|
HS Code |
557834 |
| Chemicalname | 2-Chloro-4-Bromophenol |
| Casnumber | 1574-68-5 |
| Molecularformula | C6H4BrClO |
| Molecularweight | 223.45 |
| Appearance | White to off-white solid |
| Meltingpoint | 58-61°C |
| Boilingpoint | 280°C |
| Density | 1.82 g/cm3 |
| Solubilityinwater | Slightly soluble |
| Refractiveindex | 1.630 |
| Synonyms | 2-Chloro-4-bromo-1-hydroxybenzene |
| Smiles | C1=CC(=C(C=C1O)Cl)Br |
As an accredited 2-Chloro-4-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with secure screw cap containing 100 grams of 2-Chloro-4-Bromophenol; labeled with hazard and identification information. |
| Shipping | 2-Chloro-4-Bromophenol is shipped in tightly sealed containers, protected from light, heat, and moisture. It should be handled with appropriate safety precautions, following all applicable regulations for hazardous chemicals. Proper labeling and documentation must accompany the shipment to ensure safe and compliant transportation. Store in a cool, well-ventilated area upon arrival. |
| Storage | 2-Chloro-4-Bromophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Store at room temperature and protect from moisture. Label the container clearly and handle with appropriate personal protective equipment to prevent contact with skin and eyes. |
Competitive 2-Chloro-4-Bromophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Making specialty chemicals calls for persistence, precision, and a commitment to continuous improvement. We have worked with 2-Chloro-4-Bromophenol year after year, optimizing production, understanding the chemistry behind its formation, and developing a clear sense of how tiny tweaks in process conditions change its performance. This compound (CAS No. 877-45-2) has become a mainstay in our line, valued by our regular clients in agrochemical, pharmaceutical, and specialty organic synthesis. Our long-running partnerships with research labs and formulation sites spring out of the traceability and batch consistency this product delivers. It finds real-world use as both a key intermediate and a starting material for higher complexity molecules.
Our process wraps around a careful halogenation window on a phenol base, holding tight to temperature gradients, catalyst dosing, and time-at-reaction to ensure mono-substitution without over-chlorination or bromine scrambling. Waste management and air handling prevent cross-contamination or off-odor migration, both of which can undermine downstream purity. With every batch, technicians monitor the unique color and solubility behavior that sets this material apart from other halogenated phenol cousins. The final product stands out for its pale yellow to off-white crystal appearance, free-flowing for straightforward weighing and charging, batch after batch.
Halogenated phenols include a large family of compounds, but each molecular skeleton brings distinct features. We focus on the 2-chloro, 4-bromo version because its regioselectivity supports predictable reactivity in Suzuki couplings and etherifications, avoiding side reactions that can plague analogs such as 2,4-dibromophenol or 2,4,6-tribromophenol. While both chlorines and bromines add bulk and electron withdrawing effects, the combination here delivers a balance: it’s reactive enough for synthetically valuable transformations but stable enough to allow for storage. Chemists working with 2,4-dihalophenols often mention issues like melting point drift or mixed halide impurities, yet our controls and purification steps deliver tight analytical windows batch after batch. The difference isn’t just packaging or labeling—it lies in the minute-by-minute stewardship at the reactor.
Formulators and process chemists often seek a phenolic halide that can serve as a versatile intermediate—able to participate in both nucleophilic substitutions and selective coupling reactions—without the fuss of complicated deprotection steps or excess byproduct formation. 2-Chloro-4-Bromophenol opens those doors. Its use is common in crop protection agent synthesis, where the dual halogen pattern can remain through several steps before cleavage or transformation. API builders appreciate its dual handle, relying on both the chloride and bromide as programmable points for functionalization. In-house, we have heard from downstream partners that our material shows a lower baseline of trace polychlorinated or polybrominated byproducts compared to generic sources. That often translates into fewer headaches during late-stage purifications or scale-ups.
The physical handling advantages matter too. With some phenolics, static or dustiness can frustrate cleanroom operators, but the granular, crystalline habit of our product has repeatedly allowed for lossless charging. With material science clients, a consistent physical form means less risk of rogue particles during solvent exchanges or filter press operations. Even those using the material for small-batch pilot projects have commented on its reliable dissolution behavior in common polar aprotic solvents.
Those who work with 2-Chloro-4-Bromophenol routinely care about appearance, assay, water content, and halide trace impurities. Our specification has evolved after conversations with analytical chemists who demand transparency about each pass/fail boundary, not just a data sheet handed down from upstream. TLC and HPLC profiles consistently confirm that our approach yields a single peak—so cross-reactive signals from ortho- or para-isomers have been virtually eliminated.
Kilogram lots through to multi-ton campaigns, the dry product stands up to moisture, with Karl-Fischer titration numbers holding steady thanks to both pre-drying and humidity-controlled packing lines. In recent campaigns, a sharp vigilance on residual solvents further reassures users of its safety profile when moving to the next synthetic stage. Clients in regulated industries require validated analytical data, and we share full chromatograms, not just summary sheets, since transparency builds trust the more critical your application becomes.
From experience, switching between halogenated phenols—even among those close in molecular weight—can bring unexpected bottlenecks or even whole-lot rejections. 2,4-Dichlorophenol, sometimes considered as a possible analog, can underperform in coupling reactions, often stalling out under mild conditions or producing off-path byproducts in downstream arylations. By contrast, the mixed 2-chloro, 4-bromo configuration balances leaving group performance so that the user can tune conditions for their specific case.
There’s a niche group of users seeking high bromine loading, who occasionally consider tribromophenol. Over the years, we’ve watched these efforts hit snags in purification, as well as broader waste stream complications, often because of solubility and handling risks. Our product sidesteps most of these pain points and fits regulatory expectations for both transport and process-scale use. Even compared to monohalophenols, our 2-Chloro-4-Bromophenol offers a much more controlled substitution pattern, which translates to cleaner structure-activity relationships in medicinal chemistry campaigns.
Bulk storage of 2-Chloro-4-Bromophenol sometimes meets resistance from solvent compatibility questions or potential volatility. Years of monitoring have shown the product handles well in dry, cool storage. Operators appreciate predictable scoop-ability without caking, and with packaging tailored for rugged transport. Moisture ingress often makes the difference between a batch moving seamlessly to formulation and one requiring costly re-work; real-time feedback from our warehouse has prompted us to keep a close eye on humidity exposure. As a manufacturer, each process adjustment—down to fine mesh sieving—draws from hands-on experience, not just literature precedent.
Documentation doesn’t stop at a COA. Over half of our inbound queries focus on use history, process deviations, and post-delivery technical support. We build every outbound shipment on that expectation. With complex phenolic halides, knowing the story behind each drum is more valuable than just seeing a purity figure. Most customers have rigorous internal standards, so we share not just our certificate, but also run histories and spectral archives. In cases where a partner requests re-testing or lot-specific data, that information comes from our in-lab records, not third parties or unsourced documentation.
Early days of making 2-Chloro-4-Bromophenol ran into throughput bottlenecks that could throw off the entire batch’s impurity profile. Through practice, process safety reviews, and the occasional factory shutdown, we’ve sharpened every aspect for consistency. Heat transfer refinement, vessel material upgrades, and improved analytical detection for minor byproducts have all flowed from joint pushback between quality assurance and synthesis teams. Operating at scale means that every step, from raw material receiving to final QC, reflects what we’ve learned from trial and improvement.
Greater scale also calls for vigilance in environmental controls. As a direct manufacturer, we’ve tackled waste handling not just for our own permits, but because improper treatment of halogenated byproducts can haunt downstream processing. Air and liquid waste profiles are tracked with every run, and we’ve developed solvent recycle and neutralization strategies that meet stricter standards put in place in recent years. In practice, these changes ensure the final product remains true to its benchmark properties, both chemically and environmentally.
From customer-side formulators to upstream raw material suppliers, our network provides direct feedback on every shipping lot. Process chemists in pharmaceutical synthesis share analytical overlays or report subtle differences in yield based on our batch records. We regularly receive sample requests from regulatory audit teams needing detailed impurity logs before scale-up permission. By treating each inquiry as a chance to strengthen the product’s reputation, our support team closes the loop—logging minor deviations, tracking delivery cold-chain history, and gathering real-world performance metrics during the material’s use.
Our team has spent years learning from returns, operator handling incidents, and minor complaint trends. Not only does each feedback cycle make the next batch tighter, it also makes us better equipped to suggest process optimizations for our regular users. This iterative pattern has helped us reduce off-spec batch rates and align specification improvements with customer SOBs (standards of business).
Manufacturing rarely unfolds without hiccups. In the field, the difference between a smooth project and a delayed campaign often hinges on fast, honest transparency. That begins on our production lines, where each step from charge to finish draws oversight from operators with years of first-hand experience. We keep redundant bridging stock on hand to solve sudden supply crunches, and we empower our coordination staff to make direct adjustments when a shipment’s delayed or compromised.
As soon as a discrepancy shows up—be it an offspec reading or unexpected carryover—we report directly to end users with a full spectrum of analytical data and workaround guidance. Much of the trust we’ve built with global clients comes from these moments: not from perfection, but from repeatable patterns of problem-solving and accountability.
The halogenated aromatics sector faces a growing web of safety and regulatory rules. We work constantly to interpret and apply guidance, ensuring that our production, waste control, and labeling meet up-to-date requirements. More importantly, our team channels those demands into practical information for those who actually work with the material. End-users seldom want boilerplate—they want a summary of impact on process safety, waste streams, and audit reporting.
For customers handling multinational projects, paperwork range can get overwhelming. We streamline as much as possible by preparing both regulatory compliance statements and direct documentation tailored to agency requirements—rather than just loading forms onto a website and calling it a day. We also collaborate closely with downstream technical leads, supporting them on joint agency audits or supplying dossier-ready impurity breakdowns.
Responding to changing end-user requirements keeps the learning curve steep. Incoming requests for new impurity panels, alternate packaging sizes, or tighter physical specs prompt us to look again at how the product is made and delivered. Our technical, manufacturing, and QA teams meet regularly to assess process drift, review global regulatory updates, and consider customer proposals for product evolution.
Requests for increased traceability and closer oversight arise more frequently as the industry leans into digitalization and data-centric batch records. We have begun pilot projects surrounding greater batch transparency through blockchain-backed lot histories and more reliable on-demand shipment tracking. While digital tools increase transparency, the core difference remains the same: deep process knowledge from years in the factory and ongoing, direct collaboration between chemists and operators.
2-Chloro-4-Bromophenol has earned its place in our roster through real application and problem-solving. The compound’s utility, combined with batch after batch of consistent output, supports advances in new chemical product pipelines across sectors. From our perspective, each production order stands as a test of learned skills, process discipline, and readiness to engage openly with partners working at every stage of the value chain.
We keep investing in both our operators and our analytic capabilities, not only because standards get stricter every year, but also because process expertise carries through to every gram shipped. Looking back at where we started, it’s clear that every line of feedback, every analytical anomaly, and every successful campaign has combined to shape a product—and a manufacturing approach—that’s ready for tomorrow’s challenges in specialty chemistry.
