|
HS Code |
229744 |
| Chemical Name | 2-Bromo-4,5-Difluorophenol |
| Molecular Formula | C6H3BrF2O |
| Molecular Weight | 208.99 g/mol |
| Appearance | White to off-white solid |
| Cas Number | 180778-76-1 |
| Melting Point | 67-70 °C |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Smiles | C1=C(C=C(C(=C1O)Br)F)F |
| Inchi | InChI=1S/C6H3BrF2O/c7-5-3(8)1-4(10)2-6(5)9/h1-2,10H |
As an accredited 2-Bromo-4,5-Difluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with secure screw cap, labeled "2-Bromo-4,5-Difluorophenol, 25g," featuring hazard symbols and handling instructions. |
| Shipping | 2-Bromo-4,5-Difluorophenol is shipped in tightly sealed containers to prevent leakage and exposure. It should be transported as a hazardous chemical, following relevant regulatory guidelines. Keep the chemical upright and protected from heat, moisture, and physical damage. Ensure labeling is clear, and include safety documentation for handling emergencies during transit. |
| Storage | **2-Bromo-4,5-Difluorophenol** should be stored in a tightly sealed container, protected from light, moisture, and incompatible substances such as strong oxidizing agents. Keep it in a cool, dry, and well-ventilated area, preferably in a dedicated chemical storage cabinet. Properly label the container and ensure storage at room temperature, away from sources of ignition and direct sunlight. |
Competitive 2-Bromo-4,5-Difluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Producing 2-Bromo-4,5-Difluorophenol over the years has taught us where the real value lies in this specialty compound. As a direct manufacturer, we pay close attention to the fine details in each batch, starting from raw material sourcing to final drum filling. There’s a deep sense of responsibility at every stage, as anybody relying on building-blocks for synthetic chemistry knows that a product’s reliability makes a world of difference. Chemists working in medicinal, agrochemical, or material research rely on purity and reproducibility, but they also want something that behaves in a predictable way through various reaction conditions. Building trust in this field comes from being transparent about our process, maintaining robust in-house analytics, and pushing beyond the bare minimum.
We offer 2-Bromo-4,5-Difluorophenol in our standard range with a molecular formula of C6H3BrF2O and a registered CAS number for clarity in documentation. In everyday operation, purity is never just a statistic for us—it’s a reflection on the rigor of our process. We routinely deliver product with GC and HPLC purity over 98%, backed up by NMR verification. Purity checks do not just flag contaminants; they help anticipate reactivity shifts or downstream problems users can encounter. Moisture and residual solvent content stay low, which matters for chemists who run sensitive couplings or organometallic reactions. Particle size and appearance vary between batches given crystal growth and handling, but we respond to special requirements by adjusting filtration, crystallization, or drying conditions, not by using fancy language.
Our customers use 2-Bromo-4,5-Difluorophenol in several key ways. As a building block in pharmaceutical research, this compound enables the introduction of both bromine and fluorine atoms on the phenol ring—a functional combination not easy to achieve by mixing other halogenated phenols. The two fluorine atoms at the 4 and 5 positions give a unique electronic effect, altering the phenol’s reactivity in cross-coupling reactions as well as classic SNAr substitutions. The bromine atom works as a convenient handle for palladium-catalyzed couplings, making Suzuki, Heck, or Buchwald–Hartwig routes open up with fewer surprises. Medicinal chemists value the balance of reactivity and stability, as well as the ability to tune their substitutions for SAR studies.
In materials science, we’ve seen this molecule being used as a precursor to specialty polymers or advanced coatings. The hydrophilic phenolic group can help chemists design surface-active agents or dendrimers by providing a versatile anchor, while the two fluorine atoms contribute to higher thermal and chemical stability. Agrochemical and crop protection developers have also explored it for its potential in new active ingredients or as an intermediate in multi-step syntheses of fluorinated analogs.
It’s easy to underestimate the importance of regiochemistry in a molecule until a synthesis project reaches a dead end. We have made and supplied many halogenated phenols, and we know that swapping the order or positions of the bromine or fluorines changes everything. With 2-Bromo-4,5-Difluorophenol, the substitution at the 4 and 5 positions is rarely replicated by other difluorinated phenols, which often have their fluorines at 2, 3, or 6. These differences are not a matter of trivial nomenclature—they directly impact reactivity, solubility, and the success of downstream reactions. The phenolic hydrogen remains available, giving access to etherifications or further functionalizations, while the ring’s electronic distribution limits undesired side reactions or decomposition under basic or metal-catalyzed conditions.
For chemists wrestling with multi-step routes, using this compound weeds out unnecessary protection/deprotection cycles. Standard 2,4-difluorophenol or simple monohalogenated derivatives can’t offer the same versatility. Even close analogs like 2-Bromo-3,4-difluorophenol give different outcomes in reactions relying on precise electronic effects near the reactive handle. From a practical manufacturing point, achieving high positional selectivity in the difluorination and bromination steps requires process know-how and reliable equipment. An off-center substitution makes purification a headache, as the minor isomers can closely mimic the desired product in some methods.
Making 2-Bromo-4,5-Difluorophenol in consistent quality is not straightforward. The most efficient routes involve selective difluorination of a pre-functionalized ring or controlled bromination of a protected difluorophenol. Reaction control at each stage shapes the impurity profile, and each lot’s behavior under industrial-scale recrystallization or chromatography shifts when the weather or humidity changes. Our team tracks these shifts and applies process control not just after problems pop up, but preemptively, informed by prior runs and batch analytics.
Waste management cannot be an afterthought. Fluorinated by-products or spent reagents from halogenation steps require safe disposal and regular monitoring. We designed our workflow to limit the generation of persistent waste and recapture solvents where feasible. Each kilogram of product made thus reflects not just its technical value, but a conscious approach to minimizing our environmental footprint. We work with upstream suppliers to get the cleanest possible starting materials—costlier at times, but it protects the downstream reactions and eases final purification. Downtime and scheduling delays are common pain points in chemical production, so we keep flexible intervals between runs for dedicated tank cleaning or filter changes to minimize cross-contamination.
As the industry moves toward more diverse and complex molecular targets, custom synthesis requests become routine. Our on-site development team follows a protocol to scale up promising variants, like chloro or methyl modifications at other ring positions, based on client feedback. Working directly with the manufacturer gives customers more direct lines of communication—special solvent systems, tighter control of residual metals, or certificates of analysis on unusual parameters can be managed faster.
Document control and regulatory support have grown in importance, especially for clients preparing regulatory filings in Europe, North America, or Asia. We keep reference samples from every batch made, allow site audits, and share primary analytical data without requiring six layers of back-and-forth. Experience shows that clients juggling multiple intermediates for complex targets appreciate a straight answer about whether a lot meets a particular downstream need. Our on-site chemists can run quick test reactions, providing solid feedback on compatibility in real-world coupling or substitution conditions, rather than selling a compound "off the shelf" with no insight into its actual utility.
The demand for halogenated and fluorinated phenols keeps rising as advanced synthesis trends point to increased fluorine content in pharmaceuticals and high-performance materials. Historically, specialty intermediates like 2-Bromo-4,5-Difluorophenol were sourced only in small lots and treated as niche items. Now, pharmaceutical and material R&D teams scale from milligrams to kilograms quickly, needing assurances about quality at each step. We’ve invested in modular reactor systems that switch between campaign-scale and smaller development runs, giving our team the flexibility to adapt to new projects without interrupting existing supply commitments.
Process sustainability matters. We focus on reducing solvent use, optimizing yields, and reclaiming by-products for downstream recycling or safe disposal. Recent advances in flow chemistry and automated monitoring have enabled us to improve selectivity, cut waste, and identify optimal process windows more quickly. Our team consults regularly with academic collaborators and process engineers, aligning commercial output with the expectations of a new era of science—one where traceability and environmental impact weigh as heavily as chemical performance.
Anybody who’s run late-night reactions, watched GC traces fill with mystery peaks, or scrubbed gummy materials from glassware knows that trusted starting materials make life simpler. People may talk about "innovation," but the daily reality is that getting a reliable supply of key intermediates lets researchers and process chemists focus on the science, not troubleshooting. By keeping lines of communication open, tracking what really matters in batch records, and being willing to answer tough questions about quality, we bring value beyond simple supply. Our team’s experience—facing real-world production constraints, variable demand, and evolving safety regulations—translates into better batches and fewer headaches for those at the frontlines of discovery.
We believe that high-quality 2-Bromo-4,5-Difluorophenol should give researchers the flexibility to push their science forward. Whether scaling a lab hit into a commercial route, running structure-activity studies, or probing new uses for halogenated phenols, our production team’s experience in making this compound work for real users stands as our most reliable reference. No one can promise a world with zero problems, but approaching production with a hands-on mindset, keeping a real dialogue with users, and responding fast to new challenges has kept us moving forward year after year.
Fluorinated intermediates used to be a specialty domain. As newer pharmaceuticals, agrochemicals, and high-tech materials specify higher levels of fluorination, the market for multi-halogenated phenols has followed suit. Projects that used to require simple monofluorophenols now demand molecules with a precise arrangement of halogens. Firms that limit themselves to standard product lists miss opportunities for discovery and problem-solving.
Our approach borrows from both the academic and industrial playbook. We support exploratory projects, small batches for method development, and rapid process updates when a customer encounters unexpected results. By watching how each batch performs in real chemistry, our feedback loop keeps improving. This process of learning—batch by batch, gram by gram—is not glamorous, but it is what builds confidence in both the product and the broader relationship between manufacturer and researcher.
2-Bromo-4,5-Difluorophenol continues to illustrate how genuine attention to production details yields benefits far beyond those promised on paper. While new uses emerge as science advances, one constant remains: clients need openness, accountability, and honest feedback about what makes a compound fit their purpose. We strive to offer just that in every lot we produce.
No chemical, particularly those bearing multiple halogens, is without health and safety concerns. We maintain direct oversight of safety data generation and risk assessments to ensure our materials conform to international standards as well as practical laboratory guidelines. Production lines are designed for safe handling, air filtration, and spill containment. Anyone using 2-Bromo-4,5-Difluorophenol in sensitive or scale-up operations should expect access to up-to-date safety documentation, not just a copy-paste set of general instructions. Our safety team supports research requests ranging from analytical standards for trace impurity detection to risk communication for regulatory checking.
Synthesis is only one part of the equation. The way each compound interacts with solvents, catalysts, and other reagents marks the line between progress and frustration. Over the years, direct dialogue with chemical engineers, supervisors, and production workers has given us a practical sense of what helps and what hinders. Clean supply, honest reporting, and backup runs in case of unforeseen downtime shape how effective a given project can be. Our manufacturing philosophy centers around technical honesty, practical support, and adaptability in the face of changing chemical demands.
Our journey producing 2-Bromo-4,5-Difluorophenol hasn’t been without its learning curve. Mastery comes through hard work, willingness to adapt, and never losing sight of the details that shape real chemical progress. The compound’s unique configuration makes it an indispensable intermediate for labs and industrial teams pushing boundaries in pharmaceuticals, agrochemicals, and advanced materials. As we refine techniques, draw on deep hands-on experience, and prioritize transparent, accountable supply relationships, the value of working directly with a dedicated manufacturer becomes clear. We strive every day to be the partner that scientists, engineers, and process teams trust to turn synthetic ambitions into reality, batch after batch.
