Product Name: 2-Nitro-p-Cresol
Chemical Formula: C7H7NO3
Chemical Family: Nitrophenols
Synonyms: 4-Methyl-2-nitrophenol, p-Cresol-2-nitro
CAS Number: 88-75-5
Recommended Use: Laboratory research, chemical synthesis
Restrictions on Use: Avoid non-industrial and non-laboratory settings
Manufacturer/Supplier: Refer to manufacturer SDS
Emergency Contact Number: Local Poison Control Center, Emergency Medical Services
GHS Classification: Acute Toxicity – Oral (Category 4), Skin Irritation (Category 2), Eye Irritation (Category 2A), Specific Target Organ Toxicity – Single Exposure (Category 3)
Label Elements: Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes skin and eye irritation; may cause respiratory irritation.
Pictograms: Exclamation Mark
Precautionary Statements: Do not breathe dust or fumes, wear protective gloves and eye protection, wash hands thoroughly after handling.
Other Hazards: Dust may form explosive mixtures in air, avoid static discharge.
Chemical Name: 2-Nitro-p-Cresol
Concentration: ≥ 99% by weight
Impurities: May include small traces of structurally related nitrophenols
Additives: No stabilizing agents typically added
Inhalation: Remove person to fresh air, keep at rest, seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical attention if irritation persists.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical care.
Ingestion: Rinse mouth with water, do not induce vomiting, get medical assistance right away.
Most Important Symptoms: Coughing, shortness of breath, skin or eye irritation, headache, nausea.
Notes to Physician: Treat symptomatically; for severe exposures consider monitoring for methemoglobinemia.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray.
Unsuitable Extinguishing Media: Water jet may scatter powder.
Hazards: Thermal decomposition releases toxic gases such as nitrogen oxides and carbon monoxide.
Protective Equipment: Self-contained breathing apparatus, full protective gear.
Special Procedures: Keep run-off water out of drains and sewers, use water spray for cooling containers.
Personal Precautions: Avoid dust formation, ventilate area, use appropriate personal protective equipment including gloves and goggles.
Environmental Precautions: Prevent entry into sewers, surface or ground water, contain product with sand or inert material.
Methods for Cleaning Up: Scoop or vacuum up without generating dust, place in labeled containers for disposal, flush area with water if feasible and safe.
Reference to Other Sections: Refer to sections on personal protection and disposal for handling of materials after spillage.
Handling: Handle in a chemical fume hood, avoid breathing dust or fumes, keep container tightly closed, ground equipment to prevent static discharge.
Hygiene Practices: Do not eat, drink, or smoke during use, wash hands and any contacted skin before breaks or leaving work area.
Storage: Store in original container, tightly sealed and clearly labeled in a dry, cool, well-ventilated area, isolate from incompatible substances such as oxidizing agents and strong acids.
Recommended Container Materials: Glass or specific chemical-resistant packaging.
Incompatibilities: Strong acids, reducing agents, bases, combustible material.
Occupational Exposure Limits: No established ACGIH TLV or OSHA PEL, minimize exposure.
Engineering Controls: Local exhaust ventilation, safety shower and eyewash station.
Respiratory Protection: Use NIOSH-approved respirator if dust or vapor concentration exceeds safe levels.
Skin Protection: Chemical-resistant gloves, lab coats or aprons.
Eye/Face Protection: Safety goggles or face shield.
Environmental Exposure Controls: Minimize release to the environment through closed processes and proper waste containers.
Appearance: Yellow to orange crystalline solid.
Odor: Characteristic, phenolic.
Odor Threshold: Not established.
pH (aqueous solution): Slightly acidic.
Melting Point/Freezing Point: About 116–120°C.
Boiling Point: Decomposes prior to boiling.
Flash Point: Not established, expected to be above room temperature.
Evaporation Rate: Not available.
Flammability: Not classified as flammable.
Vapor Pressure: Very low at room temperature.
Vapor Density: Not applicable.
Relative Density: 1.3–1.4 g/cm³ (estimate).
Solubility: Slightly soluble in water, soluble in organic solvents.
Partition Coefficient (log Kow): Not readily available.
Auto-Ignition Temperature: Not available.
Decomposition Temperature: Not determined.
Viscosity: Solid at room temperature.
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Non-reactive under normal handling.
Conditions to Avoid: Heat, open flame, direct sunlight, moisture, incompatible materials.
Incompatible Materials: Strong acids, strong bases, reducing agents, oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Polymerization: No hazardous polymerization expected.
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Symptoms: May cause headache, dizziness, cough, respiratory irritation, skin and eye redness or pain, gastrointestinal discomfort if swallowed.
Acute Toxicity: Data limited, based on structurally similar nitrophenols LD50 oral rat estimated at ~200–600 mg/kg.
Chronic Health Effects: Repeated or prolonged exposure may cause damage to nervous system, blood, liver, kidneys.
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA.
Reproductive Effects: No data available for this specific compound.
Mutagenicity: Not sufficiently studied.
Other Toxic Effects: Risk of methemoglobinemia with high exposure.
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Poorly biodegradable, can persist in soil and water.
Bioaccumulation Potential: Moderate, due to limited water solubility and persistence.
Mobility in Soil: Low to moderate, likely to bind to soil particles.
Other Adverse Effects: Avoid release into the environment; no known ozone depletion potential.
Waste Treatment Methods: Dispose of in accordance with local, regional, national, and international regulations.
Waste Disposal Recommendations: Incineration in a licensed facility, do not release into drains or the environment.
Contaminated Containers: Rinse thoroughly before recycling or disposal, manage as hazardous waste.
Special Precautions: Use services of a licensed hazardous waste disposal company for large quantities or laboratory-scale disposal.
UN Number: UN2811
UN Proper Shipping Name: Toxic Solid, Organic, N.O.S. (Contains 2-Nitro-p-Cresol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant.
Special Transport Precautions: Protect from physical damage, prevent spillage during transport, follow regulatory requirements for transport of hazardous materials.
Regulatory Transport Labels: Toxic Substances
OSHA Status: Hazardous chemical according to OSHA Hazard Communication Standard.
TSCA (Toxic Substances Control Act): Listed.
DSL/NDSL (Canada): Listed or reporting required.
SARA Title III (Sections 311/312): Acute health hazard.
CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act): Not assigned a reportable quantity.
California Proposition 65: Not listed.
WHMIS Classification (Canada): D2B (Toxic material causing other toxic effects).
Other International Regulations: Comply with EU REACH and international chemical regulatory requirements where relevant.
