|
HS Code |
791459 |
| Productname | 2-(2-Aminoethyl)Phenol |
| Casnumber | 103-67-3 |
| Molecularformula | C8H11NO |
| Molecularweight | 137.18 g/mol |
| Appearance | White to light yellow solid |
| Meltingpoint | 59-63°C |
| Boilingpoint | 280°C |
| Density | 1.161 g/cm³ |
| Solubilityinwater | Moderate |
| Purity | Typically ≥98% |
| Synonyms | O-Tyramine; 2-Hydroxyphenylethylamine |
| Flashpoint | 144°C (closed cup) |
| Chemicalstructure | C1=CC=C(C(=C1)CCN)O |
| Storageconditions | Store at 2-8°C, tightly closed |
As an accredited 2-(2-Aminoethyl)Phenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(2-Aminoethyl)phenol supplied in a tightly sealed amber glass bottle with hazard labeling for safe laboratory handling. |
| Shipping | 2-(2-Aminoethyl)Phenol is shipped in tightly sealed containers, protected from moisture and light. It is classified as a hazardous chemical and handled according to safety regulations. Package labeling includes hazard and handling information. Standard shipping involves temperature control and cushioning to prevent leaks or breakage during transit, ensuring safe delivery. |
| Storage | 2-(2-Aminoethyl)Phenol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers and acids. Protect from moisture and direct sunlight. Use chemical-resistant shelving and ensure appropriate labeling. Personal protective equipment should be worn when handling the chemical to prevent exposure. |
Competitive 2-(2-Aminoethyl)Phenol prices that fit your budget—flexible terms and customized quotes for every order.
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Every batch of 2-(2-aminoethyl)phenol tells a story about carefully monitored synthesis and practical know-how. Our chemists have handled countless production runs, refining parameters to produce a material that meets expectations time and again. With a chemical structure featuring an aminoethyl group at the ortho position to the hydroxy group on the phenolic ring, 2-(2-aminoethyl)phenol stands out during intermediate synthesis steps. It owes its value to the precise balance of reactivity and stability, which supports further transformations in pharmaceuticals, fine chemicals, and polymer chemistry.
In our production environment, 2-(2-aminoethyl)phenol goes by its common chemical name, yet in some circles, colleagues refer to it as o-aminophenylethanol or O-AEPh. Industry catalogs might assign a CAS identifier, but at the manufacturer’s bench, focus remains on purity, physical consistency, and how these characteristics impact reactions downstream.
Focusing on purity lets us avoid process complications down the line. Working with 2-(2-aminoethyl)phenol in white to pale yellow crystalline form reduces chances for misidentification compared to darker or impure analogs. We maintain tight moisture control—often below 0.5%—as even small water content can trigger side reactions or complicate crystal handling. Solid content and melting point indicators help us catch impurities that could hamper reactivity.
We regularly face the reality that not all customers need ultra-high purity grades, so we offer multiple specification tiers, from lab-grade to industrial grade. Many times, a customer who formulates epoxy hardeners finds a lower grade with controlled levels of carbonyl or chloride impurities meets their price-performance balance. Those in peptide synthesis, though, usually demand stricter specifications. We have spent years refining the recrystallization and purification steps to serve both ends of the market and can tailor lots as needed.
Synthetic chemists who handle this compound recognize its sensitivity to moisture and air. Left open on a benchtop, the powder picks up humidity and browns over days. So we always recommend airtight, light-protected storage, and we use inert gas covers in larger drums. These steps might look like small details, but they make a difference in product consistency during shelf life or shipment.
On several occasions, we have encountered issues from improper storage—stale odors or tacky product—coming back from warehouses unfamiliar with specialty chemicals. Direct feedback from clients led us to develop double-layered foil packs for high-value shipments and upgraded labeling that clearly marks lot numbers and shelf life. Over time, this tighter chain of custody cuts down waste, returns, and customer frustration.
The versatility of 2-(2-aminoethyl)phenol comes from the combination of its amine and phenolic groups. These functionalities make it efficient as a building block in the synthesis of pharmaceutical intermediates, as well as a valuable component in hardener formulations for epoxy systems or in surface-modification chemistry.
One frequent application involves coupling reactions during the manufacture of active pharmaceutical ingredients. The ortho-substituted ethylamine allows for nucleophilic substitution and Michael addition reactions that simpler cresols or anilines cannot support. Plant engineers turn to this molecule when designing polymer backbones or linkers, often because its structure offers higher flexibility compared to straight-chain diamines. In our experience, switching to 2-(2-aminoethyl)phenol in coupling steps can reduce total reaction time and sometimes improve yields—based on its electron-rich ring and accessibility of the amine group.
Epoxy formulations are another field where our clients rely on this product. The phenol and amine together interact with resin backbones, leading to adhesives that set faster and hold up well against chemical exposure. We consult with customers to tweak amine:phenol ratios, helping them reach their desired mechanical strengths. As a result, some of the tougher, solvent-resistant adhesives on the market trace their durability back to our O-AEPh molecules.
We regularly see customers comparing 2-(2-aminoethyl)phenol to related aromatic amines and phenols—such as 4-aminophenol or 2-aminoethanol. While structurally related, the position of the aminoethyl group on the ring transforms both the physical and chemical reactivity. 4-aminophenol lacks the ethyl side chain, so it participates less efficiently in certain ring-closure or crosslinking reactions. Meanwhile, 2-aminoethanol, entirely lacking the aromatic system, performs quite differently as a nucleophile and delivers lower selectivity in coordinated-catalyst chemistry.
Customers have told us that in diagnostics and linker chemistry, the ortho positioning of the side chain on the phenol ring allows for site-specific binding or crosslinking that no other readily available intermediate matches. Even small differences in side-chain length or position result in dramatically different behavior—solubility in polar solvents, susceptibility to oxidation, and critical temperatures for melting and degradation all shift.
In one example, a customer substituting 2-(2-aminoethyl)phenol for meta-aminophenylethanol in a bioconjugation step saw improved reaction throughput and substantially fewer side products. Small tweaks to the molecule bring noticeable results, and our feedback loop with users keeps revealing more such cases.
Raw material costs evolve constantly. Shortages in petrochemical feedstocks or increases in energy prices push us to revisit routes and optimize yields. We have seen increased demand for greener, solvent-minimized manufacturing. Our technical teams respond by tweaking reaction solvent proportions, deploying in-process monitoring, and going beyond textbook methods to reduce byproducts.
End-users are looking for lower residual solvents and trace metals. We routinely measure these parameters through instrument analysis, instead of relying on vendor certificates alone. By running independent checks on each lot, we catch issues before product goes out the door and avoid costly QC problems in downstream production.
At the bench, updates to regulatory standards—GMP for pharmaceuticals or stricter REACH compliance for Europe—drive many of our process improvements. These efforts haven’t only ensured continued market access but have made handling and storage safer for workers and customers alike.
Producing 2-(2-aminoethyl)phenol isn’t just a matter of mixing chemicals. The route usually starts with phenol derivatives and involves controlled functionalization, reductive amination, and careful purification steps. Over many batches, our staff has seen small fluctuations in temperature or reaction atmosphere create off-colors and coupled byproducts. Frequent hands-on monitoring and reliable analytical techniques allow us to keep every run in spec.
We continue to experiment with catalyst choices and oxidation prevention strategies. For example, moving away from legacy stirred-tank processes toward more continuous systems has helped us control reaction exotherms and increase safety margins. Recovering more than 95% of product from each run means we can keep waste to a minimum and stay competitive when raw material prices rise.
We have also invested in in-line process analytical tools, which alert us in real time if trace byproducts drift upward. Such steps can seem costly on paper, but years of operational data prove they prevent expensive rework and recalls later. This level of process control delivers reliable, reproducible material for our partners working in API synthesis or advanced materials R&D.
Though 2-(2-aminoethyl)phenol does not present the same health risks as some more reactive intermediates, it’s not just another benign powder. We have worked with both chemical workers and EH&S professionals to develop guidelines for careful weighing, solvent handling, and spill containment. The powder’s fine crystalline texture makes it prone to dust formation, so local exhaust and PPE are built into our plant routines.
As part of routine audits, we test wastewater and scrubber effluent for residual organics and adjust methods to stay ahead of local emission requirements. Simple engineering tweaks—such as modified vacuum lines and secondary containment—cut accidental releases and improve recovery. We share practical safety lessons with customers, based on our own incident records and near misses, knowing that open communication helps the entire value chain.
We encourage direct dialogue with end users about needs and problems. Our tech support team, many with years of hands-on lab or plant experience, offers troubleshooting—not just sales pitches. If a customer’s formulation shows an unexpected odor or discoloration traced to storage, or if a reaction yield drifts off target, we step in with analysis and recommendations.
A lot of improvements have come directly from customer challenges. We first learned there was a need for micro-packed, desiccated material sizes for pharmaceutical developers in response to early feedback about degraded samples. Switching to smaller, nitrogen-flushed packaging kept product fresh without the extra cost of reprocessing. For industrial users requiring bulk volumes, we devised tote configurations with bottom-drain valves that reduced worker exposure and product loss.
Longstanding clients in Japan once reported batch-to-batch reactivity issues linked to trace iron picked up during drying. Fast corrective action—installing a new dedicated dryer system—eliminated the contamination and improved our reputation for consistency. These examples show that listening and learning from feedback makes production smoother and customer operations more reliable.
Researchers continue to push the boundaries of what 2-(2-aminoethyl)phenol can do. For instance, a surge of work in surface-grafting and modification depends on its unique reactivity profile. We have supplied material for early-stage trials in biomedical device coating, where amine–phenol chemistry enables precise binding of proteins and enzymes onto polymer surfaces. This blend of academic curiosity and industrial execution gives rise to coatings with stability and biocompatibility.
Polymer developers exploiting the cross-linking ability of the compound come to us for insight in scaling up from gram to multi-kilogram amounts. The feedback from these teams has encouraged us to monitor parameters like particle size and dissolution rate, which, though less critical for analytical use, become key factors in large-scale blending and reactor charging.
We stay in close touch with universities and pilot plants, sometimes providing small research lots free of charge if a project promises new market opportunities. These interactions not only help us stay at the forefront of technology but also shape quality standards for everyone downstream.
Shipping specialty chemicals across borders takes more than a customs code. We regularly review country-specific requirements for labeling, documentation, and allowable impurity profiles. Our logistics team tracks evolving regulatory environments and updates export paperwork accordingly. This focus on compliance assures our customers that materials meet expectations whether delivered to a nearby research park or an overseas production facility.
Documentation, ranging from analysis certificates to traceability records, stays available for every batch. We help users pass audits by providing ingredient origin data and safety validation. Years of export experience equip us to anticipate and address each country’s unique concerns.
The demand for 2-(2-aminoethyl)phenol shows no sign of slowing, as both established industries and fast-evolving technology sectors recognize its versatility. At the same time, managing supply chain disruptions, meeting ever-stricter purity benchmarks, and keeping prices stable challenge manufacturers everywhere. We continue to reinvest in people and equipment to keep up.
Finding ways to recycle or recover spent intermediates adds both cost and operational complexity, but we treat it as a necessary commitment instead of a burden. Trials with solvent recovery systems and pilot programs in waste minimization give us workable models to address shifting regulations and customer expectations about environmental stewardship.
Our position enables us to offer real-world insight, not just catalog descriptions. We know by experience that the consistency and performance of 2-(2-aminoethyl)phenol rest on day-to-day decisions on the factory floor as well as innovation in response to customer needs. By sharing our perspective openly, we aim to build confidence across the chemical community that relies on this versatile building block.
