Product Name: 3-Bromophenol
Chemical Formula: C6H5BrO
CAS Number: 591-20-8
Synonyms: Meta-Bromophenol, m-Bromophenol
Recommended Uses: Laboratory reagent, chemical synthesis intermediate, pharmaceutical research
Manufacturer Information: Supplier contact details required for shipment or large-scale purchase; laboratory procurement often involves chemical distributors specializing in research-grade materials.
GHS Classification: Acute Toxicity (Oral, Category 4), Skin Irritant (Category 2), Eye Irritant (Category 2A)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation; harmful if swallowed; inhalation of vapors can irritate the respiratory system.
Precautionary Statements: Wash exposed skin thoroughly after handling; avoid inhaling dust, vapor, or spray; wear protective gloves and eye protection.
Potential Health Effects: Contact with eyes and skin can cause redness, pain, or allergic response; ingestion can lead to gastrointestinal upset, headache, nausea; inhalation may cause sore throat, dizziness.
Substance Name: 3-Bromophenol
Chemical Identity: Pure substance
Concentration: Typically >99% by weight for laboratory use
Impurities: Minor organic contaminants possible (<1%), usually specified by manufacturer certificate of analysis
Molecular Weight: 173.01 g/mol
General Notes: Move individual from exposure area into fresh air immediately; trained personnel should use gloves and appropriate personal protective equipment before assistance.
Eye Contact: Rinse with water for 15 minutes, remove contact lenses if present and easy, continue flushing; seek medical attention for persistent irritation.
Skin Contact: Wash exposed skin with soap and water; remove contaminated clothing and shoes; laundering required before reuse. Contact a healthcare provider if irritation or redness persists.
Inhalation: Take the person outdoors or to well-ventilated space; keep at rest and comfortable for breathing; medical evaluation always required following chemical inhalation.
Ingestion: Rinse mouth out with water, do not induce vomiting; seek immediate medical attention; keep victim calm and avoid giving liquid without advice from medical professionals.
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical powder; use appropriate extinguishing agent for surrounding fire.
Specific Hazards: During combustion, produces toxic fumes including hydrogen bromide, carbon monoxide, carbon dioxide; dense smoke may reduce visibility.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus; chemical-resistant clothing required; avoid inhalation of combustion products.
Firefighting Measures: Cool closed containers exposed to fire with water spray; move containers from fire area if possible without risk.
Personal Precautions: Evacuate personnel to safe areas; use respiratory protection in case of vapors; safety goggles, gloves, and lab coat recommended for all spill response.
Environmental Precautions: Prevent runoff or release into drains, surface water, and soil; contain spillage using absorbent inert material.
Method for Containment and Cleaning: Avoid dust formation; scoop up or absorb material, transfer to secure chemical waste container; wet mop residues; ventilate area and wash surfaces thoroughly.
Reporting: Notify regulatory authorities if chemical escapes to environment, as per local compliance rules.
Precautions for Handling: Maintain good industrial hygiene; avoid contact with skin, eyes, and clothing; never eat, drink, or smoke in working area; handle only in a chemical fume hood or ventilated area
Storage Requirements: Store in tightly closed, chemically resistant container; label storage vessel clearly with hazard information; keep at controlled room temperature away from direct sunlight; isolate from incompatible materials such as strong oxidizers and acids
Incompatibility: Strong bases, oxidizing agents, reducing agents
Special Storage Instructions: Secondary containment suggested for large volumes; proper shelving to prevent accidental fall or breakage.
Occupational Exposure Limits: No established OSHA, ACGIH limits for 3-Bromophenol, local regulations may apply
Engineering Controls: Use fume hood or proper exhaust ventilation; avoid aerosol and vapor formation
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles, long-sleeved lab coat likely to provide effective barrier
Respiratory Protection: Required in poorly ventilated environments or handling bulk quantities; NIOSH-approved cartridge respirators for organic vapors preferred
Hygiene Measures: Wash hands thoroughly after handling; remove and wash protective clothing after chemical use; avoid bringing contaminated equipment or clothing outside work area.
Appearance: Off-white to pale beige crystalline solid
Odor: Phenolic, sharp
Odor Threshold: Not available
pH: Slightly acidic (aqueous solution)
Melting Point: 63-66°C
Boiling Point: 238°C
Flash Point: 119°C (closed cup)
Evaporation Rate: Not determined
Flammability: Not highly flammable but combustible
Vapor Pressure: Low at room temperature
Solubility: Slightly soluble in water, miscible in many organic solvents (ethanol, ether)
Density: 1.74 g/cm³
Partition Coefficient (n-octanol/water): Estimated 2.4
Autoignition Temperature: Not available
Decomposition Temperature: Above 250°C
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Low, but susceptible to slow oxidation in presence of air
Incompatible Materials: Strong oxidizers, strong bases, strong acids
Hazardous Decomposition Products: In high heat or fire, expect formation of toxic gases such as hydrogen bromide and carbon oxides
Polymerization Hazard: Does not polymerize under normal laboratory conditions.
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: May cause moderate toxicity based on animal studies and phenolic compound profiles; oral LD50 (rat): estimated 700-900 mg/kg
Skin Corrosion/Irritation: Definite irritation, possible allergic response
Serious Eye Damage/Eye Irritation: Irritant; potential for corneal injury with direct exposure
Respiratory Effects: Irritation to upper respiratory tract, coughing, sore throat
Mutagenicity/Carcinogenicity: No long-term animal studies available; not classified as carcinogen by IARC, NTP, or OSHA
Other Effects: Overexposure may amplify toxicity symptoms; prolonged exposure often not recommended without robust risk controls.
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects; acute LC50 in fish estimated in low mg/L range
Persistence and Degradability: Not easily biodegradable; may persist in environment for extended period
Bioaccumulative Potential: Potential for concentration in aquatic organisms due to moderate partition coefficient
Mobility in Soil: Moderate mobility; may leach to groundwater under certain conditions
Other Adverse Effects: Large accidental releases to waterways may cause local disruption of aquatic ecosystems.
Waste Treatment Methods: Collect and containerize waste for delivery to licensed hazardous waste disposal facility; never discharge into sewer or surface water
Contaminated Packaging: Triple-rinse and discard as hazardous chemical waste; labeling of containers with content and hazard is non-negotiable for safety
Special Instructions: Follow national and local regulations concerning disposal; consult environment or waste safety officer at institution for best practices.
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 3-Bromophenol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Toxic (skull and crossbones); exact labeling requirements often depend on amount, packaging, and destination
Environmental Hazards: Possibly hazardous to aquatic environment—special transport provisions may restrict inland transport or air shipment
Special Precautions: Secure containers, keep upright, avoid conditions leading to leakage or accidental release.
TSCA Status: Listed on TSCA inventory (United States)
EU Regulation: Registered under REACH regulations; restrictions apply for commercial and industrial use
OSHA Status: Considered hazardous chemical under OSHA Hazard Communication Standard
WHMIS Classification: D2B (Toxic material causing other toxic effects)
Other Regulations: SARA Title III (313) listed, subject to reporting requirements; always check current regulations prior to purchase, use, or shipment across borders.
