|
HS Code |
603212 |
| Chemicalname | (2-Adamantyl)-4-Bromophenol |
| Casnumber | 150154-82-6 |
| Molecularformula | C16H19BrO |
| Molecularweight | 307.23 |
| Appearance | White to off-white solid |
| Meltingpoint | 149-151°C |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Storagetemperature | Room temperature, keep tightly closed |
| Smiles | C12C3CC(C1)CC(C3)C2C4=CC=C(C=C4)BrO |
| Inchikey | ULIBPQHSUHXLKN-UHFFFAOYSA-N |
As an accredited (2-Adamantyl)-4-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 5-gram amber glass bottle labeled “(2-Adamantyl)-4-Bromophenol,” tightly sealed, with hazard and handling information displayed. |
| Shipping | (2-Adamantyl)-4-Bromophenol is shipped in sealed, chemical-resistant containers to ensure stability and safety during transit. The package includes appropriate labeling and documentation, complying with relevant chemical transport regulations. Temperature control and secondary containment are used as necessary to prevent degradation or leaks. Delivery typically follows standard hazardous materials protocols. |
| Storage | (2-Adamantyl)-4-Bromophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep it separate from incompatible materials such as strong oxidizers and acids. Use appropriate chemical safety labeling, and store the compound at room temperature unless otherwise specified by the manufacturer’s guidelines. |
Competitive (2-Adamantyl)-4-Bromophenol prices that fit your budget—flexible terms and customized quotes for every order.
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At our chemical plant, (2-Adamantyl)-4-bromophenol sits among a family of high-purity intermediates. Manufactured onsite in tightly controlled reaction vessels, this compound stands out for its rigid adamantyl core, which imparts steric bulk and unique electronic properties. The presence of a bromine atom on the para position of the phenol ring means it responds differently during further synthesis steps than structures lacking this feature or substituting it with lighter halogens. Over the years, we’ve prioritized its purity and batch consistency to meet strict criteria necessary for downstream transformations.
We select raw materials with traceable origins, ensuring each lot of 2-adamantanone and phenolic substrates exhibits minimal cross-contamination. Our reactors see frequent calibration, and temperature profiles run gently to prevent side reactions, such as ortho-substitution or overbromination. At the molecular level, the rigid adamantyl group brings three fused cyclohexane rings, so it shields the phenol from unwanted reactivity. We designed our bromination protocol to direct substitution to the para-position with minimal impact on the rest of the aromatic system. There’s no shortcut—our process avoids excessively high temperatures, which would crack the adamantane or degrade the phenol.
Most buyers inquire about consistency. We produce this compound with a target purity exceeding 98% by HPLC, ensuring the final product arrives as a crystalline solid, not a sweaty powder or oily residue. Each batch receives a detailed chromatogram and NMR trace. We monitor for subtle impurities—sometimes minor halogenated byproducts that can alter reactivity in cross-coupling reactions. Other manufacturers shortcut with less selective routes, but those batches often require further purification before usage in pharmaceutical or material R&D.
The adamantyl moiety adds size and rigidity. This feature is no accident. Medicinal chemists employ the adamantyl group to resist metabolic breakdown in vivo, and bromine’s reactivity opens doors for palladium-catalyzed arylation or Suzuki couplings. This means (2-adamantyl)-4-bromophenol is not just a lab curiosity—it often becomes part of building blocks for drug candidates with enhanced metabolic stability or physical properties for specialty polymers. Some product lines offer the ortho- or meta-bromo analogs, but those behave quite differently in both chemical reactivity and biological assays.
Labs ask for our product by name because chain-of-custody and trace impurity levels affect their own results. In medicinal chemistry, a few milligrams of unknown impurity will throw off structure-activity relationship data. We’ve supplied kilo-scale lots to contract research organizations working on central nervous system targets. The adamantyl group resists enzymatic oxidation, protecting drug candidates long enough to reach desired tissues. A smaller percentage goes into specialty coatings, where rigidity and bulkiness raise the glass transition temperature of the resulting polymers.
One mid-scale electronics customer explained their own testing: phenol-based intermediates with bulky substituents help tune the refractivity of specialty resins. Impurities can hamper performance by weakening crosslinks. Our internal testing matches their needs—each batch sees a final melt point determination, which helps us catch contamination even where HPLC or NMR alone might miss it. That’s grounded factory know-how, not just academic theory.
It’s not uncommon for clients to ask about less expensive alternatives, like using tert-butyl or cyclohexyl substituents in place of adamantane. Each step away from the adamantyl group shifts the ultimate product’s properties. Tert-butyl doesn’t resist oxidation as well, and cyclohexyl systems lack the same steric protection for the phenol. Those changes ripple through downstream applications. We’ve seen researchers try to substitute p-bromophenol lacking the bulky adamantane, only to run into low yields or poor selectivity in subsequent reactions. Our process delivers a homogenous product designed for minimum frustration in the lab, not just for minimum price per gram.
Other suppliers may offer mixed-isomer products. We steer clear of this shortcut. Mixing in the ortho-bromo isomer drastically impacts both chemical and pharmaceutical performance. Drug projects rely on the specific 4-bromo motif, avoiding the off-target binding that accompanies unselective substitution. Most importantly, only the para isomer with adamantyl at the 2-position delivers the sought drug-like balance between lipophilicity and metabolic stability.
This compound carries the same handling precautions our operators see with other halogenated phenols. Gloves and fume hoods are standard in both sampling and loading. Some users worry about bromine’s persistency, but in routine handling, any off-gassing concerns remain minimal. We store bulk lots in sealed HDPE drums to prevent moisture pickup. Once, a customer reported clumping after six months of storage in humid conditions; our plant responded with extra drying steps and moisture-indicating packets for future shipments.
Scale-up didn’t happen overnight. Early on, cracking of the adamantane ring caused headaches until process changes lowered the bromination temperature. The payoff: crystalline material with tight melting ranges, improving both isolation yields and shelf life. The little improvements over many batches—like tweaking solvent ratios during recrystallization—minimize troublesome polymorphs. Our experience tells us quality control isn’t just an acronym; batch after batch, we catch marginal lots before they reach clients.
Years ago, a customer flagged a lot just outside their specification on chloride content. The feedback forced us to bring on new in-line detection equipment for ionic impurities. That customer feedback loop improved reliability for all of our clients. Another request involved detailed documentation beyond the certificate of analysis: request for residual solvents, heavy metals, and extended stability data. All new customers now receive updated reports without extra paperwork. Regulatory expectations ratchet up each year. Even if most customers develop their own final products under research-use-only guidelines, we pattern our manufacturing and data capture after GMP-style workflows.
We never claim absolute impurity elimination. Instead, we focus on detectable, actionable thresholds. Most downstream users can tolerate trace residual solvents, but we target below 500 ppm to ensure compatibility even for sensitive applications. In chromatography, our analysts trace back each unusual peak. Our setup doesn’t rely solely on final testing, but process control at every step to limit side product formation. Every improvement comes from prior real-world setbacks and customer questions.
Supplying (2-adamantyl)-4-bromophenol also means answering technical calls and sharing practical synthesis tips. Our team provides real spectroscopic data—we’ve walked customers through interpretation of minor peaks or troubleshooting failed Suzuki couplings. One large client discovered degradation in a cross-coupling reaction after using an off-brand source. We guided them through comparison runs using our material, restoring their yields and validating their process for regulatory filings. Sometimes, we share best practices for solvent cleaning or help interpret melt point irregularities.
The real impact of a specialty intermediate like this is not just in grams shipped. Feedback from our partners informs our analytics—if a batch ever fails their incoming QC, we can track raw material lots and reaction logs, closing the gap between production and end-use performance. As research moves more rapidly from bench to pilot scale, every hour saved troubleshooting is worth as much as a kilogram of raw product. Our responsibility is not just manufacturing, but transparency and technical support that makes new product development less risky.
Even a minor deviation in raw material purity leads to complications downstream. Our purchasing team learned the hard way that not all commercial adamantane meets the standards needed for sensitive pharmaceutical research. Routine supply checks, once considered a formality, now include GC-MS screening before any vendor re-approval. Another challenge: bromine handling and on-site storage. We invested in exhaust trapping and secondary containment to avoid cross-contamination—this benefits both worker safety and batch-to-batch consistency.
On occasion, downstream customers seeking ultra-low halogen quotas run into trouble. Trace bromine comes with the territory for products like this. Solutions often include working with our technical team to develop custom washing steps or more aggressive chromatographic purifications. Such cooperation improves the outcome, even if it means sacrificing yield—real-world applications often demand more than what’s promised on a paper specification.
Learning from each shipment, our logistics partners track the effect of transport vibration, temperature swings, and customs hold times on material integrity. These lessons build up in small increments. Years of accumulated customer feedback, coupled with internal QC data, have transformed what started as a niche batch run into a trusted supply resource for critical projects.
Some buyers want price leadership above all; others need absolute documentation for regulatory filings. Our approach, honed by years at the production line, is direct about both capabilities and limits. If a lot misses spec—due to unforeseen impurity or run deviation—we pull it rather than risk anxiety for end-users. No manufacturer enjoys owning up to off-spec product, but the alternative: delays, troubleshooting, and retesting at a customer site, costs everyone more in the long run. By setting real-world limits instead of overpromising, we earn second and third orders.
Our plant batches run under experienced eyes, not just algorithms. Operators catch subtle signs of trouble—slight color drift, pack density shifts, endothermic blips in an otherwise “perfect” batch profile. These observations, matched to precise analytical records, feed back into process improvements.
Designing (2-adamantyl)-4-bromophenol for modern R&D means adapting, not standing still. Requests from biotech startups and international pharma majors push us to refine both our analytical toolkit and material handling protocols. Real-world feedback drives us to lower residual contaminants, anticipate downstream compatibility issues, and speed delivery on short notice while keeping documentation robust. In a landscape where every discovery moves faster, our job is producing not just molecules, but confidence and clarity that allows researchers to stretch beyond yesterday’s limits.
Products like this don’t rest on laurels. The difference between a “good enough” intermediate and a batch tailored for process reliability or regulatory approval lies in every action from raw material selection to final analytic review. We’ve found that customers who return for (2-adamantyl)-4-bromophenol do so as much for our record-keeping as for our chemistry. They trust that if an anomaly appears, we’ll trace its root and correct it, rather than paper it over. That reputation carries further than price promotions or spec-sheet promises.
Day to day, our focus lands on rigorous process control and open communication with research partners. Their priorities—batch traceability, impurity control, analytical transparency—inform every process change. Simple details, such as improved drum closures or double-wrapped packaging for humidity control, stem directly from on-the-ground reports. We regularly update methods for melting point determination, solvent residual analysis, and shelf-life tracking based on shifting needs in pharmaceuticals, electronics, and advanced materials.
What distinguishes our (2-adamantyl)-4-bromophenol isn’t a slogan or single feature, but cumulative effort: every plant tweak, feedback session, and delivery handled as if future breakthroughs depend on this very lot. In practice, they often do. Specialty chemicals like this underpin critical discovery and innovation. By investing in improvement at every step, we serve not only researchers’ immediate needs, but the wider chain of discovery, development, and production built on reliable molecules and trust earned by hands-on partnership.
