|
HS Code |
278310 |
| Cas Number | 3195-78-6 |
| Molecular Formula | C9H12O2 |
| Molecular Weight | 152.19 g/mol |
| Iupac Name | 2-Isopropoxyphenol |
| Synonyms | o-Isopropoxyphenol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 241-243 °C |
| Density | 1.066 g/cm3 |
| Solubility In Water | Slightly soluble |
| Flash Point | 101.1 °C |
| Refractive Index | 1.547 |
As an accredited 2-Isopropoxyphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 100 grams of 2-Isopropoxyphenol, tightly sealed with a screw cap, labeled with safety and identification information. |
| Shipping | 2-Isopropoxyphenol should be shipped in tightly sealed containers, away from heat, sparks, and open flames. Handle with appropriate protective equipment and comply with local, national, and international regulations. Ensure clear labeling and include safety data sheets. Store and transport in a cool, well-ventilated area to prevent degradation or hazards. |
| Storage | 2-Isopropoxyphenol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers and acids. Protect from direct sunlight and moisture. Use appropriate safety labeling and store at a stable temperature to prevent degradation. Keep out of reach of unauthorized personnel. |
Competitive 2-Isopropoxyphenol prices that fit your budget—flexible terms and customized quotes for every order.
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Years of producing 2-isopropoxyphenol have taught us that there’s more to a specialty chemical than its textbook description. Many customers searching for CAS 3104-15-6 expect a clear technical delivery, but the real story comes out in the lab and on the production line. This phenolic ether, structurally similar to guaiacol with an isopropoxy group in place of methoxy, stands apart from everyday phenolic solvents and intermediates. The difference becomes evident during formulation, storage, and development cycles.
Every batch that leaves a manufacturer’s reactor represents more than the numbers on a certificate of analysis. The GC spectra, water content, and residual isopropanol levels aren't just for paperwork—they define the outcome in your process. We've standardized our offering to a purity of at least 99% by GC, using a careful fractional distillation process. Color plays a role, too, with our finished product holding a pale yellow to almost colorless appearance, thanks to strict controls on oxidation and air exposure during transfer.
Our experience tells us that 2-isopropoxyphenol’s melting and boiling points seem ordinary at first glance, but stability through multiple freeze-thaw cycles, as well as reactivity in pilot formulations, matter far more. Many users have asked about stabilizers or anti-oxidants. We’ve found, in repeated pilot plant tests, that controlling storage atmosphere and avoiding metal ions do more for shelf stability than any additive approach.
Industry finds its own uses for compounds, sometimes surprising even the original manufacturer. Over the years, we have seen 2-isopropoxyphenol become a regular ingredient in selective etherification reactions where conventional alkoxyphenols fail due to steric hindrance. This compound’s structure offers a unique balance between lipophilicity and electronic effects on the phenolic ring, making it useful in synthesizing various pharmaceutical building blocks.
Our largest volumes head off to the agrochemical sector, where intermediate synthesis requires both reactivity and robust shelf life. Colleagues in research have relied on the isopropoxy group for tuning hydrophobicity in bioactive molecules, reporting improved selectivity in certain enzyme inhibition assays. Commodity-grade phenols often lead to broad reactivity and poor yields; with this molecule, we see cleaner transformations and less byproduct formation under well-managed conditions.
Some customers experiment with it in resin modification, searching for adhesives or coatings that withstand higher thermal cycling. Our formulation chemists regularly work with partners testing these boundaries, often uncovering subtle differences in final properties due to minute variances in side-chain branching or aromatic substitution, making the manufacturing route central to the end product’s performance.
We often hear: “Does your 2-isopropoxyphenol hold up after extended storage?” Years back in our own warehouse, we saw small-batch samples lose potency because trace acidic impurities promoted slow decomposition. From that point, our purification protocol changed. We introduced low-temperature storage and improved atmospheric sealing on all product drums. After those corrections, end users reported higher consistency in their batch syntheses, resulting in less rework.
A common question involves comparison to more available alkoxy phenols such as 2-methoxyphenol or 4-isopropoxyphenol. Structurally, position is everything. We’ve tested, side-by-side, the effects on reactivity with nucleophiles and electrophiles. The 2-position isopropoxy group blocks ortho substitution, and in our tests, gives greater control over regioselectivity, especially in multi-step syntheses that require predictable outcomes. In resin formulations, thermal and oxidative stability shifts when using this model rather than more common isomers—the differences are not academic, they change product performance.
Lab-book specs don’t always match real-world observations. Over years of scale-up, our teams watched 2-isopropoxyphenol’s solubility in ether, alcohols, and hydrocarbon solvents play out differently than the textbooks suggest. We have documented the formation of clear solutions in high-concentration alcohol mixtures while note cloudiness when paired with chlorinated solvents. These technical details guide decisions for large-scale synthesis and downstream formulation.
During one scale-up from a 100-L pilot to 2,000-L batch reactors, a change in agitation speed revealed phenolic oxidation that color tests alone might miss. After retrofitting our process for inert-gas blanketing and refining our filtration steps, finished material held both color and purity across the storage periods customers expect.
Scale touches stability, too. Small bench-scale returns don’t always predict long-term warehouse stock. Several seasons back, a shipment left to stand for longer shipping durations revealed minor sediment formation. Analysis traced it to trace mineral contamination from a poorly maintained storage vessel. Since then, we’ve maintained regular monitoring and upgraded drum linings, resulting in cleaner material and fewer customer complaints about filter clogging.
The best insights come from users who push the product boundaries. A pharmaceutical developer once reported inconsistent recovery rates with solvent extraction, which led us to dig deeper into water residue levels in our product. Our lab found that even nominal increases in water content—on the order of a tenth of a percent—could affect solubility and partition during those extractions. This prompted a review and tightening of our drying process, and since the adjustment, customer reports of variability have dropped sharply.
Another partner used 2-isopropoxyphenol in the synthesis of flavor intermediates for fine chemistry applications. Here, trace aroma contributed by minor secondary impurities presented a distinct challenge. It took multiple rounds of vacuum distillation and careful isopropanol management to bring neutral scent and avoid off-notes in downstream products.
Modern supply chains produce new challenges each year. Whether it’s supply volatility or regulatory shifts for certain aromatic ethers, we rely on flexible plant scheduling and prompt quality follow-ups. Our facility schedules routine tests by GC-MS and HPLC to monitor batch consistency—not just at the start, but after every drum sits through typical transit and storage timelines. This approach, born from prior mistakes and near-misses, delivers repeatability that allows technical customers to trust every drum, sack, and flask that leaves our lot.
Every research and production effort asks the same thing: is this alkoxyphenol worth it over a more mainstream option? Our own experience shows several features tip the scale. The steric bulk of isopropoxy at the 2-position limits side-reactions seen in both Friedel–Crafts alkylation and oxidative coupling. In side-by-side trials with 2-methoxyphenol and 4-isopropoxyphenol, ours delivers fewer unwanted by-products under standard reaction conditions, smoothing process control for downstream steps.
With the move toward higher purity standards in pharmaceuticals and crop protection, even small amounts of off-spec compound build risk in regulatory compliance. The batch records from our facility indicate how rigid process controls—from isopropanol source testing through reactor cleaning routines—make a difference at scale. Researchers looking for high reactivity combined with predictable aromatic behavior find this compound returns better molar yields and cleaner spectra than most in the class.
We have worked with buyers weighing cost versus performance. Rather than pushing the product for every application, we suggest 2-isopropoxyphenol in syntheses sensitive to para versus ortho substitution, enzymatic specificity, or where higher hydrophobicity fine-tunes interactions in biological or environmental matrices. This targeted advice, built on our own bench trials and years handling feedback, aligns with performance goals beyond general solvent use.
No commentary on chemical production skips over safety and environmental responsibility. Our plant abides by strict process controls, integrating real-time atmospheric monitoring for both isopropanol emissions and phenolic vapor release. Staff receive regular training on safe transfer and containment; open lines of communication mean any deviation, however minor, gets immediate investigation.
Waste handling and lifecycle impact hold higher stakes with aromatic ethers. All spent catalysts and wastewater streams pass through multilayered treatment prior to disposal, in line with local and international guidelines. Our product moves in high-barrier drums to reduce vapor loss and protect warehouse staff from exposure. No shortcut ever proved worth the downstream risk, and customers with audits and compliance reviews have access to full protocols covering every step.
Over the years, we have fielded more requests for details on renewable production methods or green-chemistry approaches. Although the industry has not yet mainstreamed fully biogenic feedstocks for 2-isopropoxyphenol, we are testing routes using fractionated bio-isopropanol as a source. Our experience shows that switching feedstocks changes impurity profiles, so we approach every new process with careful stability and application testing before changing any standard supply line.
Few products warrant a one-size-fits-all handbook. With every request, our technical team pulls lessons from earlier collaborations and current plant output. A typical resin developer may require low color and minimal residual ion content, while a pharmaceutical R&D group will inspect for minor impurity signals by advanced chromatography. To bridge the gap, we share our own NMR, IR, and MS snapshots—not generic third-party certificates—allowing customers to benchmark against their needs sector by sector.
We encourage users to present process challenges directly, whether in high-pressure, high-temperature environments, or in mild conditions that prioritize product purity above speed. This technical dialogue doesn’t end with a sale. Our plant runs periodic retrospectives on user feedback, adopting incremental changes to purification, packaging, or even drum closures based on specific requests. One notable example: after a batch sent to a large manufacturing partner lost brightness within weeks, we trialed improved liner technology and instantaneously saw color and odor stability improve both in our own storage and post-delivery.
For the chemical manufacturer, living up to user expectations means more than meeting baseline specifications. Continuous investment in monitoring equipment and analytical training pays dividends every year. We operate a verification loop where on-site QC teams receive anonymized product for retesting, and their findings feed directly into our production routines. Outliers, whether in boiling point, GC retention time, or minute color drift, get immediate team review—catching issues before they grow.
Looking at industry trends, regulatory bodies now demand more rigorous documentation and traceability for aromatic compounds. We keep our batch records, origin tracking, and analytical run logs for extended periods, and allow pre-audit inspection for customers with strict compliance needs. These practices have grown from experience—not because of a regulatory checklist, but because every unforeseen deviation costs in yield, rework, and business relationships.
Innovation never stops for a producer of specialty chemicals. Market needs shift as regulatory requirements tighten, application fields broaden, and new synthetic pathways emerge. We stay in close contact with development labs in the pharmaceuticals and agricultural sectors, responding to changes in building block preferences and application testing protocols. Around half a decade ago, broader adoption in crop protection intermediates forced our team to upgrade both reactor volume and purification gear. Our in-house R&D now investigates whether green solvents paired with our standard process can yield the same product stability—early data looks promising.
We keep watch on global supply chain trends to limit risk for partners relying on timely supply of high-purity 2-isopropoxyphenol. Early warning flags on raw material shortages led us to diversify our isopropanol sourcing and build extra buffer inventory, which has allowed us to maintain steady deliveries even through unexpected demand surges.
At the end of the day, the quality embodied by each drum of 2-isopropoxyphenol traces back to the people behind it. Experience includes hundreds of adjustments, many after actual field failures or odd results in downstream customer use. Every controlled variable in the plant—water content, atmospheric composition, trace metal level, distillation cut—derives from direct interaction with both chemists and end users, not marketing literature alone.
For those weighing whether to choose this compound, consider not just the molecular structure but the chain of decisions, know-how, and corrective actions taken by a manufacturer who has tackled the whole range of production, shipping, and downstream application challenges. The chemistry is only as good as its real-world reliability, something that comes with years of collaboration and technical transparency between supplier and user.
