|
HS Code |
229421 |
| Product Name | 2,3-Difluoro-4-Bromophenol |
| Molecular Formula | C6H3BrF2O |
| Molecular Weight | 208.99 g/mol |
| Cas Number | 136676-11-6 |
| Appearance | White to off-white solid |
| Melting Point | 39-42°C |
| Density | 1.80 g/cm³ (estimated) |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Smiles | C1=CC(=C(C(=C1F)F)O)Br |
| Inchi | InChI=1S/C6H3BrF2O/c7-3-1-2-4(8)6(10)5(3)9/h1-2,10H |
| Synonyms | 4-Bromo-2,3-difluorophenol |
| Storage Conditions | Store at room temperature, protected from light and moisture |
| Hazard Class | Irritant (may cause respiratory and skin irritation) |
As an accredited 2,3-Difluoro-4-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 10-gram amber glass bottle with a secure cap, labeled "2,3-Difluoro-4-Bromophenol, CAS 1435-51-6, for laboratory use only." |
| Shipping | 2,3-Difluoro-4-bromophenol is shipped in sealed, chemically-resistant containers to prevent leaks and contamination. It should be transported under dry, cool conditions, protected from heat and direct sunlight. Proper labeling and documentation following regulatory guidelines are required, with handling precautions for hazardous substances during transit to ensure safe delivery. |
| Storage | 2,3-Difluoro-4-bromophenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers and bases. Protect from moisture and direct sunlight. Use proper chemical storage cabinets and clearly label the container to prevent accidental misuse or exposure. |
Competitive 2,3-Difluoro-4-Bromophenol prices that fit your budget—flexible terms and customized quotes for every order.
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No matter how long we have been behind glassware and reactors, every crop of 2,3-Difluoro-4-Bromophenol reminds us what careful synthesis can achieve. The compound, which carries the chemical identity of 2,3-difluoro-4-bromophenol and molecular formula C6H3BrF2O, continues to hold a special place in our workflow. Our tank systems are tuned for its efficient production, and our analytical teams have dialed in every step from weighing out phenol to measuring conversion rates and final titrations.
We design and calibrate each batch of this compound, aware of the minute shifts that halogen placement brings to reactivity. The two fluorines at the ortho and meta positions next to the phenolic group don’t just change the boiling point—they directly shape every downstream reaction. Compared to simpler halophenols, this structure gives chemists a sharper tool, opening doors in medicinal, crop protection, and material sciences.
Years of bench experience show that halogen substitutions rarely go unnoticed in fine chemical synthesis. Fluorine brings both electron-withdrawing properties and unique hydrogen bonding patterns, and bromine contributes to reactivity without the volatility of lighter halogens. This particular arrangement—two fluorines flanking a bromine on the aromatic ring—makes 2,3-Difluoro-4-Bromophenol more than just another building block.
During Suzuki, Buchwald, or Ullmann couplings, the presence of the fluorines often controls selectivity in reactions that lead to pharmaceutical intermediates or advanced materials. The phenolic group gives chemists the opportunity for further functionalization, by protecting group strategies or participation in coupling reactions. Those working in crop protection value both the stability and the specific activity profile conferred by the halogen pattern.
Running full-scale production, we always watch for trace impurities that would hamper the compound’s efficacy in any reaction. We conduct continuous GC and HPLC analysis to confirm purity, with targeted controls for residual starting materials and byproducts that would otherwise find their way into synthetic campaigns further downstream.
It’s easy to overlook how much work goes into a single kilogram of 2,3-Difluoro-4-Bromophenol. Our process begins long before the final vessel gets charged. Sourcing pure starting materials shapes what’s possible in the reactor. Each fluorination and bromination run demands consistency in temperature, solvent ratios, quenching steps, and hold times. Even small variations can ripple through the batch, leading to fluctuation in overall yield or crystal size—not acceptable when downstream users rely on predictable quality.
Crystallization, filtering, and drying might look like clean-up steps, but they decide whether the end user receives a powder that works for reproducible research or gets stuck with frustration at the bench. We use gravimetric and spectroscopic checks at every stage. Experience teaches which solvents give the best filtration times, which drying protocols minimize retained solvents, and how to package the product to avoid light or moisture exposure that could trigger phenolic oxidation.
The requests we handle for 2,3-Difluoro-4-Bromophenol span more than just volume; they reflect how widely this molecule is used in practical contexts. Researchers in pharmaceutical labs reach out for custom batch sizes when scaling up lead compounds that feature this building block in their synthesis. Crop protection innovators want guarantees that their API candidates start from materials free from trace halide contamination.
Among those working on specialty materials, we see demand for 2,3-Difluoro-4-Bromophenol as a precursor to fluorinated polymers and advanced aromatic compounds. The specific substitution pattern means the resulting products often have unique physical properties—altered solubility, improved chemical resistance, or modified optical absorption.
Feedback cycles with our partners aren’t just formality. Each report back from process engineers and research scientists helps us tune every future batch, whether we’re supporting high-throughput medicinal chemistry or industrial-scale campaigns.
Chemical substitutions tell their story most clearly through day-to-day results. Looking at analogues—such as 2,4-difluorophenol, 4-bromophenol, or fully fluorinated compounds—helps us understand the real value of this specific molecule. The two fluorines on both ortho and meta positions reduce the phenolic hydrogen’s activity, which has real implications for both reactivity in couplings and overall metabolic stability in pharmaceutical compounds.
By contrast, simple bromophenols often react too easily or don’t provide enough environmental stability, while molecules with more than two fluorines frequently lose solubility or become unwieldy to handle. The 2,3-Difluoro-4-Bromophenol occupies a sweet spot: enough reactivity for electrophilic substitutions, yet enough halogenation to resist oxidative conditions and metabolic breakdown.
Some users ask about substituting with trifluoromethyl groups or shifting the bromine. Our hands-on experience tells us the resulting compounds rarely match the original in downstream reactivity or application profile. The balance found in this motif saves time and effort when carrying out multi-step syntheses in the lab.
What chemists receive from us flows directly into their daily routines. We keep our specifications strict, but past experience has taught us what to watch for in the real world. Moisture and air exposure are common pitfalls, so packaging choices matter. Our technical teams always store and ship this compound in amber glass or high-quality HDPE, using nitrogen flushing where possible to maintain stability through transit.
The finished product leaves our production line only after batch numbers match up with full documentation—COA, MSDS, and analytical printouts. Our customers prefer this transparency to guesswork. If they find a spark of pink on the filter paper or unexpected residue after evaporation, they can call us knowing that our process history is traceable all the way to the starting phenol and acid chloride sources.
Whether the next stop is a kilo lab, pilot plant, or high-throughput screening facility, users know we don’t cut corners on handling protocols. Stable material, consistent granulation, and minimal static charge help to minimize weighing errors and dissolution problems on their side.
Since its introduction to our catalog, interest in 2,3-Difluoro-4-Bromophenol has grown across both developed and emerging markets. Research programs keep pushing the limits on organofluorine chemistry, and our records show growing inquiries for higher-purity grades and custom formulations—evidence that the compound continues to open new research and commercial directions.
We track these shifts closely, working with R&D teams to stay ahead of new synthesis challenges. Standard products rarely solve every problem. Some partners request adjusted particle size distributions for high-throughput screening robots. Others need additional tests to screen for trace halides or peroxide residues for highly sensitive applications. Our role as a chemical manufacturer—rather than a trader or distributor—lets us implement changes right on the production floor, cutting the turnaround time from months to days.
Our experience with halophenol synthesis includes more than just the chemistry. Efforts to reduce waste solvents and recycle purification media have changed the environmental profile of each batch. The switch to greener solvents, process intensification, and additional scrubbers on gas vent lines mark concrete improvements. We monitor overall resource use and routinely review process risk assessments to minimize any emissions or byproducts.
Where possible, we’ve implemented closed-loop solvent recovery. Some process steps can now recycle upwards of 70% of mother liquors, with spent brominating agents neutralized and recovered for industrial partners. The result isn’t just cleaner operations, but also the ability to keep production costs in check as input material prices fluctuate in the wider market.
Working with other manufacturers through local industry groups, we help share process innovations and practical solutions—these efforts reduce both our own environmental impact and raise standards across the sector.
Teams working on new kinase inhibitors or next-generation fungicides often look for building blocks that can stand up to tough reaction conditions. The stability profile of 2,3-Difluoro-4-Bromophenol, together with its halogen and phenol pattern, makes it a trusted starting point for complex target molecules. Fast dissolution in common polar aprotic solvents shortens setup times. Its clean melting and re-solidification means researchers avoid wastage in preparation steps.
Some of our ongoing collaborations have seen this compound take a place in the synthesis of fluorinated biphenyls, advanced OLED precursors, and agricultural leads. Successful process transfers—moving from 100-gram to 10-kilogram batches—reflect what happens when upstream and downstream teams keep direct lines of communication. Sharing process data and analytical findings closes the loop that too often gets broken with off-the-shelf intermediates from anonymous sources.
Increased demand brings real logistical challenges. Sourcing high-purity starting materials and specialty reagents sometimes involves coordination with custom syntheses upstream. Schedules are often tight on both sides: research teams need shorter lead times, and upstream partners face regulatory hurdles or transportation bottlenecks.
We address these by keeping dedicated inventory for active, long-term collaborators while building in process flexibility on the shop floor. Regular supplier audits give confidence in raw material consistency, and direct relationships with logistics providers help smooth out delays. Rapid regulatory response, especially for export documentation and customs clearance, forms part of our routine way of working. When storm-induced disruptions or customs backlogs threaten a shipment, these relationships allow us to adjust and keep pipelines flowing.
For partners in North America, Europe, and Asia, we ship in both small-scale research containers and industrial drums, always following local and international guidelines for the safe transport of aromatic and halogenated compounds.
Our track record with 2,3-Difluoro-4-Bromophenol has grown in step with the changing needs of chemical researchers and industrial partners. Whether it is custom labeling for easier batch tracking, anti-caking additives for bulk orders, or detailed impurity profiling for regulatory submissions, we adapt our process offerings to match technical and logistical requirements as we learn from every collaboration.
Direct contact with chemists and engineers gives us real-time feedback, both positive and critical. If a batch appears discolored or doesn’t dissolve as expected, technical teams are ready to react rather than passing along responsibility. Many of our support staff have lab or plant backgrounds, translating customer feedback into adjustments and improvements with an understanding of practical impact.
Keeping 2,3-Difluoro-4-Bromophenol processes up to date has meant continuous engagement with the broader scientific community. Attending conferences and industry seminars gives fresh insight into reaction techniques and purification technologies. Collaboration on reference standards and cross-validation of analytical methods ensures that both internal and external laboratories speak the same language when it comes to quality control.
These learning cycles feed right back into the plant. Newer analytical instruments, upgraded process controls, or more robust sampling protocols often come from lessons shared by researchers in the field. This direct knowledge exchange bridges the classic divide between the plant and the laboratory researcher.
Compliance isn’t just paperwork: it shapes how every kilogram of 2,3-Difluoro-4-Bromophenol reaches research and commercial partners. Documentation trails support traceability from raw material through final product, and we regularly undergo both internal and third-party audits to confirm these systems work. Formal risk assessments for environmental release, worker safety, and batch-to-batch variability feature in process design and implementation.
For users preparing to move candidate molecules into clinical or regulatory review, we support with comprehensive data packages—spectra, impurity profiles, and supply chain statements. This transparency saves time for partners, avoids duplication of compliance efforts, and strengthens trust in the material supply chain.
Occasional synthesis hurdles crop up regardless of planning. Years ago, a pilot facility struggled with filtration times due to slight overbromination in their supplied intermediate. After collaborating on reaction modifications, our technical support team traced the issue to a solvent swap and iodine carryover. Addressing small upstream changes brought filtration back within specification, allowing both sides to meet tight project timelines.
Another example came from a pharmaceutical team that encountered unexpected color development after storage. Joint analytical runs revealed trace impurities from plasticizers in their storage vessels—not from any process change on our end. This case not only resolved the immediate issue, but added a detail to process documentation for future storage guidelines. Feedback from hands-on experiments regularly improves both our own production and downstream partner outcomes.
Each month brings fresh challenges and opportunities tied to 2,3-Difluoro-4-Bromophenol production. Regulatory shifts influence allowable solvent emissions. Downstream research points to ever-stricter tolerances for impurities and particle size. Our teams continue to invest in process improvement and analytical capability, always learning from both successes and setbacks.
Manufacturing this compound is a practical science. As chemical manufacturers, our contribution goes beyond simple delivery. It consists of real partnership, respect for the details that shape everyday lab work, and the drive to support advances in research and industry.
