|
HS Code |
105257 |
| Chemicalname | 2-Amino-4-Bromophenol |
| Casnumber | 15761-38-3 |
| Molecularformula | C6H6BrNO |
| Molecularweight | 188.02 g/mol |
| Appearance | Light brown to beige solid |
| Meltingpoint | 113-117 °C |
| Solubility | Slightly soluble in water |
| Purity | Typically ≥98% |
| Density | 1.7 g/cm³ |
| Smiles | c1cc(c(c(c1)Br)O)N |
| Inchi | InChI=1S/C6H6BrNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2 |
As an accredited 2-Amino-4-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Sealed amber glass bottle containing 25g of 2-Amino-4-Bromophenol, labeled with safety information, chemical formula, and hazard warnings. |
| Shipping | 2-Amino-4-Bromophenol is shipped in tightly sealed containers to avoid moisture and contamination. Packages are clearly labeled and cushioned to protect from damage. It is transported according to applicable regulations for hazardous chemicals, with documentation and handling guidelines provided to ensure safe and compliant delivery. Store in a cool, dry place upon receipt. |
| Storage | 2-Amino-4-bromophenol should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers. Protect from light and moisture. Ensure the storage area is equipped with appropriate spill containment, and label all containers clearly. Use proper protective equipment and follow standard laboratory safety protocols when handling. |
Competitive 2-Amino-4-Bromophenol prices that fit your budget—flexible terms and customized quotes for every order.
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As manufacturers deeply invested in the practical chemistry shaping current and future industries, we take pride in the quality of our 2-Amino-4-Bromophenol): an aromatic intermediate whose simple structure belies its significance. For years, our synthesis teams have fine-tuned the preparation of this compound, identified both by its chemical formula C6H6BrNO and by its characteristic off-white to tan appearance, to achieve a product that meets the expectations of dye makers, pharmaceutical labs, and advanced material researchers alike.
The core of 2-Amino-4-Bromophenol lies in its versatility. The reactivity toward coupling and substitution comes from the combined influence of the amino group at the ortho position and the bromine at the para position. This unique arrangement provides both activating and directing effects. In our experience, achieving the right balance between purity and reactivity has everything to do with attention to micro-crystalline habit, minimal metal contamination, and maintaining an optimal moisture content during storage.
Our manufacturing process centers around stringent in-process controls, from the selection of aniline derivatives to the bromination and controlled hydrolysis that follow. We frequently test each batch via HPLC and ensure melting point conformity within the range typical for high-purity grades. Impurity profiles often receive more attention than basic purity percentages. Careful control reduces the presence of polybrominated by-products and enhances the consistency required for lab-scale and pilot-plant scale-up.
Particle size distribution can challenge formulators, especially in applications demanding rapid dissolution or precise metering, so our process avoids excessive fines or oversized agglomerates. This adaptation arose from feedback gathered during years of working with downstream specialty chemical plants. Meeting practical needs beats adhering to textbook parameters; our experience in drying and fractionation reduces batch-to-batch variation that would otherwise add uncertainty for our customers.
Our clients make broad use of 2-Amino-4-Bromophenol, but two fields drive sustained demand: specialty dyes and active pharmaceutical intermediates. The amino functionality proves highly effective in coupling reactions during azo dye synthesis. Its bromine atom opens options for Suzuki or Buchwald-Hartwig cross-couplings, leading to tailored benzenoid structures not easily accessible with other scaffolds. Downstream, these transformations enable the design of vibrant, stable colorants resilient to environmental stressors.
Pharmaceutical researchers find that 2-Amino-4-Bromophenol presents a practical entry point for small-molecule APIs with complex substitutions. Its halogen enables selective functionalization, often reducing total synthetic steps compared to similar phenolic starting materials. In medicinal chemistry, saving one or two steps can translate into significant time and cost savings during both lead optimization and scale-up phases. Our chemists frequently collaborate on process improvements alongside these partners, bringing a real-world edge to laboratory ambitions.
Beyond these main sectors, we have seen increased interest from those working in agrochemical actives and polymer modification. This demand responds to both the electron-donating and electron-withdrawing resonance effects present in the molecule. Compared to plain aminophenols or bromophenols, the reactivity profile of 2-Amino-4-Bromophenol allows for multi-phase derivatization without the stability issues some alternatives present, especially when process temperatures must rise.
The question often arises: Why not simply use 4-bromophenol or 2-aminophenol instead? Manufacturing experience underscores the difference. While 4-bromophenol offers a good leaving group for certain substitutions, it lacks the ortho-amino group that dramatically enhances some coupling and acetylation reactions. 2-aminophenol, on the other hand, brings reactivity but misses the site-specific oxidative, halogenated tailoring that bromine brings.
In multi-step synthesis work, the presence of both an electron-donating amino group and a halogen in precise locations streamlines synthetic logic. This was illustrated clearly by a project with a dye intermediates plant, where a shift from separate aminophenol and bromination steps to direct use of our 2-Amino-4-Bromophenol reduced error rates, increased selectivity, and led to purer final material. Fewer purification cycles meant reduced solvent use and less operator handling, a benefit that goes beyond paperwork numbers.
Scaling up from pilot to commercial manufacture rarely proceeds in a straight line. Our first-hand experience during plant trials taught several lessons in batch reproducibility and safe bromination. Robust mixing and precise control of exotherm profiles help prevent runaways and uneven product. Maintaining material stability, especially with highly functionalized phenols, calls for inert atmospheres during post-synthesis drying and storage. Years ago, we occasionally observed microcrystal color changes and odor shifts when humidity crept above recommended limits—hence, our production suites received significant upgrades in dehumidification equipment.
No batch leaves the handling area before passing through a series of quality checks. We emphasize trace impurities, particularly any residual precursors or overbrominated by-products. In practical terms, this scrutiny arose from a few episodes where marginal contamination in third-party sourced intermediates led to significant yield drops in downstream sulfonation steps. As a direct result, we have since invested in supply chain controls, including ongoing third-party audits and close partnerships with raw material suppliers using validated synthetic routes.
The presence of both amino and phenolic groups in 2-Amino-4-Bromophenol brings practical handling concerns. While not classified as acutely toxic under many hazard protocols, the compound should not be treated casually. Our operators receive specialized training on dust management, spill response, and proper use of local exhaust ventilation. Packaging uses lined containers with vapor barriers to avoid oxidative discoloration and maintain product quality during longer transits, especially under humid conditions.
Disposal pathways receive careful attention as well. We design our processes to minimize halogenated waste streams. Recovery and recycling of process solvents occur at multiple stages, and continuous improvement pushes us toward even lower emissions targets. These efforts arise not from compliance pressure alone, but from a long-term mindset: operating cleanly preserves both worker health and the broader environment we share.
As with many aromatic intermediates, we urge those using this compound in R&D and production to work alongside EHS professionals. Proper storage away from strong acids and oxidizers, routine housekeeping, and regular review of site safety protocols serve as the baseline for safe and productive operations.
The chemical industry, especially in the space between crude synthesis and fine organic specialities, faces increasing scrutiny over quality assurance, traceability, and sourcing. Many end-users ask for more than just a consistent product—they want responsible raw material management, clear documentation, and partnership when troubleshooting arises. Our commitment to open dialogue with customers, whether in dealing with unexpected assay variances or optimizing for new synthesis routes, has shaped our internal culture over decades.
In the last few years, regulatory regimes covering raw material trace metals and residual halogenated organics have tightened. We respond by employing advanced analytical protocols: inductively coupled plasma (ICP) analysis for trace elements, GC-MS screening for volatiles, and ongoing method validation for emerging contaminants. A specific example came during a routine customer audit, where questions arose over possible bromoanisole formation. Thanks to preemptive sample archiving and our regular monitoring, we resolved concerns before scaling up campaigns, building confidence and saving both parties time.
From R&D chemists screening new catalytic systems to established dye works needing consistent color quality between batches, application needs drive our ongoing adaptation. We adjust packaging formats to accommodate both kilo-lab and bulk requests, and we keep our technical team available for process optimization support. This requires more than standard QC paperwork; experienced operators, chemists, and application specialists compare data, troubleshoot, and offer practical suggestions based on real plant knowledge, not just theoretical expertise.
For example, during the development of a custom pigment, a client found that a subtle shift in melting point cut their filter clogging by half. By tracing this back to minor differences in residual starting materials, our team adapted drying protocols, leading to tighter control not just on melting but on flow properties as well. This practical engagement reflects our view that manufacturing quality happens at the interface of technology and people, not just on an assay invoice.
Global sourcing remains in flux, with trade disruptions and raw material volatility impacting many specialty chemical sectors. Our commitment to in-house manufacture of 2-Amino-4-Bromophenol means that customers receive product whose pedigree is fully transparent. Knowing the upstream route—and its associated environmental footprint—gives our partners peace of mind in compliance-heavy fields.
We communicate openly regarding sustainable sourcing of bromine compounds and our shift towards greener oxidation and recovery methodologies. For instance, process water recycling and secondary containment installations grew out of early assessments of regional water stress and the desire to reduce both costs and ecological risks. The push for lower-energy, less hazardous bromination once met skepticism among old-line plant managers; practical successes in waste reduction and consistent output soon changed opinions. Clear tracking from raw material to finished drum now stands as a top priority, both for audits and for day-to-day operating confidence.
Trust forms the foundation of every long-term supplier relationship. Earning that trust means delivering not just on specifications but on process transparency, product knowledge, and technical support. Experience, hands-on engagement, and learning from both successes and setbacks anchor our approach.
We encourage site visits by current and prospective partners, offer in-depth production insights without hiding behind technical jargon, and share batch histories to demonstrate not just consistency but improvement over time. Each process change, from upgrading reagent feed systems to adjusting quenching sequences, results from rigorous, documentable evaluation. Customers—whether dye formulators, pharma innovators, or specialty materials developers—can rely on direct answers, not just sales claims.
In practical terms, this means technical managers and plant chemists act as resources for users tackling scale-up, regulatory, or process troubleshooting. For those facing analytical or formulation challenges, our experience and data archives often provide the missing pieces, saving costly “trial-and-error” cycles. Collaboration and problem-solving based on mutual expertise define the relationships that support growth in specialty chemistry, no matter how markets and regulatory frameworks shift.
In our experience as direct manufacturers of 2-Amino-4-Bromophenol, focus on quality stems from tackling day-to-day headaches in real plants and labs, not from chasing abstract ideals. Reliable raw material, robust process controls, and a commitment to honest, technical engagement make the difference—both in successful syntheses and in building partnerships that last. We continue to learn, invest, and improve so that every drum of 2-Amino-4-Bromophenol leaves our facility ready for challenge, scrutiny, and real-world performance.
