Chemical Name: 4-Aminophenol
Synonyms: p-Aminophenol, 4-Hydroxyaniline, para-Aminophenol
CAS Number: 123-30-8
Product Use: Intermediate in dye manufacture, photographic developer, pharmaceutical ingredient
Manufacturer: Refer to supplier label for specific contact details
Emergency Phone: Refer to the company’s 24-hour emergency contact
GHS Classification: Acute Toxicity (Oral, Dermal), Eye Damage/Irritation, Skin Sensitization
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin, causes serious eye irritation, may cause allergic skin reaction
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear protective gloves and eye protection, do not eat, drink, or smoke during use
Potential Health Effects: Inhalation leads to respiratory tract irritation, skin absorption can cause methemoglobinemia, repeated exposure could cause sensitization
Chemical: 4-Aminophenol
Purity: 98% or higher
Molecular Formula: C6H7NO
Molecular Weight: 109.13 g/mol
Impurities: Trace (<2%) related aromatic amines
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids for thorough irrigation, seek medical attention
Skin Contact: Remove contaminated clothing right away, wash skin vigorously with soap and water, get medical care if irritation persists or symptoms develop
Inhalation: Move exposed person to fresh air without delay, give oxygen if breathing is difficult, perform artificial respiration if not breathing, call medical help
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, get medical advice
Most Common Symptoms: Eye or skin irritation, blue lips or nails, dizziness, headache, risk of methemoglobinemia
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Wear full protective gear and self-contained breathing apparatus
Advice for Firefighters: Isolate area, fight fire from upwind, prevent run-off from entering drains or water courses, cool adjacent containers with water
Personal Precautions: Evacuate area, put on appropriate personal protective equipment
Environmental Precautions: Prevent powder or solution from entering drains, surface water, or soil
Clean-Up Methods: Sweep up and place in a suitable container, avoid generating dust, ventilate the spill area, dispose of in compliance with local regulations
Safe Handling Tips: Avoid contact with skin, eyes, and clothing, use in a chemical fume hood, do not breathe dust
Storage Conditions: Store in tightly closed containers, keep in dry, well-ventilated area, protect from light, store away from incompatible substances like oxidizers and acids
Exposure Limits: ACGIH TLV not established, workplace dust exposure limits apply
Engineering Controls: Use local exhaust ventilation, eye wash facilities, and safety showers
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, laboratory coat, approved respirator if exposure limits are exceeded or dust forms
Appearance: White or yellowish crystalline powder
Odor: Slightly phenolic
Melting Point: 186°C
Boiling Point: Decomposes
Solubility: Moderately soluble in water, soluble in alcohol and ether
pH: 5-6 (1% solution in water)
Density: 1.293 g/cm³
Partition Coefficient (log Pow): 0.47
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable (decomposes)
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with oxidizing agents and strong acids
Hazardous Reactions: May cause formation of toxic fumes under heat or fire
Conditions to Avoid: Excessive heat, moisture, light, open flames
Incompatible Materials: Acids, strong oxidizers, strong bases
Acute Toxicity: Oral LD50 (rat) 375 mg/kg, dermal LD50 not well-documented
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Symptoms: Methemoglobinemia, cyanosis, headache, dizziness, nausea, shortness of breath
Chronic Exposure: May cause skin sensitization, prolonged exposure can affect liver and kidneys
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: Data suggests potential mutagenic risk in certain test systems
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Partial biodegradation occurs in soil and water, not considered readily biodegradable
Bioaccumulative Potential: Low based on partition coefficient
Mobility in Soil: Compound is likely to leach into groundwater due to moderate solubility
Other Adverse Effects: Toxic to fish and invertebrates at low concentrations
Waste Treatment Methods: Dispose of as hazardous chemical waste, use an approved incineration or chemical treatment facility
Contaminated Packaging: Triple rinse, then dispose as chemical waste
Do Not: Dispose to sewer, surface water, or soil
Local Regulations: Follow all applicable federal, state, and local disposal requirements
UN Number: 2512
UN Proper Shipping Name: 4-Aminophenol
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions: Secure packaging, avoid container damage, provide complete documentation for shipping
OSHA: Considered hazardous
SARA Title III: Not listed as an extremely hazardous substance, but subject to reporting under general CERCLA release provisions
TSCA: Listed
REACH Registration: Required for importation or manufacture in the EU
California Proposition 65: Not identified as a chemical known to cause cancer or reproductive toxicity
WHMIS: Class D-2B (Toxic Material Causing Other Toxic Effects)
