Chemical Name: 3-Nitrophenol
Synonyms: m-Nitrophenol, meta-Nitrophenol
CAS Number: 554-84-7
Molecular Formula: C6H5NO3
Molecular Weight: 139.11 g/mol
Recommended Use: Laboratory reagent, intermediate for dyes, pharmaceuticals, and pesticides
Supplier: Manufacturer or distributor details available on request
Emergency Number: Local regulatory authority or 24-hour emergency contact
Classification: Toxic if swallowed, inhaled, or absorbed through skin; irritant to eyes, skin, and respiratory system
GHS Label Elements: Skull and crossbones symbol, exclamation mark, health hazard pictogram
Signal Word: Danger
Hazard Statements: Causes damage to organs, harmful if swallowed, toxic to aquatic life, may cause allergic skin reactions
Precautionary Statements: Avoid skin and eye contact, do not breathe vapor or dust, use only in well-ventilated areas, wash thoroughly after handling
Target Organs: Liver, kidneys, central nervous system
Routes of Exposure: Skin, eyes, ingestion, inhalation
Symptoms of Overexposure: Irritation, headache, dizziness, nausea, weakness, vomiting, cyanosis
Substance: 3-Nitrophenol
Chemical Formula: C6H5NO3
Concentration: 100% (pure substance), no significant impurities
CAS No: 554-84-7
Eye Contact: Immediately flush with plenty of water for at least 15 minutes, seek medical attention
Skin Contact: Rinse skin with water for 15 minutes, remove contaminated clothing, get medical help
Inhalation: Move person to fresh air, keep at rest, provide oxygen if breathing is difficult, consult a doctor
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical care
Rescue Precautions: Use personal protective equipment to prevent exposure, provide care only if safe to do so
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Media: Strong water jet (can spread material)
Hazardous Combustion Products: Toxic fumes of nitrogen oxides, carbon oxides
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Fire and Explosion Hazards: Dust can form explosive mixtures with air, containers can burst in fire
Firefighting Instructions: Stay upwind, evacuate area, prevent water runoff from entering drains or waterways
Personal Precautions: Wear chemical-resistant gloves, goggles, protective clothing, respirator if dust present
Spill Cleanup Procedures: Ventilate affected area, avoid generating dust, collect material using inert absorbent, place in container for disposal
Environmental Precautions: Prevent spill from entering drains, sewers, or water sources
Decontamination: Wash spill site after cleanup is complete, dispose of all waste according to local regulations
Precautions for Safe Handling: Handle in chemical fume hood, use personal protective equipment, avoid contact with skin and eyes, do not breathe dust or vapors
Advice on General Occupational Hygiene: Do not eat, drink, or smoke when working with chemicals, wash hands after use, keep work area clean
Storage Conditions: Store in tightly closed containers, in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers and reducing agents
Incompatible Materials: Strong bases, strong oxidizers, reducing agents
Storage Class: Toxic substances, store separately from food and feedstuffs
Exposure Limits: No established OSHA or ACGIH limits; minimize exposure due to toxicity
Engineering Controls: Use chemical fume hood, local exhaust ventilation, closed systems
Personal Protective Equipment: Nitrile gloves, safety goggles, lab coat, mask or respirator (NIOSH-approved for dust/fume), face shield for large volume handling
Environmental Controls: Prevent release into environment, use spill containment
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing promptly
Appearance: Pale yellow to light brown crystalline solid
Odor: Slightly phenolic
Melting Point: 96 to 98°C
Boiling Point: 279°C at standard pressure
Solubility: Moderately soluble in water, soluble in alcohol and ether
Vapor Pressure: Low at room temperature
Density: About 1.48 g/cm3 at 20°C
pH: Acidic in aqueous solution
Flash Point: Not readily flammable
Auto-ignition Temperature: Not determined
Explosive Properties: Dust may present risk in air
Partition Coefficient (log Kow): 1.47
Chemical Stability: Stable under standard conditions, sensitive to light
Reactivity: May react with strong oxidizers, strong bases, reducing agents
Possibility of Hazardous Reactions: Strong exothermic reactions with incompatible chemicals
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, toxic vapors
Conditions to Avoid: Heat, open flame, sunlight, moisture, incompatible materials
Polymerization: Does not undergo hazardous polymerization
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat) about 210 mg/kg, toxic by inhalation and skin absorption
Effects on Health: Irritation to skin, eyes, respiratory tract; systemic toxicity including headache, dizziness, cyanosis, convulsions
Chronic Exposure: Risk of organ damage, mutagenicity not ruled out, possible impacts on reproductive health in animal studies
Symptoms: Nausea, vomiting, difficulty breathing, anemia, methemoglobinemia
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Sensitization: May cause allergic reactions in susceptible individuals
Additional Toxicological Information: Data on effects in humans limited, handle with appropriate caution
Ecotoxicity: Harmful to aquatic organisms, may cause long-term negative effects in aquatic environments
Persistence and Degradability: Degrades slowly under standard environmental conditions
Bioaccumulation Potential: Moderate risk of bioaccumulation
Mobility in Soil: Likely to leach into groundwater in large spills
Results of PBT and vPvB Assessment: Does not meet full criteria for persistent, bioaccumulative, or toxic but presents environmental risks
Other Adverse Effects: Avoid release to natural waters; follow local guidelines for disposal
Waste Treatment Methods: Dispose as hazardous chemical waste
Disposal Containers: Place material and contaminated items into approved, sealed containers
Incineration: Use approved facility with gas scrubbing systems to limit atmospheric contaminants
Sewer Disposal: Never discharge into drains, surface waters, or soil
Contaminated Packaging: Treat as hazardous waste, triple rinse before disposal, comply with all local and national regulatory requirements
Recommended Handling: Contact licensed disposal service, provide MSDS information to service provider
UN Number: 2662
UN Proper Shipping Name: Nitrophenols, solid (including 3-Nitrophenol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (substances presenting a minor risk in transport)
Environmental Hazards: Toxic to the aquatic environment, may require marine pollutant labeling
Transport Conditions: Keep well-sealed, upright, separate from incompatible substances, report leaks or spills promptly to authorities
Special Precautions: Emergency response documentation required on vehicles
OSHA: Regulated as hazardous chemical with mandatory safety training
SARA Title III: May be listed due to acute toxicity, check Section 313 for reporting requirements
TSCA Status: Listed in inventory
RCRA: Classified as hazardous waste, requires special handling and tracking
EU Regulations: Classified as toxic and dangerous for the environment, full hazard labeling necessary
California Proposition 65: Not listed but handle as hazardous
Other Applicable Laws: Compliance with all state, federal, and international transportation, storage, and use regulations is critical
