Product name: 2-Aminophenol
Synonyms: o-Aminophenol, 2-Hydroxyaniline
CAS number: 95-55-6
Molecular formula: C6H7NO
Molecular weight: 109.13 g/mol
Recommended use: Laboratory reagent, photographic developer, dye intermediate
Supplier: Standard chemical distributor or manufacturer contact details
GHS classification: Acute toxicity (Oral) Category 4, Skin irritation Category 2, Eye irritation Category 2A, Specific target organ toxicity (single exposure) Category 3
Signal word: Warning
Hazard statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gloves, eye protection, and respiratory protection if dust exposure cannot be avoided.
Hazard pictograms: Exclamation mark
Most important hazards: Potential respiratory and skin sensitization; eye and gastrointestinal tract irritation
Chemical Name: 2-Aminophenol
Concentration: >99%
CAS Number: 95-55-6
EC Number: 202-431-1
Impurities contributing to hazard: None reported at significant levels
Stabilizers or additives: Not present in typical pure material
After inhalation: Move to fresh air immediately. If breathing becomes difficult, provide oxygen and get medical attention. Seek emergency care for persistent cough or symptoms.
After skin contact: Wash skin with plenty of soap and water. Remove contaminated clothing and footwear. Get medical attention for persistent irritation or if symptoms develop.
After eye contact: Rinse cautiously with water for several minutes, lifting eyelids to ensure thorough flushing. Remove contact lenses if present and easy to do. Continue rinsing and get medical assistance as soon as possible.
After ingestion: Rinse mouth with water without swallowing. Do not induce vomiting unless directed by medical personnel. Give water, seek medical advice immediately.
Most important symptoms: Irritation to mucous membranes, eyes, skin; possible respiratory distress; nausea or headache possible after exposure
Extinguishing media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide for fire involving 2-Aminophenol.
Specific hazards: Combustion produces irritating or toxic gases including nitrogen oxides, carbon monoxide, carbon dioxide.
Advice for firefighters: Wear self-contained breathing apparatus and full protective clothing.
Explosion hazard: Dust may form explosive mixtures with air in confined spaces.
Special protective equipment: Positive pressure SCBA, chemical splash suit to prevent skin contact and inhalation of hazardous fumes.
Personal precautions: Evacuate area. Avoid breathing dust or vapors. Wear protective gloves, dust mask, goggles, and appropriate clothing.
Environmental precautions: Prevent entry to sewers, stormwater drains or watercourses using sand or earth to contain spillage.
Methods for cleanup: Collect spill with inert absorbent material (sand or earth). Sweep up and transfer to a suitable, clearly labeled container for disposal. Avoid generating dust.
Reference to other sections: See Section 8 for protective equipment and Section 13 for disposal guidelines.
Handling: Work in a well-ventilated area or with local exhaust extraction. Minimize dust generation and accumulation. Keep containers closed when not in use. Wash thoroughly after handling and before eating, drinking, or smoking.
Storage: Store in a cool, dry, well-ventilated place away from heat sources, incompatible substances like strong oxidizers, acids, and bases. Protect from moisture and light. Keep container tightly closed and properly labeled.
Engineering controls: Use local exhaust ventilation or process enclosure to maintain airborne concentrations below recommended exposure limits.
Occupational exposure limits: No OSHA PEL, ACGIH TLV, or NIOSH REL specifically established for 2-Aminophenol; keep exposure as low as practicable.
Personal protection: Use chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, protective clothing to reduce skin exposure. Respirator relying on workplace assessment when dust exceeds exposure limits.
Hygiene measures: Wash hands, forearms, and face after use; remove contaminated clothing and clean before reuse; avoid eating or drinking during handling.
Appearance: White to off-white crystalline powder
Odor: Faint, amine-like
Odor threshold: Not determined
pH: Slightly basic, soluble in water
Melting point: 170-174 °C
Boiling point: Decomposes
Solubility: Soluble in water, ethanol, ether
Vapor pressure: Negligible at room temperature
Relative density: 1.293 g/cm³
Flash point: >80 °C (closed cup)
Partition coefficient (log Kow): Not available
Auto-ignition temperature: Data not available
Decomposition temperature: Above melting point
Viscosity: Not applicable
Chemical stability: Stable under normal conditions of storage and handling.
Conditions to avoid: Heat, sparks, open flame, moisture, static discharge.
Incompatible materials: Strong oxidizers, strong acids and bases.
Hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide, other toxic or irritating gases.
Possibility of hazardous reactions: Reacts with oxidants, can form combustible dust concentrations in air.
Likely routes of exposure: Skin, eyes, inhalation, ingestion
Acute toxicity: Oral LD50 (rat): 375 mg/kg; skin and inhalation toxicity data not conclusive
Skin irritation: Causes irritation with possible redness and discomfort
Eye irritation: Causes pain, redness, watering; possible conjunctivitis
Respiratory effects: Cough, throat irritation, shortness of breath if inhaled
Sensitization: No strong evidence for dermal sensitization in humans
Chronic effects: Repeated exposure may cause skin dermatitis or effects on blood (methemoglobinemia reported for related compounds)
Carcinogenicity/mutagenicity: Not classified as carcinogenic in humans by IARC, NTP, or OSHA; data insufficient for mutagenicity or reproductive toxicity.
Toxicity: Harmful to aquatic life; LC50 (fish, 96hr): 57 mg/L. Data for invertebrates and plants show moderate toxicity.
Persistence and degradability: Moderately biodegradable under typical environmental conditions.
Bioaccumulation: Low potential for bioaccumulation (no significant log Kow value).
Mobility in soil: Mobile in most soils due to water solubility.
Other adverse effects: Disrupts local ecosystems at high concentrations; best to minimize release into the water supply or environment.
Disposal: Manage as hazardous chemical waste in accordance with local, state, and national regulations. Do not dispose down the drain, into surface water, or landfill without proper authorization.
Unused product: Recycle or dispose at permitted facility.
Contaminated packaging: Empty containers should be rinsed thoroughly and treated as hazardous waste.
Special precautions: Wear appropriate protective gear during cleanup or disposal.
Physical/chemical properties affecting disposal: Combustible; avoid mixing with incompatible waste streams.
UN number: Not regulated in small quantities, may be listed as UN 2811 (toxic solid, organic, n.o.s.) in some regions.
Proper shipping name: 2-Aminophenol or hazardous solid, organic NOS.
Transport hazard class: 6.1 (toxic substances), variable by region and concentration
Packing group: III (for significant quantities)
Environmental hazards: Not a marine pollutant but should avoid accidental spillage.
Special precautions for transport: Secure packaging, avoid dust generation, cushion against physical shock to containers.
US TSCA: Listed
EU EINECS/ELINCS: 202-431-1
SARA Title III: Not subject to SARA 302; SARA 313 reportable chemical in some US states
OSHA HazCom: Hazardous chemical
WHMIS (Canada): D2B (toxic material causing other toxic effects)
REACH status: Registered substance in the EU
Other regulations: Follow local workplace safety rules and chemical hygiene practices specific to 2-Aminophenol or related aromatic amines
