|
HS Code |
855380 |
| Chemicalname | 3-Bromo-2-Iodophenol |
| Casnumber | 89648-30-2 |
| Molecularformula | C6H4BrIO |
| Molecularweight | 314.90 |
| Appearance | Light yellow to brown solid |
| Meltingpoint | 94-98°C |
| Purity | Typically ≥98% |
| Density | 2.45 g/cm³ (estimated) |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Smiles | C1=CC(=C(C(=C1)Br)O)I |
| Inchi | InChI=1S/C6H4BrIO/c7-4-2-1-3-5(9)6(4)8 |
| Synonyms | 2-Iodo-3-bromophenol |
| Storageconditions | Store at 2-8°C, keep container tightly closed |
As an accredited 3-Bromo-2-Iodophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 5 grams of 3-Bromo-2-Iodophenol, tightly sealed with a screw cap and tamper-evident seal. |
| Shipping | 3-Bromo-2-Iodophenol is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. The package is clearly labeled as hazardous, following all relevant regulations for transport of chemicals. It is typically shipped with cold packs or under temperature-controlled conditions to ensure stability and safe delivery. |
| Storage | 3-Bromo-2-Iodophenol should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizing agents. Properly label the container and store it within a designated chemical storage cabinet, ideally for halogenated and organic compounds, to ensure safety and chemical integrity. |
Competitive 3-Bromo-2-Iodophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Every year, the world of advanced chemistry leans a little further on specialized molecules that don’t just fit in the toolkit — they open up new possibilities for molecular design. For anyone looking for halogenated building blocks in organic synthesis, 3-Bromo-2-Iodophenol stands out with a chemical structure that invites a deeper look at its reactivity and performance in real laboratory settings. Our team focuses on purity and batch-to-batch consistency because research can’t pause for uncertainty.
As a crystalline organic compound, 3-Bromo-2-Iodophenol (CAS 1832-57-7) reflects its dual halogenation through a unique behavior in coupling and substitution reactions. The molecular structure places iodine and bromine on an aromatic ring with the hydroxyl group at the ortho position relative to the halogens. Chemists value this layout when site-selective activation or halogen-metal exchange comes into play. Our standard grade offers high assay, low moisture, and controlled particle size distribution, which supports functionalization, cross-coupling, or other transformations.
Through years of synthesis scale-up, careful crystallization, and solvent system refinement, we’ve witnessed how trace impurities with similar halogenated phenols can affect your final outcome. Relying on experience, we implement multiple purification checkpoints after iodination and bromination, followed by advanced chromatography and spectroscopic identification. This workflow reduces the sort of cross-contamination that often slips past a single distillation or basic silica purification. Our aim here is to prevent downtime during reaction troubleshooting or product isolation. In every batch analysis, we monitor for halide byproducts and oxidation artifacts so users can work with confidence.
Within the broader category of bromoiodo derivatives, this compound brings both reactivity and stability to synthetic planning that other molecules often struggle to balance. Perhaps the strongest difference comes from the unique distribution of halogen atoms on the ring, which drives selectivity during metalation or transition metal catalysis. Our own kilo-lab observations have shown that, for Suzuki, Sonogashira, or Buchwald–Hartwig couplings, the ortho-iodo group ensures rapid oxidative addition, while the para-bromo site remains available for secondary modifications. Chemists tackling multistep syntheses in pharmaceuticals or agrochemicals recognize the value of this kind of control. Removal of the hydroxy group under mild conditions, or site-specific protection, fits well with custom ligand development and heterocycle formation.
A practical edge comes from minimizing side reactions. Our internal data and customer feedback point to higher yields and cleaner downstream separations compared with other halogenated phenols. In actual use, we’ve seen demand grow from research groups exploring new kinase inhibitor scaffolds, custom dye molecules, and intermediates for active pharmaceutical ingredients. The ability to suit a range of amination, etherification, or Grignard formation strategies has supported contract projects in our own pilot plant and encouraged repeat orders from academic collaborators. We’ve also noticed the value of this compound for radio-labeling or cross-coupling with boronic acids containing sensitive side chains or protecting groups.
Our staff has worked hands-on with 3-Bromo-2-Iodophenol across scales ranging from gram trials to multi-kilogram production. Storage conditions affect stability and shelf life. By maintaining a dry, low-light environment and using airtight containers, we consistently maintain assay integrity and physical appearance over extended durations — essential when research schedules stretch over several months. Batch records reflect moisture testing via Karl Fischer, as well as headspace GC investigations for any trace residual solvents.
Lessons learned over the years matter. During one upscaling run, the team observed a faint color change linked to photodegradation. Careful handling under subdued lighting and the use of sealed amber packaging have since become part of our protocol. These practical adjustments save both time and material, especially for end-users running sensitive photochemical or catalytic experiments. For those unsure about compatibility with their solvent systems or workups, we offer direct guidance based on process experience, not just generic literature recommendations.
After decades in synthesis, one thing becomes clear: not every halophenol performs the same way just because the name appears familiar. Comparing 3-Bromo-2-Iodophenol with 4-bromo-2-iodophenol, 2-iodophenol, and 3-bromophenol, the differences go beyond simple substitution patterns.
The ortho effect dominates certain transformations. In direct arylation, ortho-iodo groups have proven to streamline palladium-catalyzed cross-coupling steps — a convenience that para- or meta-iodo phenols rarely provide without additional reagents or more strenuous conditions. Our team observed this preference repeatedly during medicinal chemistry campaigns, where unwanted rearrangements or side halogenations cost both time and material. Bromoiodophenol, with both substituents positioned for differentiated activation, makes sequential functionalization more practical in complex molecule synthesis.
We’ve tracked dozens of exploratory reactions at both bench and pilot scales, logging the tendency for certain analogs to form persistent side-products or resist complete conversion. The hydroxy group, positioned as it is, provides a useful anchor for further substitutions—allowing easy access to ethers, esters, or protected intermediates used in fine chemical production. Our process chemists routinely select 3-Bromo-2-Iodophenol over similar structures when yield preservation and predictable reactivity become top priorities.
Research chemists and process engineers know the routine: scale-up rarely goes according to plan if the starting material contains critical impurities or features awkward solubility. In our own kilo-lab, 3-Bromo-2-Iodophenol has proven adaptable, dissolving cleanly in common polar organic solvents—tetrahydrofuran, dichloromethane, acetonitrile—without sticky residues or delayed reactions. This behavior means fewer surprises in process optimization and less downtime for cleaning and filtration.
Drug discovery groups have approached us for batches destined for heteroaryl coupling, specifically for preparation of kinase inhibitors or modified non-steroidal anti-inflammatory compounds. Custom dye houses request the compound for further bromine or iodine exchange, shifting absorption spectra to develop novel imaging agents or analytical probes. We’ve met requests for scalable quantities, from 50 grams up to tens of kilograms, supporting high-throughput screening campaigns as well as advanced medicinal chemistry efforts.
Every halogenation route presents real production challenges. In the case of 3-Bromo-2-Iodophenol, selectivity must balance without over-iodinating, brominating non-target positions, or introducing trace heavy metals. By conducting continual process evaluation and raw material auditing, we’ve adjusted stoichiometry, temperature profiles, and purification methods to boost both environmental compliance and product reliability. Our team tracks byproducts, monitors effluent, and manages multilayer solvent recovery, reducing hazardous waste volumes and meeting increasing regulatory scrutiny.
In scaling up the iodination step, integrating safer, less volatile iodinating agents cut both exposure risks and waste. Further, we’ve invested in closed reaction systems with improved fume extraction—lessen operator risk and maintain a healthy working environment. In response to customer interest in “green chemistry,” we’ve started trials with alternative reaction media and recyclable solvents, though progress sometimes brings its own setbacks. Any time a procedural upgrade looks promising, we trial at bench and pilot scale, document any shift in yield or impurity profile, and share those results with long-term clients.
Direct dialogue with chemists and procurement teams remains central. Over the years, collaboration has brought us challenges—a client in Europe dealing with slow recrystallization, an academic group needing advice on downstream reduction, a contract manufacturer adjusting for cross-coupling conditions. In response, our support extends far beyond sales, as we document real process hurdles and help identify solutions grounded in actual lab and plant experience.
On packaging, we offer tailored options—small ampoules, mid-sized jars, or lined drums—because there is no “one size fits all” for storage and shipping. We monitor temperature and humidity during long-haul transport and provide evidence from our own stability testing. Detailed certificates of analysis accompany every order, outlining assay, related substances, water content, and appearance as determined by strict in-house protocols.
Chemistry evolves, but the expectations around reliability and transparency hold steady. Our technical staff remains accessible for troubleshooting, whether the question concerns scaling up a Suzuki reaction or managing subtle differences between bromoiodo isomers. We believe that the mistakes and discoveries made in our own lab can shorten the learning curve elsewhere.
A meaningful supplier relationship doesn’t end at the point of purchase. For many clients, supply chain integrity matters just as much as purity or cost. As a manufacturer, our experience has shaped sourcing choices: buying well-audited bulk halides, verifying supply line continuity, and developing fallback production schedules for rush orders or disruptions. These behind-the-scenes choices help keep customer projects on track during what can be unpredictable research or scale-up cycles.
Providing technical notes, reproducibility examples, and guidance for analytical testing comes standard — we have seen how overlooked assay or identity tests cost precious time. Our longtime partners count on us to point out subtle but pivotal differences between similar molecules so that reaction schemes proceed with as few surprises as possible. Many first-time buyers have become steady collaborators after troubleshooting together through unexpected bottlenecks or analytical snags.
Feedback often drives our most meaningful improvements. Chemists in the field regularly report on product performance, reaction outcomes, or storage quirks they’ve encountered. Recently, a development chemist flagged a slight reduction in melting point tied to one unusual lot—after tracing the root cause, a small tweak in post-synthesis filtration fixed the issue for future runs. This kind of honest exchange builds trust and guides better quality practices than any survey or external audit alone.
We log every meaningful client report and routinely cross-check internal results against independently generated chromatograms or spectroscopic data. Reproducibility, shelf stability, and clear documentation all stem from real conversations, not theoretical ideals. This feedback loop enables us to deliver a product better suited to the unpredictable and demanding reality of laboratory and production work.
Market expectations for halogenated phenols continue to shift with every new patent, synthetic method, or therapeutic lead. We push for improvements where it matters—better process atom economy, more selective reactions, safer manufacturing, and practical support for end-users. Drawing from hands-on experience, the next phase of our development focuses on expanding both scale and flexibility, opening up production capacity for larger projects while refining smaller, custom-lot synthesis when required.
Process safety, environmental stewardship, and user support dominate our ongoing priorities. By investing in staff training, equipment upgrades, and analytical innovation, we aim to serve both established partners and new customers facing technical risks in halogenated phenol chemistry. Each production run represents more than a batch of chemicals — it carries our record of service, learning, and adaptation.
Decades of real manufacturing work have taught us that numbers on a data sheet only tell part of the story. Factors like ease of workup, compatibility in multi-step sequences, and shelf stability only reveal themselves after months of practical use in real labs. As chemists ourselves, passionate about both production and molecular design, we strive to offer more than just material; we support innovation, troubleshooting, and discovery from the first inquiry to scale-up and delivery.
3-Bromo-2-Iodophenol has earned a unique place in our product catalog, not just as a high-purity material, but as a tool refined through thousands of real-world reactions, process improvements, and open conversation with the global research community. As your projects continue to evolve, our shared knowledge and experience are here to keep pace with each new challenge.
