|
HS Code |
503325 |
| Chemical Name | 3-Chloro-5-(Trifluoromethyl)Phenol |
| Molecular Formula | C7H4ClF3O |
| Molecular Weight | 196.56 |
| Cas Number | 376-08-1 |
| Appearance | White to off-white crystalline powder |
| Melting Point | 54-57°C |
| Boiling Point | 213-215°C |
| Density | 1.56 g/cm3 |
| Purity | ≥98% |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Smiles | C1=C(C=C(C=C1Cl)O)C(F)(F)F |
| Inchi | InChI=1S/C7H4ClF3O/c8-5-2-4(7(9,10)11)1-3-6(5)12/h1-3,12H |
As an accredited 3-Chloro-5-(Trifluoromethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with secure cap, labeled "3-Chloro-5-(Trifluoromethyl)Phenol, 25g," hazard symbols and handling instructions included. |
| Shipping | 3-Chloro-5-(Trifluoromethyl)Phenol is shipped in tightly sealed containers, protected from light and moisture. It is classified as a hazardous chemical and should be handled according to safety regulations. Transport is typically via ground or air with proper labeling and documentation, complying with local, national, and international shipping guidelines. |
| Storage | 3-Chloro-5-(trifluoromethyl)phenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and incompatible materials such as strong oxidizing agents. Protect from direct sunlight and moisture. Proper chemical safety labeling is essential. Store at room temperature and avoid prolonged exposure to air to prevent degradation. |
Competitive 3-Chloro-5-(Trifluoromethyl)Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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Our team began producing 3-Chloro-5-(Trifluoromethyl)Phenol long before it became a staple for research and industrial labs. For chemists who spend their days searching for the right molecular building blocks, tweaks like a chloro group at position 3 and trifluoromethyl at 5 are not small changes—they make or break yields, create or kill side reactions, shift boiling points and flash points. We did not set out to chase an “exotic intermediate.” Instead, our own lab work kept leading back to this phenol. Now a known tool in fine chemical synthesis, it earns respect for practical reasons.
Few phenols offer this blend of electron power and steric structure. The chloro atom doesn’t just stand as a decoration—it’s an anchor for further modification, and its position controls electron density that can drive selective coupling. The trifluoromethyl group adds more than just mass and electronegativity; it places a chemical “gate,” shifting reactivity over the aromatic ring and increasing stability in harsh conditions. Put these features on a phenolic skeleton and a compound emerges that holds value for pharma, agrochemicals, electronics, and specialty polymers.
Model number and batch characteristics lose relevance if the user can’t trust reproducibility. We invest time in controlling process parameters—solvent purity, temperature ramps, quench conditions, and even the grade of raw material. Minor contamination or a tough-to-purge byproduct means cost and frustration down the road, especially for customers scaling their ideas toward the tons. In every step, our focus sticks to purity—routinely at or above 99% by HPLC, with key trace impurities below 0.2%. Color, melting point, and moisture all carry weight, since downstream transformations depend on predictability. The analytical certificate comes from the same set of machines and techniques we count on internally, not a third-party.
The technical process itself isn’t only about following the literature recipe. For a molecule with reactive groups, batch reactions can drift. Our scale-up required changes to agitation rates and heat transfer that didn’t show up on an academic bench. We choose glass-lined kettles to avoid leaching metal ions, double-check filtration step-by-step, and work under dry nitrogen because ambient moisture can hydrolyze both the product and reagents. Some suppliers cut corners here; small cost savings amplify troubles later, especially in pharmaceuticals, where every impurity is suspect and can end up in the final compound or catalyst residue.
A good example lies in its use for aryl ether and aryl amine formation. The phenol moiety sets up high reactivity for nucleophilic aromatic substitution, yet the electronic effects steer the selectivity and rate. In our own work supporting pharmaceutical synthesis, we’ve seen chemistries that only move forward with this arrangement of substituents—too much deactivation, the reaction stalls; too little, unwanted isomers or tars form.
When academics or process chemists ask why not stick with plain phenol or simple monochloro phenols, experience points the way. Tuning the electron balance with the trifluoromethyl at the meta site creates the window for selectivity, while the chloro at 3 forces reactions to those positions not shielded by both. Yields rise, byproducts fall, and column chromatography goes from a nightmare to an afterthought.
Customers involved with agricultural compound discovery run into similar barriers. Sulfonation and etherification reactions go wrong when regular phenols lead to multiple products—or deteriorate under reaction conditions. Once they switch to our purified 3-Chloro-5-(Trifluoromethyl)Phenol, they find a consistent reaction partner, eliminating the costly reruns that often come from less engineered intermediates.
Manufacturing specialists in electronics gravitate toward this phenol for its unique balance. Trifluoromethyl groups bump up resistance to oxidation, and the phenol lends itself to building block status for coatings and resist-forming materials used in lithographic processes. Some customers note that with other similar phenols, polymerization steps fail, but the correct substitution pattern delivers stable films and sharp definition.
Many years of experience with halogenated and fluorinated phenols revealed the limits of similar molecules. A monochloro phenol with no trifluoromethyl rarely survives aggressive downstream chemistry; the trifluoromethyl alone, without a tactical chloro, opens too many sites to unwanted substitution, which means chromatography and recrystallization headaches.
We have run comparisons against 2-Chloro-5-(Trifluoromethyl)Phenol on the same reaction grid; regioisomeric drift means the wrong chloro placement leads to slower rates and more side reactions. The 4-chloro variant, meanwhile, often brings insolubility or makes it tricky to separate final products. Our hands-on batches consistently show that the 3-chloro configuration, paired with 5-trifluoromethyl, creates a delicate balance between deactivation and activation. Reactivity stays predictable.
Our application chemists describe situations where users bought competitors’ batches—synthesized under less rigorous control or with recycled solvents—and ran into color bodies, elevated heavy metal content, or batches that changed color on standing. Our product, when stored in sealed amber containers and managed within stated shelf life, holds pale color and stability for extended periods. This seems minor until sensitive downstream reactions—especially those involving metal catalysts—depend on every fraction of a percent.
From our side as manufacturers, continuous process improvement is not just a slogan. Every year, new literature data and customer feedback push us to modify purification steps or revalidate impurity profiling. Analytical standards have become more demanding over the last decade, especially from pharmaceutical and electronics clients, who require documentation right down to the ppm level. We treat these requests seriously—unlike some newcomers to the industry, who only see increased paperwork, we see customer trust as the cost of doing business.
Improvement sometimes comes in the form of better drying—adding a vacuum strip after a standard drying oven, or shifting to nitrogen-purged packaging lines. Other times, problems like sublimation losses required us to change container types or add a zero headspace step. Our own analytical chemists take the process as far as time permits, checking each lot against both standard analytical fingerprints and customer-reported issues.
Every container marked with batch numbers traces back to a production date, set of raw materials, operator logs, and control lab records. Problems, if any emerge, are quickly diagnosed. On the customer’s end, securing this level of traceability gives confidence as new processes scale beyond gram-level runs.
Controlling environmental impact becomes more than just a regulatory requirement. Our team explored solvent recovery options to reduce lifecycle waste, as the halogenated and fluorinated nature of the material requires thoughtful waste management. Each product cycle involves energy use, equipment wear, and careful raw material selection to balance purity, cost, and environmental health.
We regularly consult with partner facilities on closed-system handling, vapor controls, and automation to minimize worker exposure and environmental emission. The choice to run certain synthesis steps under full containment—extra cost on the equipment side—came from real-world experience where leaks and exposures could not be eliminated by technique alone.
Lab staff and operators wear personal gas detection, and we use active ventilation—steps that keep our workplace safe, clean, and in line with industry standards. With highly volatile or persistent intermediates, this careful handling means cleaner batches, lower cross-contamination, and a safer working environment over years of production runs.
From the desk of a chemical manufacturing team, everyday lessons shape each new campaign. Over the years, requests have grown from a few grams for research to multi-ton lots destined for plant-scale syntheses. Customers lean on us not just for material, but for technical answers and troubleshooting across synthesis, purification, and storage. Our technical team works alongside researchers, process chemists, and production managers to accommodate particular storage concerns, packaging requirements, or analytical validations unique to their system.
We see new frontiers in both biotechnology and organic electronics that call for derivatives of 3-Chloro-5-(Trifluoromethyl)Phenol, and along with that, stricter criteria around trace metals, halide content, and even packaging material selection. Increased scrutiny from environmental and quality management standards only sharpens our attention to process controls and documentation—a path we willingly tread because reliability pays off with repeat business and lasting partnerships.
As makers, our take on 3-Chloro-5-(Trifluoromethyl)Phenol draws on thousands of hours in both lab and plant. This product took years to reach its current reliability, through trials, mistakes, and constant re-tuning. What seems simple on paper—one molecule, two substitutions, high purity—marks a much more challenging commitment to good chemistry, tight process control, and customer dialogue.
Every customer story helps refine how we create, analyze, and deliver this compound. Wide use in pharmaceuticals, crop protection, and advanced materials means we never stop learning. Our hope is that by combining deep hands-on knowledge with strict quality oversight, we set a standard for what specialty chemical manufacturing must offer, even as demands and applications evolve.
