|
HS Code |
602931 |
| Productname | 2-Amino-3,5-Difluorophenol |
| Casnumber | 141205-44-7 |
| Molecularformula | C6H5F2NO |
| Molecularweight | 145.11 |
| Appearance | Solid |
| Meltingpoint | 87-92°C |
| Boilingpoint | Unknown |
| Solubility | Soluble in common organic solvents |
| Purity | Typically ≥ 98% |
| Smiles | c1c(c(c(c(c1O)F)N)F) |
| Inchi | InChI=1S/C6H5F2NO/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H,9H2 |
| Density | Unknown |
| Synonyms | 2-Amino-3,5-difluoro-1-hydroxybenzene |
| Storageconditions | Store at 2-8°C, keep container tightly closed |
As an accredited 2-Amino-3,5-Difluorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 2-Amino-3,5-Difluorophenol is packaged in a 25g amber glass bottle with a secure cap and detailed labeling. |
| Shipping | **Shipping Description:** 2-Amino-3,5-Difluorophenol should be shipped in tightly sealed containers, protected from moisture and light. It must be labeled according to applicable chemical transport regulations. Store and transport at ambient temperature. Ensure packaging prevents leaks or contamination. Handle as a chemical substance, following all relevant safety guidelines and documentation requirements. |
| Storage | 2-Amino-3,5-difluorophenol should be stored in a tightly sealed container, away from moisture and incompatible substances such as strong oxidizers. Keep it in a cool, dry, and well-ventilated area, preferably at room temperature. Protect from light and sources of ignition. Ensure proper labeling and secure storage to prevent accidental exposure or spillage. |
Competitive 2-Amino-3,5-Difluorophenol prices that fit your budget—flexible terms and customized quotes for every order.
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From the manufacturing floor to chemist’s bench, we see firsthand that not all fluorinated building blocks deliver the same consistency, stability, and versatility as 2-Amino-3,5-Difluorophenol. Working hands-on with this compound for years, our team developed a strong sense of its unique structural features and practical role in real industrial projects. With a molecular formula of C6H5F2NO and typically processed as a crystalline powder, this compound enters the scene where selective substitution matters—especially within pharmaceuticals, agrochemicals, and advanced material syntheses that demand predictable performance and clean reactions.
The difference between 2-Amino-3,5-Difluorophenol and more conventional phenol derivatives starts at the level of the ring itself. Placing fluorine atoms directly at the 3 and 5 positions on the phenol ring dramatically alters both reactivity and product properties in follow-up steps. In practice, we’ve observed that these fluorines boost resistance to unwanted side reactions. This means fewer by-products and higher yields—advantages that become tangible when time on the reactor is valuable and downstream purification is expensive. The amino group at the 2 position brings more than just reactivity; it provides an easy entry point for further chemical modifications, making this compound more adaptable than mono-fluorinated or unsubstituted phenol alternatives.
Colleagues in our R&D labs often highlight the cleaner insertion and reduced degradation when compared to non-fluorinated amino phenols. Firmer bonds and subtle shifts in electronic distribution give 2-Amino-3,5-Difluorophenol a reliable edge in challenging multi-step synthesis. For projects that focus on active pharmaceutical ingredients (API’s), our partners prioritise this compound, trusting its purity and behavior across diverse reaction environments—acidic, basic, or neutral.
We manufacture 2-Amino-3,5-Difluorophenol through a multi-stage process that calls for close control of temperature, solvent choice, and reaction times. Our process grew out of both industry literature and practical troubleshooting right here in our production halls. Each batch undergoes multiple distillation and recrystallization steps before meeting our standard for contaminants and impurities. Controlling trace metals and residual solvents became a core focus as pharmaceutical and electronics clients imposed ever-stricter requirements. This dedication to detail traces back to what we learned plugging leaks, recalibrating monitors, and cross-validating analytical equipment between shifts—quality starts with daily vigilance, not just paperwork.
Our on-site quality assurance analytical team employs high-performance liquid chromatography (HPLC), mass spectrometry, and NMR to screen every lot. Sometimes we’ll spot a fluctuation: maybe a tiny shift in melting range, or a drift in elemental analysis. We investigate the cause. One winter, we discovered that humidity in the main storage area was causing minute levels of hydrolysis—something only real-world handling could reveal. Adjustments to packaging and storage environments followed quickly. That kind of practical learning isn’t found in published protocols, but by getting our hands dirty and staying curious, we keep our batches consistent. This level of care ranks high for customers where trace-level reliability shapes the fate of their formulations.
Over the years, 2-Amino-3,5-Difluorophenol has moved beyond lab curiosity and become central to a range of real-world projects. In pharmaceuticals, we regularly supply this compound as a core building block for kinase inhibitors and other fluorinated drug scaffolds. Customers convene with our technical staff to troubleshoot coupling reactions or optimize protection/de-protection sequences involving the phenolic or amino groups. That dialogue leads to practical tweaks in batch sizes, solvent systems, or reaction temperatures—modifications grounded in theory but proven under pressure as deadlines loom.
For agrochemical applications, durability and selectivity matter. Our clients focus on crop-protection products that withstand harsh field conditions. The dual fluorine presence in 2-Amino-3,5-Difluorophenol improves moisture resistance and shelf stability of active agents, translating into lower application rates and less frequent field treatment. We’ve partnered with formulation chemists at several agrochemical firms: together we found that this intermediate helps reduce problems with product decomposition under sunlight or humidity, an improvement farmers notice in lower reapplication costs.
Research institutes value our experience when integrating this compound into fluorescent probes or molecular imaging agents. In these advanced materials, purity and predictable absorption/emission behavior directly tie back to the manufacturing process. One memorable project came from a university team synthesizing novel probes for neurological imaging. Their initial batches showed inconsistent signal strength. Working together, we pinpointed a micro-contaminant introduced during our filtration stage. By changing filter media and refining cleaning cycles in our technical setup, we fixed the issue—an improvement that benefited not just them, but subsequent orders facing similar demands.
The chemical market offers a wide array of phenol building blocks, many with listings that look similar on paper but perform quite differently in practice. Fluorinated, chlorinated, methylated—each substitution pattern brings its own quirks. Through years of side-by-side synthesis and benchmarking, we’ve found significant advantages with 2-Amino-3,5-Difluorophenol.
Mono-fluorinated or non-fluorinated amino phenols offer good reactivity, but they rarely match the stability during scale-up that our customers need for industrial runs. Over time, we watched competitors offer one-size-fits-all phenols, which often falter outside strictly controlled lab settings. By contrast, the dual-fluorinated backbone here consistently produces better stability in multi-step or prolonged reactions. Fewer color changes, less exotherm, and diminished risk of decomposition—small things in one run, big problems for a hundred runs.
Compared to similar benzenes with chlorine or methyl substitutions, our product stands out for its combination of electron-withdrawing strength and hydrogen-bonding ability. These properties open up unique synthetic pathways, like selective amide or ether formation. Chemists often report higher coupling yields when using this specific isomer, particularly in reactions where ring activation plays a crucial role. Over time, our experiences show the choice of starting material shapes not just price per kilo, but time, waste, and success at the final product stage.
Shipping sensitive compounds demands more than a sealed container and a COA. Our factory teams know where pitfalls lurk: poorly sealed drums in humid weather can jeopardize stability. To deliver uncompromised quality, we use airtight packaging with desiccants and tamper-seals. This routine precaution arose after a summer shipment picked up signs of surface ‘blooming,’ which traced back to moisture ingress. We overhauled our packaging protocols after that incident, and to this day we test sample jars off the line before final dispatch—a lesson earned, not assumed.
On the handling side, safety wins out. Any aromatic amine warrants cautious respect—so our personnel don full protective gear and monitor air quality in the plant. After a minor leak near our blending tanks years ago, we installed vapor sensors and retrained new staff. Reports from large-scale buyers reinforce the wisdom here: even with glovebox or closed transfers, users appreciate knowing we design our protocols from real incidents. This culture of safety radiates outwards; partners often request our input when scaling up their own operations.
Freshness matters more than most realize, especially for building blocks used in pharmaceutical or diagnostic applications. Over extended storage, subtle chemical changes can occur, affecting both melting point and purity. Out in the real world, we field requests for both immediate delivery and long-term stockpiles. We’ve learned that optimal shelf stability comes from cool, moisture-free environments and strict rotation policies. Batches more than a year old degrade ever so slightly, reflected in trace impurities or a dusty overtone on crystallines. We supply full traceability, so customers can check age and condition before launching key syntheses.
Partner feedback and our own QC results shape our recommendations. Where shorter shelf-life batches fit a just-in-time workflow, others prefer annual shipments held under nitrogen. We comply with both, educating our customers about the best way to store the product for their conditions. This transparency reduces wasted time and excessive reanalysis, building the trust our long-term clients rely on.
Fluorinated intermediates face growing scrutiny from both regulators and buyers. Our team keeps up with changing environmental standards and best practices in manufacturing waste management. Recovering solvents and limiting emissions go beyond paperwork—they make a difference to the bottom line and our surroundings. Years ago, we invested in solvent reclamation units, driven not just by compliance, but by the practical savings on solvent use and reduced hazardous waste fees. In our view, minimizing environmental footprint protects the industry’s future.
Wastewater from 2-Amino-3,5-Difluorophenol preparation contains specific organic residues. We treat these streams on-site, break down fluorinated fragments with advanced oxidation processes, and run regular audits with third-party labs to confirm elimination rates. The drive for cleaner operations brought new challenges, particularly balancing output speed with safe chemical neutralization. Through trial-and-error and collaborations with environmental engineers, we reached reliable removal targets without slowing down production. These lessons eventually attracted customers who value responsible sourcing as much as purity specs; for some buyers, sustainability weighs just as heavily as cost per kilogram.
Ideas for process upgrades don’t originate from boardrooms—they start with plant operators, lab chemists, and even packers who handle the product daily. We listen when a technician spots a quicker filter change or a senior chemist suggests an alternate solvent stream. Real innovation happens in the small details. Recently, we cracked a bottleneck in the crystallization stage that plagued us for months. The breakthrough came when two staff members, analyzing batch profiles manually, noticed a timing pattern in crystal size variation. By adjusting chilling times based on their recommendations, we boosted batch yield and reduced fines. No machine or software caught it; people did.
We encourage every team member to offer solutions, and learning from failures has driven our success with 2-Amino-3,5-Difluorophenol. Sometimes the fixes seem obvious in hindsight—yet only emerge from hard-earned experience. We share these findings with our customers, offering practical guidance instead of generic claims. By trading notes with end users and incorporating their feedback, future batches benefit from a cycle of real-world testing and constant refinement.
Pharmaceutical chemists looking for versatile starting materials come to us asking whether 2-Amino-3,5-Difluorophenol can handle tough coupling steps, multiple protection strategies, or harsh solvents. Across dozens of troubleshooting calls and on-site visits, our team has seen this compound outperform competitors in both solution and solid-state synthesis. Its fluorinated core shrugs off oxidation and withstands a broader range of pH swings than most amino phenols. In our process support, we’ve guided partners as they push for faster reaction cycles, higher exposure to heat, or challenging feedstock combinations.
During scale-up from gram to kilo and metric ton, risk of by-product formation climbs quickly if starting materials lack stability. We get involved in pilot-scale trials, sometimes catching subtle foaming, precipitation, or discoloration that would derail a rapid, untreated ramp-up. Each time, tuning reaction conditions for 2-Amino-3,5-Difluorophenol plays a role in controlling process economics and outcome reproducibility. Some of our clients repurpose downstream filtrate waste or tap side streams for reprocessing, and our input has fine-tuned recoverability in those setups.
Our mission goes beyond moving inventory. Each batch of 2-Amino-3,5-Difluorophenol reflects the collective lessons, setbacks, and improvements earned through experience. We approach every project not by offering a static catalog item, but by applying hands-on knowledge to overcome real-world challenges. Whether it’s achieving repeatable yields for a new pharmaceutical ingredient, optimizing shelf stability for global shipment, or streamlining environmental controls, our team brings practical expertise backed by daily production realities.
Choosing this compound isn’t just about molecular structure—it’s about partnering with a manufacturer that meets demands for both current needs and tomorrow’s advances. We continue to drive improvements and share what we learn, grounding every decision in real performance on the chemical manufacturing floor.
