Chemical Name: 4-Isopropylphenol
Synonyms: p-Isopropylphenol, para-Isopropylphenol, 4-Propan-2-ylphenol
CAS Number: 99-89-8
EC Number: 202-799-1
Molecular Formula: C9H12O
Molecular Weight: 136.19 g/mol
Recommended Use: Laboratory chemicals, chemical synthesis, intermediate for pharmaceuticals and fragrance manufacture
Supplier: Name, address, contact number of the manufacturer or distributor
Emergency Phone: 24-hour emergency contact specific to the supplier
Classification: Skin irritation (Category 2), Serious eye irritation (Category 2A), Acute toxicity—oral (Category 4), Specific Target Organ Toxicity—single exposure (Category 3, narcotic effects)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes skin and eye irritation; may cause respiratory irritation and drowsiness or dizziness
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust, fume, gas, mist, vapors, spray; wash hands thoroughly after handling; use only outdoors in well-ventilated area; wear eye protection and gloves; if in eyes—rinse cautiously with water for several minutes
Substance: 4-Isopropylphenol
Chemical Identity: C9H12O
Purity: ≥98%
Impurities: Phenolic impurities may be present in trace amounts
Concentration: 100% for pure bulk chemical
CAS Number: 99-89-8
Eye Contact: Immediately flush thoroughly with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do. Get medical attention if irritation persists.
Skin Contact: Rinse skin with soap and water, remove contaminated clothing and shoes. Seek medical advice if irritation or redness develops.
Inhalation: Move to fresh air, keep airways open, and rest. If breathing difficulties or symptoms occur, seek medical help.
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel. Seek immediate medical attention. Give victim water if they are fully conscious.
Most important symptoms: Redness, burning or irritation of skin and eyes, possible nausea, headache, respiratory irritation.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Special Hazards: Vapors may form explosive mixtures with air. Combustion products include carbon monoxide and carbon dioxide. Potential for dangerous fumes in a fire.
Protective Equipment: Wear full protective gear, including self-contained breathing apparatus, chemical-resistant suit, gloves, and boots
Advice for Firefighters: Move containers from fire area if safe, cool containers with water spray; avoid inhaling combustion gases
Far Distance Danger: Fight fire from a safe distance due to risk of container rupture and vapor travel
Personal Precautions: Evacuate unnecessary personnel, ventilate area well; use personal protective equipment to avoid skin and eye contact
Methods for Cleaning Up: Contain and collect spillage with non-combustible absorbent material like sand or earth. Place in a chemical waste container. Prevent entry into drains, water courses, and soil.
Environmental Precautions: Avoid release to the environment, do not allow substance to enter sewers or water bodies
Emergency Procedures: Isolate spill area and deny unnecessary entry until clean-up is complete, use spark-proof tools and explosion-proof equipment if spill is large
Handling: Use in a well-ventilated area only, avoid contact with skin, eyes, and clothing, avoid inhalation of vapor or mist. Do not eat, drink, or smoke during use. Wash thoroughly after handling. Ground and bond containers to prevent static discharge.
Storage: Store in a tightly closed container in a cool, dry, well-ventilated place, away from sources of ignition, heat, and direct sunlight. Separate from strong oxidizers and strong acids. Keep container clearly labeled and protected from physical damage.
Incompatible Materials: Strong oxidizing agents, strong acids
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits for 4-Isopropylphenol
Engineering Controls: Use exhaust ventilation to keep airborne concentrations below recommended exposure limits. Emergency eyewash and safety showers must be accessible.
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile, neoprene), lab coat or suitable clothing, and use of approved respiratory protection if exposure limits are exceeded or if ventilation is inadequate.
Hygiene Measures: Do not eat, drink, or smoke in work area. Wash hands before breaks and end of shift. Remove contaminated clothing and wash before reuse.
Appearance: White crystalline solid or powder
Odor: Mild, phenolic odor
Odor Threshold: Not available
pH: Not available
Melting Point: 55–58°C
Boiling Point: 221–223°C
Flash Point: 98°C (closed cup)
Evaporation Rate: Not determined
Flammability: Combustible solid
Vapor Pressure: 0.007 mmHg at 25°C
Vapor Density: Not available
Relative Density: 0.96 g/cm³
Solubility in Water: Slightly soluble
Partition Coefficient (log Kow): 2.90
Auto-ignition Temperature: Not available
Decomposition Temperature: Not determined
Viscosity: Not available
Chemical Stability: Stable under normal conditions and recommended storage conditions
Reactivity: May react with strong oxidizing agents and acids
Hazardous Reactions: Hazardous polymerization does not occur
Decomposition Products: May produce toxic fumes of carbon monoxide and carbon dioxide during thermal decomposition
Conditions to Avoid: Excessive heat, open flames, incompatible materials, and prolonged exposure to light and moisture
Acute Toxicity: Oral LD50 (rat): 890 mg/kg
Skin Contact: Causes irritation, prolonged exposure may cause dermatitis
Eye Contact: Causes serious eye irritation, possible corneal injury
Inhalation: Vapors may cause respiratory irritation, headache, drowsiness, and dizziness
Chronic Effects: No available data on chronic toxicity. Long-term exposure could potentially result in damage to the central nervous system.
Routes of Exposure: Skin, eyes, inhalation, ingestion
Symptoms: Redness, pain, blisters, coughing, shortness of breath
Carcinogenicity: Not listed by IARC, NTP, OSHA as a known carcinogen
Sensitization: Possible allergic reactions in sensitive individuals
Ecotoxicity: Harmful to aquatic life with long lasting effects. Fish LC50 (96 h): 12 mg/L (estimated).
Persistence and Degradability: Likely biodegradable under environmental conditions; persistent in high concentrations in water or soil
Bioaccumulative Potential: Moderate potential for bioaccumulation; log Kow suggests some risk
Mobility in Soil: Limited mobility; partitions to soil and sediment
Other Adverse Effects: May contribute to oxygen demand in aquatic systems if spilled in bulk
Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations. Incinerate in a chemical incinerator equipped with afterburner and scrubber.
Container Disposal: Decontaminate and dispose of empty containers through a licensed contractor.
Contaminated Packaging: Handle as hazardous waste
Do Not: Discharge into drains, surface waters, or soil
UN Number: Not regulated as a hazardous material for transportation
Proper Shipping Name: 4-Isopropylphenol
Transport Hazard Class: Not classified under current transport regulations (ADR/RID, IMDG, IATA)
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant as per IMDG
Special Precautions: Package securely, avoid damage or spills during transit
TSCA (Toxic Substances Control Act): Listed
DSL (Canada): Listed
REACH (European Union): Exempted due to volume; otherwise subject to registration above 1 tonne/year
SARA Title III: Not subject to Section 302, 304, 313 reporting
OSHA Hazard Communication: Hazardous chemical as defined by OSHA
WHMIS (Canada): D2B – Toxic Material Causing Other Toxic Effects
California Prop 65: Not listed as a chemical known to cause cancer or reproductive harm
Other International Inventories: Listed or compliant with most national chemical inventories
