Product Name: Isobutylamido Thiazolyl Resorcinol
Synonyms: Thiazolyl Resorcinol, IBTR
Chemical Family: Amide, Thiazole, Phenol derivative
Recommended Use: Cosmetic ingredient, skin-lightening agent
Supplier Information: Reference trusted biotechnology distributors and chemical suppliers
Emergency Contact: Refer to local poison control center or manufacturer emergency hotline
GHS Classification: Not classified as hazardous in most cosmetic formulations; always confirm local regulations for full hazard statement
Main Hazards: Skin and eye irritation possible upon direct contact; inhalation may cause respiratory irritation in powder form
Health Risks: Prolonged exposure might cause dermatitis or allergic reactions in sensitive users
Appearance-Related Hazards: Dust formation can lead to mild discomfort if inhaled, though not considered highly toxic
Chemical Name: Isobutylamido Thiazolyl Resorcinol
Molecular Formula: C14H16N2O2S
CAS Number: 1246616-47-6
Purity: Typically above 98% for lab and cosmetic production
Impurities: Trace organic solvents, water possible; generally within accepted commercial limits
Other Ingredients: None, unless diluted with carrier substances in proprietary blends
Eye Contact: Rinse with clean, lukewarm water for at least 15 minutes, remove contact lenses, get medical help if irritation remains
Skin Contact: Wash area with soap and water, remove contaminated clothing, medical attention if redness or rash persists
Inhalation: Move individual to fresh air, assist breathing if necessary, seek medical advice if symptoms worsen
Ingestion: Do not induce vomiting, rinse mouth, get immediate medical support if discomfort appears or persists
Extinguishing Media: Use carbon dioxide, dry chemical, foam, or water spray
Fire Hazards: Product is not highly combustible, but thermal decomposition may produce harmful gases including carbon oxides, nitrogen oxides, and sulfur oxides
Protective Equipment: Firefighters should wear standard protective gear and self-contained breathing apparatus at all times
Explosion Data: No unusual explosion risk; dust may form combustible mixtures in air at very high concentrations
Spill Procedure: Isolate area, avoid raising dust; collect material mechanically with appropriate vacuum or non-sparking tools
Personal Precautions: Wear protective gloves, goggles, mask to prevent inhalation or direct skin contact
Environmental Precautions: Prevent product from entering drains, waterways, or soil; contain spill with suitable absorbent
Disposal Concern: Dispose of collected residue in accordance with local, national, and environmental guidelines
Safe Handling: Work in well-ventilated surroundings, avoid breathing powder and direct skin contact
Hygiene Measures: Wash hands thoroughly after handling, prohibit eating and drinking in work areas
Storage Conditions: Keep container tightly sealed, store in a cool, dry, and well-ventilated location away from incompatible chemicals
Storage Incompatibles: Strong oxidizing agents, acids; keep out of reach of unsupervised personnel
Packaging Materials: Use high-density polyethylene, glass, or other chemically resistant containers
Engineering Controls: Local exhaust ventilation, use of closed handling systems in high-volume facilities
Personal Protection: Proper lab coats, gloves (nitrile or neoprene), safety goggles, approved particulate respirator if dust forms
Workplace Exposure Limits: Not established by OSHA or NIOSH for this specific compound; exercise standard practices as with similar powdered chemicals
Environmental Controls: Ensure regular cleaning of surfaces; prevent accumulation of airborne dust
Appearance: Off-white to pale yellow crystalline powder
Odor: Mild or faint, not pungent
pH: Slightly acidic to neutral in solution
Melting Point: Range around 185–190 °C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Over 200 °C
Solubility: Low in water, higher in ethanol, propylene glycol, and certain glycols
Vapor Pressure: Negligible at room temperature
Density: 1.3–1.5 g/cm3
Partition Coefficient: Moderate lipophilicity
Chemical Stability: Stable under normal storage and handling temperatures
Reactivity: Avoid exposure to strong oxidizing agents and acids
Decomposition: Exposure to extreme heat might generate hazardous fumes; always keep away from ignition sources
Polymerization: No risk of hazardous polymerization noted
Acute Toxicity: Oral, dermal, and inhalation toxicity considered low based on available studies
Skin Irritation: Slight to moderate irritation seen in patch tests for sensitive groups
Eye Irritation: May cause redness or stinging upon direct exposure
Chronic Effects: No reliable evidence linking the compound to chronic toxicity, cancer, or mutagenic effects in animal studies
Allergenicity: Reports of contact sensitization rare but possible at high concentrations
Target Organs: Primarily affects the skin on repeated exposure
Sensitization: Occasional allergic reaction possible; discontinue use at first sign of persistent discomfort
Environmental Fate: Degrades slowly in the environment; bioaccumulation potential judged low to moderate
Aquatic Toxicity: Minor toxicity towards fish and aquatic invertebrates at high concentrations; effect in typical use scenarios minimal
Soil Mobility: Tends to bind to organic matter; leaching into groundwater unlikely
Ecotoxicological Data: Limited field data available, though lab-scale tests show moderate persistence
Waste Disposal Methods: Dispose in accordance with regional, national, and local regulations; incineration or chemical landfill preferred for bulk quantities
Containers: Triple-rinse and render unusable before recycling or discarding
Precaution: Never pour into drains, surface water, or uncontrolled locations
UN Number: Not regulated as a dangerous good for ground, air, or sea
Transport Hazard Class: No special classification for standard shipping
Packing Group: None assigned
Transport Labels: Follow standard labeling for chemicals; no hazard symbol required
Precaution in Transit: Protect from moisture and physical damage during shipment
Inventory Status: Listed in major chemical inventories such as TSCA (US), EINECS/ELINCS (EU), AICS (Australia) where applicable
International Regulations: Approved for cosmetic use at limited concentrations in regions including the EU, United States, and Asia
Workplace Regulations: General dust and chemical exposure measures apply; no substance-specific standards set
Labeling: Not classified as hazardous, though safety information should be provided on packaging and safety data sheets
