Boxa Chemical Group Ltd
Knowledge

Material Safety Data Sheet: Respiratory Quinone

Identification

Product Name: Respiratory Quinone
Chemical Family: Quinones
Chemical Formula: Varies (commonly C13H8O4 for ubiquinone-1)
Synonyms: Ubiquinone, Coenzyme Q, CoQ10, Benzoquinone derivative
Recommended Use: Laboratory reagent, biochemical research, mitochondrial studies
Supplier Identification: Manufacturer address and emergency contact, including telephone and email details for immediate reference
CAS Number: 1339-63-5 (for ubiquinone-10)
UN Number: Not assigned for common forms
Emergency Contact Number: National poison center and supplier emergency numbers

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal), Skin irritation, Eye irritation
Hazard Statements: Harmful if swallowed or inhaled, Causes mild skin and eye irritation, May cause respiratory tract irritation
Pictograms: Exclamation mark for acute hazard
Precautionary Statements: Avoid contact with skin and eyes, Use in well-ventilated area, Wear protective clothing and eye protection
Signal Word: Warning
Hazard Routes: Inhalation, skin contact, ingestion

Composition / Information on Ingredients

Chemical Name: Ubiquinone (respiratory quinone)
Purity: ≥99% (research grade)
Impurities: Trace solvents and byproducts possible depending on synthesis method
Formula: C59H90O4 (ubiquinone-10); other variants exist based on side-chain length
EC Number: 215-679-5
Component Breakdown: No hazardous additives noted at high purity; consult supplier specifics if used in mixes

First Aid Measures

Inhalation: Move affected person to fresh air and keep comfortable, seek medical attention for persistent symptoms such as coughing or shortness of breath
Skin Contact: Immediately wash skin with plenty of soap and water; remove contaminated clothing; seek medical advice if irritation persists
Eye Contact: Rinse with plenty of lukewarm water for at least 15 minutes, lifting eyelids occasionally; seek immediate medical help if irritation or redness continues
Ingestion: Rinse mouth thoroughly, do not induce vomiting; give water to drink if victim is conscious; contact poison control or physician immediately
Notes for Medical Personnel: Treat symptomatically; monitor for allergic reactions or systemic effects

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, or water spray for larger fires
Unsuitable Extinguishing Media: Direct water jet as it may spread burning material
Specific Hazards: Emits toxic fumes of carbon monoxide, carbon dioxide, and organic vapors under fire conditions
Protective Equipment: Wear self-contained breathing apparatus, chemical-resistant suit, gloves, and face shield
Special Procedures: Keep containers cool by spraying with water to avoid pressure build-up and explosion; avoid inhaling smoke or vapors

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid breathing dust or vapors, put on protective gear
Environmental Measures: Prevent discharge into soil, waterways, drains; alert local authorities if significant spill occurs
Cleanup Methods: Sweep up or absorb liquid with inert material, transfer to a chemical waste container for proper disposal, clean spill area thoroughly with water and detergent
Decontamination: Do not touch or walk through spilled material; use non-sparking tools and equipment during removal

Handling and Storage

Handling Practices: Use in rigorously ventilated spaces, avoid contact with skin, eyes, or clothing, handle away from heat sources, never inhale vapors or dust, use proper grounding for containers
Storage Conditions: Store in tightly closed containers in a cool, dry, and well-ventilated place, shield from direct sunlight, keep away from incompatible substances such as strong oxidizers or acids
Special Precautions: Label all containers clearly, use secondary containment for bulk amounts, limit storage quantities to necessary volumes only

Exposure Controls and Personal Protection

Exposure Limits: Occupational exposure limits not established for most forms; minimizing exposure remains important
Engineering Controls: Employ local exhaust ventilation, fume hoods, and air filtration for large-scale use
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile or similar), lab coat, respiratory protection (N95 mask or higher for powder or vapor exposure)
Hygiene Measures: Wash hands, face, and exposed skin after handling; avoid eating, drinking, or smoking in work areas

Physical and Chemical Properties

Appearance: Orange-yellow crystalline powder
Odor: Faint, characteristic quinone odor
Odor Threshold: Not identified by most references
pH: Not applicable (insoluble in water)
Melting Point: 48-52°C (varies with quinone type and purity)
Boiling Point: Decomposes before boiling
Flash Point: Over 100°C; not classified as highly flammable
Evaporation Rate: Not determined due to low volatility
Flammability: May burn at high temperatures
Vapor Pressure: Negligible at ambient temperature
Solubility: Insoluble in water, soluble in organic solvents such as ethanol or chloroform
Partition Coefficient (n-octanol/water): LogP 10+ for ubiquinone-10; indicates strong lipophilicity
Decomposition Temperature: Above 190°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: May react with strong oxidizing agents
Conditions to Avoid: High temperature, exposure to light or air, sources of ignition
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, assorted volatile organic compounds upon combustion or decomposition
Polymerization: Not known to occur under normal working conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >2000 mg/kg; considered low acute toxicity for most quinones, though irritation possible
Chronic Toxicity: Prolonged or repeated contact may cause dry skin or mild irritation; long-term health effects not fully studied
Eye Effects: May cause redness and watering upon contact
Skin Effects: Possible mild irritation or dermatitis with repeated exposure
Inhalation Effects: Dust may irritate mucous membranes, coughing or shortness of breath in sensitive individuals
Ingestion Effects: Possible gastrointestinal upset if significant amount consumed
Sensitization: Data suggests low risk of skin sensitization; inhalation sensitization not reported
Carcinogenicity: Quinones less likely to show mutagenic effects as a group, but full long-term studies lacking for respiratory quinone

Ecological Information

Ecotoxicity: Limited aquatic toxicity; bioaccumulation possible due to hydrophobic nature
Aquatic Toxicity: EC50 (Daphnia, algae): Not thoroughly assessed, presumed low at standard usage levels
Mobility in Soil: Low water solubility; strong soil adsorption expected
Persistence and Degradability: Biodegradable in natural conditions, slow rate due to high lipophilicity
Bioaccumulative Potential: High due to strong n-octanol/water partition coefficient; monitoring recommended for environmental release
Other Adverse Effects: None reported from standard lab use; unrestricted disposal into environment discouraged

Disposal Considerations

Waste Treatment Methods: Collect in designated chemical waste containers, label appropriately for hazardous organic compounds
Disposal of Residues: Dispose according to local, regional, or national regulations; do not discharge to surface waters, sewers, or general waste
Packaging Disposal: Rinse containers with suitable solvent, puncture if allowed, render unusable; deposit with licensed chemical disposer
Precautions: Never dispose of down laboratory drains; consult institutional guidelines for hazardous chemical waste

Transport Information

UN Number: Not specifically listed for most respiratory quinone compounds
Proper Shipping Name: Organic solid, not otherwise specified (check for further classification if mixed with solvents)
Transport Hazard Class: Not regulated under standard shipping conditions; confirm with carrier if shipping in bulk or internationally
Packing Group: Not assigned unless bundled with hazardous solvents
Environmental Hazards During Transit: Prevent leakage into surface waters during accidental release
Special Precautions: Protect packaging from crushing, store upright, indicate chemical identity on outer cartons

Regulatory Information

Inventory Listings: Listed on major chemical inventories (TSCA, EINECS, DSL, ENCS for ubiquinone-10)
Labeling Requirements: Identify substance and hazards on primary and secondary storage, follow laboratory or workplace rules for chemicals
Regulatory References: OSHA Hazard Communication Standard, EC Regulations for chemical handling, National chemical safety standards
Other Regulations: Workplace-specific rules may apply for storage quantity and use; waste handling and disposal governed by hazardous waste regulations
Restrictions: No consumer restrictions noted; laboratory and industrial use only for research and development in most jurisdictions