|
HS Code |
186148 |
| Iupac Name | 2-Bromo-6-chloro-4-fluorophenol |
| Molecular Formula | C6H3BrClFO |
| Molecular Weight | 225.44 g/mol |
| Cas Number | 218301-79-0 |
| Appearance | Solid (typically white to off-white powder) |
| Boiling Point | Decomposes before boiling |
| Solubility In Water | Low |
| Density | Approx. 1.8 g/cm³ |
| Smiles | C1=C(C=C(C(=C1Br)O)F)Cl |
| Inchi | InChI=1S/C6H3BrClFO/c7-4-1-3(9)2-5(8)6(4)10/h1-2,10H |
As an accredited 2-Bromo-6-Chloro-4-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | White powder supplied in a 25g amber glass bottle, tightly sealed, with hazard labeling and product information displayed on the outside. |
| Shipping | 2-Bromo-6-Chloro-4-Fluorophenol is shipped in tightly sealed containers, protected from moisture and light, and clearly labeled with hazard information. The chemical is transported according to relevant regulations for hazardous materials, ensuring safety and compliance with international and local shipping guidelines. Temperature and handling instructions are included to prevent deterioration or accidents. |
| Storage | Store 2-Bromo-6-Chloro-4-Fluorophenol in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances (such as strong oxidizers). Protect from moisture and sources of ignition. Use appropriate personal protective equipment when handling. Clearly label the container, and store it in a designated area for hazardous chemicals. |
Competitive 2-Bromo-6-Chloro-4-Fluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615380400285 or mail to sales2@liwei-chem.com.
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Tel: +8615380400285
Email: sales2@liwei-chem.com
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Stepping into our lab first thing in the morning, the sharp, faintly medicinal aroma of highly functionalized phenols hangs in the air. It’s familiar and, in its own way, reassuring. This scent comes from specialty chemicals like 2-Bromo-6-Chloro-4-Fluorophenol, a product we have spent years refining, both in purity and in reliability. From the raw materials that enter our facility to the sealed, labeled drums leaving the shipping dock, every step is steered by teams who live and breathe chemistry, not simply trade it.
Back when we set out to synthesize halogenated phenols, each candidate on the drawing board offered a different combination of groups for tuning reactivity. 2-Bromo-6-Chloro-4-Fluorophenol stood out early on. By balancing electron-withdrawing effects at three positions, chemists saw it as a workhorse for downstream transformations. Its structure — bromine at position 2, chlorine at 6, and fluorine at 4 on a phenolic ring — gives it unique reactivity, different from any of the mono- or dihalogenated phenols stocking the average bench.
Through years of process improvements, fault-finding missions, and hands-on troubleshooting, our team shaped a robust synthesis pathway. Early batches needed improvement; our product once held traces of unreacted starting materials by the time it reached the filtration step. That would never cut it for customers looking to create precision intermediates for agrochemistry or pharmaceuticals. So, we changed our approach: we refined purification until the product consistently reached over 98% purity by HPLC, confirmed by NMR and GC-MS for residual solvents and unknowns.
Chemical manufacturers eye halogenated phenols for their roles as building blocks. Here, the unique substitution of halogens changes everything. The interplay of bromine, chlorine, and fluorine across the aromatic ring varies electronic density and steric profile. That confers selective reactivity during further transformations — not only for traditional electrophilic substitution, but also for tailored cross-coupling reactions on the aromatic system.
We pack and ship this product to customers who transform it into advanced intermediates. Often, it reaches an R&D bench or pilot reactor where a single variable halogen can make or break a synthesis route. Many have shared their feedback: with 2-Bromo-6-Chloro-4-Fluorophenol, they exploit the unique ortho/para orientation for specific Suzuki or Buchwald-Hartwig couplings. In one case, switching to our material cut by-product levels by 7% compared to a similar dihalophenol. These differences matter in the final cost structure of both laboratory-scale and industrial campaigns.
Molecules like this play a central role in exploring new modes of biological action, especially in the preclinical stages. We’ve talked to process teams at innovator companies who start with our product before modifying the ring for advanced screening projects. Having all three halogens lets medicinal chemists tune key metrics like metabolic stability or logP. In more advanced projects, our chemists help customers adopt our phenol into combinatorial libraries.
Our own application team has evaluated this molecule’s utility for several crop protection scaffolds. Adding three distinct halogens provides a chance at a “scaffold hop,” where the activity profile changes just enough to skirt around patent constraints or resistance mechanisms. Years ago, one of our customers sought a route that bypassed their old synthetic bottleneck: the alternative using 2-Bromo-6-Chloro-4-Fluorophenol delivered a cleaner profile, reducing the time spent on downstream purification. It made their plant runs more predictable — the kind of impact you only see when working closely with real production teams, not just reading a datasheet.
Long before an order goes out, our team looks for subtle signs in every batch: color, melting point, residual halides. Some would gloss over these, but those details tell stories about process reliability. We run tight controls on every precursor, use high-vacuum drying, and triple-check all outputs, especially since traces of hydrolyzable halides or phenolic impurities could foul downstream synthesis steps for our customers.
Manufacturing doesn’t end at synthesis. Storage and packaging are just as vital. If this product sits in a humid corner too long, sensitive phenolic sites could absorb water, which causes shelf-life headaches for customers. In our facility, all inventory moves under nitrogen, packed in opaque drums with validated seals. You only get this level of detail by walking the warehouse, rolling up sleeves, and checking every seal — a lesson you only learn after a batch or two comes back flagged for environmental moisture.
Some ask why they shouldn’t just use the tried-and-tested monochloro or monobromo phenols. The answer is in reactivity and adaptability. Bromine at the ortho position to the phenol group opens up cross-coupling, while fluorine and chlorine at the para and other ortho positions push or pull electron density, fine-tuning nucleophilicity. In practical synthesis, this means different selectivity, less unwanted rearrangement, and fewer side reactions.
Take a process where substitution patterns matter for downstream amination: standard halogenated phenols often force extra steps, sometimes using protection-deprotection tactics just to achieve the right regio-chemistry. With 2-Bromo-6-Chloro-4-Fluorophenol, those workarounds drop away. Its three-way substitution opens direct access to intermediates that others only reach after extra steps.
Colleagues in medicinal chemistry point out another benefit — fluorine’s presence reduces metabolic liability, a factor pharma companies watch closely. Drugs or agrochemicals based on this scaffold often linger longer in planta or animal studies, thanks in part to the stabilizing effect of fluorine on the aromatic ring. Replacing a hydrogen or methyl with a fluorine atom, and positioning it specifically, often leads to better performance of the end product.
Traceability means everything in our business. Every kilo leaving our factory can be tracked back to batches of precursors, reactor conditions, and analyst sign-offs. This system doesn’t just help with regulatory audits; it gives researchers and procurement teams confidence that no hidden variable taints their own innovation pipeline. Recently, one customer flagged a subtle shift in their downstream process performance. Within a day, our QA team traced it to a microchange in precursor supplier lots, corrected the issue, and updated all batch records. This level of responsiveness is only possible when manufacturers keep their hands on the actual reactors, not pass orders through intermediaries.
Our sales engineers often work directly with formulation teams. We talk openly about production details, achievable purity, and any side reactions we’ve encountered. We’ve even invited long-term partners to tour our site, see the lines, and understand firsthand the care that goes into keeping final product quality on point.
On the shop floor, handling phenols requires vigilance. Everyone here knows the importance of proper protective equipment. Over the years, we designed containment for every process transfer step — closed-loop filtration, sealed reactor ports, and ventilation controls to minimize exposure and environmental release. These were not just regulatory protocols on paper: they grew out of hands-on work, seeing how phenols behave in the real world, and learning always to treat every new lot with a mix of respect and scrutiny.
Storage lessons also stick with us. Early batches once arrived at a customer’s site showing faint discoloration that traced back to light exposure during cross-country transit. We responded by shifting to opaque, UV-protected containers, now standard for every drum we send out. Customers no longer grapple with unpredictable color changes; instead, they see the same pale, crystalline powder batch after batch.
The regulatory bar keeps rising for specialty chemicals, especially for those destined for pharmaceutical or crop protection applications. We run our own compliance lab, testing for restricted impurities under ICH Q3A and REACH guidance, and submit samples for third-party validation. This work goes beyond just ticking boxes: our teams want to ensure customer labs stay audit-proof, and that no surprise contaminant gets in the way of their product registration.
Disposal and environmental impact have their place in every manufacturing discussion. We reclaim halogenated waste streams, distill and recycle solvents, and work with downstream partners for compliant destruction. Early on, our local regulators flagged our phenol waste for additional monitoring, so we upgraded our treatment to close the loop. Focusing squarely on minimizing environmental releases adds expense, but also protects the community around our plant. Team members who live nearby have a stake in safe operations; this personal connection keeps standards high.
Raw materials come from a network of suppliers who know we pay attention to consistency. We lean on long-term partnerships rather than chasing short-term price wins. For 2-Bromo-6-Chloro-4-Fluorophenol, each precursor comes in stability-tested drums, with batch certificates attached and validated upon arrival. Trace halogen contamination can foul a whole reactor load, so the incoming QC process goes deep. Over time, this diligence has paid off, letting us scale up from pilot lots to bulk manufacturing without stumbling over variances in impurity profiles.
Scalability also pushes us to tweak our process: exothermic reactions grow challenging at the ton scale, so we use in-reactor monitoring and rapid quench systems to keep every variable tight. Veteran operators guide every scale-up, bringing practical know-how honed over decades in the trenches of the chemical industry. Moving from lab glassware to commercial reactors is never a straight copy-and-paste. We adapt, streamline, and tune each step, learning from both successes and stumbles.
Over the years, we have seen that reliability, not just cost or theoretical purity, wins lasting business. It only takes one poor lot to lose a partner’s trust, and that lesson has shaped every process review and vendor negotiation. We support our customers by sharing insights gained from hands-on experience: if an alternate route or substitute fits their needs better, we guide them there, even if it means a smaller sale for us. Building a chemical business isn’t just about throughput; stewardship and relationships shape every batch and every customer conversation.
It’s common for innovators to reach back downstream, looking for deeper input from the people who actually make their core intermediates. We welcome this dialog. We track the market for regulatory shifts, talk trends with peer manufacturers, and keep our R&D pipeline open for new derivatives. Our own staff attend technical conferences, present findings, and collaborate on published research — a habit that began years ago from wanting to build not just sales, but genuine scientific progress using the chemical specialties we produce.
The market for advanced halogenated phenols keeps evolving. Chemical supply chains face pressure from regulation, raw materials sourcing, and the ongoing need for higher purity and faster analytical turnarounds. We see these as challenges worth taking head-on. Our quality and technical teams meet regularly to chart process improvements, trial new purification systems, and diversify supply lines for key precursors.
We also invest in training for our operators and lab technicians. Sharing experience from the field, especially lessons learned from actual batch campaigns, shortcuts the learning curve for new team members. This collective expertise sustains process reliability. When a customer asks a technical question about reactivity, impurity risks, or solubility, they won’t hear rehearsed lines from a call center. They’ll connect directly with the people overseeing synthesis — chemists, engineers, and quality leads who know the process not just from paper, but from hands-on experience.
Science is often portrayed as solitary, but good chemistry thrives on collaboration. When our customers face a problem in route scouting, we welcome calls to brainstorm alternatives. Years ago, we helped a pharmaceutical team adapt a new hydrogenation protocol around the unique features of 2-Bromo-6-Chloro-4-Fluorophenol, sidestepping deactivation issues linked to other substituted phenols. That problem-solving mindset benefits all sides, and it only happens when manufacturers open their doors and share what works and what doesn’t.
Along with product, we offer perspective. Working directly with industry’s challenges — purity drift, regulatory hurdles, process bottlenecks — gives us a front-row seat to the evolving needs of modern chemical manufacturing. We value transparency, continuous learning, and the belief that consistent, honest feedback builds solutions that work in the real world.
2-Bromo-6-Chloro-4-Fluorophenol is much more than a catalog listing to us. It represents years of persistent work, real problem-solving, and direct conversation with the chemists who rely on its unique properties for their most challenging projects. Each drum we ship carries not just a product, but experience—ours, and that of the chemists, engineers, and operators who depend on our commitment to quality.
If you need insight, real-world advice, or technical support built on years of hands-on manufacturing experience, we’re here to help. Our doors—and our benches—are always open to those who share the drive to make precise, reliable chemistry part of every breakthrough.
