|
HS Code |
820662 |
| Chemicalname | 2,5-Difluoro-4-Nitrophenol |
| Casnumber | 100371-27-1 |
| Molecularformula | C6H3F2NO3 |
| Molecularweight | 175.09 |
| Appearance | Yellow solid |
| Meltingpoint | 102-104°C |
| Solubility | Soluble in organic solvents |
| Purity | Typically ≥98% |
| Synonyms | 4-Nitro-2,5-difluorophenol |
| Smiles | c1c(cc(cc1F)N(=O)=O)F |
| Inchi | InChI=1S/C6H3F2NO3/c7-3-1-4(8)6(10(12)13)2-5(3)9/h1-2,9H |
| Storageconditions | Store at room temperature, in a dry, sealed container |
As an accredited 2,5-Difluoro-4-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 2,5-Difluoro-4-Nitrophenol, sealed with a screw cap and labeled with hazard symbols. |
| Shipping | **Shipping Description for 2,5-Difluoro-4-Nitrophenol:** Ship in tightly sealed, chemically resistant containers, stored in a cool, dry, and well-ventilated location. Protect from moisture, heat, and incompatible substances. Ensure correct labeling as a hazardous chemical. Follow all local, national, and international regulations regarding the transport of toxic and environmentally hazardous substances. |
| Storage | 2,5-Difluoro-4-nitrophenol should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers and bases. Protect it from moisture, heat, and direct sunlight. Ensure proper labeling and secondary containment. Use corrosion-resistant shelving and store separately from food and drink. |
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Over the past decade in our production labs, chemists have watched fluorinated phenolic compounds gain traction for the precise way they interact with organic frameworks. Here, 2,5-Difluoro-4-Nitrophenol stands out due to its carefully balanced electronic properties. The introduction of nitro and fluoro groups changes both the reactivity and the physical profile of phenols, which has practical consequences for how downstream products behave.
We prepare this compound so researchers and innovators can count on reliable, high-purity material with a clear reaction profile. The two fluorines on the benzene ring at the 2 and 5 positions result in strong electron-withdrawing effects. That not only increases oxidative stability, it reshapes how the molecule takes part in nucleophilic aromatic substitution and related transformations. Meanwhile, the para-position nitro group brings added reactivity in reduction and coupling processes. The value of this molecular layout appears most clearly when the preparation of fluorinated analogues or structurally complex intermediates calls for both versatility and selectivity.
Our primary batch model emphasizes purity suitable for pharmaceutical intermediates, crop protection research, and advanced material chemistry. The typical product comes as an off-white to faintly yellow crystalline powder. We adhere to a rigorous in-house protocol for moisture content, melting range, and impurity profile; the average lot exceeds 98% GC and HPLC area purity, with residual water and solvent well below the 0.5% range every time. This level of consistency shows up in downstream synthesis—higher yields, fewer chromatographic purifications, and reduced by-product formation. By controlling critical parameters tightly, unintended halogen exchange and aromatic degradation shrink to the lowest measurable limits.
Different phenol derivatives can look similar, especially on paper, but modifications shift their whole chemical personalities. In my earlier years handling simple monofluorophenols, reaction bottlenecks slipped in, including uncontrolled over-nitration or sluggish halogen substitution. Switching to the difluoro-nitro version, we began to see crisper coupling with electron-rich nucleophiles, and key steps required less aggressive conditions. That change influenced both project timelines and waste solvent output.
Because both fluorine and nitro moieties influence the ring’s electron density, this molecule often serves as a springboard for more sophisticated motifs: cyclization, photochemistry, and cross-coupling with metal catalysts. Some researchers bring up specific substrate selectivity in Suzuki–Miyaura or Buchwald–Hartwig reactions. The presence of two fluorines changes the LUMO energy profile, encouraging coupling at defined sites, reducing side-reactions during aryl-heteroatom bond formation. Our material avoids browning or caking over time—another detail, but these keep sensitive transformations consistent from pilot run to gram-scale work.
Our experience with phenolic chemistry leads us to respect the subtle differences between fluoro, nitro, bromo, and even trifluoromethyl-substituted frameworks. Certain bromo derivatives offer an easier entry for palladium-catalyzed couplings but at the cost of byproduct complexity. Mono-nitro phenols enable classic electrophilic substitution, but their selectivity narrows in multi-step routes. Trifluoromethylphenol pushes up hydrophobicity, which steers compatibility in medicinal chemistry but limits hydrogen bonding or crystal engineering options.
2,5-Difluoro-4-Nitrophenol serves projects that need a more evenly distributed set of electronic effects, while the classic para-nitrophenol or 2,4-difluorophenol only meet part of the synthetic demands. We have observed among our customers a shift toward this intermediate for agrochemical scaffolds—appreciating both the enhanced oxidative resistance and clean aromatic substitution. By working directly with the sources of upstream fluoro intermediates, our process offers a reproducible starting point for targeted molecule design.
Chemists in drug discovery start with small-scale screens; 2,5-Difluoro-4-Nitrophenol appeals because its predictable reactivity lets them chase new lead compounds with fewer synthetic hurdles. The molecule has appeared in patent filings for kinase inhibitor scaffolds, as well as late-stage intermediates for anti-inflammatory agent families. Crop protection research groups have flagged this compound for developing safer agrochemical candidates—its metabolic resistance in field toxicity screens traces back to the stability of those fluorine groups.
Materials scientists have pressed these nitrofluorophenols into more specialized fluorescent dye investigations and as building blocks for fine-tuning molecular electronics. Modifications of the parent motif give rise to materials with altered bandgaps and persistent luminescence—a line of work that connects to sensor and OLED technologies. The nitro group, once selectively reduced, easily produces an array of amines, azos, or even polymerizable bases that slot into established synthetic strategies.
Every batch starts with controlled fluoro-substitution of a nitro precursor. By carefully adjusting temperature ramps and solvent choice, we minimize site-selectivity issues and avoid multi-halogen scrambling, a recurring annoyance for less optimized procedures. Early on, we discovered that small temperature deviations invite the formation of 2,3,5- or 2,4,5-isomers—a detail not always visible by simple melting point or color observation. Our quality labs use 1H, 19F, and 13C NMR to confirm all batch identities, so researchers receive exactly what their reaction pathway calls for, without surprises.
Controlling exothermic events during synthesis keeps throughput both scalable and safe. By investing in recirculating chillers and jacketed vessels, we manage process temperatures without resorting to ultra-slow addition or unnecessary dilution. This approach increases single-batch size, while allowing us to supply both exploratory and semi-commercial projects without a loss in quality. Residual byproducts, especially polynitro or over-fluorinated aromatics, are separated by continuous-flash systems, and our downstream workup makes for clean filtrations that seldom challenge compliance with process safety regulations.
For anyone working with tailored building blocks, unreliable supplies of critical intermediates can delay development, force compromise on downstream chemistry, and even cloud regulatory approvals. Often, small impurities left from incomplete reactions or careless workups surface at formulation scale, leading to blocked registrations or costly revalidation. Our warehouse tracks each shipment back through production records, so every drum’s journey is transparent—it protects both our customer’s projects and regulatory standing.
Our logistics team listens to seasonal bottlenecks. Fluorinated aromatics come from a linchpin set of starting materials. Pandemic disruptions and local production halts showed the value of on-site inventory and backup supplier agreements. We invest in local warehousing and strategic partnerships within the raw material space. This lets us sidestep repeated production pauses or last-minute freight scrambles that have tripped up less integrated suppliers.
Toxicological profiles for nitroaromatics, especially those with multiple halogens, require careful handling and documentation. We communicate best storage advice based on long-run stability assays—ambient, dry conditions, in sealed packaging prevent both hydrolysis and photodegradation. Contamination risks are lower for phenols compared to amines, but nitro groups remain sensitive points for proper disposal.
We do not cut corners on labeling or documentation. Chemists working under GLP or GMP conditions rely on Certificates of Analysis batch-matched to each container. We follow both REACH and local regulatory expectations, both for workplace safety and downstream registration. That means every lot ships with clarity about what’s inside, how it was produced, and how to stay compliant. Some customers care less about paper trails, more about real performance, but both groups get full disclosure.
Production of fine chemicals like 2,5-Difluoro-4-Nitrophenol, by its nature, generates both solvent waste and challenging filtrate. Our plant runs closed-loop solvent recovery for primary process streams, extending the working life of chlorinated and polar solvents by at least two to three passes. Acidic and alkaline process waters undergo in-house neutralization before off-site treatment—an expense, but one that shrinks the environmental burden.
In recent years, environmental scrutiny has only increased for halogenated intermediates. We continue to review synthetic steps to lower resource intensity, and our energy audit teams report real improvements after swapping to high-efficiency distillation and process controls. Our frontline chemists play a part, flagging opportunities to rework mother liquors or consolidate media changes, keeping both footprint and cost in check. The activist community sometimes calls out “legacy chemistries’’ for slow reform—fair, but as chemists, we chase real process improvements that deliver both bottom line and environmental integrity.
In specialty chemicals, product lifecycles turn quickly as researchers identify new technical needs. Our ongoing dialogue with academic collaborators, pilot companies, and in-house R&D helps spot trends ahead of the curve. The recent uptick in ring-fluorinated heterocycles for CNS active agents pivots on building blocks like this; medicinal chemists value the unusual balance between lipophilicity and metabolic resilience. For new applications in advanced manufacturing—think next-generation OLEDs or electroluminescent polymer films—structural variation in nitrofluorophenols opens up custom performance envelopes.
Collaboration matters here. Our process scientists worked directly with electronics partners to tweak crystallization protocols. The goal was to ensure consistent polymorphism—a subtle but critical aspect for charge-carrier mobility in organic electronics, and a differentiator that many commodity producers overlook. Custom requests don’t happen every month, but we welcome the challenge.
Quality control goes deeper than passing a spec sheet. Where commodity operations might rely mainly on final-product scans, our in-process monitoring lets us catch deviations before they leave the reactor. This avoids ongoing batch corrections, lowers waste, and makes for a product that handles predictably in sensitive transformations.
Anecdotally, chemists report that purified lots from less meticulous manufacturers leave trace contaminants—sometimes with no clear NMR or HPLC alarm bells, but enough to crash scale-up routes or cause unexplained yield losses. Our internal pilot-scale tests rerun priority coupling or reduction steps using finished product from the same drums our customers receive. If any deviation surfaces, we investigate and adapt—not just note, then move on.
Our link to the end user keeps us sharp. Feedback from users drives not only minor process tweaks, but also packaging upgrades, logistics choices, and sometimes even prompts whole new synthetic pathway evaluations. Those who synthesize at kilo scale often request detailed traceability, not just a lot code. Our records respond, detailing every checkpoint from raw material to finished package. For start-ups or academic labs, smaller pack sizes keep entry convenient, but every lot receives the same scrutiny.
The pursuit never ends. Improvements—like optimizing filtration to keep micron-level particles low or adjusting drying parameters to maximize free-flowing powder—can decide batch success for sensitive users. We balance efficiency with flexibility, adapting according to feedback, changes in downstream economics, and evolving safety requirements.
Markets can shift suddenly. A few years ago, regulatory reclassification in key export markets turned procurement for nitroaromatics into a procurement puzzle. Our response combined direct advocacy, transparent communications, and partnerships with local agencies. The result: more reliable access and reduced risk of customs delays, an outcome that enables research and industrial customers to keep programs moving.
We are not insulated from global turbulence—price swings, energy cost surges, and changing rules shape everything from batch sizes to stock levels. Our team adapts with foresight, building contingency into sourcing and planning to minimize disruption. We remain committed to the experience and trust that long-standing customers expect, even if achieving that standard asks for extra effort behind the scenes.
2,5-Difluoro-4-Nitrophenol has carved out a solid role in both the research and production landscapes. Getting the most from this intermediate depends on mutual understanding between producer and user, attention to detail at every step, and a willingness to adapt as the demands of chemistry evolve. We continue to invest in the science, the systems, and the relationships that keep our product relevant—a commitment born from long hours and deep respect for the craft.
For those seeking to harness new chemical space, build out safer molecules, or tackle the complexity of contemporary synthesis, this compound stands ready to support progress. Our door stays open to new challenges, and our work reflects the day-to-day, hands-on experience of bringing tailored chemicals into the world, one batch at a time.
