|
HS Code |
378448 |
| Productname | 2-Amino-3-Fluorophenol |
| Casnumber | 399-95-1 |
| Molecularformula | C6H6FNO |
| Molecularweight | 127.12 g/mol |
| Appearance | Off-white to light brown solid |
| Meltingpoint | 65-69°C |
| Boilingpoint | 251°C |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Density | 1.33 g/cm³ |
| Storagetemperature | Store at 2-8°C |
| Smiles | C1=CC(=C(C(=C1)O)N)F |
| Inchi | InChI=1S/C6H6FNO/c7-4-2-1-3(8)6(9)5(4)10/h1-2,9H,8H2 |
As an accredited 2-Amino-3-Fluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 2-Amino-3-Fluorophenol is supplied in a 25-gram amber glass bottle with a secure screw cap, labeled with safety information. |
| Shipping | 2-Amino-3-Fluorophenol is shipped in tightly sealed containers, protected from light and moisture, and at ambient temperature. Packaging complies with chemical safety regulations, including proper labeling and documentation. Ensure the chemical is handled by trained personnel and transported according to local and international hazardous materials shipping guidelines. |
| Storage | 2-Amino-3-Fluorophenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Protect from moisture, direct sunlight, and sources of ignition. Label the container clearly, and ensure the storage area complies with all relevant chemical safety regulations. Use appropriate personal protective equipment when handling. |
Competitive 2-Amino-3-Fluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
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In the evolving field of chemical synthesis, the demand for well-defined, high-purity building blocks stands out. 2-Amino-3-Fluorophenol takes its place in this landscape as a specialized aromatic intermediate. Manufacturing this compound means navigating nuanced process control, and over the decades we have gathered a clear set of reasons why customers, from pharmaceuticals to agrochemical research, seek out this product directly from source manufacturers like us.
2-Amino-3-Fluorophenol belongs to a family of substituted phenols prized for their reactivity and selectivity in multi-step synthesis. Its structure—featuring both an amino and fluorine functionality on a benzene ring—plays a decisive role in certain transformations, particularly where regioselectivity or substitution patterns cannot be compromised. This molecule’s melting point, solubility profile, and compatibility with standard solvents have all been fine-tuned through controlled crystallization and purification.
Our output generally falls within the range of high purity, above 98% by HPLC, because trace impurities in such a scaffold can wreak havoc in downstream coupling, cyclization, and diazotization reactions. Consistency remains non-negotiable, especially when clients rely on the outcome of chiral syntheses or scale-up validation—one off-batch can send an entire development window back weeks. Our focus extends to packaging; we select container linings based on feedback from users working at different temperature and humidity extremes to avoid caking or incremental moisture uptake.
Many researchers weigh the merits of locally synthesized versus imported intermediates. Our position as manufacturer removes a chain of uncertainties. Synthesizing 2-Amino-3-Fluorophenol in-house means direct accountability from raw material inspection to the finished lot, with batch records available for audit. Years of scaling from lab to pilot plant have taught us that upstream aniline or fluorobenzene-derived contaminants leave a stubborn fingerprint not easily removed by a single recrystallization. Regular refinement of our process, guided by customer applications and real batch results, keeps our specification tight. Over the years, certain batches have flagged unrecognized by-products, driving process improvements. Process transparency is a point of pride; most procurement teams report fewer headaches with documentation and batch-to-batch reproducibility when working directly with the source.
On specification, labs sometimes settle for broader acceptance ranges on shelf intermediates simply because they lack alternatives. From experience, we know that those forced trade-offs cost dearly in subsequent synthetic steps. By delivering 2-Amino-3-Fluorophenol that meets both internal and evolving client benchmarks—tightening the control over isomeric ratio, residual solvents, and endotoxin levels—we keep timelines realistic and costs transparent.
We do not produce intermediates in a vacuum. Discussions with partners spanning active pharmaceutical ingredients, crop protection actives, and specialty dye development have illustrated how the slightest deviation in our material’s grade, moisture or lot age changes outcomes in their processes. Customers in pharmaceutical synthesis, for example, cite the amino and fluorine groups’ impact on reactivity within heterocycle formation, where our product offers not just a functional group but a predictable starting point for discovery chemistry.
Anecdotally, several teams have logged that using our 2-Amino-3-Fluorophenol saves them from troubleshooting unexpected side products in Suzuki and Buchwald couplings—problems linked back to suspect input quality. Textile dye researchers, on the other hand, need a sharp color performance, and their formulas respond almost too sensitively to background contamination or retained solvent not always specified in the open market grades.
Chemical manufacturing, particularly with substituted phenols, is rarely linear. Achieving high-purity 2-Amino-3-Fluorophenol requires stepwise control of moisture, careful monitoring of pH throughout hydrolysis and amination stages, and, crucially, a clean work-up to prevent oxidation or color drift. Years ago, we discovered through customer feedback that minuscule residual base introduced a yellow hue to final downstream products, which, while inconsequential for research, could not be tolerated by those running regulated synthesis for human pharmaceuticals.
Daily hands-on involvement in reaction monitoring—rather than delegated supervision—alerts us to these subtle process levers. Monitoring endpoint with both NMR and HPLC, verifying fluorine placement by 19F NMR, and revalidating after every process tweak means that each kilogram we ship aligns with what the client expects, not just what a spec sheet declares. Such diligence does not come from bulk blending or outsourcing; it evolves from years of repetition and responsive process troubleshooting.
2-Amino-3-Fluorophenol shares functional similarities with other aminophenol derivatives or fluoroaromatic compounds, but those with hands-on experience recognize the practical distinctions. For example, switching to the 4- or 5-fluoro analogues rarely yields the same biological or polymer compatibility, given subtle changes in electronic effects and hydrogen-bonding potential. 2-Amino-4-Fluorophenol, for example, appears similar and yet resists certain nucleophilic substitutions needed in active pharmaceutical ingredient synthesis. Substitution patterns also influence safety handling during diazotization; the ortho arrangement in our product often limits unwanted exothermic events seen with meta- or para-isomers.
Generic fluorophenol blends typically found via aggregation platforms rarely justify cost savings when the risk of impurity profiles—ring-substituted tars, trace acids, or unintended aniline reduction by-products—translate to overtime spent in purification or regulatory compliance. Our direct synthesis navigates that risk, and customers have reported smoother downstream processing compared to shipments bundled via intermediary suppliers.
The difference becomes pronounced in the controlled environments of medicinal chemistry labs, where regulatory scrutiny of trace element content, endotoxin carryover, or unknown peaks in chromatograms is fierce. Having observed dozens of tech transfer projects, colleagues across regulatory-focused sectors confirm that using origin-tracked, tightly specced 2-Amino-3-Fluorophenol shortens project risk-reviews and eliminates the need to revalidate every new shipment for batch equivalency.
Shipping chemicals like 2-Amino-3-Fluorophenol presents logistical and technical challenges beyond what many non-manufacturers appreciate. We have fielded inquiries about cold-chain transport, tamper-evident packaging, and static build-up in containers destined for high humidity zones. Delivering consistent product means anticipating the reality of warehouse conditions and customs delays, not just ticking compliance boxes. Our staff have built a catalogue of solutions—poly-liner drums for large volume, UV-resistant glass with custom closures for specialty research, and detailed labelling that matches regulatory specifics by region.
More than once, our production team has tracked heat exposure risks in transcontinental freight, implementing packaging tweaks after observing color drift in warmer climates. We have also worked with specialty carriers, and responded to emergencies where misrouted shipments required re-certification. The lessons learned inform changes in our packaging SOPs and storage recommendations, which go well beyond what a product data file covers. Our front-line warehouse managers spot trends in seasonal humidity fluctuations and run parallel moisture analyses, ensuring nothing leaves the dock at off-target water content. These steps assure partners—especially those under regulatory pressure—that quality holds through every link in the chain.
Chemical intermediates, and particularly niche products like 2-Amino-3-Fluorophenol, are integral to innovation. The expectation in today’s market has shifted; clients do not only ask for a COA and a precise CAS number, but clear, stepwise traceability, documented chain of custody, evidence of contaminant monitoring, and, increasingly, digital lot histories that can be integrated directly into corporate compliance systems. Our in-house production allows for single-source documentation; clients appreciate being able to audit everything from starting material provenance to on-the-day operator logs.
Long-term clients, especially global pharmaceutical houses, have passed rigorous site audits based on transparent traceability from our side. We have responded to inquiries on residual genotoxic impurities, provided in-depth impurity profiling for registration dossiers, and have performed on-the-spot revalidation trials on API projects facing regulatory scrutiny. Direct access to manufacturing records avoids the multi-week lag often experienced with third-party traders, allowing development to progress without bureaucratic obstruction.
Our relationships with R&D teams and scale-up chemists have given us a keen sense of what holds back or accelerates project milestones. The practical value of working with a manufacturer is often clearest when something goes awry—a container damaged in transit, an atypical analytical result, or a need for a specialized batch within a compressed timeline. We recall more than a few collaborations where swapping out an off-target purchased sample for freshly synthesized 2-Amino-3-Fluorophenol brought a long-stalled synthesis back online within days.
We have addressed requests for batch customization—matching particle size to fit a certain automated weigh feeder, reducing residual metals for application under ICH Q3D guidelines, or pre-diluting to a standardized solution for direct use in high-throughput screening. Each adaptation was born from a face-to-face exchange with experienced chemists or process engineers, not abstracted through a procurement portal. This back-and-forth has led to protocol refinements that we have shared with users, enhancing outcomes across the supply chain.
Recalling one instance, a client scaling up an experimental oncology drug required 2-Amino-3-Fluorophenol free of a specific chlorinated by-product not regulated in general pharma QA guidelines. Instead of reverting to stock, our process control team built a targeted purification module within a week, producing the needed grade without interruption to clinical timelines. Similar requests for green chemistry adaptations—swapping a solvent or minimizing aqueous waste—have led to process optimization passed on for regulatory submission, benefiting both sides.
It has become clear over the years that the real value of direct-sourced chemical intermediates lies not only in the certificate of analysis or purity figure, but in reliability and the willingness to adapt. As chemistry evolves toward more sustainable methods and regulatory frameworks tighten around trace contaminants, manufacturers with hands-on familiarity—as opposed to catalogue aggregators—hold a unique advantage. We find ourselves now not just as suppliers of molecules, but as active partners in method development, troubleshooting, and compliance strategy.
Recent demand for specialized derivatives for oncology, sensor chemistry, and advanced materials has led us to diversify our offering. Some groups request micron-scale lots for rapid screening, while full-scale plants ask for multi-kilogram volumes, each batch requiring its own analytical workup and shipping strategy. Customer inquiries drive our next iterations, especially as bioavailability and metabolic stability take center stage in drug candidate selection. Several projects report higher yields and cleaner working solutions when feeding in our lot-tracked 2-Amino-3-Fluorophenol, documenting how tightening the input variable pays dividends all the way down the developmental value chain.
Sustained commitment to product support has also encouraged clients to push beyond typical applications—generating new reaction methodology, resilient pigments, and performance polymers using 2-Amino-3-Fluorophenol as a platform. Such collaborations grant mutual benefit: we gain process insight while our partners shave weeks from their development cycles. Over the years, we have provided not just a chemical, but a route to practical problem solving, with teams returning feedback that improves our offering for everyone.
Decades working the synthesis, packaging, and delivery of 2-Amino-3-Fluorophenol have confirmed what seasoned users already know—the difference between source-manufactured and off-the-shelf intermediates is not theoretical. Consistency, adaptability, and process-backed support matter in complex, regulated, or high-value buildouts. Each kilogram that leaves our facility benefits from accumulated practical know-how and continuous improvement.
Moving forward, we welcome candid dialogue with partners across research, production, and regulation. The relationships built on steady delivery and shared technical language bridge the gap between molecule and market, making every advance in the supply chain more efficient and predictable. For those building the next generation of pharmaceuticals, dyes, or specialty chemicals, 2-Amino-3-Fluorophenol crafted by direct manufacturer experience becomes more than a raw material: it becomes a guarantee of progress built on mutual trust and expertise.
