|
HS Code |
791506 |
| Chemical Name | 3-(Difluoromethoxy)phenol |
| Molecular Formula | C7H6F2O2 |
| Molecular Weight | 160.12 g/mol |
| Cas Number | 261762-24-7 |
| Appearance | White to off-white solid |
| Melting Point | 45-49 °C |
| Boiling Point | 235-237 °C |
| Density | 1.36 g/cm3 |
| Solubility | Soluble in organic solvents |
| Smiles | C1=CC(=CC(=C1)O)OCF2 |
| Inchi | InChI=1S/C7H6F2O2/c8-7(9)11-6-3-1-2-5(10)4-6/h1-4,7,10H |
| Synonyms | 3-Hydroxyphenyl difluoromethyl ether |
| Refractive Index | 1.525 (predicted) |
| Storage Temperature | Store at 2-8°C |
| Purity | Typically ≥98% |
As an accredited 3-(Difluoromethoxy)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 25g, screw-cap sealed, labeled with chemical name, CAS number, hazard pictograms, and safety instructions. |
| Shipping | 3-(Difluoromethoxy)phenol is typically shipped in tightly sealed containers to prevent contamination and moisture ingress. It should be packaged according to relevant chemical safety guidelines, protected from light and extreme temperatures, and clearly labeled. Shipment complies with local and international regulations, ensuring safe transit and handling, with proper documentation included. |
| Storage | 3-(Difluoromethoxy)phenol should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and protected from moisture and incompatible substances, such as strong acids and bases. Store at room temperature, and ensure proper labeling and secondary containment to prevent leaks or accidental exposure. Follow all relevant safety protocols. |
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Making specialty aromatic compounds demands more than careful process control and a trusted team. Every time we produce 3-(Difluoromethoxy)Phenol, we draw on decades spent fine-tuning reaction conditions and optimizing purification techniques. As the direct manufacturer, every batch runs through our reactors, our hands calibrate the feedstocks, and our chemists check the quality before any product heads to customer sites. This way of working grounds everything we do.
Within the world of fluoroaromatic intermediates, 3-(Difluoromethoxy)Phenol fills a practical role that lasts beyond the lab. Our typical output maintains strict purity standards (above 98%), tailored for pharmaceutical synthesis, agrochemical development, or as a key intermediate for specialty materials. We avoid additives that muddy downstream reactions. Packing is done in-house, under climate-controlled conditions, with genuine attention—the vessels get checked off by our own logistics team.
The core structure—consisting of a phenolic ring sporting a difluoromethoxy substituent at the meta position—may sound routine to a chemist, but it opens up a strong range of reactivity. Each year our team reviews the process parameters for this compound. We monitor every pressure point, every swing in pH, and every temperature hold. Raw material checks catch trace contaminants even before we open the drums. Chromatographic and NMR tests are built into our schedule rather than tacked on for show. These steps curb the risk of residual starting materials or process byproducts.
Over time, we’ve ironed out issues that commonly crop up across the industry—batch-to-batch color variations, solvent residues, or slight deviations in assay levels. We value direct conversations with users who scale up process development. Feedback from process chemists motivates our continuous improvement, whether it’s adjusting for a slightly tighter melting range, cleaner filtration profile, or denser packing for shipment. We keep clear records on the sourcing of the starting phenol, the difluoromethoxy precursor, and every catalyst, because transparency traces straight to trust.
Our customers typically draw on 3-(Difluoromethoxy)Phenol for a blend of reasons. In pharmaceuticals, the difluoromethoxy group resists metabolic breakdown, creating routes to more robust drug candidates. Medicinal chemists often use our product as a foundational building block, inserting it into complex scaffolds to modulate hydrogen-bonding, lipophilicity, and bioavailability. Every kilogram we produce is vetted so project timelines don’t get held up by unexpected impurities.
In agrochemicals, this molecule helps introduce fluorine into targeted syntheses. The difluoromethoxy group tunes electronic effects, shaping both activity and plant uptake profiles. Many customers scale their development programs with kilograms sourced directly from our plant, knowing they aren’t introducing uncontrolled byproducts. Analytical research labs run reactivity and stability studies with our batches, appreciating the assurance that comes from a manufacturer’s certificate of analysis backed by real, replicable QC results.
Polymer makers and fine chemicals formulators have also found utility in this compound, particularly for projects requiring high chemical resistance or modification of optical characteristics. Our experience producing to customer specification means we can accommodate both small trial-batch requests and larger campaigns with consistent analytical support at every step.
Producing 3-(Difluoromethoxy)Phenol in-house lets us own every part of the process. As direct manufacturers, we’re not waiting for another supplier, and we don’t cut corners on solvents or safety. Our responsibility covers worker safety, waste treatment, and compliance with environmental standards. We verify emissions from every batch and monitor effluent quality, recognizing that regulatory changes are constant. In our facility, managing waste streams and capturing fugitive emissions aren’t afterthoughts—they are non-negotiable steps.
By controlling every link in the production chain, we guarantee that every lot meets the agreed analytic profile. Procurement teams can audit our process if needed. Finished product lots receive stability monitoring in climate chambers based on customer storage expectations. Peak performance documentation comes from real datasets, not marketing promises. This commitment results in fewer delays during scale-up and lower risk of unexpected supply interruptions.
3-(Difluoromethoxy)Phenol often gets compared to other fluoroaromatic intermediates. The difference comes down to both placement and functionality—our compound introduces a difluoromethoxy group at the meta position, delivering unique electron-withdrawing effects without introducing steric congestion. Monofluorinated analogues change the reactivity, often requiring recalibration for downstream couplings.
We’ve observed that difluoro-substituted phenolic ethers offer a better handle for coupling reactions in both Suzuki and Buchwald-Hartwig protocols. The meta positioning broadens the scope for ortho and para chemistry without excessive deactivation or hindrance. In direct substitutions or oxidations, the difluoromethoxy group tunes reaction rates and selectivity more reliably than bulkier trifluoromethoxy analogues. Based on our records, this translates to higher overall yield and greater tolerance for temperature and pressure swings during multi-step syntheses.
These nuanced differences aren’t just theoretical. Customers report sharper NMR spectra and cleaner MS fragmentation patterns compared to isomeric and homologous phenolic building blocks. Our internal comparison studies indicate fewer side products, less coloration on storage, and lower tendency to absorb moisture. These properties matter when working toward scale or aiming for reproducible patent filings.
We don’t gloss over practical obstacles in handling specialty phenols. Our product comes as a white or off-white solid, flowing freely by the time it leaves our packing line, with minimal caking under normal humidity. As primary handlers, we provide real advice: the product tolerates shipping in all but the wettest climates, but, to maximize shelf life, cool, dry storage in the original sealed packaging is always preferred. Every batch is checked for residual organic volatiles before leaving our site.
Customers sometimes encounter longer lead times with upstream supply disruptions—something we’ve prepared for. Our raw material chain isn’t dependent on single-source suppliers, and we stock ample intermediates to buffer short-term swings in demand. This planning keeps most orders filled within agreed delivery windows, even during heightened market volatility. Our focus on transparency means frequent updates in case of force majeure or logistics hiccups, not silence. We won’t compromise on quality to meet a deadline.
The chemical market for fluoroaromatics ebbs and flows, but direct manufacturing lets us offer consistency. We know that project schedules hang on the arrival of every shipment. Every week, our operations board reviews stock levels, order history, and upcoming production runs. We pre-stage enough inventory to avoid stockouts, and we maintain clear lines of communication with all customers, regardless of project size. Feedback always gets routed straight to our manufacturing team, not filtered through middlemen.
Documentation isn’t just a checkbox for us. It clips right to every lot leaving the site—analytical methods, test reports, purity profiles, and, if requested, stability data. We keep samples of every lot archived in our facility. If a question comes up, we have real product to retest, not just paperwork.
Every decision we make—from raw material approval to process validation—anchors around clarity and traceability. If a specification requires tightening, or if a trace impurity appears, we launch a root-cause trace using batch records and raw material logs. Downstream users can request detailed analytics, and we share chromatograms, spectra, and full analytic history as needed. We understand what it means to develop regulated products, so compliance with ISO, ICH, or other frameworks is built into the process.
While making 3-(Difluoromethoxy)Phenol isn’t simple, maintaining rigorous documentation habits is part of how real manufacturers build trust. We don’t claim perfection, but every deviation or complaint receives full investigation by our laboratory. If an issue touches downstream development, customers receive a comprehensive action report, not marketing spin.
Support for our partners doesn’t end when a shipment leaves the dock. We offer process information and share practical notes relevant to scale-up, whether a project requires enhanced filtration, adjusted solvent selections, or fine-tuned drying procedures. Our technical team’s background covers both research-scale and commercial production runs, so we provide feedback that’s rooted in experience, not guesswork.
For new applications, we collaborate on pilot batches. This includes shipping gram or multi-kilogram quantities under custom packing or extended stability data—the result of direct discussions, not a catalog system. If storage or transportation obstacles surface, we connect customers straight to our logistics manager for resolution. Our philosophy holds that building new chemistry should bring out the best in both the manufacturer and user—problems get tackled collaboratively, not left unresolved.
Like any specialty intermediate, 3-(Difluoromethoxy)Phenol raises its own challenges. Over the years we’ve faced off-spec raw materials, unexpected scale-up obstacles, and shifting regulatory frameworks for fluorinated organics. Rather than masking these realities, we openly communicate with customers about what’s changing. We invest in process control—recently, updated temperature-control technology and new filter media cut runtimes and raised recovery yields. Even under pressure from shifting market prices, these choices keep the long-term quality consistent.
Growth comes from listening to customer concerns. More users want minimized residual solvents and stricter limits on heavy metals—so we updated our purification sequence and lengthened quality screening, at increased cost, but without compromise. Drawing from process analytics, we’re shifting toward greener solvents where possible, spending the extra effort up front to cut waste and simplify downstream handling.
Innovation in aromatic fluorination isn’t limited to university labs. In our own pilot facility, we develop modifications for etherification and aromatic substitution, drawing on what actually works at scale. Sometimes, changes mean additional pressure for our QC teams. New routes promise higher atom economy or lower energetic input, but every method gets documented and qualified before going commercial. Customers interested in process improvements get early access to trial-grade material and joint development opportunities before final specs get locked in.
We welcome inquiries about custom analogs or scale-dependent modifications. Every new variant gets its own risk assessment for analytical differentiation and storage stability. Experience shows that what works at a hundred grams may not run cleanly at a hundred kilos—so R&D and operations keep their work tied closely together. Communication runs openly between chemists, scale-up engineers, and commercial managers.
Sourcing, handling, and distributing fluorinated intermediates now involves more than simply hitting a purity target. Global regulations for environmental and occupational health demand careful monitoring. Our compliance teams track evolving standards for emissions, transportation, and pack-out procedures. If a customer requires supporting documentation for drug master filings or regulatory submissions, we collaborate directly with their regulatory departments to answer with scientific backing, not just summaries.
We address sustainability from the ground up. This covers everything from solvent recovery to waste water treatment—a topic we care about because our facility sits close to agricultural land and sensitive waterways. Every improvement to green chemistry and energy use works toward both compliance and community trust. Risk assessments for new routes include resource usage and recycle loops, not just yield and purity. By integrating these practices, we assure our partners of a chemical supply that’s built for the long term.
Our approach to 3-(Difluoromethoxy)Phenol goes further than formula sheets or catalog listings. Hands-on production ties every order to our expertise and experience. Regular maintenance, raw material screening, and batch documentation create a reliability that downstream users notice right away. Advice on storage, handling, and application comes from genuine familiarity with both the molecule and the market’s needs—not just a printed MSDS.
Customers who scale new syntheses or test formulations benefit from transparent supply and clear technical support. Our routine keeps the supply chain grounded; from initial order to long-term partnership, the reliability of every shipment stands on the experience of people who handle and test the material at every stage. We believe this is what gives direct manufacturing its edge in a complex, evolving industry.
