|
HS Code |
121605 |
| Chemicalname | 3-Bromo-5-Fluorophenol |
| Casnumber | 198646-18-1 |
| Molecularformula | C6H4BrFO |
| Molecularweight | 191.00 |
| Appearance | White to light beige solid |
| Meltingpoint | 77-81°C |
| Purity | Typically >98% |
| Solubility | Soluble in organic solvents (e.g., DMSO, ethanol) |
| Smiles | C1=C(C=C(C=C1Br)F)O |
| Inchi | InChI=1S/C6H4BrFO/c7-5-1-4(9)2-6(8)3-5/h1-3,9H |
| Synonyms | 5-Fluoro-3-bromophenol |
| Storageconditions | Store in a cool, dry, and well-ventilated place |
As an accredited 3-Bromo-5-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 3-Bromo-5-Fluorophenol, sealed with a screw cap and labeled with safety information. |
| Shipping | 3-Bromo-5-Fluorophenol is shipped in tightly sealed containers compliant with chemical safety regulations. The package is clearly labeled with hazard warnings and transported as a hazardous material. It should be kept away from heat, sparks, and incompatible substances, and handled only by trained personnel during shipping and receiving processes. |
| Storage | 3-Bromo-5-Fluorophenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and bases. Keep it away from direct sunlight and sources of ignition. Store under inert atmosphere if possible to minimize moisture exposure, and ensure proper chemical labeling for safe identification and handling. |
Competitive 3-Bromo-5-Fluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615380400285 or mail to sales2@liwei-chem.com.
We will respond to you as soon as possible.
Tel: +8615380400285
Email: sales2@liwei-chem.com
Flexible payment, competitive price, premium service - Inquire now!
In our years of hands-on experience with aromatic intermediates, 3-Bromo-5-Fluorophenol stands out for its smart design that balances the strengths of two key substituents on the phenol ring. We recognize the role of halogenated phenols not only in complex pharmaceutical synthesis but also in custom-developed chemical technologies driving forward research and industrial progress. In our facility, we consistently witness how this molecule, with the chemical formula C6H4BrFO, integrates into advanced organic synthesis, helping chemists meet demanding purity and yield targets.
3-Bromo-5-Fluorophenol offers both a bromine and fluorine atom on the aromatic framework, opening the door to reactivity profiles not found with single-substituted phenols. Laboratories and plants aiming for unique substitution patterns frequently choose this compound to access new heterocycles, chiral ligands, and drug scaffolds with enhanced metabolic stability or bio-selectivity. It consistently appears in development projects requiring precise ortho or para control, and its core design is versatile enough for both stepwise synthesis and direct coupling strategies.
Producing 3-Bromo-5-Fluorophenol on an industrial scale usually draws on our extensive expertise with electrophilic aromatic substitution and halogen management. Process optimization doesn’t end with lab-scale recipes – stepping up to full runs in reactors requires deep attention to reaction temperatures, batch concentration adjustments, gas containment, and multi-stage washing. The final phenolic purity often reaches a minimum of 98%, with thin-layer chromatography and NMR confirming regioselectivity and minimal halo-impurity carryover.
Our batches undergo multiple QC checkpoints. High-performance liquid chromatography, melting point, and halogen quantification routines ensure every shipment matches strict specifications demanded by contract partners. Years of building this process streamlines yields and keeps the final cost stable, even during periods of raw material volatility. Customers from pharmaceutical R&D and custom synthesis value the consistency – the lot-to-lot repeatability in both physical characteristics and chemical assay gives their teams fewer surprises and more reliable project outcomes.
Many phenolic intermediates look similar on paper, but working closely with 3-Bromo-5-Fluorophenol in real-world projects makes its unique properties clear. The addition of both bromine and fluorine gives a dual effect – bromine acts as a strong leaving group, allowing Suzuki and Heck coupling without excessive catalyst loading, while fluorine can drive electronic effects that guide subsequent selectivity and reactivity. These features reduce cleanup steps and simplify purification, which often goes unnoticed until deadlines loom.
We frequently support teams moving from research-scale batches to scale-up, and their project leads notice the difference when the intermediate handles cleanly in cross-coupling and nucleophilic aromatic substitution. A single misplaced substituent or poorly controlled side-reaction can drop yields and stall projects. With 3-Bromo-5-Fluorophenol, the well-defined substitution pattern – bromine at the 3-position, fluorine at the 5-position – avoids ambiguity or contamination seen in poorly regulated alternatives.
Synthetic chemists are known for looking past labels and focusing on backbone structure. In our experience, the combined presence of bromine and fluorine has a practical impact on candidate molecule designs. Substituting halogens often means controlling not just for size or leaving group ability, but for the electronic character introduced to the ring. Bromine, heavier and more polarizable than chlorine, helps in subsequent Pd-catalyzed reactions. Fluorine, given its high electronegativity, quietly shifts π-electron density, making the phenol ring more resistant to over-oxidation and enabling milder reaction conditions downstream.
Compared to analogs like 3-Bromophenol or 5-Fluorophenol, this dual substituted compound gives users both synthetic handles in a single scaffold, trimming extra reaction steps and cutting down on protected intermediate isolation. These are not small differences when costs tally across hundreds of kilos and pilot batches. Our technical support staff has documented cases where a process originally built around separate monohalogenated phenols was streamlined significantly by switching to this molecule, eliminating unnecessary intermediate purifications and cutting cycle time by several days.
3-Bromo-5-Fluorophenol’s specialty emerges in parts of pharmaceutical, agrochemical, and material sectors where exotic substitution patterns are needed to unlock a patent or a novel property. Medicinal chemists leverage this intermediate when building non-natural aryl scaffolds or seeking metabolic profiles shielded from oxidative degradation. Several antineoplastic and antivirals have drawn on its reactivity, where direct arylation or phenol derivatization occurs without excessive side-reactions.
Agrochemicals also see value in this fluorinated-brominated phenol, where soil mobility, environmental persistence, or selective binding often demands fine-tuned aromatic cores. We’ve supported research targeting new fungicide candidates and pesticide trials requiring unique activity profiles. In some projects, agro R&D selects this intermediate to diversify lead compound libraries, enabling structure-activity testing by direct coupling or C–N bond formation.
In advanced material research, our customers choose the compound for specialized resins, photoactive materials, or as a precursor in the construction of rigid, electronically active frameworks. These users put a premium on well-controlled purity, minimal residual halides, and batch documentation – lessons learned from hard-won process troubleshooting.
Large-scale manufacture of halogenated phenols brings process safety and environmental responsibility into sharp focus. We know firsthand the risks associated with handling hydrobromic acid formation, exothermic reactivity, and byproduct containment. Over years of operational refinement, our staff has updated reactor automation and containment to keep both operators and the environment protected. We partner closely with local environmental agencies and internal EHS teams. This means routes of synthesis draw on solvent recycling, in-line gas quenching, and documented destruction of halogenated byproducts.
Regulatory questions often come from partners in pharmaceutical development focused on ICH Q3D elemental impurity guidelines. Our QC approaches account for these: we hold analytical certifications and archivable batch records to support customer filings and regulatory reviews. For new applications where downstream use might enter food or pharma supply chains, we support audit requests and provide impurity traceability. Experienced process engineers on our team routinely tune reaction conditions to push unwanted side-products to levels well below regulatory concern, which keeps client compliance efforts on-schedule and prevents last-minute reprocessing headaches.
Scaling from laboratory rounds to full manufacturing scale in the halobenzene space means jumping more than just a few liters at a time. Engineers notice small temperature fluctuations and unexpected pressure swings that don’t show up in glassware. Our process troubleshooting library covers real-life examples, from runaway exotherms to shoulder peaks on chromatograms. Reproducibility at the 100-liter scale takes practice and close attention to detail. Many custom orders require us to adapt for delivery schedules, mixing protocols, or downstream compatibility. We welcome interaction with client teams to deliver a product that behaves predictably, blending with their process feeds and minimizing hold-up volumes.
We document our learnings from each campaign, feeding this knowledge into the next batch. Valve calibrations, filtration fixes, and solvent reuse schemes come out of decades of direct experience, not just SOPs. Our in-house chemical analysts benchmark each lot to guide adjustments to reactor ramp rates, define endpoint monitoring methods, and avoid difficult-to-detect over-reactions. The result is a stable supply that gives process chemists confidence, even under tight timelines or shifting project needs.
End-users rarely deal with our technical teams, but the insight collected from collaborative troubleshooting shapes our approach to this compound. In pharma settings, new drug proposals often move too fast for sluggish intermediate deliveries. We build on earlier delays by tight-lining logistics and working with transport partners who understand halogenated organics. Customized packaging, vapor protection, and transport hazard documentation reflect feedback from both shipping managers and bench scientists alike.
On the research side, specialists notice how this molecule speeds up diversity-oriented syntheses or allows analog construction with fewer protection–deprotection cycles. Many report cleaner reaction profiles, easy crystallization, and lower solvent use in work-up, all translating to saved manpower and a shorter route from starting material to target. Custom project teams highlight fewer unknown signals on NMR spectra, attributing this to a combination of high-purity input and stable downstream reaction planning.
Halogenated phenols form a crowded landscape, but few offer the specific balance of substitution seen in 3-Bromo-5-Fluorophenol. Chlorinated variants often cause functional group interference or complicate waste neutralization. Monosubstituted phenols, lacking the dual reactivity, force multistep syntheses that drag on cycle time and cost. Our technical partners turn to this compound especially when dual functionality is a value driver, or where late-stage modifications are planned with minimal reagent switching.
In comparison to isomeric structures, the 3-bromo and 5-fluoro arrangement reliably supports regioselective Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and directed ortho-lithiation. This allows research chemists to access key structural motifs in fewer steps, and minimize wasteful trial reactions. We see more robust project timelines and more rapid movement to final product registration in partners who adopt this intermediate in their innovation pipeline.
Further, our continuous refinement in crystallization and drying increases long-term stability and upholds consistent shelf-life. Some analogs in the market tend to degrade, liberate halide gases, or shift in color with minor exposure to moisture – issues our standard containment and packaging now avoid effectively.
Over decades of relationship-building, our work with 3-Bromo-5-Fluorophenol extends beyond mere supply. Clients rely on technical advice drawn from head-to-head process comparison, route troubleshooting, and pilot batch scale-up. By providing transparent batch records and direct access to analytical results, we maintain confidence not simply in the delivered product but in each collaborative step taken to reach project goals.
For every new drug proposal, specialty polymer run, or crop protection lead, we understand a rapid response sometimes matters more than minor price fluctuations. Our team routinely advises on long-term inventory, safety stock placement, and recall readiness. This helps customers avoid costly stoppages or regulatory hiccups — insights only gained by being inside the production and shipment cycle for years on end.
Innovation at the manufacturing level reaches past new routes or catalyst discoveries. It’s built on changed habits, operator feedback, and hard data from repeat runs. With 3-Bromo-5-Fluorophenol, these practical tweaks to reactor fill, drying time, or temperature ramps translate into measurable gains in throughput and operator safety. Our lab teams structure improvement efforts around field experience and open dialogue, feeding back every small win to raise the bar for future campaigns.
We draw on a pool of technical mentors, internal process historians, and experienced plant operators who guard against shortcuts and keep each kiloton batch as reliable as the first. Our partner community knows they aren’t selecting a simple commodity – they depend on decades of iterative process design and field-based troubleshooting that back every drum and package.
3-Bromo-5-Fluorophenol, through real-world use and process-bench collaboration, proves itself as more than just a chemical input. The well-planned combination of bromine and fluorine gives synthetic users advanced options in complexity and efficiency they don’t get by trying to adapt single-substituent phenols. By focusing on practical support, long-term reliability, and an openness to technical improvement, manufacturers like us equip researchers, process chemists, and product developers to create new answers to tomorrow’s application challenges.
