Product Name: Tri-O-Cresyl Phosphate
CAS Number: 78-30-8
EC Number: 201-104-9
Synonyms: TOCP, Trixylenyl Phosphate, Tricresyl Phosphate
Recommended Use: Plasticizer, flame retardant in polymers, hydraulic fluids, lubricant additive
Manufacturer: Reference supplier information accompanying the shipment
Emergency Contact: Refer to local regulations or manufacturer-supplied numbers
Classification: Acute toxicity (oral, dermal, inhalation), reproductive toxicity, chronic aquatic toxicity
Hazard Statements: Harmful if swallowed, harmful in contact with skin, may cause damage to nervous system through prolonged or repeated exposure, toxic to aquatic life with long lasting effects
Pictograms: GHS07, GHS08, GHS09
Signal Word: Danger
Precautionary Statements: Do not breathe dust, fumes, gas, mist, vapors or spray. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear protective gloves, clothing, eye, and face protection. Wash exposed skin thoroughly after handling.
Chemical Name: Tri-o-cresyl phosphate
Concentration: ≥ 99%
Molecular Formula: C21H21O4P
Molecular Weight: 368.37 g/mol
Impurities: o-Cresol, isomers of cresyl phosphate (may be present in trace amounts)
Inhalation: Remove person to fresh air, seek immediate medical attention if breathing is difficult or irregular.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least 15 minutes. Obtain medical attention.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing, get medical help.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Call a physician or poison center at once.
Symptoms: Stomach pain, nausea, cramps, central and peripheral nervous system effects, muscle weakness, paralysis in severe cases.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, water spray (do not use water jet).
Specific Hazards: Thermal decomposition releases toxic gases including phosphorous oxides and carbon monoxide.
Protective Equipment: Full face self-contained breathing apparatus, chemical protective suit.
Fire-Fighting Instructions: Use water spray to cool fire-exposed containers. Avoid inhaling fumes or vapors. Move containers away from fire area if safe to do so.
Personal Precautions: Evacuate area, ventilate, use personal protective equipment as indicated under exposure controls.
Environmental Precautions: Prevent runoff into drains, sewers, and waterways. Notify authorities if entry into environment is likely.
Methods for Cleanup: Absorb with inert material such as dry sand or earth, then shovel into container for disposal. Clean affected area with plenty of water and mild detergent.
Spill Reporting: Report large spills to local emergency services as required by regulations.
Handling: Use appropriate personal protective equipment and avoid contact with skin and eyes. Use only in well-ventilated areas. Keep away from heat, open flame, and sources of ignition.
Hygiene Measures: Wash hands and face after handling Tri-O-Cresyl Phosphate; remove contaminated clothing and wash before reuse.
Storage: Store in tightly closed containers, in a cool, dry, well-ventilated area. Keep containers away from incompatible materials such as strong oxidizers, acids, and bases. Protect from sunlight and moisture.
Occupational Exposure Limits: 0.1 mg/m³ (OSHA, ACGIH TLV - consult latest national/local standards)
Engineering Controls: Use local exhaust ventilation, safety showers, and eyewash stations in work area.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), full body covering, safety goggles, and face shield. In case of insufficient ventilation use respirators approved by NIOSH or equivalent. Wash thoroughly after handling.
Appearance: Oily, colorless to pale yellow liquid
Odor: Mild, phenolic
Odor Threshold: Not determined
pH: Not applicable
Melting Point: -30°C
Boiling Point: 410°C
Flash Point: 225°C (closed cup)
Evaporation Rate: Not available
Flammability: Not highly flammable under normal conditions
Vapor Pressure: <0.01 hPa at 20°C
Vapor Density: 1.3 (air = 1)
Relative Density: 1.16 g/cm³
Solubility: Insoluble in water; soluble in alcohols and organic solvents
Partition coefficient n-octanol/water (log Kow): 5.1
Decomposition Temperature: >400°C
Viscosity: 65 cP at 25°C
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Avoid strong oxidizing agents, strong acids, and bases.
Hazardous Decomposition Products: Phosphorous oxides, phenolic compounds, carbon monoxide, carbon dioxide.
Polymerization: Not expected to occur.
Conditions to Avoid: Heating above decomposition temperature, exposure to open flames or sources of ignition, contact with incompatible materials.
Acute Toxicity: LD50 (oral, rat): 23 mg/kg; LD50 (dermal, rabbit): 250 mg/kg
Inhalation: May cause headache, dizziness, nausea, respiratory tract irritation
Skin Contact: Prolonged or repeated contact causes redness and possible dermatitis
Eye Contact: Irritation, redness, blurred vision possible
Chronic Effects: Damage to nervous system (organophosphate-induced delayed neuropathy), potential reproductive toxicity
Carcinogenicity: Not classified as carcinogenic by IARC or NTP
Other Effects: Symptoms may not appear immediately; exposure can result in delayed neurological effects.
Ecotoxicity: Very toxic to aquatic life; fish LC50 (96h): 0.7 mg/L (Oryzias latipes), Daphnia EC50 (48h): 0.8 mg/L
Persistence and Degradability: Low to moderate biodegradability; persists in soil and sediment
Bioaccumulative Potential: High (log Kow >5), potential for accumulation in aquatic organisms
Mobility: Low in soil; adsorbs strongly to sediment and organic matter
Other Adverse Effects: May disrupt aquatic ecosystems long-term if released in large quantities
Waste Treatment Methods: Dispose of content/container in accordance with local, regional, national, and international regulations. Backend incineration with flue gas scrubbing is preferred. Do not release into environment.
Packaging Disposal: Triple rinse containers, puncture and dispose at authorized hazardous waste facility.
Considerations: Do not mix with municipal waste streams. Prevent dispersal of spilled material and runoff, and contact with soil, waterways, drains, and sewers.
UN Number: 2574
UN Proper Shipping Name: Tri o cresyl phosphate
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Hazard Label: Toxic
Environmental Hazards: Marine pollutant
Special Precautions: Avoid exposure during transport. Emergency response guide and spill kit should accompany bulk loads.
OSHA Status: Regulated hazardous chemical
TSCA: Listed
REACH Registration: Registered, subject to authorization under Annex XIV
SARA 313: Listed as a toxic chemical requiring reporting
Other Regulations: Controlled substance under multiple countries for specific applications. Compliance with international shipping and handling requirements is mandatory. Employers must provide workers with workplace training, regular health surveillance, and access to updated safety information sheets.
