Product Name: 2,5-Di-Tert-Butylhydroquinone
Synonyms: DTBHQ
Chemical Formula: C14H22O2
CAS Number: 88-58-4
Recommended Use: Antioxidant, laboratory reagent
Supplier: Chemical manufacturers, research providers
Contact Details: Refer to supplier’s emergency contact information on sourcing documentation
Emergency Contact: National Poison Control Center or company emergency number
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2, Eye Irritation Category 2A, Specific Target Organ Toxicity (Single Exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Use personal protective equipment, avoid inhalation and contact with skin or eyes, wash thoroughly after handling, seek medical advice if necessary
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Hazard Overview: Prolonged or repeated exposure might aggravate effects, particularly through respiratory and dermal routes, and can lead to organ effects with chronic exposure.
Chemical Name: 2,5-Di-Tert-Butylhydroquinone
CAS Number: 88-58-4
Concentration: ≥98% pure substance
Impurities: Minor related compounds possible due to manufacturing process
Stabilizers/Additives: Typically none present in pure laboratory material
Inhalation: Remove victim to fresh air immediately, keep at rest in a position comfortable for breathing, administer artificial respiration if breathing has stopped, seek medical attention if symptoms persist
Skin Contact: Take off contaminated clothing, rinse skin with water or shower for at least 15 minutes, consult medical personnel if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, get medical attention if irritation remains
Ingestion: Rinse mouth, offer water if conscious, do not induce vomiting, call a poison center or physician, monitor for delayed effects
Most Important Symptoms: Burning, itching, redness on skin or eyes, throat irritation and headache if inhaled, nausea or gastrointestinal discomfort if ingested
Notes to Physician: Treat symptomatically, monitor for respiratory distress or serious eye damage
Suitable Extinguishing Media: Water spray, dry chemical powder, alcohol-resistant foam, carbon dioxide
Unsuitable Media: Direct water jet may spread powders
Specific Hazards: May release irritating or toxic fumes such as carbon oxides on combustion
Protective Equipment for Firefighters: Wear full protective gear including self-contained breathing apparatus
Advice for Firefighters: Move containers away from fire area if it can be done without risk, cool exposed containers with water spray, avoid inhaling combustion products
Personal Precautions: Evacuate unnecessary personnel, wear appropriate protective equipment, avoid dust formation
Environmental Precautions: Prevent entry into drains, sewers, or waterways
Methods for Clean-Up: Collect spillage with non-sparking tools, sweep up and place in appropriately labeled containers, ventilate area, wash spill site after material pickup completed
Disposal of Contaminated Materials: Handle as chemical waste under regulatory requirements
Safe Handling Guidelines: Use in well-ventilated spaces, avoid creation of dust or aerosols, avoid contact with eyes, skin, and clothing
Hygiene Recommendations: Wash hands after handling, do not eat, drink or smoke during use, clean contaminated clothing before reuse
Storage Requirements: Store in tightly closed containers in cool, dry, well-ventilated area, keep away from strong oxidizers, acids, and incompatible materials, protect from light
Incompatibilities: Strong oxidizing agents, acid chlorides, acid anhydrides
Control Parameters: No occupational exposure limits established; maintain airborne concentrations as low as practicable
Engineering Controls: Use fume hood or local exhaust ventilation for large scale handling
Personal Protective Equipment: Safety goggles, protective gloves (chemical-resistant materials), lab coat, recommended respiratory protection for dusty conditions or inadequate ventilation
Environmental Exposure Controls: Avoid release to environment, use containment traps or filters where feasible
Appearance: White to off-white crystalline powder
Odor: Mild, not significant
pH: Not applicable (insoluble in water)
Melting Point/Freezing Point: 127-130°C
Boiling Point: Not established (decomposes before boiling)
Flash Point: >113°C (closed cup, estimate)
Flammability: May be combustible as dust
Vapor Pressure: Negligible at 20°C
Density: 1.044 g/cm³ at 20°C
Solubility: Practically insoluble in water, soluble in organic solvents such as ethanol and ether
Partition Coefficient n-octanol/water (log Kow): Estimated at 4.2
Decomposition Temperature: Data not fully established
Other Data: Stable under recommended storage conditions, forms dust easily if disturbed
Chemical Stability: Stable under normal conditions of storage and use
Possibility of Hazardous Reactions: No polymerization expected, may react exothermically with strong oxidizers or acids
Conditions to Avoid: Heat, light, moisture, incompatibles as previously mentioned
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Under combustion, may release carbon monoxide, carbon dioxide, possibly other toxic fumes
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Harmful if swallowed (oral rat LD50 ~1800 mg/kg based on related hydroquinone compounds)
Skin Corrosion/Irritation: Causes irritation when in prolonged contact
Serious Eye Damage/Irritation: Risk of serious injury with direct exposure
Respiratory or Skin Sensitization: May cause allergic reactions in sensitive individuals on repeated or prolonged exposure
Germ Cell Mutagenicity: No data available
Carcinogenicity: Not classified as carcinogenic by IARC, ACGIH, NTP, or OSHA
Reproductive Toxicity: No data confirming reproductive or developmental toxicity
Target Organ Toxicity: Possible liver, kidney, or airway effects with significant exposure
Aspiration Hazard: Not anticipated due to physical state
Ecotoxicity: No comprehensive data; related hydroquinones show toxicity to aquatic organisms
Persistence and Degradability: Not readily biodegradable, may remain in environment for extended periods
Bioaccumulative Potential: High log Kow suggests possible bioaccumulation
Mobility in Soil: Limited mobility due to low water solubility, likely to adsorb to soil and sediments
Other Adverse Effects: Possible long-term adverse effects to aquatic environments from persistent material
Disposal Methods: Handle in accordance with local, regional, and national regulations for hazardous chemical waste
Product Disposal: Burn in a controlled, permitted incinerator or dispose of via licensed chemical waste contractors
Contaminated Packaging: Rinse and dispose, or collect for controlled incineration, never reuse containers for unrelated purposes
Special Precautions: Do not release into environment, maintain closed waste containers
UN Number: Not classified as dangerous for transport under most international regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not considered a marine pollutant
Transport in Bulk: Follow chemical hygiene and regulatory policies for bulk transport
Special Precautions: Protect against physical damage or moisture during transit, prevent loss of container integrity
OSHA Status: Not specifically listed under hazardous chemicals, general Laboratory Standard applies
SARA Title III: Not subject to reporting requirements under Sections 302, 304, or 313
TSCA Status: Listed
REACH Status (EU): Pre-registered or exempted, confirm with supplier for status
WHMIS (Canada): Classified as hazardous under Canadian regulations
Other International Lists: Included in inventories in Australia (AICS), Japan (ENCS), Korea (KECL), China (IECSC), Philippines (PICCS)
Label Requirements: Comply with GHS/CLP labeling for user safety and hazard communications
Restrictions: Ensure workplace controls and training on chemical safety, monitor for changes in jurisdictional regulations affecting use or disposal
