|
HS Code |
703981 |
| Name | 2,6-Dimethyl-4-Cyanophenol |
| Molecular Formula | C9H9NO |
| Molecular Weight | 147.18 g/mol |
| Cas Number | 35321-33-0 |
| Appearance | White to off-white solid |
| Melting Point | 128-131 °C |
| Solubility In Water | Slightly soluble |
| Synonyms | 2-Hydroxy-2,6-dimethyl-4-cyanobenzene |
| Smiles | CC1=CC(=C(C=C1O)C#N)C |
| Inchi | InChI=1S/C9H9NO/c1-6-3-8(5-10)4-7(2)9(6)11/h3-4,11H,1-2H3 |
| Pubchem Cid | 23073049 |
| Storage Conditions | Store in a cool, dry place, tightly closed |
As an accredited 2,6-Dimethyl-4-Cyanophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The packaging is a 100-gram amber glass bottle, labeled with chemical details, hazard symbols, and securely sealed to prevent contamination. |
| Shipping | 2,6-Dimethyl-4-Cyanophenol is shipped in tightly sealed containers under cool, dry conditions. The packaging complies with regulatory standards for hazardous chemicals, ensuring protection from moisture, sunlight, and extreme temperatures. Proper labeling, documentation, and handling instructions are provided to ensure the safe and secure transport of this chemical. |
| Storage | 2,6-Dimethyl-4-cyanophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents and acids. Keep it away from direct sunlight and sources of ignition. Use appropriate chemical storage cabinets, and label containers clearly. Personal protective equipment is recommended when handling to avoid skin and eye contact. |
Competitive 2,6-Dimethyl-4-Cyanophenol prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615380400285
Email: sales2@liwei-chem.com
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As a manufacturer with hands-on experience in aromatic chemistry, we have seen how details in the production process shape the performance and consistency of chemicals. Our offering, 2,6-Dimethyl-4-Cyanophenol, embodies this approach, stemming from a commitment to reliable sourcing, quality chemical processing, and continuous refinement of methods. Over the years, we have witnessed fluctuating feedstock markets, tightened purity standards, and evolving demand from downstream users in pharmaceuticals and specialty materials. Each step, starting from the methylation of xylenols to precision-controlled cyanation, receives full attention in our facility to deliver a compound that meets expectations where it matters most—in applied chemical synthesis.
2,6-Dimethyl-4-Cyanophenol stands apart for its unique substitution pattern on the aromatic ring, combining two methyl groups at the ortho-positions and a para-cyano functionality with a phenolic hydroxyl. This structure grants it high value as an intermediate, especially where both lipophilicity and active reactivity are required. Through direct daily involvement with material characterization, our technical team recognizes that even small variations in isomeric composition or residual impurities can impede downstream processes. So, we maintain careful control over moisture content, color, and trace byproducts—an effort that pays dividends for users demanding predictable outcomes in their syntheses.
Our journey with 2,6-Dimethyl-4-Cyanophenol began by responding to requests from advanced materials firms aiming to introduce new functionalities in resins and high-performance coatings. Feedback from field users highlighted the compound’s robust nucleophilicity and good solubility in polar organic solvents, providing clean conversion in etherification, esterification, and nucleophilic substitution reactions. In pharmaceutical R&D, we have seen researchers use it to build custom benzene scaffolds with ortho-substitution for enhanced bioisosteric effects, leading to compounds that display improved selectivity and metabolic stability. This firsthand knowledge, gained from supporting pilot projects and troubleshooting scale-ups, led us to fine-tune aspects such as drying temperature, packaging integrity, and shipment turnaround, reflecting the practical realities of specialty chemical logistics.
A question that arises frequently in project meetings with chemists concerns why 2,6-Dimethyl-4-Cyanophenol offers value over other substituted cyanophenols. In the lab, side-by-side testing with related isomers—such as 2,4-dimethyl-6-cyanophenol or 3,5-dimethyl-4-cyanophenol—often reveals key differences. The steric hindrance provided by the two ortho-methyl groups in our product reduces unwanted side reactions and enhances shelf stability, compared to less hindered analogues that oxidize or polymerize under ambient conditions. These methyl groups also influence solubility profiles, favoring faster dissolution in certain organic solvent blends used by our partners. Comparisons with unsubstituted 4-cyanophenol highlight how the added methyl groups modulate both boiling point and resin-compatibility, allowing for better handling during formulation steps.
Over the years, users in fluorophore synthesis and UV-curable resin production have remarked that other cyanophenol isomers either introduce unwanted color bodies, leading to yellowish products, or suffer from batch-to-batch variability in purity. Drawing on this feedback, we implemented a multi-stage crystallization procedure and routine GC/MS batch release profiling. These measures reduce colored trace byproducts as well as inconsistent cyano group integration, resulting in a white to very pale-yellow powder that meets project color requirements for finished products.
One challenge that our quality team confronts daily is ensuring that the same batch quality holds from day shift to night shift. Controls for oven drying parameters and careful clean-out of reaction vessels prevent cross-contamination—issues that can crop up in less controlled settings. Having seen firsthand how residual iron or copper traces from reactors can accelerate product degradation and discoloration, we devote extra effort to using low-metal contact surfaces and frequent equipment passivation. In practice, these improvements translate to longer shelf life and fewer unexpected failures on the customer’s end. We have watched our technical support team field troubleshooting calls where an unnoticed trace impurity in a competitor’s product triggered failed pilot reactions. These cases underscore why quality at source remains critical and shape the upgrades we make year after year.
Direct engagement with application chemists has shown us that textbook reactions rarely match reality in the plant or the lab. New customer uses—whether in agrochemical actives discovery, dye precursor synthesis, or small-scale polymerization—drive us to adjust batch sizes, solvent preferences, and drying step parameters. Smaller lots for advanced research often demand higher purity than bulk commodity shipments, so we run high-resolution NMR and additional drying cycles upon request. During technical visits, we have seen how the physical form of 2,6-Dimethyl-4-Cyanophenol—fine powder versus larger granules—impacts both ease of weighing and static charge management, especially when users handle the material in glovebox atmospheres. These field observations prompt additional sieving or anti-static packaging options for sensitive projects.
Having trained new process operators on safe chemical handling, we know that 2,6-Dimethyl-4-Cyanophenol requires respect in the workplace. Phenols introduce specific health risks, so staff on the floor don full protective equipment, including gloves resistant to both solvents and phenolic compounds, and use local exhaust ventilation at powder transfer points. Training emphasizes prompt cleanup of spilled powder and routine surface swabbing, based on our observations of how phenolic dust accumulates and how unnoticed exposures can impact long-term health. Instead of relying purely on paperwork or third-party advice, our safety protocols arise from practical experience and incident investigation, leading to ongoing adjustments in how we stage, transport, and sample the material.
Our strongest progress often comes from candid discussions with experienced users. For example, receiving samples returned from a customer’s failed reaction allows us insight into subtle product changes or handling missteps. By testing returned material using FTIR and HPLC under varying solvent conditions, we learn which minor side-products or moisture content deviations really matter. Customers in API research have provided feedback on the trace amine levels that interfere with downstream steps, prompting us to invest in higher purity ammonia scavengers during final workup. This collaborative troubleshooting helps us align our standards directly with practical needs rather than theoretical specs, creating trust and repeat business across multiple industries.
We see the value of regular feedback loops in quantifiable metrics: lower batch rejection rates at the user’s site, fewer technical support claims, and increased uptake in projects moving from pilot to production scale. Our mindset focuses on closing gaps between what chemists want in the flask and what leaves our warehouse, using data from repeat testing and in-plant discussions to tighten every control point, from lot marking to shipping documentation.
No synthesis occurs in a vacuum. Over the past decade, we have had to adjust to stricter customs requirements, global transport bottlenecks, and shifting raw material landscapes. We have learned the hard way how changes upstream—such as new supplier standards for xylenol feedstocks or transport interruptions for cyanides—can force week-to-week adjustments in our purchasing and scheduling. Experience has taught us to maintain redundancy in sourcing, keep buffer inventories, and maintain open lines with logistics partners, especially when shipping to international markets. These adaptations reduce risks and help our customers avoid shortages that would delay their critical R&D or manufacturing schedules.
Environmental regulations, especially those targeting phenolic emissions and cyanide handling, have required us to upgrade waste treatment and emission capture equipment. Our environmental staff, drawn from both chemical engineering and plant operations, walk the line daily between regulatory compliance and cost control. Adjustments in our plant—like closed-system product transfer and on-site cyanide scavenging—were put in place following regulatory visits and through voluntary industry partnerships. These investments cost time and capital, but they pay off with smoother audits and fewer compliance disruptions.
Interactions with process chemists and R&D professionals over many years illustrate the far-reaching impact of small process innovations. By integrating real-time analytical monitoring during cyanation and methylation steps, we raised process yields and reduced off-spec batches—directly benefitting customers who otherwise struggle with inconsistent supply. These improvements stem not from abstract methodologies but from pilot-scale tinkering, real-world troubleshooting, and pragmatic changes on the plant floor.
Innovative partners challenge us to re-examine everything from catalyst selection to solvent recycle methods. Adopting greener processes, such as using recyclable solvents or recovering methylating agents, has become more pressing as customers align with sustainability goals. Customers request product stewardship support not confined just to regulatory checkboxes, but to genuine reduction of environmental risk from purchase through use and disposal. In response, we have introduced customer-facing documents on responsible handling, and we share practical tips to reduce waste and promote safe, compliant practices in everyday lab and plant work.
Building confidence with customers requires substance, not just paperwork and certificates. Technical documentation only goes so far; open dialogue about experiences in the lab or plant means more. Many users of 2,6-Dimethyl-4-Cyanophenol have requested custom solutions, whether in tailored lot sizes, alternative packaging, or expedited shipment for urgent projects. We meet these needs by maintaining direct channels with technical and purchasing contacts, so that every concern about delivery conditions, storage temperature, or product form can be quickly addressed. From sending pre-shipment samples for inbound verification, to actively consulting on analytical troubleshooting, we see our job as facilitating project progression rather than erecting barriers behind technical jargon or one-size-fits-all solutions.
Behind every kilogram produced, packed, and shipped, there’s a cascade of decisions guided by hands-on knowledge. Seeing firsthand how nuanced processing tweaks improve reproducibility or how minor shipping delays derail customer timelines brings constant awareness of the bigger picture. Every improvement in filtration, every incremental reduction of hazardous byproducts, every small boost in consistency ties back to how end users experience our product in real-world applications. Meeting demand for 2,6-Dimethyl-4-Cyanophenol at scale without losing precision remains a daily challenge—one that rewards long-term investments in process control and end-to-end transparency.
Manufacturing and supplying 2,6-Dimethyl-4-Cyanophenol means more than filling drums; it requires a proven record of practical problem solving, continuous attention to feedback, and a willingness to view every process as improvable. Every batch carries the mark of adjustments made in the face of real-world complexity, not theoretical perfection. The evolving needs of pharmaceuticals, advanced materials, and specialty chemical projects challenge us to think beyond formulas and adjust to practical experience. As more research and development turns to specialized intermediates like this compound, we stand ready with the accumulated know-how and flexible support that help turn ambitious projects into tangible successes.
