|
HS Code |
460877 |
| Productname | 2,5-Dimethoxythiophenol |
| Casnumber | 2150-18-7 |
| Molecularformula | C8H10O2S |
| Molecularweight | 170.23 g/mol |
| Appearance | Pale yellow to light brown liquid |
| Meltingpoint | 17-20 °C |
| Boilingpoint | 120-122 °C at 20 mmHg |
| Density | 1.18 g/cm3 |
| Solubility | Soluble in organic solvents (e.g. ethanol, ether) |
| Refractiveindex | 1.578 (at 20 °C) |
| Flashpoint | 87 °C |
| Smiles | COC1=CC(=C(S1)OC)S |
| Purity | Typically ≥98% |
| Synonyms | 2,5-Bis(methoxy)benzenethiol |
As an accredited 2,5-Dimethoxythiophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 2,5-Dimethoxythiophenol, tightly sealed with a plastic screw cap and hazard labeling. |
| Shipping | 2,5-Dimethoxythiophenol is shipped in tightly sealed containers to prevent exposure to air and moisture. It is typically packaged in amber glass bottles, cushioned and labeled according to hazardous material regulations. The shipment is accompanied by a Safety Data Sheet (SDS) and handled following all relevant chemical transportation safety guidelines. |
| Storage | 2,5-Dimethoxythiophenol should be stored in a tightly sealed container under an inert atmosphere, such as nitrogen or argon, to prevent oxidation. Keep it in a cool, dry, and well-ventilated area away from sources of heat, light, and incompatible substances like oxidizing agents. Proper labeling and secondary containment are recommended to prevent leaks and accidental exposure. |
Competitive 2,5-Dimethoxythiophenol prices that fit your budget—flexible terms and customized quotes for every order.
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2,5-Dimethoxythiophenol stands out among aromatic thiols for its dual methoxy groups positioned ortho and para to the thiol on the benzene ring. We craft this compound with careful attention to yield, stability, and purity, offering a model that meets stringent research and industrial applications. Direct knowledge and hands-on experience with each batch give us the confidence to shape processes that drive real results for our partners in pharmaceutical development, material science, and fine chemical synthesis.
Researchers searching for a reliable thiol with electron-donating substituents will find the unique features of 2,5-Dimethoxythiophenol irreplaceable in certain synthetic schemes. The two methoxy groups activate the aromatic ring, changing reactivity profiles in comparison to relatives like unsubstituted thiophenol or 4-methoxythiophenol. This adjustment influences how the molecule participates in cross-coupling, nucleophilic substitution, and as a building block for sulfur-containing heterocycles and APIs.
We began producing this compound by first responding to the requests of medicinal chemists. Their work with privileged scaffolds often demanded selectivity in both electrophilic and nucleophilic aromatic substitution. By tweaking process conditions, we were able to fine-tune the electron density on the ring, giving researchers another level of control over regioselectivity in their syntheses. This attribute distinguishes 2,5-Dimethoxythiophenol from more conventional thiols, where side reactions may be more pronounced due to less controlled electron flow.
Variability in raw materials can devastate downstream chemistry, which is why we source all inputs through vetted suppliers. Purity checks throughout production and final GC-MS and NMR analysis assure our customers that contaminants like residual methoxybenzenes, sulfur impurities, or related phenolics do not slip past. Typical purity exceeds 98%. Appearance shows as a pale to medium yellow liquid at room temperature. Odor remains unpleasant but manages to drift less than more volatile family members, a feature appreciated by bench chemists working with sensitive reactions.
Moisture content and oxidation to disulfides were early challenges in our scale-up work. Taming ambient air from the process and storing material under nitrogen gave superior shelf stability. Freshness matters, especially for custom syntheses, so we package only as ordered, minimizing the risk of decomposition. Several partners have commented on the way our material remains free-flowing and clear, even on standing, because packaging teams follow batch records down to the last digit and continuously monitor for trace metal contamination that speeds up degradation.
Our customers’ feedback is the sharpest test of real-world performance. Those working on producing benzothiophene cores cite faster reaction times—likely tied to the activated ring system. Organic electronics researchers report improved yields in donor-acceptor systems when swapping in our 2,5-dimethoxythiophenol, compared to starting from the unsubstituted phenol as a precursor. We have also seen several patents reference our material in processes aimed at constructing sulfonated dye intermediates.
Some clients rely on it for thiol-ene reactions that demand swift conversion with fewer byproducts. Others have used it to functionalize metal surfaces where the dual methoxy arrangement tunes binding strength, changing polymer or metal-thiol interface properties. The subtle electron push from the two methoxy groups tempers the sulfur, making this thiol both an efficient nucleophile and less prone to overoxidation than less protected versions.
Material science teams comment that thioether linkages derived from this compound resist oxidation more robustly in the presence of the two methoxy groups. These insights circulate back to us, informing batch process control, so our customers’ challenges educate our chemists. Each reformulation starts with new bench tests, not guesswork, to prove gains in thermal stability or to trim away bottle-to-bottle variation.
For those accustomed to working with unsubstituted thiophenol, switching to 2,5-dimethoxy substitution is a foundational change. The electron-donating effect of two methoxy groups makes the aromatic system far more reactive toward electrophilic attack in the ortho and para positions—already blocked in this molecule. In practical terms, side reactions that plague simple thiophenol, such as para-sulfonation or overoxidation, drop away, especially at moderate temperatures.
Compared to 4-methoxythiophenol, the additional methoxy at the ortho position tugs further at the electron cloud, opening up possibilities for regioselective synthesis and impacting the rate of metal-catalyzed cross-couplings. In coupling chemistry, each method must compete with substrate-specific reactivity, and 2,5-dimethoxythiophenol brings a sharper, more targeted footprint. Its solubility in common reaction solvents—like ethers, alcohols, and even some apolar alkanes—advances work in both batch and flow systems, contrasting with something like 2,4,6-trimethoxythiophenol, which can be cumbersome to dissolve or purify.
Laboratory teams transitioning from monomethoxy to dimethoxy derivatives report not only improved chemical yields, but also cleaner spectroscopic profiles, because fewer tars and polymeric byproducts form during heated steps. Handling becomes more manageable, with measurable drops in unpleasant vapor even in less-ventilated workspaces. Less odor migration does not just improve the bench experience; it actually signals the lower volatility of the product, an outcome of the methoxy-induced increase in molecular weight and boiling point.
Stability used to be the Achilles’ heel for many aromatic thiols. Fresh material, often requested by high-tech labs, proved difficult for traders or secondary suppliers to offer. By synthesizing only enough for monthly or custom batch sales, we cut warehouse stays and the associated oxidative breakdown. Doing this at the manufacturer level, rather than relying on middleman inventory, assures working chemists receive material only a few weeks old at shipment.
The key to reliable supply is redundancy in upstream intermediates. Our team sources primary aromatic precursors from more than one partner, each subject to routine qualification, and we do this within a closed supply circle. This tight control means that shifts in global feedstock prices or trade restrictions cannot bring work to a halt. Flexibility in our synthetic route also allows pivoting should regulatory or purity standards shift; we already run parallel validation lines for pharma-grade and electronics-grade product.
Our relationship with end users is never static. Pharmaceutical partners often suggest tweaks to the impurity profile they observe by LC-MS. We treat these notes as prompts for change rather than as criticisms. After a customer reported ultratrace levels of ortho-quinone formation, we installed inline filtration and animated nitrogen transfers, which eliminated the issue in subsequent lots. Multinational electronic materials producers asked about minimizing chloride content for specialized downstream catalysis: our QC added silver nitrate and combustion testing to flag withhold shipments showing any residual halide.
Chemical synthesis is never a perfect science. We talk to bench chemists directly, not through a tangle of sales channels, absorbing pain points and frustrations. If a batch comes back due to a handling mishap, we use direct feedback to modify not just the packaging, but also the stability-inducing additives. By staying present during process development and production, our scientists recognize problems early, keeping unreliable performance at arm’s length. These conversations build a loop of information, guiding us to improvements in purification and preventing premature aging or unplanned odor development.
We focus on delivering quantities that match actual demand, rather than pushing minimum order sizes or warehousing dead stock. Custom batch orders and kilogram-scale drums stand ready upon request, while five to fifty gram packs ship within days for research-scale needs. Sensitive packing, sometimes under dry ice or with headspace nitrogen, shows the same attention as our process chemistry, keeping decomposition below detectable limits.
We watch each shipping method ourselves. Seasons change—transit trucks or container ships can spike storage temperature unexpectedly, pushing up the chance for byproduct formation. Logistics teams schedule replenishments on actual usage reports, so material spends less time sitting and more time in the lab. Should an issue ever come through in QC or user testing, batches flagged for recall are quickly replaced. We would rather eat the loss than have a customer’s synthesis falter due to an unstable input.
As the complexity of research in materials, catalysis, and APIs grows, more partners expect consistency with no hidden changes. We’ve invested in automation not just for capacity, but for tighter parameter control in every production run. GC-MS baseline mapping, chromatogram archiving by batch, and ongoing access to technical staff mean every shipment is traceable back to the reaction kettle.
We welcome transparency requests. Sharing insights on why certain impurity profiles creep up or batch color shifts can help inform downstream processing teams. End-to-end oversight shortens response times if regulatory changes or source disruptions affect any part of our input stream. Feedback loops—both formal and informal—strengthen in-house expertise, letting us fine-tune product scope for emerging synthetic demands.
Strict environmental and regulatory norms continue shaping how specialty thiols are produced. We have adopted closed-loop solvent recovery and low-waste synthesis steps from the earliest scale-up phase. In addition, we work closely with disposal partners so post-lab residues and packaging do not threaten worker health or the local environment.
Anyone comparing 2,5-dimethoxythiophenol to similar products quickly notices more than just chemical differences. Material origin, hands-on knowledge, and an open dialog with the research community make the real difference. We refine our process to suit not just a test method or regulatory threshold, but to help turn promising chemistry into successful process routes. Our manufacturing story is not about large-scale anonymity, but about knowing precisely whose experiment each kilogram will support.
By making and owning each gram from raw input to packed bottle, we draw a clear line of sight between the needs at the bench and the molecules arriving in the bottle. We believe that such close work between manufacturer and chemist yields not just a better compound, but a better experience for every user setting up a new synthetic challenge in their lab.
