better control in esterification and improved selectivity in oxidative couplings—especially in flow chemistry and continuous manufacturing setups.
Engineers appreciate its lower environmental footprint during solvent recovery, since the ethyl side chain keeps boiling points compatible with standard recovery loops. Technicians notice less residue left in reaction vessels, streamlining cleaning cycles. For those in pilot-scale or small-batch work, this means more uptime, less solvent use, and sharper chromatographic performance. These are not theoretical marketing lines, but feedback from years of field experience.
A major pharmaceuticals group approached us needing a fluorinated phenol with tight control over ortho substitution, to support a new series of kinase inhibitor candidates. Their prior batches imported from a commodity producer failed purity tests, with halide contaminants and color variations complicating purification. We adapted our process, increased sampling frequency, and began sending detailed GC traces with every lot. Their trust grew, process reproducibility followed, and over two years the company scaled up both demand and collaboration, resulting in two new analytical collaborations.
A custom polymer manufacturer needed a robust aromatic alcohol for introduction into a new photoresist resin line. Most off-the-shelf phenols showed early yellowing on UV exposure. By leveraging the stabilizing influence of fluorine in 3-ethyl-2-fluorophenol, the development team pushed shelf life upward and reduced premature decomposition in testing. The project manager commented that material drums retained original clarity well beyond the six-month mark, a result traced directly to our high-purity synthetic approach.
Even small academic labs benefit. A professor running medicinal chemistry screens for neuroactive compounds struggled with unreliable supply and inconsistent impurity profiles with other phenolic intermediates. After switching to our product, the lab saw yield increases and improved bioactivity clarity, making student research faster and their published data more robust. Each of these users values not just a chemical, but the reliability of craftsmanship behind it.
Handling fluorinated phenols often calls for upgraded safety gear—impervious gloves, eye protection, and good ventilation. From a manufacturing perspective, we continuously reinforce this with our customers, not as a compliance box-tick but out of direct knowledge. We have witnessed near-misses turn into teachable moments, and believe in staying transparent about storage, transport, and waste practices.
Long-term storage works best under nitrogen with cool ambient conditions. 3-ethyl-2-fluorophenol holds up against light oxidation but still benefits from being away from sunlight or sources of heat. Customers working in less temperate regions often schedule regular replenishment to avoid extended storage times; our logistics team works closely with them to minimize spoilage and cuts.
Waste management represents both a duty and a technical hurdle. The fluorine atom changes the breakdown path of organic waste, necessitating specialized incineration or chemical treatment. We hand out detailed disposal recommendations and coordinate with certified handlers—because sidestepping responsible disposal only leads to problems for both user and manufacturer.
A large part of our development budget targets new catalyst systems that can further tighten the selectivity of fluorination steps, thus reducing both by-products and purification time. Every process tweak and new analytical technique adds a layer of confidence to the final product, keeping user applications running smoothly.
We remain closely attuned to process chemistry literature and end-user feedback, regularly adjusting parameters such as base strength, phase-transfer agent selection, and post-reaction handling. One ongoing project examines how changing the source of the ethyl group affects downstream shelf life and oxidation rates. Early evidence suggests subtle shifts in source material trace impurities can cascade into real effects for users handling the product under sensitive conditions.
We have invested in digital tracking for every batch, allowing both us and our customers to review full manufacturing and testing history. This kind of transparency reduces risk, increases confidence, and brings deeper collaboration into what is often seen as a simple supply transaction.
Environmental and occupational rules continuously redefine how specialty chemicals get made and shipped. We proactively plan for these shifts, investing in VOC abatement, closed-system reactor upgrades, and comprehensive staff training. Several years ago, before wider industry adoption, our site phased out older solvent systems in favor of lower-impact alternatives.
Each new regulatory challenge spurs collaboration across the production, logistics, and application teams. We cross-train staff in hazard communication and routinely review incident management with external auditors. Internal audits run quarterly to keep documentation complete, not just for compliance but as a routine standard that yields traceable, reliable product for every user.
Waste reduction targets keep us searching for novel separation techniques, either through membrane-based purification or advanced crystallization. These developments often spring from collaboration with customers who share in our environmental goals—another reason repeat users tend to stay loyal over the long term.
Supply chains change quickly in the world of intermediates—geopolitical events, logistics snags, or upstream shortages each threaten stable delivery. What smooths out the turbulence is a blend of inventory planning, honest forecasting, and routine dialogue with users. Our role extends beyond molecule-making; it includes forecasting demand shifts and co-planning projects based on both our own and our customers’ timelines.
We do not view our customers as mere recipients. Laboratories and plants using our 3-ethyl-2-fluorophenol often update us on emergent needs or bottlenecks. These conversations motivate refinements in our production flow, help us keep lead times reasonable, and inspire new technical targets. For us, making a differentiated compound means standing behind every shipment, ready to answer technical questions or engage in process troubleshooting.
Strong relationships with carriers and customs brokers also help ensure reliable transit, even in periods of border slowdowns or new regulatory checks. Over time, our team has learned the unique documentation requirements for each export destination, reducing delivery slowdowns and supporting customers with practical guidance through country-by-country shipment rules.
We treat every order as a new test of our best practices. Even with years of accrued know-how, changes in customer expectations and new regulatory frameworks keep us seeking better procedures, more consistent analytics, and more sustainable methods. Each investment in plant infrastructure or staff training adds value beyond that reflected in unit price alone; it builds reputation and resilience.
To us, 3-ethyl-2-fluorophenol is more than just another aromatic intermediate. This product distills years of process optimization, user feedback, and a drive for repeatable, honest technical results. The community of scientists and industrial designers relying on it consistently raise the bar, pushing us to support new applications, tighter quality standards, and broader environmental safeguards. Our approach as a manufacturer draws from every challenge and success, aiming always for a better, cleaner, and more reliable product.
