|
HS Code |
943582 |
| Chemical Name | 2,6-Difluoro-4-Methoxyphenol |
| Molecular Formula | C7H6F2O2 |
| Molecular Weight | 160.12 g/mol |
| Cas Number | 246047-72-9 |
| Appearance | White to off-white solid |
| Melting Point | 60-64°C |
| Solubility In Water | Moderate |
| Density | 1.34 g/cm³ (estimated) |
| Pka | Estimated 9.4 (phenolic hydrogen) |
| Smiles | COC1=CC(=C(C=C1F)O)F |
| Inchi | InChI=1S/C7H6F2O2/c1-11-5-2-4(8)7(10)3-6(5)9/h2-3,10H,1H3 |
| Synonyms | 4-Methoxy-2,6-difluorophenol |
As an accredited 2,6-Difluoro-4-Methoxyphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 25g, tightly sealed with screw cap, labeled “2,6-Difluoro-4-Methoxyphenol,” includes hazard and handling instructions. |
| Shipping | 2,6-Difluoro-4-Methoxyphenol is shipped in tightly sealed containers to prevent contamination and protect from moisture and light. It should be handled as a laboratory chemical, with appropriate labeling and documentation. Shipping complies with relevant safety and regulatory guidelines, including hazard communication, and typically uses ground or air transport based on customer requirements. |
| Storage | **2,6-Difluoro-4-Methoxyphenol** should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. It should be kept away from incompatible substances such as strong oxidizers and acids. Always store at room temperature and ensure proper labeling to prevent accidental misuse or exposure. |
Competitive 2,6-Difluoro-4-Methoxyphenol prices that fit your budget—flexible terms and customized quotes for every order.
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We have manufactured 2,6-Difluoro-4-Methoxyphenol for years, supplying pharmaceutical and specialty chemical clients. The industry’s demand for pure and well-characterized fluorinated phenols has grown, especially in discovery research, pilot synthesis, and commercial formulations. Our direct experience with this compound, made under strict process control, supports innovations in medicinal chemistry and advanced materials.
The model typically rolling out of our reactors features a purity above 99%. Fluorination at the 2 and 6 positions changes the electronic environment of the methoxyphenol core, increasing metabolic stability and tuning reactivity. The presence of two fluorine atoms along with the methoxy group sets this phenol apart. It remains a crystalline solid at ambient temperature, suitable for extended storage and easy handling in glassware or industrial-grade plastic containers. An efficient melting range, usually between 40 and 43°C, benefits scale-up and temperature-controlled applications.
Chemists looking to use it as an intermediate in active pharmaceutical ingredients care about trace impurity levels. We monitor not just overall purity, but also fluoride and halide content, water, and methoxy byproducts by gas chromatography and high-performance liquid chromatography. Exceeding established specifications consistently brings clients back for repeat batches.
Fluorinated aromatics behave differently from their non-fluorinated cousins. 2,6-Difluoro-4-Methoxyphenol favors greater chemical stability in demanding downstream steps. Chemists can introduce further substituents on the aromatic ring or test the molecule’s performance directly as a pharmacophore. The dual fluorine presence boosts the molecule’s resistance to oxidative degradation, which leads to longer shelf life in intermediates and less waste.
Functional chemistries requiring highly specific substitution patterns rely on such products. The combined electron-withdrawing effects of fluorines and the electron-donating methoxy contribute to unique reactivity windows. Our partners in agrochemical development often point out that certain herbicidal scaffolds hinge on this precise arrangement. As someone who’s worked on both pilot and commercial scales, the distinguishing reactivity of this compound simplifies planning for synthetic routes.
Developing a multi-kilogram synthesis for 2,6-Difluoro-4-Methoxyphenol took our team several years. Each step, from raw fluorinated anisole feedstock to controlled phenolation, required fine-tuning. Scale brings its own challenges. What succeeds at ten grams needs re-optimization anywhere above one kilo. Our reactors are built with corrosion-proof linings, preventing metal contamination or product decomposition. Dosing and mixing get controlled with precision, using flows monitored in real time.
Purification routes get selected after running process analytics—sometimes simple crystallization suffices, in other cases careful vacuum distillation is needed to meet the desired specification. We track impurity trends lot by lot, especially the halide levels, since even a few parts per million can impact sensitive applications in medicinal chemistry or electronics. Investing in high-grade analytical tools like NMR, mass spectrometry, and Karl Fischer titration keeps every lot within tight standards. Feedback from clients sharpens our process even further.
Clients often ask why 2,6-Difluoro-4-Methoxyphenol outperforms other phenolic building blocks. Two stories come to mind. One pharmaceutical group made a highly selective enzyme inhibitor, only seeing good results after switching from a non-fluorinated isomer to our product. Metabolic studies showed the dual fluorine atoms shielded the molecule against rapid breakdown, extending biological half-life. Another customer came back to us after side products appeared while scaling up synthesis using lesser grades from traders; our tighter control over halogen content and color values helped them reach the purity they aimed for.
The methoxy group adds both solubility and tunable reactivity in nucleophilic aromatic substitution. Customers using it in material science cite cleaner reaction profiles and sharper spectral features thanks to the purity level we guarantee. Many researchers underestimate how residual solvents or minor halide impurities affect crystallization and downstream analysis. These kinds of details set manufactured product apart from re-labeled commodities.
Few users realize the importance of careful packaging and handling, especially at scale. Our staff uses sealed drums and oxygen-barrier liners to limit moisture uptake and accidental exposure. Experience showed us that open-air transfer leads to unnecessary product loss and compromised purity. Regular monitoring of storage temperature and humidity brings a longer shelf life and fewer degradation batches. In the lab, smaller packs in amber bottles protect against light-induced decomposition.
Clients scaling up syntheses have reported that bulk shipments drawn from uncontrolled stockpile sources picked up unacceptable water content or turned tan, signaling oxidation. Sourcing from a consistent manufacturing run avoids these headaches. Our technical support team regularly shares guidance with new users to head off potential issues.
Think about standard 4-methoxyphenol or unsubstituted phenol—both have roles as precursors, but lack the full spectrum of benefits. Without fluorine substituents, aromatic rings show lower stability in outdoor or biological conditions. Synthesis sometimes detours through unwanted side products or variable yields. By contrast, 2,6-Difluoro-4-Methoxyphenol leads to shorter process times, easier purification, and higher overall success rates for target compounds integrating the molecule.
Other positional isomers do exist—3,5-difluoro, 2,4-difluoro, and similar—but most do not combine the optimal balance between electronic activation and steric hindrance seen here. Our feedback from the field, including trial comparisons, helps paint the clear difference between a carefully synthesized, highly pure difluoromethoxy phenol and more generic alternatives. This translates to better performance in bioassays, lower background reactions, and higher activity retention in final products.
As a chemical producer working under regional and international regulations, we pay as much attention to safety as to quality. Solvents, reactants, and finished products are handled and disposed of using best practices. We employ closed-system transfer, local exhaust, and risk assessments on the plant floor to cut accidents or emissions. Routine employee training and external audit review keep us ahead of stricter industry standards.
Clients regularly depend on us to provide documentation for regulatory filings in drug or crop protection development. Authentic manufacturer’s batch records, full certificates of analysis, and impurity profiles come directly from our on-site lab. We don’t outsource testing or offload compliance to third parties. Long-term relationships with users are built around traceability and open reporting.
Even after years in production, each new batch brings its own lessons. Trace peroxide formation in storage, cross-contamination from plastic scoops, even static buildup during transfer—these are real issues that have come up. Unlike resellers distanced from the shop floor, we face these hands-on. Taking steps like inert gas blanket storage, anti-static packaging, and batch-by-batch impurity checks makes a huge difference for end users.
Tech transfer teams and custom synthesis researchers come to us when early prototypes stall due to source material uncertainty. Product reactivity may shift, forming less predictable byproducts. Adjusting micron level particle size, controlling water content consistently below 0.1%, and shipping in tamper-evident packaging heads off most issues before they reach downstream reactors. We log every observed deviation, learn from root cause analysis, and fine-tune accordingly.
2,6-Difluoro-4-Methoxyphenol stands out in active pharmaceutical ingredient synthesis needing high specificity and stability on both pilot and production scale. Research into plant growth regulators, synthetic fragrances, and fine chemical intermediates has reached for this building block as molecular complexity ramps up. Our participation in collaborative problem-solving with university spinoffs and blue-chip manufacturers lets us contribute directly to both early-stage trials and late-stage launches.
Customers share feedback on everything from solubility in challenging solvents, residual color impacts, filter clogging during crystallization, and spectral purity for registration purposes. Each point makes us look deeper at our output. One group advancing an anti-infective agent credited consistent yields to our tight control of trace fluoride. It’s satisfying to see how attention on the production side translates into cleaner, repeatable performance in customer labs and plants.
Sharing best practices, our technical bulletins lay out solvent compatibility, storage guidance, and testing methodology—not just for our compound, but for its integration into larger syntheses. Year after year, we see gains in total process throughput, reduction in rework, and stronger analytical confidence, all building on the foundation set by solid starting materials.
Competitive supply of 2,6-Difluoro-4-Methoxyphenol pushes us forward. Continuous improvement means regular revalidation of plant equipment, periodic retraining on material handling, and quarterly analytics upgrades. Upstream, we work with raw material suppliers to guarantee consistent quality feedstock. Downstream, we analyze every returned sample for learning opportunities, whether it’s due to rare instability, color variance, or new impurity peaks.
Fielding requests for new batch sizes or custom packaging highlights evolving client needs. Early on, kilogram requirements were rare for this compound. Today, larger demand has moved us from bench reactors into bulk processing, involving scaleable crystallization and solvent recycling to keep environmental impact lower. Our investment in closed-loop waste management improved environmental compliance and cut overall production costs, a win for long-term cost predictability.
No product exists in isolation. The global supply chain faces challenges—logistic bottlenecks, raw material shortages, rising testing demands. Years of direct production gave us tools to ride out market turbulence and support clients through spikes and slowdowns. We keep multi-month buffer stocks on-site, communicate expected lead times accurately, and flag potential changes far in advance.
New competitors, sometimes re-packagers with little production background, regularly enter the market. Experience shows that hands-on manufacturing oversight makes the difference between surface-level compliance and genuine reliability batch after batch. Our customers see fewer delays, tighter lot-to-lot performance, and faster response times when troubleshooting hiccups.
We value transparency and technical exchange. Users who ask more questions about production methods, impurity profiles, and batch history find themselves with stronger process control. Our role remains more than just filling orders—we collaborate, share data, and welcome site visits (virtual and in person) to back up quality claims with visible proof.
Demand for robust, reliable phenolic building blocks keeps growing. 2,6-Difluoro-4-Methoxyphenol, once a niche curiosity, now occupies an important place in pharmaceutical and specialty chemical toolkits. From our perspective as primary manufacturers, what sets this compound apart is not just its structure or theoretical potential, but the real-world impact of how it’s produced, controlled, and shipped.
Attention to detail, willingness to share technical know-how, and resolve in troubleshooting plant or client-side issues define our involvement with this molecule. Clients bring us challenging questions about solubility, reactivity, and regulatory documentation. We deliver direct, complete answers, based on actual data from our processes rather than secondhand summaries. New applications crop up all the time—a testament to the potential unlocked by deep engagement throughout the compound’s lifecycle.
We continue to support diverse industries by refining all aspects of how we make and supply 2,6-Difluoro-4-Methoxyphenol. Each feedback loop, batch run, analytical result, and customer story informs ongoing improvement. That’s what it means, in our view, to deliver a consistent foundation for progress in advanced chemical synthesis.
