|
HS Code |
547478 |
| Chemicalname | 2-Nitro-6-Fluorophenol |
| Molecularformula | C6H4FNO3 |
| Molecularweight | 157.10 g/mol |
| Casnumber | 578-74-9 |
| Appearance | Yellow crystalline solid |
| Meltingpoint | 112-115°C |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Density | 1.54 g/cm³ (approximate) |
| Purity | Typically ≥98% |
| Smiles | c1cc(c(c(c1O)[N+](=O)[O-])F) |
| Inchi | InChI=1S/C6H4FNO3/c7-4-2-1-3(9)6(5(4)8)10/h1-2,9H |
| Synonyms | 6-Fluoro-2-nitrophenol |
| Storagetemperature | Store at 2-8°C |
| Hazardclass | Irritant |
As an accredited 2-Nitro-6-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2-Nitro-6-Fluorophenol is supplied in a 25g amber glass bottle with a secure screw cap, labeled with hazard information. |
| Shipping | **2-Nitro-6-Fluorophenol** should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. Transport in compliance with local regulations for hazardous chemicals. Use appropriate hazard labeling, and ensure packaging prevents leaks or spills. Handle and ship as a toxic and potentially environmentally hazardous material. |
| Storage | 2-Nitro-6-fluorophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible materials such as strong oxidizers and reducing agents. Protect it from heat, direct sunlight, and moisture. Proper labeling and secondary containment are recommended to avoid accidental release. Always follow relevant chemical hygiene and safety guidelines. |
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Within the broader landscape of fine chemical production, 2-Nitro-6-Fluorophenol has carved out a role of quiet importance. Over years of work with specialty fluoroaromatics, our team has witnessed requests for this material rising from the pharmaceutical sector and from the world of agrochemicals. Our manufacturing experience with this compound taught us early on that even minor differences in structure – here, the nitro and fluoro groups placed ortho to one another on the phenol ring – can play an outsized part in downstream chemistry. Its structure, model C6H4FNO3, features a strong nitro group at the 2-position and a fluorine atom at the 6-position, supporting unique reactivity in custom syntheses.
Through years of process development, we understood that research teams and manufacturing managers look for not just a product, but a solution to the day-to-day headaches of reliability and scale. Each batch of 2-Nitro-6-Fluorophenol we produce undergoes gas chromatography and NMR analysis, reinforcing trust that each shipment matches the assay required for pharmaceutical intermediates or fine-tuned pesticide synthesis. We designed our purification steps for low residual solvent levels to reduce worries about contamination reaching catalyst beds or finished product streams. In our facility, handling high-purity nitroaromatics safely and precisely became second nature after repeated campaigns scaling up from liters to hundreds of kilograms.
Typical applications for this compound involve either direct transformation or careful coupling reactions. Medicinal chemistry uses it in steps where introducing a balance of electron-withdrawing and electron-donating groups matters. In agrochemical labs, our material forms the backbone for new fluorinated intermediates, allowing chemists to design molecules with improved stability or selectivity. Workflow in the plant takes into account both product requirements and safe handling, as nitro compounds call for respect in every operation. Over time, we invested in robust contained production lines, integrating waste minimization protocols and regular risk assessments.
Chemists who order 2-Nitro-6-Fluorophenol from us comment on low traces of metallic impurities and repeats in melting range. We heard early feedback about color and flowability, prompting us to reexamine drying methods: ambient air drying left tiny points of decomposition, so we shifted to controlled vacuum systems, improving visual appearance and reproducibility. We log these incremental improvements, taking every customer sample complaint as a lesson for the next batch. While larger traders in the market may ship diverse lots, our hands never leave the sourcing, isolation, and finished packing of each drum. There’s a direct line between our process team and those using the compound on site, which shortens troubleshooting times and tights up batch documentation details.
We have fielded many questions over the years about traceability and transparency in specialty chemicals. Our history with 2-Nitro-6-Fluorophenol demonstrates that transparency brings real value: every synthetic and purification step, from initial nitration through crystallization and QC, stays logged and auditable. Our team welcomes customer audits, and we don’t shy away from open book reviews of process changes. This kind of manufacturing discipline isn’t taught from a manual; it evolves from decades spent watching how minor deviations cause headaches further downstream.
Every lot receives stability testing, focused on shelf life and response to temperature change. Chemists in end-use labs sometimes worry about exothermicity or odor. Through our techniques, including closed-system handling, containment, and antistatic modules, we respond with results instead of just answers. We recommend shipping in tightly sealed polyethylene-lined drums to resist hydrolysis, keeping in mind the sometimes sensitive nature of phenolic nitro compounds. If customers notice yellowing or packing-borne contamination, we step in, retrieving samples, analyzing for decomposition pathways, and refining our post-drying atmosphere controls as needed. These are not abstract quality concerns. They cost time and create project risk, so we bear the responsibility to minimize them.
Those who regularly work with nitro- or fluoro-substituted phenols see subtle tradeoffs between analogues. For example, the 4-nitro-2-fluorophenol cousin behaves differently in Suzuki couplings, and monochloro derivatives lack the same electronic modulation for certain heterocycle synthesis routes. Our experience shows that starting from 2-Nitro-6-Fluorophenol opens specific windows for reactivity, attributable to both steric and electronic effects. The interplay between the nitro and fluoro substituents at ortho positions creates sites for site-selective cross-coupling or reduction, where positional isomers would not perform as well.
Researchers and production managers visiting our plant seek more than a price list – they look for confidence that future batches will behave like the last, that real issues can be resolved through direct conversation, and that there is backup should documentation or supply chain snags appear. Because we control the process from raw material intake to quality control and delivery, recurring pain points like lot-to-lot differences or unplanned delays get solved before reaching the customer’s dock.
In our experience, pharmaceutical API synthesis teams sometimes struggle with scale-up bottlenecks due to unreliable physical properties. We responded by offering detailed physical characterization: melting point curves, particle size distribution data, and custom milling where necessary to suit batch reactors or slurry protocols. On another project, an agrochemical client wrestled with downstream solubility. We helped adapt crystal habit and drying procedure to reduce clogging in their continuous flow setup, preventing reactor downtime.
Markets shift, and regulatory regimes evolve. Requests for regulatory support – statements regarding REACH, RoHS, or compliance with environmental directives – became part of our daily work. Our in-house compliance team bridges the information gap between manufacturing and the customer’s regulatory officer. Documentation, including full traceability and regular review of controlled substances lists, stays current, with responses typically given in days, not weeks. Reliable compliance isn’t just about paperwork; customers need to know that what leaves our facility won’t halt their regulatory review or create recalls later.
Scientific innovation often depends on reliable building blocks. Medicinal chemists synthesizing kinase inhibitors or agrochemical formulators developing novel crop protection molecules can’t afford weeklong delays due to out-of-spec ingredients. This is even more crucial when projects move out of discovery and into pilot-plant or full-scale campaigns, where deviations cost not just money but weeks of progress. Continued focus on batch reproducibility, safety, and rapid troubleshooting has allowed collaborations to thrive past the experimental stage and into commercial scale.
Our plant works steadily toward reducing environmental footprint. Decades ago, aromatic nitration threw off harsh byproducts, often with poor containment. Through process redesign, energy recovery, and real-time emissions monitoring, we have been able to slash both air emissions and water use. Waste recovery – especially the stripping and reuse of spent acids, and solvent reclamation – keeps resource demands manageable as global standards tighten. Responsible manufacturing extends into closed-loop feedback from customers: if a downstream team notices elevated levels of a byproduct, we work together to trace and mitigate it at the source.
Manufacturing isn't just about chemical formulas. For us, it involves long-term partnerships and open channels. Customers ask for more than a product – they want knowledge sharing, onsite visits, and help solving unplanned industrial problems. We track lot-by-lot performance data, share lessons from other clients (with consent and confidentiality), and regularly run joint improvement projects. Feedback fuels our revision of standard operating procedures. Internal training programs are regularly updated to fold in field learnings, so future hires come up fluent in both product details and practical manufacturing realities.
Recent years have shown growing interest in advanced materials, including electronics and high-performance polymers. These new customers require the same product integrity and supply reliability as the pharma and agro sectors, but set different demands for impurity profiles and physical consistency. Our research and production teams work in tandem to adapt purification methods, separation steps, and packaging solutions for new requirements. We’ve installed pilot facilities where client process engineers can run trials side-by-side with our chemists, shortening the path between idea and scale implementation.
We do not operate as a faceless supplier. Every custom specification or specialized packing request receives direct technical review. Many of our most useful process changes started from customer site visits or collaborative troubleshooting workshops. In one case, adjusting crystallization temperature by just a few degrees shaved off an entire recrystallization step in an API synthesis chain, saving months and reducing solvent costs. By pooling expertise and treating each delivery as a point of partnership, both sides earn compounding benefits over time – not just in yield but in the speed and security of new product launches.
Every drum of 2-Nitro-6-Fluorophenol we ship represents the end of hundreds of small process decisions made by people who have come to know the chemistry intimately. Our pride comes not from processing vast volumes, but from making each campaign a little more reliable than the last. Our investment in plant safety, documentation, and batch reproducibility pays out with each customer who comes back after a smooth project. Industry keeps moving, with new demands for cleaner, tighter, and always reliable specialty chemicals. The measure of our success sits in the downstream products built from the building blocks we provide – products that improve life, protect food supplies, and underpin technologies most will never see. We stand behind our production, because every day we see how much depends on getting the core ingredient exactly right.
