|
HS Code |
656022 |
| Product Name | 2-Fluoro-3-(Trifluoromethyl)Phenol |
| Cas Number | 261762-05-2 |
| Molecular Formula | C7H4F4O |
| Molecular Weight | 180.10 |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.461 g/cm3 |
| Boiling Point | 166-168°C |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents such as dichloromethane and ethyl acetate |
| Smiles | OC1=CC=CC(C(F)(F)F)=C1F |
| Inchi | InChI=1S/C7H4F4O/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3,12H |
| Refractive Index | 1.465 (approximate) |
| Storage Conditions | Store at 2-8°C, tightly closed, in a dry place |
| Synonyms | 2-Fluoro-3-(trifluoromethyl)phenol; 3-(Trifluoromethyl)-2-fluorophenol |
As an accredited 2-Fluoro-3-(Trifluoromethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 5 grams of 2-Fluoro-3-(trifluoromethyl)phenol, sealed with a screw cap and labeled with hazard warnings. |
| Shipping | 2-Fluoro-3-(trifluoromethyl)phenol is shipped in tightly sealed containers, protected from moisture and incompatible substances. It should be handled by trained personnel using appropriate personal protective equipment. Transport is typically by road or air, following regulations for hazardous chemicals to ensure safe delivery and prevent leaks, spills, or environmental contact. |
| Storage | Store **2-Fluoro-3-(trifluoromethyl)phenol** in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances like strong oxidizers or bases. Protect from moisture and direct sunlight. Label clearly, and handle with appropriate protective equipment, such as gloves and goggles, to minimize exposure and ensure safe storage and handling. |
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At the heart of specialty chemical production, 2-Fluoro-3-(Trifluoromethyl)Phenol has earned recognition for its distinctive reactivity and high degree of selectivity within organic synthesis. As a chemical manufacturer immersed in process development and scale-up, we encounter molecular structures like this one that bring both fresh challenges and new perspectives to the lab. The journey from the drawing board to the finished drum is anything but routine, uncovering subtle details in every batch.
The molecular arrangement of 2-Fluoro-3-(Trifluoromethyl)Phenol, designated by its CAS number 801283-97-8, combines a trifluoromethyl moiety at the meta position and a fluorine at the ortho position relative to the phenolic hydroxyl. From our point of view as a producer, this combination increases both chemical stability and reactivity at defined positions of the aromatic ring. The result: chemists in pharmaceutical research, agrochemical design, and advanced materials science explore its potential in making new scaffolds, intermediates, and functional end-products.
Manufacturing fluorinated aromatics like this one requires technical discipline and process stewardship. The addition of both trifluoromethyl and fluorine onto the phenol backbone brings unusual volatility and increased environmental sensitivity. In real-world settings, those properties play out in the need for robust containment, precise temperature control in the reactor, and specialized glass or alloy equipment that shrugs off corrosion from HF and related byproducts.
From raw material sourcing through each reaction stage, we apply lessons learned from past runs—eliminating water ingress during halogen introduction, recapturing fluorinated vapors for secondary processes, calibrating purification steps so that unreacted phenols don’t compromise product purity. Building consistency means hands-on monitoring of every lot, especially when scaling from kilo lab to drum production. Visual verification and advanced analytical checks—using NMR, GC-MS, and even X-ray crystallography—support each delivery. No two lots ever quite react the same way, so vigilance trumps repetition.
What distinguishes this compound from relatives such as simple 2-fluorophenol or mono-substituted trifluoromethylphenol is how the groups work together. The electron-withdrawing nature of both substituents modifies the acidity of the hydroxyl group. In laboratory reactions, this translates into a compound that supports unique coupling reactions, selective C–H activation, and more predictable nucleophilic substitution. Synthetic chemists tell us this blend enables building blocks previously hard to access, with fewer side reactions.
Formulators for pharmaceutical or crop-protection intermediates often seek out 2-Fluoro-3-(Trifluoromethyl)Phenol as a precursor, not just for its direct transformation, but for what it allows in downstream chemistry. The dual halogenation pattern shifts reactivity to adjacent ring positions, opening new routes to libraries of ether, ester, or heterocyclic derivatives. This strategic value extends its reach into projects designing improved biological activity or enhanced metabolic stability.
In chemical manufacturing, reliability is built on attention to detail—not just at the final stages, but from the procurement of raw fluoroaromatics onward. Refrigerated storage and moisture controls in our plant keep trace water away from sensitive intermediates. Reactors are sized for both pilot and full-scale runs, using continuous agitation and precise dosing mechanisms. By recycling reaction byproducts, we reduce waste and save costs, but we also eliminate red flags that would impact downstream quality.
Once isolated, thorough distillation and crystallization steps sharpen purity further. Purity levels regularly surpass 98%, checked by both chromatographic and spectroscopic tools. Only clear, colorless to pale yellow crystalline product leaves the warehouse, a visual result of batch-by-batch discipline. In our direct conversations with industry researchers, they cite reliability and reproducibility as key reasons to keep returning to our supply.
Forming the backbone of new pharmaceutical candidates, 2-Fluoro-3-(Trifluoromethyl)Phenol is a common starting point for manufacturers working on high-affinity ligands, enzyme inhibitors, and non-natural amino acid scaffolds. Its altered electronics change the way a parent molecule binds in a biological system, often enhancing selectivity or metabolic profile. For agrochemical projects, similar pathways open up, using the unique ring electronics to improve the environmental stability or target specificity of herbicides and fungicides.
Polymer developers and material scientists also request these building blocks for the synthesis of specialty monomers. When thermal resistance and chemical durability take precedence, a trifluoromethyl and fluorine pattern resists breakdown longer than non-fluorinated phenols. As demand for electronic-grade materials and high-performance coatings increases, designers build these monomers into new high-mobility plastics and specialty films.
Working as a producer, we see many ways this product stands apart from other fluoroaromatic phenols. The combination of both ortho-fluorine and meta-trifluoromethyl substitution gives a dramatic shift in molecular polarity, leading to altered solubility in both organic and aqueous systems. Structure-activity relationships highlight not only new halogenation patterns, but also the shifting hydrogen-bond network around the phenolic OH. This gives medicinal and process chemists better control, improving solubility profiles without compromising reactivity.
Side-by-side comparison with mono-substituted analogs confirms varied spectroscopic fingerprints, distinct melting ranges, and different chromatographic behaviors—a practical boon when synthesizing libraries of fluorinated phenols. For example, differences in NMR chemical shift and retention time let labs streamline purification and tracking of multi-step syntheses, especially when working with radiolabels or isotopically marked compounds.
Tough analytical expectations come with manufacturing 2-Fluoro-3-(Trifluoromethyl)Phenol. Each campaign in the plant demands checks with HPLC and GC to measure both major and trace impurities. Modern labs tend to request batch-level data for key markers—residual halides, trace water, and volatile organic contents. We upgrade our analytics as projects grow, bringing in techniques such as two-dimensional NMR or mass spectrometry for cleaner identification and confirmation.
Shipping chemicals like this directly to R&D partners, our job extends to matching specification sheets and providing full traceability from starting materials to finished lots. Regular audits from partners keep us grounded, confirming that processes aren’t drifting or introducing unknowns. In the real world, no system is static, so we document equipment upgrades, solvent changes, and even new personnel qualification routines that touch quality at any stage.
Producers have learned that manufacturing fluorinated phenols doesn't just involve technical hurdles. Environmental and safety best practices are woven into each campaign. Handling reagents like trifluoromethyl sources calls for explosion venting, automated shutoff controls, and cross-ventilated chemical transfer lines. Many specialty fluorine reagents bring both high volatility and toxicity to the table; our teams receive dedicated training and drills for every scenario, not relying on desk protocols alone.
On the sustainability front, we invest in recovery units that reclaim hydrogen fluoride and other valuable byproducts for further processing. Water effluents undergo neutralization before release, minimizing the risk to both staff and environment. Close tracking of waste and air emissions keeps us accountable, and upgrades in our recovery systems yield bottom-line savings while keeping regulatory commitments in check.
One lesson from years in specialty chemicals: chemical buyers today expect more than just a drum or bag delivered on time. Technical support before, during, and after delivery closes the loop. Chemists setting up a new synthesis often call or write for real-world tips—solubility quirks, storage practices, and compatibility with challenging reaction partners. Our lab shares data from both routine and edge-case reactions, so users can build on previous successes (and headaches).
We learn as much from our users as any technical bulletin. Issues like color changes in storage, subtle shifts in GC purity after transport, and advice on handling the strong odors sometimes associated with fluoroaromatics all feed back into future campaigns. Many of our partners visit in person for audits or joint process troubleshooting, forging the direct relationships that keep both sides sharp. For custom projects or recurring campaigns, we can adjust drying protocols, packaging sizes, and storage recommendations to match evolving needs.
Innovating in the production of 2-Fluoro-3-(Trifluoromethyl)Phenol has more to do with practice than promises. Long before this compound reached multi-kilogram lots, lab teams tested alternate fluorination strategies, varying reaction times, solvent systems, and purification steps. Each round generated new observations—solvent-dependent yields, impact of trace metal ions, and effect on downstream couplings—feeding directly into commercial-scale routines.
Looking ahead, our R&D groups partner with both academic and commercial labs, asking whether greener fluorination reagents, less energy-intensive purification, or modular production units can deliver a cleaner, more robust finished product. These changes come slowly, proven first at the bench, then through pilot reactors, and finally at scale. The goal remains the same: increase product value by making each synthetic run more efficient, more sustainable, and more informative for the next team up the supply chain.
Some challenges come with scale, not just chemistry. Sudden spikes in demand—driven by a new pharma lead or materials contract—push us to build up raw material reserves, train flexible shifts, and partner with logistics groups familiar with regulations for fluorinated shipments. Increased demand often brings scrutiny from regulatory bodies, which translates into more audits, documentation, and revised process controls to confirm compliance at every stage.
Chemistry alone rarely solves shelf-life quirks, so we dig into issues like light exposure and humidity, testing impact on stability and appearance over time. Collaborative work with shipping partners ensures the product reaches the user in the same pristine condition as it leaves the plant, whether shipping to a local city or halfway across the world.
Nothing substitutes for the experience that accumulates from hands-on manufacturing. Each batch of 2-Fluoro-3-(Trifluoromethyl)Phenol reflects hundreds of operator hours, attention to safety, continual process refinements, and feedback absorbed from diverse customers. The work stays rooted in the lab—where paperwork, theory, and technique all come together in each finished container.
From starting materials to finished batch, the connection between process chemist, analyst, and the end user shapes the final result. Every audit, every customer call, every process deviation closure adds new knowledge, making each run smoother and more reliable than the one before. That’s the difference a real manufacturer brings to specialty chemicals: not just molecules, but long-standing experience, shared through each delivery, for every application that demands something more than standard.
