|
HS Code |
212511 |
| Cas Number | 107295-19-4 |
| Molecular Formula | C7H4F3IO |
| Molecular Weight | 288.01 g/mol |
| Appearance | White to light yellow crystalline powder |
| Melting Point | 61-65°C |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents (e.g., DMSO, methanol, acetone) |
| Smiles | C1=C(C=C(C(=C1O)I)C(F)(F)F) |
| Inchi | InChI=1S/C7H4F3IO/c8-7(9,10)4-1-2-6(12)5(11)3-4/h1-3,12H |
As an accredited 2-Iodo-5-(Trifluoromethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2-Iodo-5-(Trifluoromethyl)Phenol, 5g, supplied in a tightly sealed amber glass bottle with tamper-evident cap, labeled with safety information. |
| Shipping | 2-Iodo-5-(Trifluoromethyl)Phenol is shipped in tightly sealed containers, protected from moisture and light. It is packaged according to hazardous material regulations, typically under UN-approved packaging with appropriate labeling. Shipment is via ground or air by certified carriers, ensuring compliance with chemical safety and transportation guidelines to prevent leaks or contamination. |
| Storage | 2-Iodo-5-(Trifluoromethyl)phenol should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizing agents and bases. Store at room temperature, and avoid exposure to heat and ignition sources. Ensure appropriate chemical labeling and access only for trained personnel. |
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Working daily in chemical manufacturing means we know how each process twist changes a molecule's behavior. 2-Iodo-5-(Trifluoromethyl)Phenol (commonly referenced by chemists as 5-TFM-2-Iodophenol) captures the balance between selective reactivity and stability. Its molecular formula, C7H4F3IO, brings a unique combination of iodine and trifluoromethyl groups to the phenol ring, opening doors for both academic research and industrial applications, especially where electrophilic or oxidative substitution is needed. Tracking every lot from raw material to finished product, we witness how structural adjustments—especially something as significant as combining trifluoromethyl and iodo functional groups on a single ring—shift outcomes in methods as routine as halogen exchange or as high-stakes as late-stage pharmaceutical building block assembly.
Few intermediates handle the demand for clean substitution like this compound. It doesn’t just sit on a shelf in our plant. It runs through custom synthesis orders, pilot-scale batch work, and sometimes kilo-making, serving as a go-to phenolic substrate for numerous cross-coupling and electrophilic aromatic substitution reactions. Pharmaceutical chemists lean on its high site-selectivity, finding the iodo position a reliable handle for palladium-catalyzed couplings. Agrochemical researchers value the trifluoromethyl group for its impact on metabolic stability and bioavailability. We pay attention to purity and crystallinity, since these two qualities spell the difference between reaction successes and troubleshooting headaches in customers’ laboratories.
Decades of hands-on manufacturing have shown us why this phenol stands out: combining iodine, with its bulk and good leaving group properties, and trifluoromethyl, well-known for its strong electron-withdrawing effects, on the same aromatic core is not common synthetic practice. The synergy creates unique reactivity compared to other halogenated phenols or trifluoromethylated arenes. One of the central lessons from years in the plant is that not all halogenated phenols behave with the same convenience or safety: a chlorine atom, for example, clings more tightly, making some couplings drag or require harsher conditions. Iodine opens up milder, more efficient syntheses for Suzuki and Sonogashira reactions. Trifluoromethyl tuning, on the other hand, affects phenol acidity and changes solubility, which can help or hinder process development for a given project.
Our lines run with a deep sense of process discipline. Sourcing iodine of consistent granule size, balancing temperature ramps during trifluoromethylation, and using dedicated equipment for this class of phenols shield against contamination by halogen “crossover”—a risk manufacturers can’t afford to ignore. Finished product must pass strict purity specs, not just because analytical results look good but because downstream users—our partners—count on reproducibility. In heterogeneous catalysis experiments or as a starting point for biologically active molecule libraries, even trace impurities throw off data or scale-up efficiency. Every time a batch rolls out, analytical, purification, and drying teams compare outcomes to years of backlogged data, always checking for shifts in melting point or unwanted byproducts that signal a bad process run.
Direct experience with phenol derivatives, especially ones carrying both iodine and trifluoromethyl, has taught us crucial safety protocols. The phenolic hydroxyl means gloves and eye protection are a must on the floor—not only because of skin absorption risks, but because the compound will easily sting exposed skin. 2-Iodo-5-(Trifluoromethyl)Phenol remains stable under cool, dry storage, as long as exposure to direct sunlight and moisture stays minimal. While its vapor pressure is low, any dust should be captured under efficient local extraction to avoid accidental exposure. Safety concerns with iodoaromatics typically relate to their environmental persistence, so waste is carefully collected and routed through high-temperature incineration rather than flaring or casual disposal.
From day-to-day experience, the combination of a large halogen and a fluorinated group on the same phenol substrate distinguishes this compound from mere bromo- or chloro-analogues. 2-Iodophenol, by itself, offers similar palladium compatibility—but the moment you bolt on a trifluoromethyl at the para position, everything from solubility to reaction rate can change. Practitioners in medicinal chemistry see this in increased lipophilicity and different partition coefficients, traits attractive for tuning drug transport across biological membranes. Within the plant, operators see it too: purification requires different solvent choices, given the compound’s tendency to dissolve in medium polarity ethers and ketones rather than just simple alcohols. This specificity lets chemists leverage reactivity differences, narrowing in on transformations simply unattainable with chlorinated or methylated analogs.
On the chemistry side, production batches don’t always go smoothly, as anyone who’s synthesized multifunctional aromatics will attest. Sometimes, the iodo substituent threatens to slip off or trigger side reactions without careful process control. We’ve responded by adjusting heat profiles, monitoring entire synthetic runs with real-time analytical tools, and improving phase transfer steps to cut down on byproduct formation. Maintainers have also seen that certain glassware, heated in the presence of trace iodine or trifluorinated aromatics, can develop colored residues, making proper washing and inspection a permanent routine. By working directly with R&D departments of various downstream users, we continue to retool our purification SOPs to strip away impurities known to be problematic for specific reactions, such as trace biphenols that impact hydrogenation or coupling yields.
We’ve seen this intermediate shine brightest in several core niches. Medicinal chemists order it for routes toward kinase inhibitors, serotonin analogs, and as a synthon in fluorinated pharmaceuticals under discovery or early-stage development. Its role in crop protection chemistry grows each year—especially as new compounds need both increased metabolic stability and precise functionalization. In electronics, custom syntheses use this molecule as a precursor for certain advanced fluorinated polymers, which value both halogen activation sites and extreme stability. As a manufacturer, getting feedback from pilot projects at scale, we track results and fine-tune each batch based on how real-world reactions progress, not just by readings from bench-top test tubes.
Handling phenolic intermediates at scale reveals what matters: moisture exclusion starts in the warehouse and extends through final drum sealing. We store and ship this compound in sealed, buffered containers, preferring glass over reactive polymers whenever possible. Solid product usually appears as a crystalline powder with off-white to beige tones, which can shift slightly depending on trace residuals, though our facility consistently meets target color and melting range standards set for sensitive downstream reactions. Every batch runs through QC including GC-MS and HPLC scans—no shortcuts.
Transparency remains foundational. Clients see full batch records, photographic lot tracking, and impurity profiles with every shipment. Purity always exceeds 98% by HPLC, with residual solvents staying well below the allowable thresholds we’ve adopted after years of discussions with pharmaceutical and specialty chemical partners. By collaborating openly on impurity fingerprints, we've helped chemists at major labs and smaller scale-ups avoid common analytical pitfalls, like false positives caused by low-level iodo- or fluorinated contaminants.
Working side by side with research chemists, we have learned about issues that only come to light during real synthetic work: certain ligand/solvent combinations bring unexpected decomposition, or a seemingly minor temperature adjustment unlocks new side products. For many, 2-Iodo-5-(Trifluoromethyl)Phenol serves as a test case for developing late-stage functionalizations where both strong and weakly activating groups exist on a ring. Iodine’s ease of displacement by palladium, copper, or nickel catalysts means chemists don’t lose time with sluggish turnover rates seen in chloro-analogues. The CF3 group not only draws electron density away from the site, sometimes tuning reactivity toward otherwise less-reactive nucleophiles, but tends to suppress oxidative byproducts common with other phenols under parallel conditions.
Our team relies on direct, hands-on experimentation for quality assurance. Crystal habit and bulk density offer clues about each batch’s process history. Bad flow, caking, or faintly colored lots signal recovered solvent or minor byproduct retention, triggering retracing and if need be, reprocessing. Our assurance goes beyond “certificate of analysis”—longtime customers send back samples for cross-checking, knowing we’ll run comparative studies and provide process histories, helping pinpoint where a synthesis route drifted off spec.
Our engagement doesn’t stop at producing kilograms. We’ve partnered with several labs to develop more sustainable trifluoromethylation reagents, sidestepping perfluorinated waste. Teaming up with equipment engineers, we’ve started using enclosed reaction vessels that capture iodoarene fumes, protecting both workers and the environment. Feedback from university collaborations has nudged us toward greener solvents like methyl tert-butyl ether, away from older, riskier chlorinated solvents. All this builds on decades of in-plant learning, aiming to give users safer and more efficient syntheses while reducing long-term risk for both people and the planet.
As regulatory expectations rise and performance standards tighten, more customers specify not just purity, but traceability down to every process ingredient. For years, a typical phone call just asked for “the iodophenol with the CF3 ring.” Today, technical teams want batch numbers, synthetic routes, and even the sources of raw iodine and trifluoromethyl donors. Meeting these needs requires a robust supply chain, agile process documentation, and the willingness to invest in trace-level analytics. Our commitment goes hand-in-hand with customer teams, pursuing better end products by ensuring every shipment meets more than just written specifications.
Looking back on years of chemical manufacturing, every successful scale-up and every tough lesson from tricky plant runs shape the standards we hold today. The challenges unique to 2-Iodo-5-(Trifluoromethyl)Phenol—balancing reactivity, purity, clean waste handling, and predictive logistics—become catalysts for broader improvements that ripple out to other phenolic intermediates and halogenated building blocks. Even small process improvements, like switching to inert gas blanketing just before drum closure, reduce off-odors and on-site handling risk. Each batch that leaves our plant stands as a marker for careful, responsive manufacturing rooted in decades of real-world practice, rather than boardroom policy.
Manufacturing isn’t just about paperwork or box-ticking. Our teams spend as much time investigating synthesis issues as they do filling drums or packing bottles. When a process fails—or a customer sees something unexpected in their bench testing—we go back to the reactor, check every valve and chart, and trace the story of that batch. Success, for us, means the chemist on the next step can move forward, not circle back through troubleshooting logs. 2-Iodo-5-(Trifluoromethyl)Phenol, through direct, continuous interaction with our plant and customer laboratories, has grown into an example of what real applied chemistry manufacturing can achieve, adapting to research and industry’s evolving needs, always striving for safety, quality, and better outcomes.
