Product Name: Pentafluorophenol
Chemical Formula: C6HF5O
CAS Number: 771-61-9
Synonyms: PFP, 2,3,4,5,6-Pentafluorophenol
Recommended Uses: Laboratory reagent, organic synthesis intermediate
Manufacturer Information: Sourced from established chemical suppliers; always verify label and safety protocols from your provider
Emergency Contact: Local authorities or nearest poison control center
Hazard Class: Acute toxicity, skin/eye irritant
Signal Word: Warning
Pictogram: Exclamation mark (irritant), skull and crossbones (toxic)
Hazard Statements: Causes serious eye irritation; may cause respiratory irritation; harmful if inhaled or swallowed; contact with skin may prompt redness or discomfort
Precautionary Statements: Wash skin thoroughly after handling; avoid breathing dust or vapor; use only outdoors or in well-ventilated space; wear eye protection, gloves, and protective clothing
Chemical Name: Pentafluorophenol
Concentration: Typically supplied as pure compound or high-purity solid
Impurity Notice: Trace water or solvent may be present, check specific batch documentation
CAS Number: 771-61-9
Molecular Weight: 182.06 g/mol
Inhalation: Move person to fresh air immediately; seek medical attention if symptoms like coughing, headache, or dizziness persist
Skin Contact: Remove contaminated clothing; wash skin with plenty of soap and water; seek medical advice if irritation develops
Eye Contact: Rinse gently with water for at least 20 minutes, keeping eyelids open; get immediate medical help
Ingestion: Rinse mouth with water, do not induce vomiting; call poison control or a doctor right away
Most Important Symptoms: Respiratory discomfort, severe eye irritation, skin redness, possible nausea
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Specific Hazards during Fire: Decomposition can release toxic fumes including hydrogen fluoride, carbon oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Special Precautions: Keep runoff out of water supplies; cool containers exposed to fire with water spray; evacuate area if necessary; avoid breathing gases, smoke, and particulates from combustion
Personal Precautions: Wear protective clothing, nitrile or neoprene gloves, eye and face protection, and ensure adequate ventilation
Environmental Precautions: Prevent runoff into drains or waterways; contain spills with sand, earth, or inert absorbent
Clean-up Methods: Scoop solid product into a chemical waste container; use moistened paper towels or absorbent pads for trace amounts
Disposal: Dispose of materials through an approved chemical waste disposal contractor
Decontamination: Rinse affected surfaces with soapy water after removal of bulk material
Safe Handling: Avoid dust generation; do not breathe fumes or vapor; minimize contact with skin and eyes; use only in chemical fume hood
Hygiene Practices: Wash hands thoroughly after use; remove contaminated clothing and wash before reuse
Storage Conditions: Store in tightly sealed containers; keep in cool, dry, well-ventilated place, out of direct sunlight and segregated from incompatible substances such as strong bases and oxidizers
Incompatibles: Avoid reactive contact with strong alkalis, oxidizing agents, amines, and water-sensitive substances
Exposure Limits: No established OSHA or ACGIH exposure limits; always limit exposure as much as possible
Engineering Controls: Use local exhaust ventilation or chemical fume hood
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat, and, in dusty or vapor-heavy environments, certified respirator
Workplace Hygiene: Do not eat, drink, or smoke during use; maintain clean work area; use spill trays for additional containment
Appearance: White crystalline powder
Odor: Slight phenolic odor
Melting Point: 84-86°C
Boiling Point: 162-164°C at reduced pressure (20 mmHg)
Vapor Pressure: Low at room temperature
Solubility: Soluble in organic solvents like acetone, ether, and dichloromethane; limited solubility in water
pH: Acidic aqueous solutions
Partition Coefficient (log Kow): Measured at 2.3 (estimate)
Flash Point: Above 100°C (closed cup)
Auto-ignition Temperature: Information not widely available
Density: Approximately 1.68 g/cm³
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: Rapid reaction with strong bases or oxidizers
Conditions to Avoid: High temperatures, ignition sources, moisture, incompatible materials
Decomposition Products: Hydrogen fluoride, carbon oxides, phenolic fragments
Polymerization: Not expected under normal handling and storage
Acute Toxicity: Data shows oral LD50 in rats about 330 mg/kg, indicating moderate toxicity
Inhalation: May irritate mucous membranes and respiratory tract
Skin and Eye Contact: Causes irritation on contact; risk of serious eye damage
Chronic Effects: Long-term repeated exposure can cause skin dryness or cracking, possible respiratory sensitization
Carcinogenicity: Not listed by NTP, OSHA, or IARC as carcinogen
Mutagenicity: Not fully studied; prudent to avoid unnecessary exposure
Other Hazards: All effects more severe in poorly ventilated environment or after exposure to large amounts
Ecotoxicity: Harmful to aquatic organisms; avoid release to environment
Persistence and Degradability: Likely persistent in the environment, fluoroaromatic structure resists biodegradation
Bioaccumulation: Potential for accumulation in aquatic food chains because of hydrophobic nature
Mobility in Soil: Low volatility but may leach through soil under favorable conditions
Other Adverse Effects: Disrupts microbial processes; chemical accumulation could impact small aquatic life and soil bacteria
Safe Disposal Methods: Collect material in sealed containers, label with chemical identity and hazard class, transport to licensed hazardous waste facility
Incineration: Only in chemical incinerator equipped with afterburner and scrubber to neutralize hazardous decomposition gases
Contaminated Packaging: Rinse containers, collect rinse waters as chemical waste; follow local hazardous waste guidelines
Regulatory Disposal Guidance: Follow all applicable federal, state, and local environmental regulations; don’t pour residue into sewers or normal trash
UN Number: Not regulated for most transport scenarios, but treat as hazardous chemical
Proper Shipping Name: Pentafluorophenol, chemical, solid, organic
Hazard Class: Not specifically classified, but use standard hazardous substance protocols
Packing Group: III (estimated), for moderate hazard chemicals
Labels: Toxic, Irritant as appropriate based on concentration and packaging
Special Precautions: Package in leak-proof, double-sealed containers; protect from moisture and breakage during transit; always document quantity, hazard, and emergency contact on shipping manifest
TSCA Status: Pentafluorophenol appears on the US TSCA inventory
REACH Status: European Union importers and manufacturers must assure compliance with REACH registration
SARA/OSHA: Regulated under SARA Title III for reportable toxic substances; OSHA recommends standard handling and hazard communication protocols
Hazard Categories: Immediate (acute) health hazard
Other Regulations: Check national and state/local listings for additional restrictions or requirements; always verify compliance before shipment, purchase, or disposal
Labeling Requirements: Product label must display hazard pictograms, signal words, and precautionary/response measures per GHS standards
